Motif ID: Tlx1

Z-value: 1.046


Transcription factors associated with Tlx1:

Gene SymbolEntrez IDGene Name
Tlx1 ENSMUSG00000025215.9 Tlx1



Activity profile for motif Tlx1.

activity profile for motif Tlx1


Sorted Z-values histogram for motif Tlx1

Sorted Z-values for motif Tlx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tlx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_43730593 6.308 ENSMUST00000027217.8
 1500015O10Rik
RIKEN cDNA 1500015O10 gene
chr4_+_48045144 5.928 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr1_-_56969864 5.399 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr7_+_130936172 5.057 ENSMUST00000006367.7
 Htra1
HtrA serine peptidase 1
chr6_+_54681687 4.410 ENSMUST00000046276.6
 2410066E13Rik
RIKEN cDNA 2410066E13 gene
chr7_-_97417730 4.264 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr12_-_78983476 3.970 ENSMUST00000070174.7
 Tmem229b
transmembrane protein 229B
chr6_+_135362931 3.804 ENSMUST00000032330.9
 Emp1
epithelial membrane protein 1
chr1_+_185454803 3.623 ENSMUST00000061093.6
 Slc30a10
solute carrier family 30, member 10
chr2_-_25470031 3.549 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr18_-_78206408 3.455 ENSMUST00000163367.1
 Slc14a2
solute carrier family 14 (urea transporter), member 2
chr16_+_90831113 3.410 ENSMUST00000037539.7
ENSMUST00000099543.3
 Eva1c

eva-1 homolog C (C. elegans)

chr11_-_116654245 3.388 ENSMUST00000021166.5
 Cygb
cytoglobin
chr8_-_109251698 3.140 ENSMUST00000079189.3
 4922502B01Rik
RIKEN cDNA 4922502B01 gene
chr18_-_78123324 2.985 ENSMUST00000160292.1
ENSMUST00000091813.5
 Slc14a1

solute carrier family 14 (urea transporter), member 1

chr6_+_55452177 2.941 ENSMUST00000167484.1
 Adcyap1r1
adenylate cyclase activating polypeptide 1 receptor 1
chr3_-_85746266 2.888 ENSMUST00000118408.1
 Fam160a1
family with sequence similarity 160, member A1
chr14_+_65970610 2.862 ENSMUST00000127387.1
 Clu
clusterin
chr3_+_54156039 2.809 ENSMUST00000029311.6
 Trpc4
transient receptor potential cation channel, subfamily C, member 4
chr13_+_16011851 2.793 ENSMUST00000042603.6
 Inhba
inhibin beta-A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 97 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 10.7 GO:1902847 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of tau-protein kinase activity(GO:1902949)
0.9 6.4 GO:0015840 urea transport(GO:0015840) urea transmembrane transport(GO:0071918)
0.8 6.3 GO:0070314 G1 to G0 transition(GO:0070314)
2.0 5.9 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.3 5.4 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.4 5.3 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.8 5.1 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
0.1 4.3 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
0.3 4.1 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.8 3.8 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.2 3.8 GO:0032060 bleb assembly(GO:0032060)
0.4 3.6 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.7 3.5 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.7 3.4 GO:0015671 oxygen transport(GO:0015671)
0.2 3.2 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.1 3.2 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.2 2.9 GO:0001539 cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
0.6 2.8 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799)
0.4 2.7 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0 2.7 GO:0007018 microtubule-based movement(GO:0007018)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 10.7 GO:0034366 spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418)
0.1 8.9 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 6.4 GO:0000118 histone deacetylase complex(GO:0000118)
1.7 5.1 GO:0005595 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.1 4.1 GO:0031901 early endosome membrane(GO:0031901)
0.0 3.7 GO:0030863 cortical cytoskeleton(GO:0030863)
0.0 3.4 GO:0005802 trans-Golgi network(GO:0005802)
0.0 3.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 2.9 GO:0030017 sarcomere(GO:0030017)
0.9 2.8 GO:0043512 inhibin A complex(GO:0043512)
0.0 2.7 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 2.6 GO:0032589 neuron projection membrane(GO:0032589)
0.1 2.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 2.5 GO:0005871 kinesin complex(GO:0005871)
0.0 2.4 GO:0031225 anchored component of membrane(GO:0031225)
0.2 2.1 GO:0097449 astrocyte projection(GO:0097449)
0.0 2.1 GO:0044295 axonal growth cone(GO:0044295)
0.1 1.7 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.1 1.5 GO:0031512 motile primary cilium(GO:0031512)
0.1 1.5 GO:0097228 sperm principal piece(GO:0097228)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 10.7 GO:0051787 misfolded protein binding(GO:0051787)
1.1 6.4 GO:0015265 urea channel activity(GO:0015265)
0.4 5.9 GO:0001223 transcription coactivator binding(GO:0001223)
1.3 5.3 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0 4.0 GO:0035254 glutamate receptor binding(GO:0035254)
0.3 3.8 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.9 3.5 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.8 3.4 GO:0004096 catalase activity(GO:0004096)
0.1 3.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 3.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 3.1 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 3.0 GO:0042056 chemoattractant activity(GO:0042056)
0.5 2.8 GO:0070699 type II activin receptor binding(GO:0070699)
0.2 2.8 GO:0015279 store-operated calcium channel activity(GO:0015279) inositol 1,4,5 trisphosphate binding(GO:0070679)
0.3 2.7 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 2.7 GO:0005158 insulin receptor binding(GO:0005158)
0.4 2.6 GO:0005042 netrin receptor activity(GO:0005042)
0.0 2.5 GO:0003777 microtubule motor activity(GO:0003777)
0.1 2.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 2.2 GO:0030246 carbohydrate binding(GO:0030246)