Motif ID: Zfp423

Z-value: 0.614


Transcription factors associated with Zfp423:

Gene SymbolEntrez IDGene Name
Zfp423 ENSMUSG00000045333.9 Zfp423

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfp423mm10_v2_chr8_-_87804411_87804463-0.376.6e-02Click!


Activity profile for motif Zfp423.

activity profile for motif Zfp423


Sorted Z-values histogram for motif Zfp423

Sorted Z-values for motif Zfp423



Network of associatons between targets according to the STRING database.



First level regulatory network of Zfp423

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_29253001 3.092 ENSMUST00000071201.4
 Ntng2
netrin G2
chr2_+_180499893 2.462 ENSMUST00000029084.2
 Ntsr1
neurotensin receptor 1
chr14_+_119138415 2.255 ENSMUST00000065904.3
 Hs6st3
heparan sulfate 6-O-sulfotransferase 3
chr4_+_42917234 2.180 ENSMUST00000107976.2
ENSMUST00000069184.2
 N28178

expressed sequence N28178

chr1_-_51941261 1.895 ENSMUST00000097103.3
 Gm8420
predicted gene 8420
chr7_-_70360593 1.777 ENSMUST00000032768.7
 Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr2_-_147085445 1.601 ENSMUST00000067020.2
 Nkx2-4
NK2 homeobox 4
chr10_+_13966268 1.559 ENSMUST00000015645.4
 Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr15_-_78718113 1.476 ENSMUST00000088592.4
 Elfn2
leucine rich repeat and fibronectin type III, extracellular 2
chr6_+_110645572 1.422 ENSMUST00000071076.6
ENSMUST00000172951.1
 Grm7

glutamate receptor, metabotropic 7

chr12_+_102948843 1.267 ENSMUST00000101099.5
 Unc79
unc-79 homolog (C. elegans)
chr15_-_66286224 1.232 ENSMUST00000070256.7
 Kcnq3
potassium voltage-gated channel, subfamily Q, member 3
chr5_-_22344690 1.100 ENSMUST00000062372.7
ENSMUST00000161356.1
 Reln

reelin

chr5_-_135934590 1.043 ENSMUST00000055808.5
 Ywhag
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
chr7_+_29307924 1.040 ENSMUST00000108230.1
ENSMUST00000065181.5
 Dpf1

D4, zinc and double PHD fingers family 1

chr7_-_105633525 1.038 ENSMUST00000153371.1
ENSMUST00000106789.1
ENSMUST00000057525.7
 Trim3


tripartite motif-containing 3


chr12_-_14152038 1.019 ENSMUST00000020926.6
 Fam84a
family with sequence similarity 84, member A
chr14_+_70553687 1.017 ENSMUST00000161069.1
 Hr
hairless
chr8_+_58912257 0.947 ENSMUST00000160055.1
 BC030500
cDNA sequence BC030500
chr7_-_105633479 0.907 ENSMUST00000147044.1
ENSMUST00000106791.1
 Trim3

tripartite motif-containing 3

chr1_+_167598450 0.890 ENSMUST00000111386.1
ENSMUST00000111384.1
 Rxrg

retinoid X receptor gamma

chr7_-_25754701 0.856 ENSMUST00000108401.1
ENSMUST00000043765.7
 Hnrnpul1

heterogeneous nuclear ribonucleoprotein U-like 1

chr7_-_45870928 0.839 ENSMUST00000146672.1
 Grin2d
glutamate receptor, ionotropic, NMDA2D (epsilon 4)
chr10_-_62110945 0.766 ENSMUST00000142821.1
ENSMUST00000124615.1
ENSMUST00000064050.4
ENSMUST00000125704.1
ENSMUST00000142796.1
 2010107G23Rik




RIKEN cDNA 2010107G23 gene




chr2_+_164785994 0.715 ENSMUST00000152471.1
 Snx21
sorting nexin family member 21
chr19_+_6401675 0.713 ENSMUST00000113471.1
ENSMUST00000113469.2
 Rasgrp2

RAS, guanyl releasing protein 2

chr2_+_164785823 0.712 ENSMUST00000174070.1
ENSMUST00000172577.1
ENSMUST00000056181.6
 Snx21


sorting nexin family member 21


chr19_+_4231899 0.676 ENSMUST00000025773.3
 Pold4
polymerase (DNA-directed), delta 4
chr19_-_10869757 0.643 ENSMUST00000120524.1
ENSMUST00000025645.7
 Tmem132a

transmembrane protein 132A

chr11_+_82101836 0.614 ENSMUST00000000194.3
 Ccl12
chemokine (C-C motif) ligand 12
chr5_+_24423805 0.574 ENSMUST00000153274.1
 Slc4a2
solute carrier family 4 (anion exchanger), member 2
chr6_-_124415037 0.569 ENSMUST00000035861.5
ENSMUST00000112532.1
ENSMUST00000080557.5
 Pex5


