Motif ID: Trp53

Z-value: 0.888


Transcription factors associated with Trp53:

Gene SymbolEntrez IDGene Name
Trp53 ENSMUSG00000059552.7 Trp53

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Trp53mm10_v2_chr11_+_69580359_695803820.376.2e-02Click!


Activity profile for motif Trp53.

activity profile for motif Trp53


Sorted Z-values histogram for motif Trp53

Sorted Z-values for motif Trp53



Network of associatons between targets according to the STRING database.



First level regulatory network of Trp53

PNG image of the network

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Top targets:


Showing 1 to 20 of 155 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_6487231 3.567 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr17_+_29090969 3.297 ENSMUST00000119901.1
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr15_-_98004695 3.292 ENSMUST00000023123.8
 Col2a1
collagen, type II, alpha 1
chr15_-_98004634 3.102 ENSMUST00000131560.1
ENSMUST00000088355.5
 Col2a1

collagen, type II, alpha 1

chr2_-_69206146 2.891 ENSMUST00000127243.1
ENSMUST00000149643.1
ENSMUST00000167875.2
ENSMUST00000005365.8
 Spc25



SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)



chr17_-_33890584 2.711 ENSMUST00000114361.2
ENSMUST00000173492.1
 Kifc1

kinesin family member C1

chr10_+_56377300 2.565 ENSMUST00000068581.7
 Gja1
gap junction protein, alpha 1
chr17_-_33890539 2.552 ENSMUST00000173386.1
 Kifc1
kinesin family member C1
chr4_-_135573623 2.509 ENSMUST00000105855.1
 Grhl3
grainyhead-like 3 (Drosophila)
chr2_-_69206133 2.418 ENSMUST00000112320.1
 Spc25
SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr9_-_106158109 2.206 ENSMUST00000159809.1
ENSMUST00000162562.1
ENSMUST00000036382.6
ENSMUST00000112543.2
 Glyctk



glycerate kinase



chr5_-_116422858 2.113 ENSMUST00000036991.4
 Hspb8
heat shock protein 8
chr14_+_47001336 1.988 ENSMUST00000125113.1
 Samd4
sterile alpha motif domain containing 4
chr14_+_73237891 1.931 ENSMUST00000044405.6
 Lpar6
lysophosphatidic acid receptor 6
chr8_-_22185758 1.890 ENSMUST00000046916.7
 Ckap2
cytoskeleton associated protein 2
chr14_-_34374617 1.861 ENSMUST00000023826.4
 Sncg
synuclein, gamma
chr4_+_115057683 1.770 ENSMUST00000161601.1
 Tal1
T cell acute lymphocytic leukemia 1
chr15_+_85859689 1.735 ENSMUST00000170629.1
 Gtse1
G two S phase expressed protein 1
chr13_+_113317084 1.608 ENSMUST00000136755.2
 BC067074
cDNA sequence BC067074
chr5_-_30073554 1.590 ENSMUST00000026846.6
 Tyms
thymidylate synthase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 6.7 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
1.3 5.3 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
0.1 5.3 GO:0007052 mitotic spindle organization(GO:0007052)
1.1 3.3 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.4 3.3 GO:0071493 cellular response to UV-B(GO:0071493)
0.1 3.3 GO:0007019 microtubule depolymerization(GO:0007019)
0.9 2.6 GO:0003104 positive regulation of glomerular filtration(GO:0003104) cell communication by chemical coupling(GO:0010643)
0.3 2.5 GO:0061436 establishment of skin barrier(GO:0061436)
0.1 2.4 GO:0070986 left/right axis specification(GO:0070986)
0.2 2.3 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 2.0 GO:0045727 positive regulation of translation(GO:0045727)
0.1 1.9 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 1.8 GO:1902017 regulation of cilium assembly(GO:1902017)
0.5 1.6 GO:0046078 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177) dUMP metabolic process(GO:0046078)
0.0 1.5 GO:0009566 fertilization(GO:0009566)
0.1 1.4 GO:0097062 dendritic spine maintenance(GO:0097062)
0.1 1.4 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.4 1.3 GO:0002765 immune response-inhibiting signal transduction(GO:0002765)
0.2 1.3 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 1.3 GO:0086016 AV node cell action potential(GO:0086016) AV node cell to bundle of His cell signaling(GO:0086027) AV node cell to bundle of His cell communication(GO:0086067)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 6.4 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.9 5.3 GO:0031262 Ndc80 complex(GO:0031262)
0.3 5.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 3.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
1.1 3.3 GO:0033193 Lsd1/2 complex(GO:0033193)
1.1 3.3 GO:0070557 PCNA-p21 complex(GO:0070557)
0.2 2.6 GO:0005916 fascia adherens(GO:0005916)
0.0 2.4 GO:0043679 axon terminus(GO:0043679)
0.6 2.3 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.0 2.2 GO:0005882 intermediate filament(GO:0005882)
0.0 2.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 1.4 GO:0000235 astral microtubule(GO:0000235)
0.0 1.4 GO:0005643 nuclear pore(GO:0005643)
0.1 1.3 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 1.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.2 1.1 GO:0042627 chylomicron(GO:0042627)
0.1 1.1 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 1.0 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.2 0.9 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.1 0.9 GO:0045179 apical cortex(GO:0045179)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
1.3 5.3 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.2 3.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 3.3 GO:0070888 E-box binding(GO:0070888)
0.0 3.0 GO:0031490 chromatin DNA binding(GO:0031490)
0.5 2.6 GO:0071253 connexin binding(GO:0071253)
0.1 2.3 GO:0000400 four-way junction DNA binding(GO:0000400)
0.1 2.0 GO:0030371 translation repressor activity(GO:0030371)
0.1 1.9 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 1.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 1.6 GO:0005542 folic acid binding(GO:0005542)
0.2 1.4 GO:0008494 translation activator activity(GO:0008494)
0.1 1.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.3 1.3 GO:0042015 interleukin-20 binding(GO:0042015)
0.2 1.3 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.2 1.3 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 1.3 GO:0019905 syntaxin binding(GO:0019905)
0.1 1.2 GO:0001054 RNA polymerase I activity(GO:0001054)
0.1 1.1 GO:0004806 triglyceride lipase activity(GO:0004806)
0.2 1.0 GO:0017040 ceramidase activity(GO:0017040)