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12D miR HR13_24
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Results for Spi1
Z-value: 1.82
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Transcription factors associated with Spi1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Spi1 | mm10_v2_chr2_+_91082362_91082390 | -0.37 | 2.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Spi1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 3.9 | GO:0070488 | neutrophil aggregation(GO:0070488) |
| 0.7 | 3.7 | GO:0033277 | abortive mitotic cell cycle(GO:0033277) |
| 0.1 | 3.6 | GO:0070098 | chemokine-mediated signaling pathway(GO:0070098) |
| 0.2 | 3.3 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
| 0.1 | 3.1 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
| 0.7 | 3.0 | GO:0015827 | aromatic amino acid transport(GO:0015801) tryptophan transport(GO:0015827) |
| 0.3 | 3.0 | GO:0030886 | negative regulation of myeloid dendritic cell activation(GO:0030886) |
| 0.1 | 2.8 | GO:0032463 | negative regulation of protein homooligomerization(GO:0032463) |
| 0.1 | 2.7 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.3 | 2.6 | GO:0002553 | histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 20.0 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 4.5 | GO:0031227 | intrinsic component of endoplasmic reticulum membrane(GO:0031227) |
| 0.5 | 3.2 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.3 | 3.1 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.3 | 3.0 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.1 | 2.9 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.2 | 2.7 | GO:0001931 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 0.1 | 2.7 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.1 | 2.5 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.1 | 2.4 | GO:0032279 | asymmetric synapse(GO:0032279) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 4.8 | GO:0008009 | chemokine activity(GO:0008009) |
| 0.6 | 4.4 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) |
| 0.1 | 4.2 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.1 | 3.9 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.5 | 3.8 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.1 | 3.5 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.1 | 3.4 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.1 | 3.1 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.4 | 3.0 | GO:0008241 | peptidyl-dipeptidase activity(GO:0008241) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.1 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 7.0 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 4.4 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.1 | 4.0 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.0 | 3.3 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.2 | 2.8 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 2.6 | PID P73PATHWAY | p73 transcription factor network |
| 0.0 | 2.5 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.1 | 2.4 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 2.4 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 6.1 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.1 | 4.7 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.3 | 4.6 | REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.2 | 4.5 | REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS | Genes involved in Nucleotide-like (purinergic) receptors |
| 0.1 | 3.9 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |
| 0.1 | 3.6 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 3.5 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 2.9 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.1 | 2.8 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.1 | 2.4 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |