ISMARA results: E2f1

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avrg: 2D miR_HR1_12

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Results for E2f1

Z-value: 10.59

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Transcription factors associated with E2f1

Gene Symbol	Gene ID	Gene Info
E2f1 Ensembl NCBI MGI UniProt	ENSMUSG00000027490.11	E2F transcription factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
E2f1	mm10_v2_chr2_-_154569845_154569892	0.97	3.7e-07	Click!

Activity profile of E2f1 motif

Sorted Z-values of E2f1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr17_+_56303396 Show fit	17.49	ENSMUST00000113038.1	Uhrf1 Ensembl NCBI MGI UniProt Show fit	ubiquitin-like, containing PHD and RING finger domains, 1
chr4_-_89294608 Show fit	17.04	ENSMUST00000107131.1	Cdkn2a Ensembl NCBI MGI UniProt Show fit	cyclin-dependent kinase inhibitor 2A
chr17_+_56303321 Show fit	16.72	ENSMUST00000001258.8	Uhrf1 Ensembl NCBI MGI UniProt Show fit	ubiquitin-like, containing PHD and RING finger domains, 1
chr5_+_45669907 Show fit	16.58	ENSMUST00000117396.1	Ncapg Ensembl NCBI MGI UniProt Show fit	non-SMC condensin I complex, subunit G
chr4_+_126556935 Show fit	16.58	ENSMUST00000048391.8	Clspn Ensembl NCBI MGI UniProt Show fit	claspin
chr1_-_20820213 Show fit	15.81	ENSMUST00000053266.9	Mcm3 Ensembl NCBI MGI UniProt Show fit	minichromosome maintenance deficient 3 (S. cerevisiae)
chr13_-_55329723 Show fit	14.82	ENSMUST00000021941.7	Mxd3 Ensembl NCBI MGI UniProt Show fit	Max dimerization protein 3
chr9_+_65890237 Show fit	13.96	ENSMUST00000045802.6	2810417H13Rik Ensembl NCBI MGI UniProt Show fit	RIKEN cDNA 2810417H13 gene
chr1_-_191575534 Show fit	13.62	ENSMUST00000027933.5	Dtl Ensembl NCBI MGI UniProt Show fit	denticleless homolog (Drosophila)
chr7_+_102441685 Show fit	13.05	ENSMUST00000033283.9	Rrm1 Ensembl NCBI MGI UniProt Show fit	ribonucleotide reductase M1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.3	65.3	GO:0006270	DNA replication initiation(GO:0006270)
3.4	50.3	GO:0010216	maintenance of DNA methylation(GO:0010216)
4.8	47.8	GO:0006268	DNA unwinding involved in DNA replication(GO:0006268)
2.0	36.2	GO:0009263	deoxyribonucleotide biosynthetic process(GO:0009263)
5.9	29.4	GO:0007089	traversing start control point of mitotic cell cycle(GO:0007089)
0.4	27.3	GO:0051225	spindle assembly(GO:0051225)
1.8	26.3	GO:0007076	mitotic chromosome condensation(GO:0007076)
2.4	26.2	GO:0033314	mitotic DNA replication checkpoint(GO:0033314)
8.5	25.5	GO:0032877	positive regulation of DNA endoreduplication(GO:0032877)
1.9	24.7	GO:0019985	translesion synthesis(GO:0019985)

Showing 1 to 10 of 439 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.6	84.7	GO:0042555	MCM complex(GO:0042555)
0.3	56.8	GO:0000775	chromosome, centromeric region(GO:0000775)
0.9	54.8	GO:0005657	replication fork(GO:0005657)
0.1	52.6	GO:0005694	chromosome(GO:0005694)
4.0	39.8	GO:0000796	condensin complex(GO:0000796)
0.2	36.0	GO:0001650	fibrillar center(GO:0001650)
5.9	29.5	GO:0005971	ribonucleoside-diphosphate reductase complex(GO:0005971)
0.5	23.9	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
2.9	20.0	GO:0001652	granular component(GO:0001652)
0.2	19.8	GO:0017053	transcriptional repressor complex(GO:0017053)

Showing 1 to 10 of 218 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	56.3	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.2	46.3	GO:0001047	core promoter binding(GO:0001047)
6.9	41.7	GO:0031493	nucleosomal histone binding(GO:0031493)
0.3	36.9	GO:0004386	helicase activity(GO:0004386)
0.2	34.4	GO:0003735	structural constituent of ribosome(GO:0003735)
5.9	29.5	GO:0061731	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1	28.4	GO:0004674	protein serine/threonine kinase activity(GO:0004674)
4.5	27.0	GO:0010997	anaphase-promoting complex binding(GO:0010997)
1.0	26.8	GO:0003887	DNA-directed DNA polymerase activity(GO:0003887)
0.4	26.6	GO:0003697	single-stranded DNA binding(GO:0003697)

Showing 1 to 10 of 273 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.4	117.6	PID ATR PATHWAY	ATR signaling pathway
1.1	90.8	PID E2F PATHWAY	E2F transcription factor network
1.1	50.7	PID AURORA B PATHWAY	Aurora B signaling
2.1	28.9	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.3	26.1	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.6	16.8	PID ATM PATHWAY	ATM pathway
0.5	15.7	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.3	14.4	PID PLK1 PATHWAY	PLK1 signaling events
0.1	11.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	10.9	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms

Showing 1 to 10 of 70 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.9	78.0	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
2.9	54.7	REACTOME DNA STRAND ELONGATION	Genes involved in DNA strand elongation
0.5	48.1	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
2.6	41.0	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
2.0	34.3	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.6	29.4	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
2.1	28.8	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1	23.2	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.9	22.7	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.5	22.3	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS	Genes involved in CREB phosphorylation through the activation of Ras

Showing 1 to 10 of 120 entries

Results for E2f1

Z-value: 10.59

Motif logo

Transcription factors associated with E2f1

Activity-expression correlation:

Activity profile of E2f1 motif

Sorted Z-values of E2f1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: