Motif ID: Tlx2

Z-value: 0.971


Transcription factors associated with Tlx2:

Gene SymbolEntrez IDGene Name
Tlx2 ENSMUSG00000068327.3 Tlx2



Activity profile for motif Tlx2.

activity profile for motif Tlx2


Sorted Z-values histogram for motif Tlx2

Sorted Z-values for motif Tlx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tlx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_48662740 4.031 ENSMUST00000122009.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr16_+_91225550 2.551 ENSMUST00000035608.8
 Olig2
oligodendrocyte transcription factor 2
chr3_+_134236483 1.799 ENSMUST00000181904.1
ENSMUST00000053048.9
 Cxxc4

CXXC finger 4

chr14_-_48667508 1.760 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chr7_-_109438998 1.642 ENSMUST00000121378.1
 Stk33
serine/threonine kinase 33
chr7_-_109438786 1.573 ENSMUST00000121748.1
 Stk33
serine/threonine kinase 33
chr6_-_12749193 1.557 ENSMUST00000046121.6
ENSMUST00000172356.1
 Thsd7a

thrombospondin, type I, domain containing 7A

chr2_-_181039286 1.448 ENSMUST00000067120.7
 Chrna4
cholinergic receptor, nicotinic, alpha polypeptide 4
chr10_+_79988584 1.446 ENSMUST00000004784.4
ENSMUST00000105374.1
 Cnn2

calponin 2

chr1_-_45925570 1.357 ENSMUST00000027137.4
 Slc40a1
solute carrier family 40 (iron-regulated transporter), member 1
chr1_-_87156127 1.320 ENSMUST00000160810.1
 Ecel1
endothelin converting enzyme-like 1
chr3_+_159839729 1.306 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)
chr2_-_181039160 1.274 ENSMUST00000108851.1
 Chrna4
cholinergic receptor, nicotinic, alpha polypeptide 4
chr2_-_120154600 1.261 ENSMUST00000028755.7
 Ehd4
EH-domain containing 4
chr1_-_190170671 1.218 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr19_-_24031006 1.183 ENSMUST00000096164.4
 Fam189a2
family with sequence similarity 189, member A2
chr7_+_113766119 1.095 ENSMUST00000084696.4
 Spon1
spondin 1, (f-spondin) extracellular matrix protein
chr4_-_139833524 1.091 ENSMUST00000030508.7
 Pax7
paired box gene 7
chr18_-_31949571 1.023 ENSMUST00000064016.5
 Gpr17
G protein-coupled receptor 17
chr12_+_116485714 1.021 ENSMUST00000070733.7
 Ptprn2
protein tyrosine phosphatase, receptor type, N polypeptide 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 166 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 5.8 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.0 3.4 GO:0046777 protein autophosphorylation(GO:0046777)
0.9 2.7 GO:1903048 regulation of acetylcholine-gated cation channel activity(GO:1903048)
0.3 2.7 GO:1902715 positive regulation of interferon-gamma secretion(GO:1902715)
0.9 2.6 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1 1.6 GO:0015684 ferrous iron transport(GO:0015684)
0.1 1.4 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.0 1.4 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.4 1.3 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
0.1 1.3 GO:0031017 exocrine pancreas development(GO:0031017)
0.1 1.3 GO:0006907 pinocytosis(GO:0006907)
0.0 1.3 GO:0018345 protein palmitoylation(GO:0018345)
0.0 1.3 GO:0003016 respiratory system process(GO:0003016)
0.4 1.2 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.2 1.2 GO:0036233 glycine import(GO:0036233)
0.1 1.1 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.1 1.1 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.0 1.1 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0 1.1 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.2 1.0 GO:0097211 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.5 GO:0030426 growth cone(GO:0030426)
0.2 2.7 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 1.7 GO:0032432 actin filament bundle(GO:0032432)
0.0 1.7 GO:0005923 bicellular tight junction(GO:0005923)
0.1 1.5 GO:0005921 gap junction(GO:0005921)
0.0 1.3 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 1.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 1.2 GO:0005771 multivesicular body(GO:0005771)
0.1 1.1 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 1.1 GO:0098533 ATPase dependent transmembrane transport complex(GO:0098533)
0.2 1.0 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 1.0 GO:0014704 intercalated disc(GO:0014704)
0.0 1.0 GO:0034704 calcium channel complex(GO:0034704)
0.3 0.9 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 0.8 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.8 GO:0043218 compact myelin(GO:0043218)
0.1 0.7 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.7 GO:0032588 trans-Golgi network membrane(GO:0032588)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 113 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.4 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.2 2.7 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889)
0.2 2.7 GO:0019992 diacylglycerol binding(GO:0019992)
0.1 2.6 GO:0071837 HMG box domain binding(GO:0071837)
0.0 2.2 GO:0030165 PDZ domain binding(GO:0030165)
0.0 1.9 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 1.4 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.1 1.4 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.1 1.4 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 1.3 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 1.3 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.2 1.2 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.2 1.2 GO:0050693 LBD domain binding(GO:0050693)
0.1 1.2 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 1.2 GO:0008013 beta-catenin binding(GO:0008013)
0.1 1.1 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 1.1 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 1.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.2 1.0 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 1.0 GO:0048020 CCR chemokine receptor binding(GO:0048020)