Motif ID: Zfhx3

Z-value: 0.746


Transcription factors associated with Zfhx3:

Gene SymbolEntrez IDGene Name
Zfhx3 ENSMUSG00000038872.8 Zfhx3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfhx3mm10_v2_chr8_+_108714644_108714644-0.404.1e-02Click!


Activity profile for motif Zfhx3.

activity profile for motif Zfhx3


Sorted Z-values histogram for motif Zfhx3

Sorted Z-values for motif Zfhx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Zfhx3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_101377897 2.032 ENSMUST00000075994.6
 Pdzrn3
PDZ domain containing RING finger 3
chr10_-_110000219 1.951 ENSMUST00000032719.7
 Nav3
neuron navigator 3
chr13_-_110280103 1.759 ENSMUST00000167824.1
 Rab3c
RAB3C, member RAS oncogene family
chr17_+_35076902 1.739 ENSMUST00000172494.1
ENSMUST00000172678.1
ENSMUST00000013910.4
 Ly6g6e


lymphocyte antigen 6 complex, locus G6E


chr1_-_158814469 1.643 ENSMUST00000161589.2
 Pappa2
pappalysin 2
chr1_-_126830632 1.459 ENSMUST00000112583.1
ENSMUST00000094609.3
 Nckap5

NCK-associated protein 5

chr3_+_28263205 1.450 ENSMUST00000159236.2
 Tnik
TRAF2 and NCK interacting kinase
chrX_-_143933204 1.450 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr18_+_37518341 1.372 ENSMUST00000097609.1
 Pcdhb22
protocadherin beta 22
chrX_-_143933089 1.301 ENSMUST00000087313.3
 Dcx
doublecortin
chr4_+_101507947 1.105 ENSMUST00000149047.1
ENSMUST00000106929.3
 Dnajc6

DnaJ (Hsp40) homolog, subfamily C, member 6

chr2_-_63184253 1.072 ENSMUST00000075052.3
ENSMUST00000112454.1
 Kcnh7

potassium voltage-gated channel, subfamily H (eag-related), member 7

chr2_+_82053222 1.047 ENSMUST00000047527.7
 Zfp804a
zinc finger protein 804A
chr16_-_74411776 0.969 ENSMUST00000116586.2
 Robo2
roundabout homolog 2 (Drosophila)
chr3_+_136670076 0.964 ENSMUST00000070198.7
 Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr12_-_12941827 0.905 ENSMUST00000043396.7
 Mycn
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr5_+_107497718 0.901 ENSMUST00000112671.2
 A830010M20Rik
RIKEN cDNA A830010M20 gene
chr4_+_13743424 0.880 ENSMUST00000006761.3
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr1_-_24612700 0.839 ENSMUST00000088336.1
 Gm10222
predicted gene 10222
chr9_+_86485407 0.813 ENSMUST00000034987.8
 Dopey1
dopey family member 1
chrM_+_9870 0.779 ENSMUST00000084013.1
 mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chrX_+_163911401 0.757 ENSMUST00000140845.1
 Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr9_+_113812547 0.737 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
 Clasp2


CLIP associating protein 2


chr1_+_179961110 0.732 ENSMUST00000076687.5
ENSMUST00000097450.3
 Cdc42bpa

CDC42 binding protein kinase alpha

chr13_+_83732438 0.717 ENSMUST00000182701.1
 C130071C03Rik
RIKEN cDNA C130071C03 gene
chr11_+_24078173 0.692 ENSMUST00000109514.1
 Bcl11a
B cell CLL/lymphoma 11A (zinc finger protein)
chr2_-_63184170 0.676 ENSMUST00000112452.1
 Kcnh7
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr10_-_17947997 0.660 ENSMUST00000037879.6
 Heca
headcase homolog (Drosophila)
chr1_+_172698046 0.660 ENSMUST00000038495.3
 Crp
C-reactive protein, pentraxin-related
chr6_-_38124568 0.657 ENSMUST00000040259.4
 Atp6v0a4
ATPase, H+ transporting, lysosomal V0 subunit A4
chr5_+_107497762 0.607 ENSMUST00000152474.1
ENSMUST00000060553.7
 A830010M20Rik

RIKEN cDNA A830010M20 gene

chr2_+_3770673 0.572 ENSMUST00000177037.1
 Fam107b
family with sequence similarity 107, member B
chr11_+_24078022 0.572 ENSMUST00000000881.6
 Bcl11a
B cell CLL/lymphoma 11A (zinc finger protein)
chr4_-_32923455 0.550 ENSMUST00000035719.4
ENSMUST00000084749.1
 Ankrd6

ankyrin repeat domain 6

chrM_-_14060 0.544 ENSMUST00000082419.1
 mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr11_+_24078111 0.544 ENSMUST00000109516.1
 Bcl11a
B cell CLL/lymphoma 11A (zinc finger protein)
chrM_+_7759 0.507 ENSMUST00000082407.1
ENSMUST00000082408.1
 mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr1_-_126830786 0.504 ENSMUST00000162646.1
 Nckap5
NCK-associated protein 5
chrX_+_164373363 0.479 ENSMUST00000033751.7
 Figf
c-fos induced growth factor
chr2_-_86347764 0.461 ENSMUST00000099894.2
 Olfr1055
olfactory receptor 1055
chr12_+_71170589 0.447 ENSMUST00000129376.1
 2700049A03Rik
RIKEN cDNA 2700049A03 gene
chr8_+_83666827 0.442 ENSMUST00000019608.5
 Ptger1
prostaglandin E receptor 1 (subtype EP1)
chrM_+_14138 0.437 ENSMUST00000082421.1
 mt-Cytb
mitochondrially encoded cytochrome b
chr2_-_37647199 0.428 ENSMUST00000028279.3
 Strbp
spermatid perinuclear RNA binding protein
chr2_+_120977017 0.407 ENSMUST00000067582.7
 Tmem62
transmembrane protein 62
chr9_+_53771499 0.387 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr8_+_93810832 0.386 ENSMUST00000034198.8
ENSMUST00000125716.1
 Gnao1

guanine nucleotide binding protein, alpha O

chr5_+_25246775 0.378 ENSMUST00000144971.1
 Galnt11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11
chr2_-_165368723 0.375 ENSMUST00000141140.1
ENSMUST00000103085.1
 Zfp663

zinc finger protein 663

chr1_-_132390301 0.367 ENSMUST00000132435.1
 Tmcc2
transmembrane and coiled-coil domains 2
chr10_-_56228636 0.355 ENSMUST00000099739.3
 Tbc1d32
TBC1 domain family, member 32
chr2_-_120245157 0.339 ENSMUST00000090071.4
 Pla2g4e
phospholipase A2, group IVE
chr10_+_115384951 0.337 ENSMUST00000036044.8
 Zfc3h1
zinc finger, C3H1-type containing
chr9_-_120068263 0.329 ENSMUST00000064165.3
ENSMUST00000177637.1
 Cx3cr1

chemokine (C-X3-C) receptor 1

chr1_+_179960472 0.325 ENSMUST00000097453.2
ENSMUST00000111117.1
 Cdc42bpa

CDC42 binding protein kinase alpha

chr8_+_47713266 0.313 ENSMUST00000180928.1
 E030037K01Rik
RIKEN cDNA E030037K01 gene
chr5_-_107875035 0.312 ENSMUST00000138111.1
ENSMUST00000112642.1
 Evi5

ecotropic viral integration site 5

chr6_+_127453667 0.281 ENSMUST00000112193.1
 Parp11
poly (ADP-ribose) polymerase family, member 11
chr14_+_64588112 0.270 ENSMUST00000181808.1
 A930011O12Rik
RIKEN cDNA A930011O12 gene
chr6_-_86765807 0.253 ENSMUST00000123732.1
 Anxa4
annexin A4
chr7_+_19119853 0.248 ENSMUST00000053109.3
 Fbxo46
F-box protein 46
chr10_+_90576252 0.218 ENSMUST00000182427.1
ENSMUST00000182053.1
ENSMUST00000182113.1
 Anks1b


ankyrin repeat and sterile alpha motif domain containing 1B


chr6_-_86765866 0.211 ENSMUST00000113675.1
 Anxa4
annexin A4
chr10_+_23796946 0.196 ENSMUST00000119597.1
ENSMUST00000179321.1
 Slc18b1

solute carrier family 18, subfamily B, member 1

chr17_-_50094277 0.178 ENSMUST00000113195.1
 Rftn1
raftlin lipid raft linker 1
chr8_-_9976294 0.175 ENSMUST00000095476.4
 Lig4
ligase IV, DNA, ATP-dependent
chr2_+_110597298 0.153 ENSMUST00000045972.6
ENSMUST00000111026.2
 Slc5a12

solute carrier family 5 (sodium/glucose cotransporter), member 12

chr11_+_4986824 0.136 ENSMUST00000009234.9
ENSMUST00000109897.1
 Ap1b1

adaptor protein complex AP-1, beta 1 subunit

chr3_-_130730375 0.133 ENSMUST00000079085.6
 Rpl34
ribosomal protein L34
chr12_-_27160311 0.117 ENSMUST00000182473.1
ENSMUST00000177636.1
ENSMUST00000183238.1
 Gm9866


predicted gene 9866


chr9_-_22208546 0.101 ENSMUST00000167359.1
 1810064F22Rik
RIKEN cDNA 1810064F22 gene
chr12_-_54695829 0.100 ENSMUST00000162106.1
ENSMUST00000160085.1
ENSMUST00000161592.1
ENSMUST00000163433.1
 Eapp



E2F-associated phosphoprotein



chr7_+_55794146 0.099 ENSMUST00000032627.3
 Tubgcp5
tubulin, gamma complex associated protein 5
chrM_+_2743 0.095 ENSMUST00000082392.1
 mt-Nd1
mitochondrially encoded NADH dehydrogenase 1
chr11_+_78465697 0.093 ENSMUST00000001126.3
 Slc46a1
solute carrier family 46, member 1
chr2_-_140671462 0.089 ENSMUST00000110057.2
 Flrt3
fibronectin leucine rich transmembrane protein 3
chr8_-_67818284 0.088 ENSMUST00000120071.1
 Psd3
pleckstrin and Sec7 domain containing 3
chr7_-_34655500 0.084 ENSMUST00000032709.1
 Kctd15
potassium channel tetramerisation domain containing 15
chr1_-_168432270 0.076 ENSMUST00000072863.4
 Pbx1
pre B cell leukemia homeobox 1
chr9_+_95857597 0.066 ENSMUST00000034980.7
 Atr
ataxia telangiectasia and Rad3 related
chr4_+_82065924 0.059 ENSMUST00000161588.1
 Gm5860
predicted gene 5860
chrM_+_9452 0.042 ENSMUST00000082411.1
 mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr10_+_23797052 0.041 ENSMUST00000133289.1
 Slc18b1
solute carrier family 18, subfamily B, member 1
chr4_+_150853919 0.040 ENSMUST00000073600.2
 Errfi1
ERBB receptor feedback inhibitor 1
chr1_+_164275559 0.037 ENSMUST00000027867.6
 Ccdc181
coiled-coil domain containing 181
chr10_-_88605017 0.020 ENSMUST00000119185.1
ENSMUST00000121629.1
 Mybpc1

myosin binding protein C, slow-type

chr4_+_109343029 0.019 ENSMUST00000030281.5
 Eps15
epidermal growth factor receptor pathway substrate 15

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.3 1.0 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.3 1.4 GO:0007256 activation of JNKK activity(GO:0007256)
0.2 1.1 GO:0072318 clathrin coat disassembly(GO:0072318)
0.2 2.8 GO:0021860 pyramidal neuron development(GO:0021860)
0.1 1.8 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 0.7 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 0.7 GO:0032929 negative regulation of macrophage derived foam cell differentiation(GO:0010745) negative regulation of superoxide anion generation(GO:0032929)
0.1 0.7 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 0.5 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
0.1 0.4 GO:0033762 response to glucagon(GO:0033762)
0.1 0.3 GO:1900272 negative regulation of long-term synaptic potentiation(GO:1900272)
0.1 1.7 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.1 0.4 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.1 0.4 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.0 1.1 GO:0007097 nuclear migration(GO:0007097)
0.0 2.0 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 0.9 GO:0048712 negative regulation of astrocyte differentiation(GO:0048712)
0.0 0.2 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.0 0.6 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.2 GO:0097680 double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.0 0.1 GO:0015886 heme transport(GO:0015886)
0.0 0.1 GO:1904884 telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.0 0.5 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.8 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 0.2 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 1.8 GO:0019882 antigen processing and presentation(GO:0019882)
0.0 0.8 GO:0036465 synaptic vesicle recycling(GO:0036465)
0.0 0.9 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.0 0.1 GO:0051418 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.0 0.0 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.0 0.4 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 0.2 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.4 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.0 1.7 GO:0051291 protein heterooligomerization(GO:0051291)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.2 1.0 GO:0005955 calcineurin complex(GO:0005955)
0.1 0.7 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 0.4 GO:0045275 respiratory chain complex III(GO:0045275)
0.0 0.5 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 1.4 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.2 GO:0032807 DNA ligase IV complex(GO:0032807)
0.0 1.0 GO:0030673 axolemma(GO:0030673)
0.0 0.1 GO:0000931 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.0 2.0 GO:0031594 neuromuscular junction(GO:0031594)
0.0 1.4 GO:0070469 respiratory chain(GO:0070469)
0.0 1.4 GO:0055037 recycling endosome(GO:0055037)
0.0 1.8 GO:0008021 synaptic vesicle(GO:0008021)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
0.2 1.0 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 0.7 GO:0001849 complement component C1q binding(GO:0001849)
0.1 2.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 0.4 GO:0004954 icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955)
0.1 1.0 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 1.7 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 0.5 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 1.8 GO:0031489 myosin V binding(GO:0031489)
0.1 0.3 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.1 0.4 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 0.7 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 0.4 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 0.7 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 1.5 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.2 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 0.1 GO:0015232 heme transporter activity(GO:0015232)
0.0 0.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.3 GO:0004623 phospholipase A2 activity(GO:0004623)
0.0 1.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 1.4 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0 0.5 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 1.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.1 GO:0032405 MutLalpha complex binding(GO:0032405) MutSalpha complex binding(GO:0032407)
0.0 0.1 GO:0051011 microtubule minus-end binding(GO:0051011)