Motif ID: Zkscan3

Z-value: 0.314


Transcription factors associated with Zkscan3:

Gene SymbolEntrez IDGene Name
Zkscan3 ENSMUSG00000021327.12 Zkscan3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zkscan3mm10_v2_chr13_-_21402688_21402755-0.618.9e-04Click!


Activity profile for motif Zkscan3.

activity profile for motif Zkscan3


Sorted Z-values histogram for motif Zkscan3

Sorted Z-values for motif Zkscan3



Network of associatons between targets according to the STRING database.



First level regulatory network of Zkscan3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_+_61105844 0.811 ENSMUST00000115268.3
 Csf1r
colony stimulating factor 1 receptor
chr6_-_122856151 0.700 ENSMUST00000042081.8
 C3ar1
complement component 3a receptor 1
chr5_+_24985840 0.621 ENSMUST00000075081.6
 1500035N22Rik
RIKEN cDNA 1500035N22 gene
chr11_-_75422524 0.563 ENSMUST00000125982.1
ENSMUST00000137103.1
 Serpinf1

serine (or cysteine) peptidase inhibitor, clade F, member 1

chr11_-_75422586 0.510 ENSMUST00000138661.1
ENSMUST00000000769.7
 Serpinf1

serine (or cysteine) peptidase inhibitor, clade F, member 1

chr2_+_155775333 0.490 ENSMUST00000029141.5
 Mmp24
matrix metallopeptidase 24
chr8_+_70616816 0.490 ENSMUST00000052437.3
 Lrrc25
leucine rich repeat containing 25
chr1_-_40790642 0.465 ENSMUST00000039672.5
 Mfsd9
major facilitator superfamily domain containing 9
chr13_+_42709482 0.400 ENSMUST00000066928.5
ENSMUST00000148891.1
 Phactr1

phosphatase and actin regulator 1

chr6_+_125552948 0.396 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
 Vwf


Von Willebrand factor homolog


chr7_-_98178254 0.386 ENSMUST00000040971.7
 Capn5
calpain 5
chr2_+_32646586 0.385 ENSMUST00000009705.7
ENSMUST00000167841.1
 Eng

endoglin

chr2_+_156613664 0.381 ENSMUST00000169464.2
ENSMUST00000109567.3
 Dlgap4

discs, large homolog-associated protein 4 (Drosophila)

chr8_-_105758570 0.376 ENSMUST00000155038.2
ENSMUST00000013294.9
 Gfod2

glucose-fructose oxidoreductase domain containing 2

chr18_+_82554463 0.318 ENSMUST00000062446.7
ENSMUST00000102812.4
ENSMUST00000075372.5
ENSMUST00000080658.4
ENSMUST00000152071.1
ENSMUST00000114674.3
ENSMUST00000142850.1
ENSMUST00000133193.1
ENSMUST00000123251.1
ENSMUST00000153478.1
ENSMUST00000132369.1
 Mbp










myelin basic protein










chr11_-_102365111 0.300 ENSMUST00000006749.9
 Slc4a1
solute carrier family 4 (anion exchanger), member 1
chr8_-_124897685 0.284 ENSMUST00000098312.2
 Exoc8
exocyst complex component 8
chr5_-_73338580 0.281 ENSMUST00000087195.5
 Ociad2
OCIA domain containing 2
chr8_+_94810446 0.260 ENSMUST00000034232.1
 Ccl17
chemokine (C-C motif) ligand 17
chr11_+_116918844 0.256 ENSMUST00000103027.3
 Mgat5b
mannoside acetylglucosaminyltransferase 5, isoenzyme B
chr6_-_97459279 0.246 ENSMUST00000113359.1
 Frmd4b
FERM domain containing 4B
chr8_-_106893515 0.238 ENSMUST00000176090.1
 Chtf8
CTF8, chromosome transmission fidelity factor 8
chr12_+_76533540 0.230 ENSMUST00000075249.4
 Plekhg3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr19_-_10869757 0.222 ENSMUST00000120524.1
ENSMUST00000025645.7
 Tmem132a

