Motif ID: Trp63

Z-value: 0.584


Transcription factors associated with Trp63:

Gene SymbolEntrez IDGene Name
Trp63 ENSMUSG00000022510.8 Trp63



Activity profile for motif Trp63.

activity profile for motif Trp63


Sorted Z-values histogram for motif Trp63

Sorted Z-values for motif Trp63



Network of associatons between targets according to the STRING database.



First level regulatory network of Trp63

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_29090969 2.100 ENSMUST00000119901.1
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr7_-_116038734 2.055 ENSMUST00000166877.1
 Sox6
SRY-box containing gene 6
chr7_-_141443314 1.761 ENSMUST00000106005.2
 Lrdd
leucine-rich and death domain containing
chr1_-_9700209 1.761 ENSMUST00000088658.4
 Mybl1
myeloblastosis oncogene-like 1
chr8_-_87959560 1.530 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr19_+_53140430 1.411 ENSMUST00000111741.2
 Add3
adducin 3 (gamma)
chr14_-_122451109 1.218 ENSMUST00000081580.2
 Gm5089
predicted gene 5089
chr2_+_59612034 1.196 ENSMUST00000112568.1
ENSMUST00000037526.4
 Tanc1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr13_-_103334429 0.901 ENSMUST00000167058.1
ENSMUST00000164111.1
 Mast4

microtubule associated serine/threonine kinase family member 4

chr7_-_65370908 0.850 ENSMUST00000032729.6
 Tjp1
tight junction protein 1
chr6_+_34709610 0.824 ENSMUST00000031775.6
 Cald1
caldesmon 1
chr11_-_69948145 0.766 ENSMUST00000179298.1
ENSMUST00000018710.6
ENSMUST00000135437.1
ENSMUST00000141837.2
ENSMUST00000142500.1
 Slc2a4




solute carrier family 2 (facilitated glucose transporter), member 4




chr4_-_134018829 0.764 ENSMUST00000051674.2
 Lin28a
lin-28 homolog A (C. elegans)
chr6_+_34709442 0.763 ENSMUST00000115021.1
 Cald1
caldesmon 1
chr7_-_65371210 0.694 ENSMUST00000102592.3
 Tjp1
tight junction protein 1
chrX_+_159255919 0.668 ENSMUST00000112492.1
 Rps6ka3
ribosomal protein S6 kinase polypeptide 3
chrX_+_159255782 0.629 ENSMUST00000126686.1
ENSMUST00000033671.6
 Rps6ka3

ribosomal protein S6 kinase polypeptide 3

chr12_-_108003594 0.623 ENSMUST00000066060.4
 Bcl11b
B cell leukemia/lymphoma 11B
chr8_-_47352348 0.600 ENSMUST00000110367.2
 Stox2
storkhead box 2
chr7_-_37772868 0.545 ENSMUST00000176205.1
 Zfp536
zinc finger protein 536
chr15_+_76696725 0.494 ENSMUST00000023203.4
 Gpt
glutamic pyruvic transaminase, soluble
chr2_-_12301914 0.460 ENSMUST00000028106.4
 Itga8
integrin alpha 8
chr19_-_5875268 0.450 ENSMUST00000025728.6
 Frmd8
FERM domain containing 8
chr19_-_5875210 0.354 ENSMUST00000155227.1
 Frmd8
FERM domain containing 8
chr2_+_109917639 0.353 ENSMUST00000046548.7
ENSMUST00000111037.2
 Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr5_-_5265224 0.249 ENSMUST00000115450.1
 Cdk14
cyclin-dependent kinase 14
chr10_-_80671976 0.243 ENSMUST00000003433.6
 Mknk2
MAP kinase-interacting serine/threonine kinase 2
chr8_+_84686300 0.242 ENSMUST00000177531.1
 Trmt1
tRNA methyltransferase 1
chr11_-_101466222 0.201 ENSMUST00000040430.7
 Vat1
vesicle amine transport protein 1 homolog (T californica)
chr5_-_5266038 0.172 ENSMUST00000115451.1
ENSMUST00000115452.1
ENSMUST00000131392.1
 Cdk14


cyclin-dependent kinase 14


chr2_-_104494400 0.171 ENSMUST00000028600.7
 Hipk3
homeodomain interacting protein kinase 3
chr7_-_126160992 0.165 ENSMUST00000164741.1
 Xpo6
exportin 6
chr8_-_31918203 0.132 ENSMUST00000073884.4
 Nrg1
neuregulin 1
chr7_-_114254659 0.095 ENSMUST00000033012.7
 Copb1
coatomer protein complex, subunit beta 1
chr12_-_108003414 0.076 ENSMUST00000109887.1
ENSMUST00000109891.2
 Bcl11b

B cell leukemia/lymphoma 11B

chr4_-_96591555 0.069 ENSMUST00000055693.8
 Cyp2j9
cytochrome P450, family 2, subfamily j, polypeptide 9
chr11_-_106487796 0.063 ENSMUST00000001059.2
ENSMUST00000106799.1
ENSMUST00000106800.1
 Ern1


endoplasmic reticulum (ER) to nucleus signalling 1


chr11_-_106487833 0.047 ENSMUST00000106801.1
 Ern1
endoplasmic reticulum (ER) to nucleus signalling 1
chr2_-_170427828 0.023 ENSMUST00000013667.2
ENSMUST00000109152.2
ENSMUST00000068137.4
 Bcas1


breast carcinoma amplified sequence 1


chrX_+_136822671 0.019 ENSMUST00000033800.6
 Plp1
proteolipid protein (myelin) 1
chr5_+_142401484 0.014 ENSMUST00000072837.5
 Foxk1
forkhead box K1
chr8_-_85432841 0.009 ENSMUST00000047749.5
 4921524J17Rik
RIKEN cDNA 4921524J17 gene
chr10_-_61452658 0.004 ENSMUST00000167087.1
ENSMUST00000020288.7
 Eif4ebp2

eukaryotic translation initiation factor 4E binding protein 2

chr5_-_92083667 0.003 ENSMUST00000113127.3
 G3bp2
GTPase activating protein (SH3 domain) binding protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.1 GO:0071493 cellular response to UV-B(GO:0071493) replicative senescence(GO:0090399)
0.2 2.1 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 1.5 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 0.4 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.1 0.7 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
0.1 0.8 GO:0010587 miRNA catabolic process(GO:0010587)
0.1 0.2 GO:0002940 tRNA N2-guanine methylation(GO:0002940)
0.1 1.2 GO:0097062 dendritic spine maintenance(GO:0097062)
0.1 0.2 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.0 1.5 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 0.5 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.1 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 0.8 GO:0071470 cellular response to osmotic stress(GO:0071470)
0.0 0.2 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.0 1.6 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
0.0 0.1 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0 1.3 GO:0002224 toll-like receptor signaling pathway(GO:0002224)
0.0 0.5 GO:1903846 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.0 0.2 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0070557 PCNA-p21 complex(GO:0070557)
0.2 1.5 GO:0046581 intercellular canaliculus(GO:0046581)
0.2 1.6 GO:0030478 actin cap(GO:0030478)
0.1 0.4 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.5 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.8 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.1 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0 1.4 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 0.8 GO:0010494 cytoplasmic stress granule(GO:0010494)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.8 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.2 0.8 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.1 2.1 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.8 GO:0035198 miRNA binding(GO:0035198)
0.0 0.5 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.1 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 1.3 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.4 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.5 GO:0008483 transaminase activity(GO:0008483)
0.0 1.4 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.1 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.4 GO:0030332 cyclin binding(GO:0030332)
0.0 0.2 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)