Motif ID: Zic3

Z-value: 1.291


Transcription factors associated with Zic3:

Gene SymbolEntrez IDGene Name
Zic3 ENSMUSG00000067860.5 Zic3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zic3mm10_v2_chrX_+_58030999_580310180.774.4e-06Click!


Activity profile for motif Zic3.

activity profile for motif Zic3


Sorted Z-values histogram for motif Zic3

Sorted Z-values for motif Zic3



Network of associatons between targets according to the STRING database.



First level regulatory network of Zic3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_166254095 6.796 ENSMUST00000111416.1
 Ildr2
immunoglobulin-like domain containing receptor 2
chr13_-_29984219 5.057 ENSMUST00000146092.1
 E2f3
E2F transcription factor 3
chr13_-_95891905 4.064 ENSMUST00000068603.6
 Iqgap2
IQ motif containing GTPase activating protein 2
chr17_+_86963279 3.951 ENSMUST00000139344.1
 Rhoq
ras homolog gene family, member Q
chr15_-_94404258 3.860 ENSMUST00000035342.4
ENSMUST00000155907.1
 Adamts20

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20

chr2_-_92370999 3.496 ENSMUST00000176810.1
ENSMUST00000090582.4
 Gyltl1b

glycosyltransferase-like 1B

chr7_-_49636847 3.367 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chrX_+_71050160 3.350 ENSMUST00000082088.3
ENSMUST00000114629.3
 Mamld1

mastermind-like domain containing 1

chrX_+_73639414 3.301 ENSMUST00000019701.8
 Dusp9
dual specificity phosphatase 9
chr14_-_48665098 3.297 ENSMUST00000118578.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr2_-_92371039 3.194 ENSMUST00000068586.6
 Gyltl1b
glycosyltransferase-like 1B
chr17_+_85613432 3.095 ENSMUST00000176081.1
 Six3
sine oculis-related homeobox 3
chr4_+_124986430 3.067 ENSMUST00000030687.7
 Rspo1
R-spondin homolog (Xenopus laevis)
chr2_+_31640037 3.061 ENSMUST00000113470.2
 Prdm12
PR domain containing 12
chr5_+_139543889 2.885 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr2_-_92370968 2.881 ENSMUST00000176774.1
 Gyltl1b
glycosyltransferase-like 1B
chr13_+_44730726 2.838 ENSMUST00000173704.1
ENSMUST00000044608.7
ENSMUST00000173367.1
 Jarid2


jumonji, AT rich interactive domain 2


chr17_-_73710415 2.602 ENSMUST00000112591.2
ENSMUST00000024858.5
 Galnt14

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14

chrX_+_56454871 2.597 ENSMUST00000039374.2
ENSMUST00000101553.2
 Ddx26b

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B

chr3_-_66981279 2.505 ENSMUST00000162098.2
 Shox2
short stature homeobox 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 166 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 9.6 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.8 8.0 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.3 5.7 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
1.0 5.1 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.1 5.1 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.5 4.1 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.5 3.9 GO:1902913 positive regulation of melanocyte differentiation(GO:0045636) positive regulation of neuroepithelial cell differentiation(GO:1902913)
0.6 3.8 GO:0003383 apical constriction(GO:0003383)
0.7 3.5 GO:0006167 AMP biosynthetic process(GO:0006167)
0.2 3.4 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.8 3.3 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.3 3.3 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
1.0 3.1 GO:0097402 neuroblast migration(GO:0097402)
0.3 3.1 GO:2000254 regulation of male germ cell proliferation(GO:2000254)
0.2 3.0 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.4 2.9 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.3 2.9 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.1 2.9 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.3 2.8 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.8 2.5 GO:0046671 negative regulation of retinal cell programmed cell death(GO:0046671)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.9 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 4.1 GO:0031941 filamentous actin(GO:0031941)
0.5 3.8 GO:0033269 internode region of axon(GO:0033269)
0.2 3.3 GO:0035686 sperm fibrous sheath(GO:0035686)
0.4 3.0 GO:0001940 male pronucleus(GO:0001940)
0.0 2.9 GO:0032587 ruffle membrane(GO:0032587)
0.6 2.4 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.2 2.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 2.3 GO:0005884 actin filament(GO:0005884)
0.0 2.2 GO:0005814 centriole(GO:0005814)
0.1 2.1 GO:0001741 XY body(GO:0001741)
0.0 2.1 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.5 1.8 GO:0097165 nuclear stress granule(GO:0097165)
0.3 1.8 GO:0000796 condensin complex(GO:0000796)
0.1 1.8 GO:0097542 ciliary tip(GO:0097542)
0.0 1.8 GO:0016607 nuclear speck(GO:0016607)
0.1 1.5 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 1.5 GO:0097539 ciliary transition fiber(GO:0097539)
0.0 1.5 GO:0030426 growth cone(GO:0030426)
0.3 1.4 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 123 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 9.6 GO:0018121 imidazoleglycerol-phosphate synthase activity(GO:0000107) NAD(P)-cysteine ADP-ribosyltransferase activity(GO:0018071) NAD(P)-asparagine ADP-ribosyltransferase activity(GO:0018121) NAD(P)-serine ADP-ribosyltransferase activity(GO:0018127) 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity(GO:0043867) purine deoxyribosyltransferase activity(GO:0044102)
0.0 8.5 GO:0001047 core promoter binding(GO:0001047)
0.4 5.7 GO:0005522 profilin binding(GO:0005522)
0.0 5.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 4.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 4.3 GO:0032452 histone demethylase activity(GO:0032452)
0.0 4.2 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.4 4.1 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 3.8 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.6 3.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.2 3.1 GO:0001222 transcription corepressor binding(GO:0001222)
0.3 3.0 GO:1990226 histone methyltransferase binding(GO:1990226)
0.5 2.9 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.3 2.8 GO:0051718 DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.6 2.4 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.3 2.4 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.3 2.4 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.6 2.3 GO:0043515 kinetochore binding(GO:0043515)
0.1 2.1 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.2 1.9 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)