transmembrane protein 132A

chr2_-_30194112 0.218 ENSMUST00000113659.1
ENSMUST00000113660.1
 Ccbl1

cysteine conjugate-beta lyase 1

chr8_-_70760889 0.215 ENSMUST00000038626.8
 Mpv17l2
MPV17 mitochondrial membrane protein-like 2
chr7_+_126759601 0.211 ENSMUST00000050201.4
ENSMUST00000057669.9
 Mapk3

mitogen-activated protein kinase 3

chr11_-_102218923 0.194 ENSMUST00000131254.1
 Hdac5
histone deacetylase 5
chr11_-_88851462 0.192 ENSMUST00000107903.1
 Akap1
A kinase (PRKA) anchor protein 1
chr17_+_46110982 0.188 ENSMUST00000024763.3
ENSMUST00000123646.1
 Mrps18a

mitochondrial ribosomal protein S18A

chr1_+_132298606 0.187 ENSMUST00000046071.4
 Klhdc8a
kelch domain containing 8A
chr2_+_104095796 0.186 ENSMUST00000040423.5
ENSMUST00000168176.1
 Cd59a

CD59a antigen

chr19_+_6276725 0.184 ENSMUST00000025684.3
 Ehd1
EH-domain containing 1
chr13_-_32851176 0.184 ENSMUST00000091668.5
ENSMUST00000076352.6
 Serpinb1a

serine (or cysteine) peptidase inhibitor, clade B, member 1a

chr5_+_117976761 0.178 ENSMUST00000035579.6
 Fbxo21
F-box protein 21
chr8_+_31091593 0.173 ENSMUST00000161713.1
 Dusp26
dual specificity phosphatase 26 (putative)
chr13_-_38658991 0.169 ENSMUST00000001757.7
 Eef1e1
eukaryotic translation elongation factor 1 epsilon 1
chr8_-_106893581 0.159 ENSMUST00000176437.1
ENSMUST00000177068.1
ENSMUST00000169312.1
ENSMUST00000176515.1
 Chtf8



CTF8, chromosome transmission fidelity factor 8



chr7_-_81345189 0.156 ENSMUST00000080813.4
 Rps17
ribosomal protein S17
chr4_+_63544747 0.153 ENSMUST00000035301.6
 Atp6v1g1
ATPase, H+ transporting, lysosomal V1 subunit G1
chr9_+_87144285 0.150 ENSMUST00000113149.1
ENSMUST00000143779.1
ENSMUST00000179313.1
ENSMUST00000049457.7
ENSMUST00000153444.1
 Mrap2




melanocortin 2 receptor accessory protein 2




chr13_-_19395728 0.142 ENSMUST00000039694.7
 Stard3nl
STARD3 N-terminal like
chr6_+_127453705 0.139 ENSMUST00000039680.5
 Parp11
poly (ADP-ribose) polymerase family, member 11
chr4_+_139192899 0.138 ENSMUST00000102508.3
ENSMUST00000131912.1
ENSMUST00000102507.3
 Capzb


capping protein (actin filament) muscle Z-line, beta


chr9_+_114688782 0.133 ENSMUST00000047404.6
 Dync1li1
dynein cytoplasmic 1 light intermediate chain 1
chr18_-_34651703 0.123 ENSMUST00000025228.5
ENSMUST00000133181.1
 Cdc23

CDC23 cell division cycle 23

chr8_+_106893616 0.116 ENSMUST00000047629.5
 Cirh1a
cirrhosis, autosomal recessive 1A (human)
chr15_-_3979432 0.116 ENSMUST00000022791.8
 Fbxo4
F-box protein 4
chr17_-_35673738 0.103 ENSMUST00000001565.8
 Gtf2h4
general transcription factor II H, polypeptide 4
chr5_+_24586721 0.101 ENSMUST00000121863.1
ENSMUST00000088295.4
 Chpf2

chondroitin polymerizing factor 2

chr8_+_71396853 0.093 ENSMUST00000002473.8
 Babam1
BRISC and BRCA1 A complex member 1
chr2_+_31670714 0.079 ENSMUST00000038474.7
ENSMUST00000137156.1
 Exosc2

