Motif ID: Vsx1_Uncx_Prrx2_Shox2_Noto

Z-value: 1.022

Transcription factors associated with Vsx1_Uncx_Prrx2_Shox2_Noto:

Gene SymbolEntrez IDGene Name
Noto ENSMUSG00000068302.7 Noto
Prrx2 ENSMUSG00000039476.7 Prrx2
Shox2 ENSMUSG00000027833.10 Shox2
Uncx ENSMUSG00000029546.11 Uncx
Vsx1 ENSMUSG00000033080.8 Vsx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Uncxmm10_v2_chr5_+_139543889_1395439040.643.8e-04Click!
Shox2mm10_v2_chr3_-_66981279_669813180.366.8e-02Click!
Prrx2mm10_v2_chr2_+_30834972_308349720.164.2e-01Click!


Activity profile for motif Vsx1_Uncx_Prrx2_Shox2_Noto.

activity profile for motif Vsx1_Uncx_Prrx2_Shox2_Noto


Sorted Z-values histogram for motif Vsx1_Uncx_Prrx2_Shox2_Noto

Sorted Z-values for motif Vsx1_Uncx_Prrx2_Shox2_Noto



Network of associatons between targets according to the STRING database.



First level regulatory network of Vsx1_Uncx_Prrx2_Shox2_Noto

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_48665098 16.942 ENSMUST00000118578.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr5_+_139543889 13.143 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr3_+_159839729 8.630 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)
chr2_-_168767136 8.154 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chr7_-_49636847 7.928 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr17_+_34592248 7.687 ENSMUST00000038149.6
 Pbx2
pre B cell leukemia homeobox 2
chr13_-_53473074 7.179 ENSMUST00000021922.8
 Msx2
msh homeobox 2
chr8_-_61902669 7.085 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr2_-_168767029 7.052 ENSMUST00000075044.3
 Sall4
sal-like 4 (Drosophila)
chr10_-_45470201 6.690 ENSMUST00000079390.6
 Lin28b
lin-28 homolog B (C. elegans)
chr13_-_102905740 6.459 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr3_+_55782500 6.096 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr2_-_72986716 5.923 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr13_-_102906046 5.752 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr6_-_147264124 5.412 ENSMUST00000052296.6
 Pthlh
parathyroid hormone-like peptide
chr9_+_119063429 4.991 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
 Vill


villin-like


chr12_+_38780284 4.885 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr3_+_125404072 4.857 ENSMUST00000173932.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr2_+_20737306 4.723 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr12_+_38780817 4.479 ENSMUST00000160856.1
 Etv1
ets variant gene 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 160 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.6 18.6 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.5 15.9 GO:0007638 mechanosensory behavior(GO:0007638)
0.8 15.2 GO:0001833 inner cell mass cell proliferation(GO:0001833)
1.6 13.1 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.7 8.6 GO:0031017 exocrine pancreas development(GO:0031017)
0.5 7.9 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
2.4 7.2 GO:0048818 embryonic nail plate morphogenesis(GO:0035880) positive regulation of hair follicle maturation(GO:0048818) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
0.5 7.1 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.4 6.8 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.7 6.7 GO:0010587 miRNA catabolic process(GO:0010587)
0.2 6.1 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.7 5.5 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
1.8 5.4 GO:0048389 BMP signaling pathway involved in heart induction(GO:0003130) endodermal-mesodermal cell signaling(GO:0003133) endodermal-mesodermal cell signaling involved in heart induction(GO:0003134) intermediate mesoderm development(GO:0048389) regulation of transcription from RNA polymerase II promoter involved in kidney development(GO:0060994) pattern specification involved in mesonephros development(GO:0061227) regulation of hepatocyte differentiation(GO:0070366) comma-shaped body morphogenesis(GO:0072049) S-shaped body morphogenesis(GO:0072050) anterior/posterior pattern specification involved in kidney development(GO:0072098) negative regulation of glomerular mesangial cell proliferation(GO:0072125) ureter urothelium development(GO:0072190) negative regulation of glomerulus development(GO:0090194) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.0 5.4 GO:0008284 positive regulation of cell proliferation(GO:0008284)
0.2 5.1 GO:0006270 DNA replication initiation(GO:0006270)
0.1 5.0 GO:0051693 actin filament capping(GO:0051693)
0.0 4.9 GO:0007605 sensory perception of sound(GO:0007605)
0.8 4.7 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.2 4.5 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.3 3.8 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 20.5 GO:0005667 transcription factor complex(GO:0005667)
0.1 15.2 GO:0000792 heterochromatin(GO:0000792)
0.0 9.1 GO:0030426 growth cone(GO:0030426)
0.3 8.6 GO:0032839 dendrite cytoplasm(GO:0032839)
0.3 7.1 GO:0002102 podosome(GO:0002102)
0.6 3.6 GO:0001674 female germ cell nucleus(GO:0001674)
0.3 3.6 GO:0005915 zonula adherens(GO:0005915)
0.6 3.5 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.1 3.5 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 3.2 GO:0016459 myosin complex(GO:0016459)
0.4 3.0 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 2.7 GO:0005902 microvillus(GO:0005902)
0.0 2.5 GO:0016607 nuclear speck(GO:0016607)
0.0 2.3 GO:0000776 kinetochore(GO:0000776)
0.1 2.2 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 2.2 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 2.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 1.9 GO:0043198 dendritic shaft(GO:0043198)
0.0 1.7 GO:0043034 costamere(GO:0043034)
0.5 1.6 GO:0000172 ribonuclease MRP complex(GO:0000172)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 49.7 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.1 40.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 13.5 GO:0003779 actin binding(GO:0003779)
0.1 13.0 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 12.9 GO:0000287 magnesium ion binding(GO:0000287)
1.0 10.2 GO:0031852 mu-type opioid receptor binding(GO:0031852)
1.2 8.6 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.5 8.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.8 5.5 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.6 5.4 GO:0039706 co-receptor binding(GO:0039706)
0.5 5.0 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.2 5.0 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 3.8 GO:0008134 transcription factor binding(GO:0008134)
0.3 3.6 GO:0070097 delta-catenin binding(GO:0070097)
0.3 3.5 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 3.3 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 3.2 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.4 3.0 GO:0050693 LBD domain binding(GO:0050693)
0.1 3.0 GO:0030507 spectrin binding(GO:0030507)
0.1 2.9 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)