peroxisomal biogenesis factor 5


chr10_-_127620960 0.566 ENSMUST00000121829.1
 Lrp1
low density lipoprotein receptor-related protein 1
chr7_-_19458494 0.562 ENSMUST00000085715.5
 Mark4
MAP/microtubule affinity-regulating kinase 4
chr10_-_127620922 0.554 ENSMUST00000118455.1
 Lrp1
low density lipoprotein receptor-related protein 1
chr1_+_167598384 0.524 ENSMUST00000015987.3
 Rxrg
retinoid X receptor gamma
chr4_+_129513581 0.511 ENSMUST00000062356.6
 Marcksl1
MARCKS-like 1
chr17_-_29347902 0.487 ENSMUST00000095427.4
ENSMUST00000118366.1
 Mtch1

mitochondrial carrier homolog 1 (C. elegans)

chr11_-_33203588 0.456 ENSMUST00000037746.6
 Tlx3
T cell leukemia, homeobox 3
chr14_-_70520254 0.444 ENSMUST00000022693.7
 Bmp1
bone morphogenetic protein 1
chr9_-_37552904 0.440 ENSMUST00000065668.5
 Nrgn
neurogranin
chr8_-_41016749 0.432 ENSMUST00000117735.1
 Mtus1
mitochondrial tumor suppressor 1
chr17_+_55986494 0.427 ENSMUST00000011733.8
 Fsd1
fibronectin type 3 and SPRY domain-containing protein
chr15_+_89253035 0.405 ENSMUST00000088788.3
 Ppp6r2
protein phosphatase 6, regulatory subunit 2
chr10_-_14705459 0.398 ENSMUST00000149485.1
ENSMUST00000154132.1
 Vta1

Vps20-associated 1 homolog (S. cerevisiae)

chr9_+_120492606 0.393 ENSMUST00000007139.4
 Eif1b
eukaryotic translation initiation factor 1B
chr11_-_94474088 0.384 ENSMUST00000107786.1
ENSMUST00000107791.1
ENSMUST00000103166.2
ENSMUST00000107792.1
ENSMUST00000100561.3
ENSMUST00000107793.1
ENSMUST00000107788.1
ENSMUST00000107790.1
ENSMUST00000107789.1
ENSMUST00000107785.1
ENSMUST00000021234.8
 Cacna1g










calcium channel, voltage-dependent, T type, alpha 1G subunit










chr7_+_45705518 0.373 ENSMUST00000107740.1
ENSMUST00000107741.1
 Dbp

D site albumin promoter binding protein

chr7_-_120670256 0.368 ENSMUST00000033178.2
 Pdzd9
PDZ domain containing 9
chr19_+_10041548 0.359 ENSMUST00000115995.2
 Fads3
fatty acid desaturase 3
chr15_+_101174096 0.301 ENSMUST00000000544.9
 Acvr1b
activin A receptor, type 1B
chr2_+_133552159 0.276 ENSMUST00000028836.6
 Bmp2
bone morphogenetic protein 2
chr4_+_31964081 0.238 ENSMUST00000037607.4
ENSMUST00000080933.6
ENSMUST00000108183.1
ENSMUST00000108184.2
 Map3k7



mitogen-activated protein kinase kinase kinase 7



chr11_+_102836296 0.231 ENSMUST00000021302.8
ENSMUST00000107072.1
 Higd1b

HIG1 domain family, member 1B

chr8_-_94012558 0.211 ENSMUST00000053766.6
 Amfr
autocrine motility factor receptor
chr8_-_83699095 0.199 ENSMUST00000005616.8
 Pkn1
protein kinase N1
chr9_+_57130690 0.177 ENSMUST00000160147.1
ENSMUST00000161663.1
ENSMUST00000034836.9
ENSMUST00000161182.1
 Man2c1



mannosidase, alpha, class 2C, member 1



chr7_-_34196608 0.175 ENSMUST00000148381.1
ENSMUST00000002710.3
 Pdcd2l

programmed cell death 2-like

chr6_-_128200598 0.169 ENSMUST00000071101.6
 Gm10010
predicted gene 10010
chr2_-_30359278 0.159 ENSMUST00000163668.2
ENSMUST00000028214.8
ENSMUST00000113621.3
 Sh3glb2


SH3-domain GRB2-like endophilin B2


chr7_-_16286744 0.129 ENSMUST00000150528.2
ENSMUST00000118976.2
ENSMUST00000146609.2
 Ccdc9


coiled-coil domain containing 9


chr12_+_69184158 0.102 ENSMUST00000060579.8
 Mgat2
mannoside acetylglucosaminyltransferase 2
chr11_-_115535804 0.093 ENSMUST00000117589.1
ENSMUST00000121185.1
 Sumo2

SMT3 suppressor of mif two 3 homolog 2 (yeast)

chr10_+_82954344 0.089 ENSMUST00000095396.3
 Gm4799
predicted gene 4799
chr11_-_115536181 0.079 ENSMUST00000118155.1
ENSMUST00000153892.1
 Sumo2

SMT3 suppressor of mif two 3 homolog 2 (yeast)

chr2_-_30359190 0.056 ENSMUST00000100215.4
ENSMUST00000113620.3
 Sh3glb2

SH3-domain GRB2-like endophilin B2

chr7_-_105744312 0.051 ENSMUST00000141116.1
 Taf10
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr5_+_24423851 0.048 ENSMUST00000141966.1
 Slc4a2
solute carrier family 4 (anion exchanger), member 2
chr9_-_21127346 0.042 ENSMUST00000001036.10
 Tyk2
tyrosine kinase 2
chr10_+_81137953 0.041 ENSMUST00000117956.1
 Zbtb7a
zinc finger and BTB domain containing 7a
chr1_-_54926311 0.040 ENSMUST00000179030.1
ENSMUST00000044359.9
 Ankrd44

ankyrin repeat domain 44

chr4_+_154237525 0.020 ENSMUST00000152159.1
 Megf6
multiple EGF-like-domains 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.5 GO:1903802 positive regulation of arachidonic acid secretion(GO:0090238) L-glutamate(1-) import into cell(GO:1903802) L-glutamate import into cell(GO:1990123)
0.4 2.3 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.4 1.8 GO:0060838 lymphatic endothelial cell fate commitment(GO:0060838) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.3 1.4 GO:0001661 conditioned taste aversion(GO:0001661)
0.3 1.1 GO:0097477 lateral motor column neuron migration(GO:0097477)
0.2 1.1 GO:2000587 regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000586) negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.2 0.6 GO:2000501 natural killer cell chemotaxis(GO:0035747) negative regulation of lymphocyte migration(GO:2000402) regulation of natural killer cell chemotaxis(GO:2000501)
0.2 0.6 GO:0016561 protein import into peroxisome matrix, translocation(GO:0016561)
0.1 0.4 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.1 1.3 GO:0048149 behavioral response to ethanol(GO:0048149)
0.1 0.3 GO:0060129 BMP signaling pathway involved in heart induction(GO:0003130) endodermal-mesodermal cell signaling(GO:0003133) endodermal-mesodermal cell signaling involved in heart induction(GO:0003134) thyroid-stimulating hormone-secreting cell differentiation(GO:0060129) mesenchymal cell proliferation involved in ureteric bud development(GO:0072138)
0.1 1.2 GO:0060081 membrane hyperpolarization(GO:0060081)
0.1 0.4 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.1 0.3 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.1 0.8 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.0 0.2 GO:0097343 ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026)
0.0 1.4 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.7 GO:0000731 DNA synthesis involved in DNA repair(GO:0000731)
0.0 0.5 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.0 0.2 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.0 0.4 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 0.2 GO:0006013 mannose metabolic process(GO:0006013)
0.0 1.5 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.4 GO:1900273 positive regulation of long-term synaptic potentiation(GO:1900273)
0.0 0.4 GO:0061036 positive regulation of cartilage development(GO:0061036)
0.0 0.7 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.4 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.5 GO:0032280 symmetric synapse(GO:0032280)
0.2 1.4 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.2 0.7 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 0.3 GO:0048179 activin receptor complex(GO:0048179)
0.1 3.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.8 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.4 GO:0044327 dendritic spine head(GO:0044327)
0.0 1.0 GO:0071565 nBAF complex(GO:0071565)
0.0 1.2 GO:0043194 axon initial segment(GO:0043194)
0.0 0.2 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.0 1.4 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.6 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 1.1 GO:0005905 clathrin-coated pit(GO:0005905)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0070905 serine binding(GO:0070905)
0.2 1.8 GO:0001972 retinoic acid binding(GO:0001972)
0.2 0.6 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 1.4 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 2.5 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 0.6 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.1 1.0 GO:0042809 vitamin D receptor binding(GO:0042809)
0.1 0.4 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.1 0.8 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 0.3 GO:0016361 activin receptor activity, type I(GO:0016361)
0.1 2.3 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.1 0.2 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.0 1.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.2 GO:1904288 BAT3 complex binding(GO:1904288)
0.0 0.3 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 1.0 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 1.5 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 1.4 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.4 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.2 GO:0016215 acyl-CoA desaturase activity(GO:0016215)
0.0 0.6 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 0.6 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.7 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.2 GO:0031386 protein tag(GO:0031386)
0.0 0.0 GO:0005131 growth hormone receptor binding(GO:0005131)