Motif ID: Zic4

Z-value: 0.963


Transcription factors associated with Zic4:

Gene SymbolEntrez IDGene Name
Zic4 ENSMUSG00000036972.8 Zic4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zic4mm10_v2_chr9_+_91378636_91378646-0.366.8e-02Click!


Activity profile for motif Zic4.

activity profile for motif Zic4


Sorted Z-values histogram for motif Zic4

Sorted Z-values for motif Zic4



Network of associatons between targets according to the STRING database.



First level regulatory network of Zic4

PNG image of the network

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Top targets:


Showing 1 to 20 of 184 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_180499893 4.200 ENSMUST00000029084.2
 Ntsr1
neurotensin receptor 1
chr4_+_141368116 3.468 ENSMUST00000006380.4
 Fam131c
family with sequence similarity 131, member C
chr14_-_64455903 3.172 ENSMUST00000067927.7
 Msra
methionine sulfoxide reductase A
chr4_+_152338619 2.908 ENSMUST00000030775.5
ENSMUST00000164662.1
 Chd5

chromodomain helicase DNA binding protein 5

chr9_-_29412204 2.884 ENSMUST00000115237.1
 Ntm
neurotrimin
chr4_+_152338887 2.852 ENSMUST00000005175.4
 Chd5
chromodomain helicase DNA binding protein 5
chr6_+_141524379 2.818 ENSMUST00000032362.9
 Slco1c1
solute carrier organic anion transporter family, member 1c1
chr19_+_4855129 2.598 ENSMUST00000119694.1
 Ctsf
cathepsin F
chr17_+_46297917 2.541 ENSMUST00000166617.1
ENSMUST00000170271.1
 Dlk2

delta-like 2 homolog (Drosophila)

chr4_-_64046925 2.515 ENSMUST00000107377.3
 Tnc
tenascin C
chr1_-_43163891 2.504 ENSMUST00000008280.7
 Fhl2
four and a half LIM domains 2
chr19_-_57008187 2.386 ENSMUST00000118800.1
ENSMUST00000111584.2
ENSMUST00000122359.1
ENSMUST00000148049.1
 Afap1l2



actin filament associated protein 1-like 2



chr7_-_47133684 2.311 ENSMUST00000102626.1
 Ptpn5
protein tyrosine phosphatase, non-receptor type 5
chr5_-_139325616 2.240 ENSMUST00000110865.1
 Adap1
ArfGAP with dual PH domains 1
chr11_+_98741805 2.150 ENSMUST00000064187.5
 Thra
thyroid hormone receptor alpha
chr7_-_47133395 2.079 ENSMUST00000107617.1
 Ptpn5
protein tyrosine phosphatase, non-receptor type 5
chr14_-_29721835 2.076 ENSMUST00000022567.7
 Cacna2d3
calcium channel, voltage-dependent, alpha2/delta subunit 3
chr11_+_5861886 1.990 ENSMUST00000102923.3
 Aebp1
AE binding protein 1
chr6_+_99692679 1.990 ENSMUST00000101122.1
 Gpr27
G protein-coupled receptor 27
chr17_-_29237759 1.990 ENSMUST00000137727.1
ENSMUST00000024805.7
 Cpne5

copine V


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 5.8 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.9 4.4 GO:2001025 positive regulation of response to drug(GO:2001025)
1.1 4.2 GO:1903802 positive regulation of arachidonic acid secretion(GO:0090238) L-glutamate(1-) import into cell(GO:1903802) L-glutamate import into cell(GO:1990123)
1.3 3.9 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
0.0 3.4 GO:0046330 positive regulation of JNK cascade(GO:0046330)
0.1 3.3 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742)
0.6 3.2 GO:0030091 protein repair(GO:0030091)
0.2 3.1 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.3 2.8 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.6 2.5 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.8 2.4 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.3 2.2 GO:0032811 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811)
0.0 2.1 GO:0051924 regulation of calcium ion transport(GO:0051924)
0.7 2.0 GO:1900736 regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900736)
0.1 2.0 GO:1903861 regulation of dendrite extension(GO:1903859) positive regulation of dendrite extension(GO:1903861)
0.1 1.8 GO:0042711 maternal behavior(GO:0042711)
0.0 1.7 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.3 1.6 GO:0060050 positive regulation of protein glycosylation(GO:0060050)
0.2 1.6 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.1 1.5 GO:0010748 negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) positive regulation of fatty acid beta-oxidation(GO:0032000)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 4.4 GO:1990635 proximal dendrite(GO:1990635)
0.2 4.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 4.3 GO:0031225 anchored component of membrane(GO:0031225)
1.1 4.2 GO:0032280 symmetric synapse(GO:0032280)
0.2 2.5 GO:0005614 interstitial matrix(GO:0005614)
0.1 2.5 GO:0031430 M band(GO:0031430)
0.2 2.4 GO:0044327 dendritic spine head(GO:0044327)
0.4 2.2 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 2.2 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 2.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 1.7 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1 1.5 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 1.5 GO:0005811 lipid particle(GO:0005811)
0.3 1.4 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 1.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 1.0 GO:0005902 microvillus(GO:0005902)
0.2 0.9 GO:0033010 paranodal junction(GO:0033010)
0.0 0.9 GO:0097440 apical dendrite(GO:0097440)
0.0 0.9 GO:0045171 intercellular bridge(GO:0045171)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.4 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 4.8 GO:0035064 methylated histone binding(GO:0035064)
0.2 4.2 GO:0008188 neuropeptide receptor activity(GO:0008188)
1.3 3.9 GO:0002153 steroid receptor RNA activator RNA binding(GO:0002153)
0.6 3.4 GO:0045545 syndecan binding(GO:0045545)
0.3 3.2 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.1 3.1 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 3.0 GO:0001784 phosphotyrosine binding(GO:0001784)
0.7 2.8 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 2.6 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.2 2.4 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.2 2.3 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.4 2.2 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 2.1 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.4 1.6 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.1 1.4 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 1.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.4 1.2 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
0.0 1.2 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 1.1 GO:0043008 ATP-dependent protein binding(GO:0043008)