exosome component 2

chr7_-_27228605 0.079 ENSMUST00000003850.7
 Itpkc
inositol 1,4,5-trisphosphate 3-kinase C
chr13_-_104109576 0.074 ENSMUST00000109315.3
 Nln
neurolysin (metallopeptidase M3 family)
chr6_+_127453667 0.063 ENSMUST00000112193.1
 Parp11
poly (ADP-ribose) polymerase family, member 11
chr8_+_124897877 0.061 ENSMUST00000034467.5
 Sprtn
SprT-like N-terminal domain
chr8_-_116978908 0.052 ENSMUST00000070577.5
 1700030J22Rik
RIKEN cDNA 1700030J22 gene
chr17_-_35673517 0.049 ENSMUST00000162266.1
ENSMUST00000160734.1
ENSMUST00000159852.1
ENSMUST00000160039.1
 Gtf2h4



general transcription factor II H, polypeptide 4



chr1_-_173333503 0.033 ENSMUST00000038227.4
 Darc
Duffy blood group, chemokine receptor
chr14_+_51893610 0.023 ENSMUST00000047726.5
ENSMUST00000161888.1
 Slc39a2

solute carrier family 39 (zinc transporter), member 2

chr7_+_101896340 0.014 ENSMUST00000035395.7
ENSMUST00000106973.1
ENSMUST00000144207.1
 Anapc15


anaphase prompoting complex C subunit 15


chr6_-_113719880 0.010 ENSMUST00000064993.5
 Ghrl
ghrelin
chr10_+_80629646 0.001 ENSMUST00000085435.5
 Csnk1g2
casein kinase 1, gamma 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.2 0.8 GO:0038145 macrophage colony-stimulating factor signaling pathway(GO:0038145)
0.1 0.4 GO:0003032 detection of oxygen(GO:0003032)
0.1 1.1 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.1 0.2 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.0 0.4 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0 0.3 GO:0001927 exocyst assembly(GO:0001927)
0.0 0.2 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.0 0.5 GO:0044331 cell-cell adhesion mediated by cadherin(GO:0044331)
0.0 0.2 GO:0090272 negative regulation of fibroblast growth factor production(GO:0090272)
0.0 0.2 GO:0061668 mitochondrial ribosome assembly(GO:0061668)
0.0 0.2 GO:0000189 MAPK import into nucleus(GO:0000189)
0.0 0.2 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.0 0.1 GO:0051490 negative regulation of filopodium assembly(GO:0051490)
0.0 0.1 GO:0098528 skeletal muscle fiber differentiation(GO:0098528)
0.0 0.2 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0 0.1 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.0 0.3 GO:0006968 cellular defense response(GO:0006968)
0.0 0.1 GO:0071033 nuclear retention of pre-mRNA at the site of transcription(GO:0071033) CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043) polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.0 0.2 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.0 0.1 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.3 GO:0015701 response to activity(GO:0014823) bicarbonate transport(GO:0015701) response to arsenic-containing substance(GO:0046685)
0.0 0.0 GO:2000507 positive regulation of energy homeostasis(GO:2000507)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 0.4 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 1.1 GO:0043203 axon hillock(GO:0043203)
0.1 0.2 GO:0020018 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.0 0.4 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 0.3 GO:0033269 internode region of axon(GO:0033269)
0.0 0.1 GO:0034455 t-UTP complex(GO:0034455)
0.0 0.2 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.2 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.2 GO:0000439 core TFIIH complex(GO:0000439)
0.0 0.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.3 GO:0000145 exocyst(GO:0000145)
0.0 0.2 GO:0031143 pseudopodium(GO:0031143)
0.0 0.2 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.1 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.1 GO:0070552 BRISC complex(GO:0070552)
0.0 0.2 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0004942 anaphylatoxin receptor activity(GO:0004942)
0.1 0.4 GO:0005534 galactose binding(GO:0005534)
0.1 0.3 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 0.2 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.1 0.3 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.1 0.2 GO:0031779 melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0 0.1 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.4 GO:0019865 immunoglobulin binding(GO:0019865)
0.0 0.4 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.2 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.0 1.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.4 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 0.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.3 GO:0015106 bicarbonate transmembrane transporter activity(GO:0015106)
0.0 0.1 GO:0070012 oligopeptidase activity(GO:0070012)
0.0 0.2 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.3 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.1 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0 0.8 GO:0019955 cytokine binding(GO:0019955)
0.0 0.5 GO:0045296 cadherin binding(GO:0045296)