Motif ID: Twist1

Z-value: 1.118


Transcription factors associated with Twist1:

Gene SymbolEntrez IDGene Name
Twist1 ENSMUSG00000035799.5 Twist1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Twist1mm10_v2_chr12_+_33957645_33957671-0.348.7e-02Click!


Activity profile for motif Twist1.

activity profile for motif Twist1


Sorted Z-values histogram for motif Twist1

Sorted Z-values for motif Twist1



Network of associatons between targets according to the STRING database.



First level regulatory network of Twist1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 111 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_119053339 6.016 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
 Gli2


GLI-Kruppel family member GLI2


chr2_-_172940299 5.095 ENSMUST00000009143.7
 Bmp7
bone morphogenetic protein 7
chr9_+_60794468 4.199 ENSMUST00000050183.6
 Uaca
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr6_-_95718800 4.159 ENSMUST00000079847.5
 Suclg2
succinate-Coenzyme A ligase, GDP-forming, beta subunit
chr19_+_25610533 3.918 ENSMUST00000048935.4
 Dmrt3
doublesex and mab-3 related transcription factor 3
chr7_+_45216671 2.976 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr9_-_114844090 2.912 ENSMUST00000047013.3
 Cmtm8
CKLF-like MARVEL transmembrane domain containing 8
chrX_+_71050160 2.694 ENSMUST00000082088.3
ENSMUST00000114629.3
 Mamld1

mastermind-like domain containing 1

chr7_-_75308373 2.622 ENSMUST00000085164.5
 Sv2b
synaptic vesicle glycoprotein 2 b
chr16_-_18811615 2.557 ENSMUST00000096990.3
 Cdc45
cell division cycle 45
chr11_-_59290746 2.409 ENSMUST00000010044.7
 Wnt3a
wingless-related MMTV integration site 3A
chr9_+_65265173 2.394 ENSMUST00000048762.1
 Cilp
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr5_+_105519388 2.301 ENSMUST00000067924.6
ENSMUST00000150981.1
 Lrrc8c

leucine rich repeat containing 8 family, member C

chr2_-_180225812 2.247 ENSMUST00000015791.5
 Lama5
laminin, alpha 5
chr6_-_124813065 2.111 ENSMUST00000149610.2
 Tpi1
triosephosphate isomerase 1
chr7_+_4119556 2.110 ENSMUST00000079415.5
 Ttyh1
tweety homolog 1 (Drosophila)
chr7_-_127218390 2.035 ENSMUST00000142356.1
ENSMUST00000106314.1
 Sept1

septin 1

chr7_+_4119525 1.975 ENSMUST00000119661.1
ENSMUST00000129423.1
 Ttyh1

tweety homolog 1 (Drosophila)

chr2_-_137116624 1.958 ENSMUST00000028735.7
 Jag1
jagged 1
chr9_-_44342332 1.954 ENSMUST00000097558.3
 Hmbs
hydroxymethylbilane synthase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 6.9 GO:0060032 notochord regression(GO:0060032)
0.6 5.7 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
1.7 5.1 GO:0072076 hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme development(GO:0072076) negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.5 4.2 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.2 4.2 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
1.0 3.8 GO:0051311 spindle assembly involved in female meiosis(GO:0007056) meiotic metaphase plate congression(GO:0051311)
0.4 3.6 GO:0046645 positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645) positive regulation of uterine smooth muscle contraction(GO:0070474)
0.7 3.5 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 3.2 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.1 3.1 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.2 3.0 GO:0030903 notochord development(GO:0030903)
0.9 2.6 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.2 2.5 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 2.5 GO:0045444 fat cell differentiation(GO:0045444)
0.8 2.4 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892) dermatome development(GO:0061054) regulation of dermatome development(GO:0061183) negative regulation of dopaminergic neuron differentiation(GO:1904339) regulation of cardiac cell fate specification(GO:2000043)
0.4 2.4 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1 2.3 GO:0048255 mRNA stabilization(GO:0048255)
0.1 2.2 GO:1902476 chloride transmembrane transport(GO:1902476)
0.7 2.1 GO:0019405 alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.2 2.1 GO:0070445 oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 6.9 GO:0097542 ciliary tip(GO:0097542)
0.0 5.6 GO:0031012 extracellular matrix(GO:0031012)
1.0 4.2 GO:0043293 apoptosome(GO:0043293)
0.7 4.2 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
1.4 4.1 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.4 3.8 GO:0072687 meiotic spindle(GO:0072687)
1.2 3.6 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.1 3.6 GO:0000242 pericentriolar material(GO:0000242)
0.0 3.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.9 2.6 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.0 2.6 GO:0043195 terminal bouton(GO:0043195)
0.0 2.3 GO:0005844 polysome(GO:0005844)
0.6 2.2 GO:0043259 laminin-10 complex(GO:0043259)
0.0 2.2 GO:0034399 nuclear periphery(GO:0034399)
0.0 2.0 GO:0000793 condensed chromosome(GO:0000793)
0.0 1.9 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 1.5 GO:0032039 integrator complex(GO:0032039)
0.1 1.5 GO:0002102 podosome(GO:0002102)
0.0 1.4 GO:0005871 kinesin complex(GO:0005871)
0.0 1.3 GO:0031526 brush border membrane(GO:0031526)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.5 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.5 5.1 GO:0070700 BMP receptor binding(GO:0070700)
0.4 4.2 GO:0034943 acyl-CoA ligase activity(GO:0003996) 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity(GO:0010435) 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity(GO:0018854) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity(GO:0018855) benzoyl acetate-CoA ligase activity(GO:0018856) 2,4-dichlorobenzoate-CoA ligase activity(GO:0018857) pivalate-CoA ligase activity(GO:0034783) cyclopropanecarboxylate-CoA ligase activity(GO:0034793) adipate-CoA ligase activity(GO:0034796) citronellyl-CoA ligase activity(GO:0034823) mentha-1,3-dione-CoA ligase activity(GO:0034841) thiophene-2-carboxylate-CoA ligase activity(GO:0034842) 2,4,4-trimethylpentanoate-CoA ligase activity(GO:0034865) cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034942) trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034943) branched-chain acyl-CoA synthetase (ADP-forming) activity(GO:0043759) aryl-CoA synthetase (ADP-forming) activity(GO:0043762) 3-hydroxypropionyl-CoA synthetase activity(GO:0043955) perillic acid:CoA ligase (ADP-forming) activity(GO:0052685) perillic acid:CoA ligase (AMP-forming) activity(GO:0052686) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity(GO:0052687) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity(GO:0052688) pristanate-CoA ligase activity(GO:0070251) malonyl-CoA synthetase activity(GO:0090409)
1.0 4.1 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 3.8 GO:0005525 GTP binding(GO:0005525)
0.7 3.6 GO:0042610 CD8 receptor binding(GO:0042610)
0.0 3.6 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 3.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.5 3.1 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 2.9 GO:0005125 cytokine activity(GO:0005125)
0.3 2.6 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 2.6 GO:0015026 coreceptor activity(GO:0015026)
0.1 2.5 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.8 2.4 GO:0005110 frizzled-2 binding(GO:0005110)
0.3 2.3 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 2.2 GO:0005178 integrin binding(GO:0005178)
0.2 2.1 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 2.1 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.3 2.0 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.1 2.0 GO:0005112 Notch binding(GO:0005112)