Motif ID: Zic2

Z-value: 0.484


Transcription factors associated with Zic2:

Gene SymbolEntrez IDGene Name
Zic2 ENSMUSG00000061524.8 Zic2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zic2mm10_v2_chr14_+_122475397_122475435-0.301.3e-01Click!


Activity profile for motif Zic2.

activity profile for motif Zic2


Sorted Z-values histogram for motif Zic2

Sorted Z-values for motif Zic2



Network of associatons between targets according to the STRING database.



First level regulatory network of Zic2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66969616 1.377 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
 Ndrg1



N-myc downstream regulated gene 1



chr7_-_19699008 1.030 ENSMUST00000174355.1
ENSMUST00000172983.1
ENSMUST00000174710.1
ENSMUST00000167646.2
ENSMUST00000003066.9
ENSMUST00000174064.1
 Apoe





apolipoprotein E





chrX_+_170009892 0.976 ENSMUST00000180251.1
 Gm21887
predicted gene, 21887
chr2_-_131043088 0.967 ENSMUST00000110240.3
ENSMUST00000066958.4
ENSMUST00000110235.1
 Gfra4


glial cell line derived neurotrophic factor family receptor alpha 4


chrY_+_90784738 0.913 ENSMUST00000179483.1
 Erdr1
erythroid differentiation regulator 1
chr7_-_46179929 0.873 ENSMUST00000033123.6
 Abcc8
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
chr11_+_67586675 0.774 ENSMUST00000108680.1
 Gas7
growth arrest specific 7
chr16_+_35154870 0.713 ENSMUST00000114913.1
 Adcy5
adenylate cyclase 5
chr11_+_67586520 0.713 ENSMUST00000108682.2
 Gas7
growth arrest specific 7
chr5_-_139130159 0.709 ENSMUST00000129851.1
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr8_+_104170513 0.702 ENSMUST00000171018.1
ENSMUST00000167633.1
ENSMUST00000093245.5
ENSMUST00000164076.1
 Bean1



brain expressed, associated with Nedd4, 1



chrX_+_170009659 0.683 ENSMUST00000179760.1
 Gm21887
predicted gene, 21887
chr2_+_180499893 0.661 ENSMUST00000029084.2
 Ntsr1
neurotensin receptor 1
chr8_+_80494032 0.652 ENSMUST00000063359.6
 Gypa
glycophorin A
chr15_-_66948419 0.621 ENSMUST00000167817.1
 Ndrg1
N-myc downstream regulated gene 1
chr7_-_19698206 0.602 ENSMUST00000172808.1
ENSMUST00000174191.1
 Apoe

apolipoprotein E

chr4_+_42240639 0.599 ENSMUST00000117202.2
 Gm10600
predicted gene 10600
chr17_-_56140333 0.582 ENSMUST00000001256.4
 Sema6b
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr17_+_46297917 0.577 ENSMUST00000166617.1
ENSMUST00000170271.1
 Dlk2

delta-like 2 homolog (Drosophila)

chr9_-_107985863 0.575 ENSMUST00000048568.4
 Fam212a
family with sequence similarity 212, member A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 119 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 2.2 GO:2001139 negative regulation of postsynaptic membrane organization(GO:1901627) negative regulation of dendritic spine maintenance(GO:1902951) negative regulation of phospholipid efflux(GO:1902999) regulation of lipid transport across blood brain barrier(GO:1903000) negative regulation of lipid transport across blood brain barrier(GO:1903001) positive regulation of lipid transport across blood brain barrier(GO:1903002) negative regulation of phospholipid transport(GO:2001139)
0.2 2.0 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.3 1.1 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.0 1.0 GO:0010043 response to zinc ion(GO:0010043)
0.0 0.9 GO:0030279 negative regulation of ossification(GO:0030279)
0.2 0.8 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.1 0.8 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.2 0.7 GO:1903802 positive regulation of arachidonic acid secretion(GO:0090238) L-glutamate(1-) import into cell(GO:1903802) L-glutamate import into cell(GO:1990123)
0.1 0.7 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.1 0.7 GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.1 0.7 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.7 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843)
0.1 0.6 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.0 0.6 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.6 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.2 0.5 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.2 0.5 GO:0032430 positive regulation of phospholipase A2 activity(GO:0032430)
0.1 0.5 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 0.5 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.5 GO:0002021 response to dietary excess(GO:0002021)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 GO:0031225 anchored component of membrane(GO:0031225)
0.7 2.2 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.0 1.7 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 1.0 GO:0005606 laminin-1 complex(GO:0005606)
0.2 0.8 GO:0032280 symmetric synapse(GO:0032280)
0.1 0.8 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.2 0.5 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.2 0.5 GO:0097233 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.0 0.5 GO:0032279 asymmetric synapse(GO:0032279)
0.1 0.4 GO:0097443 sorting endosome(GO:0097443)
0.0 0.4 GO:0032590 dendrite membrane(GO:0032590)
0.1 0.3 GO:0045179 apical cortex(GO:0045179)
0.1 0.3 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.1 0.3 GO:0001652 granular component(GO:0001652)
0.0 0.3 GO:0005915 zonula adherens(GO:0005915)
0.0 0.3 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.3 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 GO:0045296 cadherin binding(GO:0045296)
0.7 2.2 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.2 1.2 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.2 1.1 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.3 1.0 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.1 1.0 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 1.0 GO:0005267 potassium channel activity(GO:0005267)
0.0 0.9 GO:0005507 copper ion binding(GO:0005507)
0.2 0.8 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.0 0.8 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.8 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 0.7 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.6 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.6 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 0.6 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.6 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.5 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.5 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.5 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)