Project
12D miR HR13_24
Navigation
Downloads
Results for Rela_Rel_Nfkb1
Z-value: 2.14
Motif logo
Transcription factors associated with Rela_Rel_Nfkb1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSMUSG00000024927.7 | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | |
| ENSMUSG00000020275.8 | reticuloendotheliosis oncogene | |
| ENSMUSG00000028163.11 | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nfkb1 | mm10_v2_chr3_-_135691512_135691564 | -0.81 | 2.2e-03 | Click! |
| Rela | mm10_v2_chr19_+_5637475_5637486 | -0.70 | 1.6e-02 | Click! |
| Rel | mm10_v2_chr11_-_23770953_23771028 | -0.64 | 3.3e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Rela_Rel_Nfkb1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 7.8 | GO:1902916 | positive regulation of protein polyubiquitination(GO:1902916) |
| 2.3 | 7.0 | GO:0070948 | regulation of neutrophil mediated cytotoxicity(GO:0070948) regulation of neutrophil mediated killing of symbiont cell(GO:0070949) |
| 0.2 | 5.4 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.0 | 4.6 | GO:0007601 | visual perception(GO:0007601) |
| 1.1 | 4.5 | GO:0060376 | positive regulation of mast cell differentiation(GO:0060376) |
| 0.6 | 4.3 | GO:2001199 | negative regulation of dendritic cell differentiation(GO:2001199) |
| 0.7 | 3.7 | GO:0001920 | negative regulation of receptor recycling(GO:0001920) |
| 0.0 | 3.7 | GO:0006888 | ER to Golgi vesicle-mediated transport(GO:0006888) |
| 0.0 | 3.7 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation(GO:0050731) |
| 0.9 | 3.4 | GO:1901740 | negative regulation of myoblast fusion(GO:1901740) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.6 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 12.3 | GO:0045121 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.1 | 4.3 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.3 | 3.9 | GO:0042581 | specific granule(GO:0042581) |
| 0.3 | 3.8 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.3 | 3.6 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 3.6 | GO:0031256 | leading edge membrane(GO:0031256) |
| 0.0 | 3.4 | GO:0016363 | nuclear matrix(GO:0016363) |
| 1.0 | 2.9 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.3 | 2.8 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 10.7 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.0 | 8.8 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.2 | 7.2 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.0 | 6.8 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 6.0 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 5.2 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.0 | 5.0 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 4.3 | GO:0005178 | integrin binding(GO:0005178) |
| 0.4 | 3.7 | GO:0001025 | RNA polymerase III transcription factor binding(GO:0001025) |
| 0.1 | 3.4 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 15.3 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.3 | 10.1 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.1 | 5.2 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 5.2 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.1 | 4.7 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.2 | 4.4 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.2 | 3.9 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.1 | 3.3 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 3.2 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.1 | 3.0 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 10.7 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.2 | 9.9 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.1 | 5.8 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.3 | 5.2 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.4 | 4.6 | REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX | Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| 0.3 | 3.9 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 3.3 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.1 | 3.1 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.1 | 3.0 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.1 | 2.9 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |