ISMARA results: Irf2_Irf1_Irf8_Irf9

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avrg: 2D miR_HR1_12

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Results for Irf2_Irf1_Irf8_Irf9_Irf7

Z-value: 2.20

Motif logo

Transcription factors associated with Irf2_Irf1_Irf8_Irf9_Irf7

Gene Symbol	Gene ID	Gene Info
Irf2 Ensembl NCBI MGI UniProt	ENSMUSG00000031627.7	interferon regulatory factor 2
Irf1 Ensembl NCBI MGI UniProt	ENSMUSG00000018899.10	interferon regulatory factor 1
Irf8 Ensembl NCBI MGI UniProt	ENSMUSG00000041515.3	interferon regulatory factor 8
Irf9 Ensembl NCBI MGI UniProt	ENSMUSG00000002325.8	interferon regulatory factor 9
Irf7 Ensembl NCBI MGI UniProt	ENSMUSG00000025498.8	interferon regulatory factor 7

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Irf2	mm10_v2_chr8_+_46739745_46739791	-0.52	8.2e-02	Click!
Irf1	mm10_v2_chr11_+_53770458_53770509	0.45	1.4e-01	Click!
Irf8	mm10_v2_chr8_+_120736352_120736385	-0.43	1.6e-01	Click!
Irf7	mm10_v2_chr7_-_141266415_141266481	0.33	3.0e-01	Click!
Irf9	mm10_v2_chr14_+_55604550_55604579	-0.15	6.5e-01	Click!

Activity profile of Irf2_Irf1_Irf8_Irf9_Irf7 motif

Sorted Z-values of Irf2_Irf1_Irf8_Irf9_Irf7 motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr7_+_104244449 Show fit	5.03	ENSMUST00000106849.2 ENSMUST00000060315.5	Trim34a Ensembl NCBI MGI UniProt Show fit	tripartite motif-containing 34A
chr8_+_61928081 Show fit	3.75	ENSMUST00000154398.1 ENSMUST00000093485.2 ENSMUST00000156980.1 ENSMUST00000070631.7	Ddx60 Ensembl NCBI MGI UniProt Show fit	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr3_+_142620596 Show fit	3.36	ENSMUST00000165774.1	Gbp2 Ensembl NCBI MGI UniProt Show fit	guanylate binding protein 2
chr3_-_113574242 Show fit	3.33	ENSMUST00000142505.2	Amy1 Ensembl NCBI MGI UniProt Show fit	amylase 1, salivary
chr7_+_104244465 Show fit	3.24	ENSMUST00000106848.1	Trim34a Ensembl NCBI MGI UniProt Show fit	tripartite motif-containing 34A
chr3_-_113574758 Show fit	3.00	ENSMUST00000106540.1	Amy1 Ensembl NCBI MGI UniProt Show fit	amylase 1, salivary
chr19_+_34640871 Show fit	2.97	ENSMUST00000102824.3	Ifit1 Ensembl NCBI MGI UniProt Show fit	interferon-induced protein with tetratricopeptide repeats 1
chr16_+_23609895 Show fit	2.83	ENSMUST00000038423.5	Rtp4 Ensembl NCBI MGI UniProt Show fit	receptor transporter protein 4
chr12_-_79007276 Show fit	2.53	ENSMUST00000056660.6 ENSMUST00000174721.1	Tmem229b Ensembl NCBI MGI UniProt Show fit	transmembrane protein 229B
chr8_-_105938384 Show fit	2.52	ENSMUST00000034369.8	Psmb10 Ensembl NCBI MGI UniProt Show fit	proteasome (prosome, macropain) subunit, beta type 10
chr4_-_40239700 Show fit	2.49	ENSMUST00000142055.1	Ddx58 Ensembl NCBI MGI UniProt Show fit	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr17_+_33919332 Show fit	2.10	ENSMUST00000025161.7	Tapbp Ensembl NCBI MGI UniProt Show fit	TAP binding protein
chr8_+_64947177 Show fit	2.05	ENSMUST00000079896.7 ENSMUST00000026595.5	Tmem192 Ensembl NCBI MGI UniProt Show fit	transmembrane protein 192
chr15_+_9436028 Show fit	2.04	ENSMUST00000042360.3	Capsl Ensembl NCBI MGI UniProt Show fit	calcyphosine-like
chr7_-_102565425 Show fit	2.02	ENSMUST00000106913.1 ENSMUST00000033264.4	Trim21 Ensembl NCBI MGI UniProt Show fit	tripartite motif-containing 21
chr4_-_40239779 Show fit	1.98	ENSMUST00000037907.6	Ddx58 Ensembl NCBI MGI UniProt Show fit	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr7_+_104244496 Show fit	1.96	ENSMUST00000106854.1 ENSMUST00000143414.1	Trim34a Ensembl NCBI MGI UniProt Show fit	tripartite motif-containing 34A
chr1_+_153751859 Show fit	1.92	ENSMUST00000182538.1	Rnasel Ensembl NCBI MGI UniProt Show fit	ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
chr11_-_53859187 Show fit	1.74	ENSMUST00000117316.1 ENSMUST00000120776.1 ENSMUST00000121435.1	Gm12216 Ensembl NCBI MGI UniProt Show fit	predicted gene 12216
chr7_-_141266415 Show fit	1.69	ENSMUST00000106023.1 ENSMUST00000097952.2 ENSMUST00000026571.4	Irf7 Ensembl NCBI MGI UniProt Show fit	interferon regulatory factor 7
chr5_-_134229581 Show fit	1.68	ENSMUST00000111275.1 ENSMUST00000016094.6 ENSMUST00000144086.1	Ncf1 Ensembl NCBI MGI UniProt Show fit	neutrophil cytosolic factor 1
chr7_-_143460989 Show fit	1.65	ENSMUST00000167912.1 ENSMUST00000037287.6	Cdkn1c Ensembl NCBI MGI UniProt Show fit	cyclin-dependent kinase inhibitor 1C (P57)
chr16_-_10785525 Show fit	1.63	ENSMUST00000038099.4	Socs1 Ensembl NCBI MGI UniProt Show fit	suppressor of cytokine signaling 1
chr13_+_33004528 Show fit	1.62	ENSMUST00000006391.4	Serpinb9 Ensembl NCBI MGI UniProt Show fit	serine (or cysteine) peptidase inhibitor, clade B, member 9
chr9_+_5298517 Show fit	1.56	ENSMUST00000027015.5	Casp1 Ensembl NCBI MGI UniProt Show fit	caspase 1
chr2_-_51972990 Show fit	1.55	ENSMUST00000145481.1 ENSMUST00000112705.2	Nmi Ensembl NCBI MGI UniProt Show fit	N-myc (and STAT) interactor
chr12_-_78980758 Show fit	1.49	ENSMUST00000174072.1	Tmem229b Ensembl NCBI MGI UniProt Show fit	transmembrane protein 229B
chr1_+_16688405 Show fit	1.44	ENSMUST00000026881.4	Ly96 Ensembl NCBI MGI UniProt Show fit	lymphocyte antigen 96
chr17_-_36042690 Show fit	1.43	ENSMUST00000058801.8 ENSMUST00000080015.5 ENSMUST00000077960.6	H2-T22 Ensembl NCBI MGI UniProt Show fit	histocompatibility 2, T region locus 22
chr9_+_107975529 Show fit	1.41	ENSMUST00000035216.4	Uba7 Ensembl NCBI MGI UniProt Show fit	ubiquitin-like modifier activating enzyme 7
chr5_+_114896936 Show fit	1.40	ENSMUST00000031542.9 ENSMUST00000146072.1 ENSMUST00000150361.1	Oasl2 Ensembl NCBI MGI UniProt Show fit	2'-5' oligoadenylate synthetase-like 2
chr12_-_26456423 Show fit	1.39	ENSMUST00000020970.7	Rsad2 Ensembl NCBI MGI UniProt Show fit	radical S-adenosyl methionine domain containing 2
chr10_-_75797728 Show fit	1.37	ENSMUST00000139724.1	Gstt1 Ensembl NCBI MGI UniProt Show fit	glutathione S-transferase, theta 1
chr6_-_125231772 Show fit	1.32	ENSMUST00000043422.7	Tapbpl Ensembl NCBI MGI UniProt Show fit	TAP binding protein-like
chr7_-_45136102 Show fit	1.31	ENSMUST00000125500.1	Flt3l Ensembl NCBI MGI UniProt Show fit	FMS-like tyrosine kinase 3 ligand
chr10_+_128270546 Show fit	1.30	ENSMUST00000105238.3 ENSMUST00000085708.2	Stat2 Ensembl NCBI MGI UniProt Show fit	signal transducer and activator of transcription 2
chr19_-_11050500 Show fit	1.29	ENSMUST00000099676.4	AW112010 Ensembl NCBI MGI UniProt Show fit	expressed sequence AW112010
chr7_+_97453204 Show fit	1.29	ENSMUST00000050732.7 ENSMUST00000121987.1	Kctd14 Ensembl NCBI MGI UniProt Show fit	potassium channel tetramerisation domain containing 14
chr1_-_155146755 Show fit	1.29	ENSMUST00000027744.8	Mr1 Ensembl NCBI MGI UniProt Show fit	major histocompatibility complex, class I-related
chr11_+_58199556 Show fit	1.28	ENSMUST00000035266.4 ENSMUST00000094169.4 ENSMUST00000168280.1 ENSMUST00000058704.8	Igtp Ensembl NCBI MGI UniProt Show fit Irgm2 Ensembl NCBI MGI UniProt Show fit	interferon gamma induced GTPase immunity-related GTPase family M member 2
chr7_-_104353328 Show fit	1.27	ENSMUST00000130139.1 ENSMUST00000059037.8	Trim12c Ensembl NCBI MGI UniProt Show fit	tripartite motif-containing 12C
chr11_+_32000452 Show fit	1.27	ENSMUST00000020537.2 ENSMUST00000109409.1	Nsg2 Ensembl NCBI MGI UniProt Show fit	neuron specific gene family member 2
chr5_+_117357274 Show fit	1.26	ENSMUST00000031309.9	Wsb2 Ensembl NCBI MGI UniProt Show fit	WD repeat and SOCS box-containing 2
chr19_+_6164433 Show fit	1.25	ENSMUST00000045042.7	Batf2 Ensembl NCBI MGI UniProt Show fit	basic leucine zipper transcription factor, ATF-like 2
chr6_+_39381175 Show fit	1.24	ENSMUST00000031986.4	Rab19 Ensembl NCBI MGI UniProt Show fit	RAB19, member RAS oncogene family
chr4_-_145246855 Show fit	1.22	ENSMUST00000030336.4	Tnfrsf1b Ensembl NCBI MGI UniProt Show fit	tumor necrosis factor receptor superfamily, member 1b
chr1_-_156674290 Show fit	1.21	ENSMUST00000079625.4	Tor3a Ensembl NCBI MGI UniProt Show fit	torsin family 3, member A
chr17_+_36837123 Show fit	1.21	ENSMUST00000179968.1 ENSMUST00000130367.1 ENSMUST00000130801.1 ENSMUST00000144182.1 ENSMUST00000123715.1 ENSMUST00000053434.8	Trim26 Ensembl NCBI MGI UniProt Show fit	tripartite motif-containing 26
chr1_-_85598796 Show fit	1.21	ENSMUST00000093508.6	Sp110 Ensembl NCBI MGI UniProt Show fit	Sp110 nuclear body protein
chr15_+_99392882 Show fit	1.20	ENSMUST00000023749.8	Tmbim6 Ensembl NCBI MGI UniProt Show fit	transmembrane BAX inhibitor motif containing 6
chr3_-_96263311 Show fit	1.18	ENSMUST00000171473.1	Hist2h4 Ensembl NCBI MGI UniProt Show fit	histone cluster 2, H4
chr2_+_104069819 Show fit	1.17	ENSMUST00000111131.2 ENSMUST00000111132.1 ENSMUST00000129749.1	Cd59b Ensembl NCBI MGI UniProt Show fit	CD59b antigen
chr19_+_34607927 Show fit	1.16	ENSMUST00000076249.5	I830012O16Rik Ensembl NCBI MGI UniProt Show fit	RIKEN cDNA I830012O16 gene
chr12_+_26469204 Show fit	1.14	ENSMUST00000020969.3	Cmpk2 Ensembl NCBI MGI UniProt Show fit	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr11_+_69964758 Show fit	1.11	ENSMUST00000108597.1 ENSMUST00000060651.5 ENSMUST00000108596.1	Cldn7 Ensembl NCBI MGI UniProt Show fit	claudin 7
chrX_-_134161928 Show fit	1.10	ENSMUST00000033611.4	Xkrx Ensembl NCBI MGI UniProt Show fit	X Kell blood group precursor related X linked
chr1_-_184732444 Show fit	1.09	ENSMUST00000174257.1	Hlx Ensembl NCBI MGI UniProt Show fit	H2.0-like homeobox
chr19_+_55741810 Show fit	1.09	ENSMUST00000111657.3 ENSMUST00000061496.9 ENSMUST00000041717.7 ENSMUST00000111662.4	Tcf7l2 Ensembl NCBI MGI UniProt Show fit	transcription factor 7 like 2, T cell specific, HMG box
chr1_+_52119438 Show fit	1.08	ENSMUST00000070968.7	Stat1 Ensembl NCBI MGI UniProt Show fit	signal transducer and activator of transcription 1
chr2_-_167062981 Show fit	1.07	ENSMUST00000048988.7	Znfx1 Ensembl NCBI MGI UniProt Show fit	zinc finger, NFX1-type containing 1
chr17_-_34862473 Show fit	1.07	ENSMUST00000025229.4 ENSMUST00000176203.2 ENSMUST00000128767.1	Cfb Ensembl NCBI MGI UniProt Show fit	complement factor B
chr7_-_45136056 Show fit	1.06	ENSMUST00000130628.1	Flt3l Ensembl NCBI MGI UniProt Show fit	FMS-like tyrosine kinase 3 ligand
chr12_+_103434211 Show fit	1.06	ENSMUST00000079294.5 ENSMUST00000076788.5 ENSMUST00000076702.5 ENSMUST00000066701.6 ENSMUST00000085065.5 ENSMUST00000140838.1	Ifi27 Ensembl NCBI MGI UniProt Show fit	interferon, alpha-inducible protein 27
chr2_-_51934943 Show fit	1.06	ENSMUST00000102767.1 ENSMUST00000102768.1	Rbm43 Ensembl NCBI MGI UniProt Show fit	RNA binding motif protein 43
chr11_+_29718563 Show fit	1.06	ENSMUST00000060992.5	Rtn4 Ensembl NCBI MGI UniProt Show fit	reticulon 4
chr19_+_29410919 Show fit	1.06	ENSMUST00000112576.2	Pdcd1lg2 Ensembl NCBI MGI UniProt Show fit	programmed cell death 1 ligand 2
chr2_-_103283760 Show fit	1.04	ENSMUST00000111174.1	Ehf Ensembl NCBI MGI UniProt Show fit	ets homologous factor
chr11_+_49087022 Show fit	1.04	ENSMUST00000046704.6	Ifi47 Ensembl NCBI MGI UniProt Show fit	interferon gamma inducible protein 47
chr4_+_45972233 Show fit	1.00	ENSMUST00000102929.1	Tdrd7 Ensembl NCBI MGI UniProt Show fit	tudor domain containing 7
chr8_+_127064107 Show fit	0.99	ENSMUST00000162536.1 ENSMUST00000026921.6 ENSMUST00000162665.1 ENSMUST00000160766.1 ENSMUST00000162602.1 ENSMUST00000162531.1 ENSMUST00000160581.1 ENSMUST00000161355.1 ENSMUST00000159537.1	Pard3 Ensembl NCBI MGI UniProt Show fit	par-3 (partitioning defective 3) homolog (C. elegans)
chr2_+_122147680 Show fit	0.98	ENSMUST00000102476.4	B2m Ensembl NCBI MGI UniProt Show fit	beta-2 microglobulin
chr9_-_111057235 Show fit	0.97	ENSMUST00000111888.1	Ccrl2 Ensembl NCBI MGI UniProt Show fit	chemokine (C-C motif) receptor-like 2
chr6_+_96113146 Show fit	0.96	ENSMUST00000122120.1	Fam19a1 Ensembl NCBI MGI UniProt Show fit	family with sequence similarity 19, member A1
chr9_+_38718263 Show fit	0.96	ENSMUST00000001544.5 ENSMUST00000118144.1	Vwa5a Ensembl NCBI MGI UniProt Show fit	von Willebrand factor A domain containing 5A
chr1_+_130826676 Show fit	0.95	ENSMUST00000027675.7	Pigr Ensembl NCBI MGI UniProt Show fit	polymeric immunoglobulin receptor
chr5_-_105239533 Show fit	0.95	ENSMUST00000065588.6	Gbp10 Ensembl NCBI MGI UniProt Show fit	guanylate-binding protein 10
chr11_+_70459940 Show fit	0.94	ENSMUST00000147289.1 ENSMUST00000126105.1	Zmynd15 Ensembl NCBI MGI UniProt Show fit	zinc finger, MYND-type containing 15
chrX_-_9469288 Show fit	0.93	ENSMUST00000015484.3	Cybb Ensembl NCBI MGI UniProt Show fit	cytochrome b-245, beta polypeptide
chr2_+_165055625 Show fit	0.92	ENSMUST00000017799.5 ENSMUST00000073707.2	Cd40 Ensembl NCBI MGI UniProt Show fit	CD40 antigen
chr11_-_48992226 Show fit	0.91	ENSMUST00000059930.2 ENSMUST00000068063.3	Gm12185 Ensembl NCBI MGI UniProt Show fit Tgtp1 Ensembl NCBI MGI UniProt Show fit	predicted gene 12185 T cell specific GTPase 1
chr12_+_37241729 Show fit	0.90	ENSMUST00000160768.1	Agmo Ensembl NCBI MGI UniProt Show fit	alkylglycerol monooxygenase
chr14_+_77904239 Show fit	0.89	ENSMUST00000022591.8	Epsti1 Ensembl NCBI MGI UniProt Show fit	epithelial stromal interaction 1 (breast)
chr19_+_5406815 Show fit	0.89	ENSMUST00000174412.1 ENSMUST00000153017.2	4930481A15Rik Ensembl NCBI MGI UniProt Show fit	RIKEN cDNA 4930481A15 gene
chr11_-_78984946 Show fit	0.89	ENSMUST00000108268.3	Lgals9 Ensembl NCBI MGI UniProt Show fit	lectin, galactose binding, soluble 9
chr8_-_111338152 Show fit	0.88	ENSMUST00000056157.7 ENSMUST00000120432.1	Mlkl Ensembl NCBI MGI UniProt Show fit	mixed lineage kinase domain-like
chr2_-_51934644 Show fit	0.88	ENSMUST00000165313.1	Rbm43 Ensembl NCBI MGI UniProt Show fit	RNA binding motif protein 43
chr11_-_70459957 Show fit	0.87	ENSMUST00000019064.2	Cxcl16 Ensembl NCBI MGI UniProt Show fit	chemokine (C-X-C motif) ligand 16
chr11_+_101582236 Show fit	0.87	ENSMUST00000039581.7 ENSMUST00000100403.2 ENSMUST00000107194.1 ENSMUST00000128614.1	Tmem106a Ensembl NCBI MGI UniProt Show fit	transmembrane protein 106A
chr13_+_37345338 Show fit	0.85	ENSMUST00000021860.5	Ly86 Ensembl NCBI MGI UniProt Show fit	lymphocyte antigen 86
chr4_+_111719975 Show fit	0.84	ENSMUST00000038868.7 ENSMUST00000070513.6 ENSMUST00000153746.1	Spata6 Ensembl NCBI MGI UniProt Show fit	spermatogenesis associated 6
chr1_-_184732616 Show fit	0.84	ENSMUST00000048572.6	Hlx Ensembl NCBI MGI UniProt Show fit	H2.0-like homeobox
chr1_-_174031712 Show fit	0.84	ENSMUST00000059226.6	Ifi205 Ensembl NCBI MGI UniProt Show fit	interferon activated gene 205
chr4_+_135728116 Show fit	0.84	ENSMUST00000102546.3	Il22ra1 Ensembl NCBI MGI UniProt Show fit	interleukin 22 receptor, alpha 1
chr6_-_54972603 Show fit	0.83	ENSMUST00000060655.8	Nod1 Ensembl NCBI MGI UniProt Show fit	nucleotide-binding oligomerization domain containing 1
chr19_+_34583528 Show fit	0.83	ENSMUST00000102825.3	Ifit3 Ensembl NCBI MGI UniProt Show fit	interferon-induced protein with tetratricopeptide repeats 3
chr9_-_45204083 Show fit	0.83	ENSMUST00000034599.8	Tmprss4 Ensembl NCBI MGI UniProt Show fit	transmembrane protease, serine 4
chr9_-_106476590 Show fit	0.83	ENSMUST00000112479.2	Parp3 Ensembl NCBI MGI UniProt Show fit	poly (ADP-ribose) polymerase family, member 3
chr5_+_117319292 Show fit	0.82	ENSMUST00000086464.4	Vsig10 Ensembl NCBI MGI UniProt Show fit	V-set and immunoglobulin domain containing 10
chr5_+_35056813 Show fit	0.82	ENSMUST00000101298.2 ENSMUST00000114270.1 ENSMUST00000133381.1	Dok7 Ensembl NCBI MGI UniProt Show fit	docking protein 7
chr15_-_98296083 Show fit	0.82	ENSMUST00000169721.1 ENSMUST00000023722.5	Zfp641 Ensembl NCBI MGI UniProt Show fit	zinc finger protein 641
chr8_-_122551316 Show fit	0.82	ENSMUST00000067252.7	Piezo1 Ensembl NCBI MGI UniProt Show fit	piezo-type mechanosensitive ion channel component 1
chr16_+_97536079 Show fit	0.80	ENSMUST00000024112.7	Mx2 Ensembl NCBI MGI UniProt Show fit	myxovirus (influenza virus) resistance 2
chr6_-_39118211 Show fit	0.80	ENSMUST00000038398.6	Parp12 Ensembl NCBI MGI UniProt Show fit	poly (ADP-ribose) polymerase family, member 12
chr3_-_32616479 Show fit	0.79	ENSMUST00000108234.1 ENSMUST00000155737.1	Gnb4 Ensembl NCBI MGI UniProt Show fit	guanine nucleotide binding protein (G protein), beta 4
chr18_+_37447641 Show fit	0.79	ENSMUST00000052387.3	Pcdhb14 Ensembl NCBI MGI UniProt Show fit	protocadherin beta 14
chr9_+_5345414 Show fit	0.78	ENSMUST00000027009.4	Casp12 Ensembl NCBI MGI UniProt Show fit	caspase 12
chr2_-_24049389 Show fit	0.78	ENSMUST00000051416.5	Hnmt Ensembl NCBI MGI UniProt Show fit	histamine N-methyltransferase
chr6_+_145121727 Show fit	0.77	ENSMUST00000032396.6	Lrmp Ensembl NCBI MGI UniProt Show fit	lymphoid-restricted membrane protein
chr5_-_120777628 Show fit	0.77	ENSMUST00000044833.8	Oas3 Ensembl NCBI MGI UniProt Show fit	2'-5' oligoadenylate synthetase 3
chr11_-_49064202 Show fit	0.77	ENSMUST00000046745.6	Tgtp2 Ensembl NCBI MGI UniProt Show fit	T cell specific GTPase 2
chr11_+_61065798 Show fit	0.77	ENSMUST00000041944.2 ENSMUST00000108717.2	Kcnj12 Ensembl NCBI MGI UniProt Show fit	potassium inwardly-rectifying channel, subfamily J, member 12
chr11_-_78984831 Show fit	0.76	ENSMUST00000073001.4 ENSMUST00000108269.3	Lgals9 Ensembl NCBI MGI UniProt Show fit	lectin, galactose binding, soluble 9
chr11_-_3931789 Show fit	0.75	ENSMUST00000109992.1 ENSMUST00000109988.1	Tcn2 Ensembl NCBI MGI UniProt Show fit	transcobalamin 2
chr5_+_147269959 Show fit	0.75	ENSMUST00000085591.5	Pdx1 Ensembl NCBI MGI UniProt Show fit	pancreatic and duodenal homeobox 1
chr17_-_34187219 Show fit	0.74	ENSMUST00000173831.1	Psmb9 Ensembl NCBI MGI UniProt Show fit	proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr5_+_117319258 Show fit	0.74	ENSMUST00000111967.1	Vsig10 Ensembl NCBI MGI UniProt Show fit	V-set and immunoglobulin domain containing 10
chr16_+_35938470 Show fit	0.73	ENSMUST00000114878.1	Parp9 Ensembl NCBI MGI UniProt Show fit	poly (ADP-ribose) polymerase family, member 9
chr5_-_120907510 Show fit	0.73	ENSMUST00000080322.7	Oas1a Ensembl NCBI MGI UniProt Show fit	2'-5' oligoadenylate synthetase 1A
chr2_-_62646146 Show fit	0.72	ENSMUST00000112459.3 ENSMUST00000028259.5	Ifih1 Ensembl NCBI MGI UniProt Show fit	interferon induced with helicase C domain 1
chr8_-_82403203 Show fit	0.72	ENSMUST00000034148.6	Il15 Ensembl NCBI MGI UniProt Show fit	interleukin 15
chr5_+_67260794 Show fit	0.71	ENSMUST00000161369.1	Tmem33 Ensembl NCBI MGI UniProt Show fit	transmembrane protein 33
chr4_-_46536134 Show fit	0.71	ENSMUST00000046897.6	Trim14 Ensembl NCBI MGI UniProt Show fit	tripartite motif-containing 14
chr1_-_173599074 Show fit	0.71	ENSMUST00000150649.1 ENSMUST00000180215.1 ENSMUST00000097462.2	Pydc4 Ensembl NCBI MGI UniProt Show fit	pyrin domain containing 4
chr10_+_116177217 Show fit	0.70	ENSMUST00000148731.1	Ptprr Ensembl NCBI MGI UniProt Show fit	protein tyrosine phosphatase, receptor type, R
chr13_+_56609516 Show fit	0.70	ENSMUST00000045173.8	Tgfbi Ensembl NCBI MGI UniProt Show fit	transforming growth factor, beta induced
chr11_+_43474276 Show fit	0.70	ENSMUST00000173002.1 ENSMUST00000057679.3	C1qtnf2 Ensembl NCBI MGI UniProt Show fit	C1q and tumor necrosis factor related protein 2
chr8_+_105427634 Show fit	0.70	ENSMUST00000067305.6	Lrrc36 Ensembl NCBI MGI UniProt Show fit	leucine rich repeat containing 36
chr13_+_42866247 Show fit	0.69	ENSMUST00000131942.1	Phactr1 Ensembl NCBI MGI UniProt Show fit	phosphatase and actin regulator 1
chr9_-_117252450 Show fit	0.69	ENSMUST00000111773.3 ENSMUST00000068962.7 ENSMUST00000044901.7	Rbms3 Ensembl NCBI MGI UniProt Show fit	RNA binding motif, single stranded interacting protein
chr2_+_24385313 Show fit	0.69	ENSMUST00000056641.8	Psd4 Ensembl NCBI MGI UniProt Show fit	pleckstrin and Sec7 domain containing 4
chr1_+_58711488 Show fit	0.69	ENSMUST00000097722.2 ENSMUST00000114313.1	Cflar Ensembl NCBI MGI UniProt Show fit	CASP8 and FADD-like apoptosis regulator
chr3_-_59130610 Show fit	0.69	ENSMUST00000065220.6 ENSMUST00000091112.4	P2ry14 Ensembl NCBI MGI UniProt Show fit	purinergic receptor P2Y, G-protein coupled, 14
chr5_-_120749848 Show fit	0.68	ENSMUST00000053909.6 ENSMUST00000081491.6	Oas2 Ensembl NCBI MGI UniProt Show fit	2'-5' oligoadenylate synthetase 2
chr2_-_51973219 Show fit	0.68	ENSMUST00000028314.2	Nmi Ensembl NCBI MGI UniProt Show fit	N-myc (and STAT) interactor
chr6_+_41392356 Show fit	0.67	ENSMUST00000049079.7	Gm5771 Ensembl NCBI MGI UniProt Show fit	predicted gene 5771
chr17_+_29660710 Show fit	0.67	ENSMUST00000130423.1	Cmtr1 Ensembl NCBI MGI UniProt Show fit	cap methyltransferase 1
chr14_+_103513328 Show fit	0.67	ENSMUST00000095576.3	Scel Ensembl NCBI MGI UniProt Show fit	sciellin
chr11_+_58215028 Show fit	0.67	ENSMUST00000108836.1	Irgm2 Ensembl NCBI MGI UniProt Show fit	immunity-related GTPase family M member 2
chr18_-_3299452 Show fit	0.66	ENSMUST00000126578.1	Crem Ensembl NCBI MGI UniProt Show fit	cAMP responsive element modulator
chr17_-_36020525 Show fit	0.66	ENSMUST00000174063.1 ENSMUST00000113760.3	H2-T24 Ensembl NCBI MGI UniProt Show fit	histocompatibility 2, T region locus 24
chr1_-_173490933 Show fit	0.66	ENSMUST00000160565.2	Gm4955 Ensembl NCBI MGI UniProt Show fit	predicted gene 4955
chr8_-_35826435 Show fit	0.65	ENSMUST00000060128.5	Cldn23 Ensembl NCBI MGI UniProt Show fit	claudin 23
chr3_+_95526777 Show fit	0.65	ENSMUST00000015667.2 ENSMUST00000116304.2	Ctss Ensembl NCBI MGI UniProt Show fit	cathepsin S
chr7_+_43797567 Show fit	0.65	ENSMUST00000085461.2	Klk8 Ensembl NCBI MGI UniProt Show fit	kallikrein related-peptidase 8
chr5_-_117319242 Show fit	0.65	ENSMUST00000100834.1	Gm10399 Ensembl NCBI MGI UniProt Show fit	predicted gene 10399
chr5_+_114923234 Show fit	0.64	ENSMUST00000031540.4 ENSMUST00000112143.3	Oasl1 Ensembl NCBI MGI UniProt Show fit	2'-5' oligoadenylate synthetase-like 1
chr1_-_192092540 Show fit	0.64	ENSMUST00000085573.6	Traf5 Ensembl NCBI MGI UniProt Show fit	TNF receptor-associated factor 5
chr3_+_27317028 Show fit	0.64	ENSMUST00000046383.5 ENSMUST00000174840.1	Tnfsf10 Ensembl NCBI MGI UniProt Show fit	tumor necrosis factor (ligand) superfamily, member 10
chr10_-_88356990 Show fit	0.63	ENSMUST00000020249.1	Dram1 Ensembl NCBI MGI UniProt Show fit	DNA-damage regulated autophagy modulator 1
chr18_-_3299537 Show fit	0.63	ENSMUST00000129435.1 ENSMUST00000122958.1	Crem Ensembl NCBI MGI UniProt Show fit	cAMP responsive element modulator
chr8_+_35375719 Show fit	0.63	ENSMUST00000070481.6	Ppp1r3b Ensembl NCBI MGI UniProt Show fit	protein phosphatase 1, regulatory (inhibitor) subunit 3B
chr16_-_24393588 Show fit	0.63	ENSMUST00000181640.1	1110054M08Rik Ensembl NCBI MGI UniProt Show fit	RIKEN cDNA 1110054M08 gene
chr10_-_75797528 Show fit	0.62	ENSMUST00000120177.1	Gstt1 Ensembl NCBI MGI UniProt Show fit	glutathione S-transferase, theta 1
chr10_+_116177351 Show fit	0.62	ENSMUST00000155606.1 ENSMUST00000128399.1	Ptprr Ensembl NCBI MGI UniProt Show fit	protein tyrosine phosphatase, receptor type, R
chr5_-_137116177 Show fit	0.62	ENSMUST00000054384.5 ENSMUST00000152207.1	Trim56 Ensembl NCBI MGI UniProt Show fit	tripartite motif-containing 56
chr5_-_52471534 Show fit	0.62	ENSMUST00000059428.5	Ccdc149 Ensembl NCBI MGI UniProt Show fit	coiled-coil domain containing 149
chr10_+_78069351 Show fit	0.62	ENSMUST00000105393.1	Icosl Ensembl NCBI MGI UniProt Show fit	icos ligand
chr17_+_37270214 Show fit	0.62	ENSMUST00000038580.6	H2-M3 Ensembl NCBI MGI UniProt Show fit	histocompatibility 2, M region locus 3
chr11_-_48871344 Show fit	0.62	ENSMUST00000049519.3	Irgm1 Ensembl NCBI MGI UniProt Show fit	immunity-related GTPase family M member 1
chr5_-_105139539 Show fit	0.62	ENSMUST00000100961.4 ENSMUST00000031235.6 ENSMUST00000100962.3	Gbp9 Ensembl NCBI MGI UniProt Show fit Gbp8 Ensembl NCBI MGI UniProt Show fit Gbp4 Ensembl NCBI MGI UniProt Show fit	guanylate-binding protein 9 guanylate-binding protein 8 guanylate binding protein 4
chr1_-_156036473 Show fit	0.61	ENSMUST00000097527.3 ENSMUST00000027738.7	Tor1aip1 Ensembl NCBI MGI UniProt Show fit	torsin A interacting protein 1
chr4_+_111720187 Show fit	0.61	ENSMUST00000084354.3	Spata6 Ensembl NCBI MGI UniProt Show fit	spermatogenesis associated 6
chr19_-_45591820 Show fit	0.61	ENSMUST00000160003.1 ENSMUST00000162879.1	Fbxw4 Ensembl NCBI MGI UniProt Show fit	F-box and WD-40 domain protein 4
chr4_+_54947976 Show fit	0.61	ENSMUST00000098070.3	Zfp462 Ensembl NCBI MGI UniProt Show fit	zinc finger protein 462
chr11_-_102296618 Show fit	0.61	ENSMUST00000107132.2 ENSMUST00000073234.2	Atxn7l3 Ensembl NCBI MGI UniProt Show fit	ataxin 7-like 3
chr9_+_118040475 Show fit	0.61	ENSMUST00000044454.5	Azi2 Ensembl NCBI MGI UniProt Show fit	5-azacytidine induced gene 2
chr7_+_58658181 Show fit	0.60	ENSMUST00000168747.1	Atp10a Ensembl NCBI MGI UniProt Show fit	ATPase, class V, type 10A
chr2_-_77170592 Show fit	0.60	ENSMUST00000164114.2 ENSMUST00000049544.7	Ccdc141 Ensembl NCBI MGI UniProt Show fit	coiled-coil domain containing 141
chr5_-_65492984 Show fit	0.60	ENSMUST00000139122.1	Smim14 Ensembl NCBI MGI UniProt Show fit	small integral membrane protein 14
chr5_-_105293699 Show fit	0.60	ENSMUST00000050011.8	Gbp6 Ensembl NCBI MGI UniProt Show fit	guanylate binding protein 6
chr12_+_51377560 Show fit	0.59	ENSMUST00000021335.5	Scfd1 Ensembl NCBI MGI UniProt Show fit	Sec1 family domain containing 1
chr5_-_92348871 Show fit	0.59	ENSMUST00000038816.6 ENSMUST00000118006.1	Cxcl10 Ensembl NCBI MGI UniProt Show fit	chemokine (C-X-C motif) ligand 10
chr11_-_100704217 Show fit	0.59	ENSMUST00000017974.6	Dhx58 Ensembl NCBI MGI UniProt Show fit	DEXH (Asp-Glu-X-His) box polypeptide 58
chr7_+_80860909 Show fit	0.59	ENSMUST00000132163.1 ENSMUST00000147125.1	Zscan2 Ensembl NCBI MGI UniProt Show fit	zinc finger and SCAN domain containing 2
chr3_-_59262825 Show fit	0.59	ENSMUST00000050360.7	P2ry12 Ensembl NCBI MGI UniProt Show fit	purinergic receptor P2Y, G-protein coupled 12
chr6_+_7555053 Show fit	0.59	ENSMUST00000090679.2 ENSMUST00000184986.1	Tac1 Ensembl NCBI MGI UniProt Show fit	tachykinin 1
chr3_+_127791374 Show fit	0.58	ENSMUST00000171621.1	Tifa Ensembl NCBI MGI UniProt Show fit	TRAF-interacting protein with forkhead-associated domain
chr6_-_129237948 Show fit	0.58	ENSMUST00000181238.1 ENSMUST00000180379.1	2310001H17Rik Ensembl NCBI MGI UniProt Show fit	RIKEN cDNA 2310001H17 gene
chr9_-_14381242 Show fit	0.58	ENSMUST00000167549.1	Endod1 Ensembl NCBI MGI UniProt Show fit	endonuclease domain containing 1
chr1_+_130826762 Show fit	0.58	ENSMUST00000133792.1	Pigr Ensembl NCBI MGI UniProt Show fit	polymeric immunoglobulin receptor
chr14_+_41105359 Show fit	0.57	ENSMUST00000047286.6	Mat1a Ensembl NCBI MGI UniProt Show fit	methionine adenosyltransferase I, alpha
chr7_+_139248477 Show fit	0.57	ENSMUST00000093993.3 ENSMUST00000172136.1	Pwwp2b Ensembl NCBI MGI UniProt Show fit	PWWP domain containing 2B
chr3_+_142530329 Show fit	0.57	ENSMUST00000171263.1 ENSMUST00000045097.9	Gbp7 Ensembl NCBI MGI UniProt Show fit	guanylate binding protein 7
chr3_+_8509477 Show fit	0.57	ENSMUST00000029002.7	Stmn2 Ensembl NCBI MGI UniProt Show fit	stathmin-like 2
chr1_+_173630847 Show fit	0.57	ENSMUST00000056071.7	Pyhin1 Ensembl NCBI MGI UniProt Show fit	pyrin and HIN domain family, member 1
chr13_-_23710714 Show fit	0.56	ENSMUST00000091707.6 ENSMUST00000006787.7 ENSMUST00000091706.6	Hfe Ensembl NCBI MGI UniProt Show fit	hemochromatosis
chr5_-_120812506 Show fit	0.56	ENSMUST00000117193.1 ENSMUST00000130045.1	Oas1c Ensembl NCBI MGI UniProt Show fit	2'-5' oligoadenylate synthetase 1C
chr3_-_137981523 Show fit	0.56	ENSMUST00000136613.1 ENSMUST00000029806.6	Dapp1 Ensembl NCBI MGI UniProt Show fit	dual adaptor for phosphotyrosine and 3-phosphoinositides 1
chr11_-_109298066 Show fit	0.56	ENSMUST00000106706.1	Rgs9 Ensembl NCBI MGI UniProt Show fit	regulator of G-protein signaling 9
chr9_-_54950954 Show fit	0.55	ENSMUST00000054018.5	AY074887 Ensembl NCBI MGI UniProt Show fit	cDNA sequence AY074887
chr2_-_173276144 Show fit	0.55	ENSMUST00000139306.1	Pmepa1 Ensembl NCBI MGI UniProt Show fit	prostate transmembrane protein, androgen induced 1
chr9_+_118040509 Show fit	0.55	ENSMUST00000133580.1	Azi2 Ensembl NCBI MGI UniProt Show fit	5-azacytidine induced gene 2
chr7_-_45136391 Show fit	0.55	ENSMUST00000146760.1	Flt3l Ensembl NCBI MGI UniProt Show fit	FMS-like tyrosine kinase 3 ligand
chr16_-_97462903 Show fit	0.55	ENSMUST00000142883.1 ENSMUST00000113768.1 ENSMUST00000023655.6	Mx1 Ensembl NCBI MGI UniProt Show fit	myxovirus (influenza virus) resistance 1
chr9_-_103761820 Show fit	0.55	ENSMUST00000049452.8	Tmem108 Ensembl NCBI MGI UniProt Show fit	transmembrane protein 108
chr7_-_46715676 Show fit	0.55	ENSMUST00000006956.7	Saa3 Ensembl NCBI MGI UniProt Show fit	serum amyloid A 3
chr2_+_58754910 Show fit	0.54	ENSMUST00000059102.6	Upp2 Ensembl NCBI MGI UniProt Show fit	uridine phosphorylase 2
chr4_+_40948401 Show fit	0.54	ENSMUST00000030128.5	Chmp5 Ensembl NCBI MGI UniProt Show fit	charged multivesicular body protein 5
chr11_+_114851142 Show fit	0.54	ENSMUST00000133245.1 ENSMUST00000122967.2	Gprc5c Ensembl NCBI MGI UniProt Show fit	G protein-coupled receptor, family C, group 5, member C
chr12_+_52699297 Show fit	0.53	ENSMUST00000095737.3	Akap6 Ensembl NCBI MGI UniProt Show fit	A kinase (PRKA) anchor protein 6

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf2_Irf1_Irf8_Irf9_Irf7

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.4	4.3	GO:1900245	positive regulation of MDA-5 signaling pathway(GO:1900245)
1.3	1.3	GO:0002589	regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589)
0.9	4.5	GO:0009597	detection of virus(GO:0009597)
0.8	1.6	GO:0042270	protection from natural killer cell mediated cytotoxicity(GO:0042270)
0.7	2.2	GO:1902524	positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.7	2.0	GO:0042196	dichloromethane metabolic process(GO:0018900) chlorinated hydrocarbon metabolic process(GO:0042196) halogenated hydrocarbon metabolic process(GO:0042197)
0.6	1.7	GO:0001878	response to yeast(GO:0001878)
0.5	1.5	GO:0050717	positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.5	1.9	GO:0061762	CAMKK-AMPK signaling cascade(GO:0061762)
0.5	1.4	GO:0034165	positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
0.5	2.3	GO:1904721	regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.4	5.9	GO:0002483	antigen processing and presentation of endogenous peptide antigen(GO:0002483)
0.4	1.5	GO:0002415	immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.4	1.1	GO:0009197	dUDP biosynthetic process(GO:0006227) pyrimidine nucleoside diphosphate metabolic process(GO:0009138) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) dUDP metabolic process(GO:0046077)
0.3	1.4	GO:0044565	dendritic cell proliferation(GO:0044565)
0.3	1.0	GO:0039530	MDA-5 signaling pathway(GO:0039530)
0.3	1.7	GO:0034124	regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
0.3	0.3	GO:1990009	retinal cell apoptotic process(GO:1990009)
0.3	1.6	GO:0043321	regulation of natural killer cell degranulation(GO:0043321)
0.3	1.9	GO:0045629	negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.3	1.3	GO:1901740	negative regulation of myoblast fusion(GO:1901740)
0.3	1.2	GO:1903896	positive regulation of IRE1-mediated unfolded protein response(GO:1903896)
0.3	1.2	GO:0033634	positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.3	0.9	GO:0045404	positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.3	2.0	GO:0090086	negative regulation of protein deubiquitination(GO:0090086)
0.3	1.1	GO:0035279	mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.3	9.8	GO:0042832	defense response to protozoan(GO:0042832)
0.3	1.1	GO:0035455	response to interferon-alpha(GO:0035455)
0.3	1.6	GO:0010533	regulation of activation of Janus kinase activity(GO:0010533)
0.3	3.8	GO:0035457	cellular response to interferon-alpha(GO:0035457)
0.3	0.8	GO:0060700	regulation of ribonuclease activity(GO:0060700)
0.3	2.3	GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.2	1.2	GO:0034239	regulation of macrophage fusion(GO:0034239)
0.2	0.7	GO:1904100	interleukin-15-mediated signaling pathway(GO:0035723) extrathymic T cell selection(GO:0045062) cellular response to interleukin-15(GO:0071350) regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100)
0.2	2.8	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.2	1.2	GO:0045918	negative regulation of cytolysis(GO:0045918)
0.2	1.3	GO:0038128	ERBB2 signaling pathway(GO:0038128)
0.2	1.3	GO:0003383	apical constriction(GO:0003383)
0.2	0.6	GO:1990166	protein localization to site of double-strand break(GO:1990166)
0.2	0.6	GO:0035934	corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.2	1.5	GO:1902746	regulation of lens fiber cell differentiation(GO:1902746)
0.2	0.6	GO:0031117	positive regulation of microtubule depolymerization(GO:0031117)
0.2	0.5	GO:0061763	multivesicular body-lysosome fusion(GO:0061763)
0.2	0.7	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.2	0.5	GO:0061357	positive regulation of Wnt protein secretion(GO:0061357)
0.2	1.7	GO:0046007	negative regulation of activated T cell proliferation(GO:0046007)
0.2	0.5	GO:0046351	disaccharide biosynthetic process(GO:0046351)
0.2	1.2	GO:1901098	positive regulation of autophagosome maturation(GO:1901098)
0.2	0.8	GO:0009730	detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.2	0.7	GO:0034769	basement membrane disassembly(GO:0034769)
0.2	0.5	GO:0019442	tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.2	1.3	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.2	0.8	GO:0052805	imidazole-containing compound catabolic process(GO:0052805)
0.2	0.5	GO:0002014	vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure(GO:0002014)
0.1	0.4	GO:0006714	sesquiterpenoid metabolic process(GO:0006714)
0.1	0.6	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.1	2.7	GO:2001275	positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.1	0.4	GO:0007161	substrate-dependent cell migration, cell attachment to substrate(GO:0006931) calcium-independent cell-matrix adhesion(GO:0007161)
0.1	0.7	GO:1902261	positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.1	0.7	GO:0098886	modification of dendritic spine(GO:0098886)
0.1	0.8	GO:0015889	cobalamin transport(GO:0015889)
0.1	0.4	GO:0097309	cap1 mRNA methylation(GO:0097309)
0.1	0.4	GO:0002302	CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.1	0.4	GO:1900247	cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.1	0.3	GO:1902523	positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.1	0.4	GO:0007290	spermatid nucleus elongation(GO:0007290)
0.1	0.6	GO:0002606	positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.1	1.1	GO:0048625	regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) embryonic hindgut morphogenesis(GO:0048619) myoblast fate commitment(GO:0048625)
0.1	0.7	GO:0071787	endoplasmic reticulum tubular network assembly(GO:0071787)
0.1	0.3	GO:0019085	early viral transcription(GO:0019085)
0.1	1.3	GO:1902187	negative regulation of viral release from host cell(GO:1902187)
0.1	0.6	GO:0035726	common myeloid progenitor cell proliferation(GO:0035726)
0.1	0.3	GO:0071332	positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990) cellular response to fructose stimulus(GO:0071332)
0.1	0.7	GO:0036476	neuron death in response to hydrogen peroxide(GO:0036476) regulation of hydrogen peroxide-induced neuron death(GO:1903207) negative regulation of hydrogen peroxide-induced neuron death(GO:1903208)
0.1	0.2	GO:0060300	regulation of cytokine activity(GO:0060300)
0.1	0.2	GO:0045351	type I interferon biosynthetic process(GO:0045351)
0.1	0.3	GO:2000563	endocardial cushion fusion(GO:0003274) positive regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000563)
0.1	1.4	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.1	0.5	GO:0051902	negative regulation of mitochondrial depolarization(GO:0051902)
0.1	0.5	GO:0010940	positive regulation of necrotic cell death(GO:0010940)
0.1	0.3	GO:0002730	regulation of dendritic cell cytokine production(GO:0002730)
0.1	0.2	GO:0031296	B cell costimulation(GO:0031296)
0.1	0.2	GO:0072734	response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.1	0.4	GO:0001905	activation of membrane attack complex(GO:0001905) regulation of activation of membrane attack complex(GO:0001969)
0.1	1.2	GO:0060330	regulation of response to interferon-gamma(GO:0060330)
0.1	0.3	GO:0071211	protein targeting to vacuole involved in autophagy(GO:0071211)
0.1	0.7	GO:0018377	protein myristoylation(GO:0018377)
0.1	0.3	GO:1905204	negative regulation of connective tissue replacement(GO:1905204)
0.1	0.5	GO:1903336	negative regulation of vacuolar transport(GO:1903336)
0.1	0.7	GO:0019348	dolichol metabolic process(GO:0019348)
0.1	0.9	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.1	0.5	GO:0045625	regulation of T-helper 1 cell differentiation(GO:0045625)
0.1	0.3	GO:0032747	positive regulation of interleukin-23 production(GO:0032747) chemokine (C-X-C motif) ligand 1 production(GO:0072566) regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000338)
0.1	0.6	GO:0010991	negative regulation of SMAD protein complex assembly(GO:0010991)
0.1	0.5	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
0.1	0.5	GO:0040032	post-embryonic body morphogenesis(GO:0040032)
0.1	0.3	GO:0046098	guanine metabolic process(GO:0046098)
0.1	0.3	GO:0048239	negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695)
0.1	0.7	GO:0070317	negative regulation of G0 to G1 transition(GO:0070317)
0.1	0.3	GO:0070460	thyroid-stimulating hormone secretion(GO:0070460)
0.1	0.5	GO:0007258	JUN phosphorylation(GO:0007258)
0.1	0.5	GO:0033564	anterior/posterior axon guidance(GO:0033564)
0.1	0.1	GO:0018307	enzyme active site formation(GO:0018307)
0.1	1.7	GO:0044458	motile cilium assembly(GO:0044458)
0.1	0.6	GO:1990416	cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.1	1.1	GO:0032463	negative regulation of protein homooligomerization(GO:0032463)
0.1	0.2	GO:0032074	negative regulation of nuclease activity(GO:0032074)
0.1	0.6	GO:0010700	negative regulation of norepinephrine secretion(GO:0010700)
0.1	0.3	GO:0034146	toll-like receptor 5 signaling pathway(GO:0034146)
0.1	0.4	GO:0060455	negative regulation of gastric acid secretion(GO:0060455)
0.1	0.3	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.1	0.2	GO:0000821	regulation of arginine metabolic process(GO:0000821)
0.1	0.7	GO:0035878	nail development(GO:0035878)
0.1	0.2	GO:1904569	regulation of selenocysteine incorporation(GO:1904569)
0.1	0.4	GO:0048133	germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.1	0.5	GO:0032621	interleukin-18 production(GO:0032621)
0.1	0.7	GO:0031642	negative regulation of myelination(GO:0031642)
0.1	0.2	GO:0009992	cellular water homeostasis(GO:0009992)
0.1	1.1	GO:0032897	negative regulation of viral transcription(GO:0032897)
0.1	0.3	GO:0090290	positive regulation of osteoclast proliferation(GO:0090290)
0.1	0.7	GO:0046321	positive regulation of fatty acid oxidation(GO:0046321)
0.1	0.6	GO:0071763	nuclear membrane organization(GO:0071763)
0.1	0.3	GO:0048496	maintenance of organ identity(GO:0048496)
0.1	0.3	GO:0071449	cellular response to lipid hydroperoxide(GO:0071449)
0.1	0.3	GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.1	0.3	GO:0008300	isoprenoid catabolic process(GO:0008300)
0.1	0.2	GO:0032474	otolith morphogenesis(GO:0032474)
0.1	0.9	GO:0010818	T cell chemotaxis(GO:0010818)
0.1	0.2	GO:0002223	stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.1	0.2	GO:0006680	glucosylceramide catabolic process(GO:0006680)
0.1	10.6	GO:0051607	defense response to virus(GO:0051607)
0.1	1.2	GO:0051044	positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1	0.2	GO:0003245	cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.1	0.2	GO:0051342	regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.1	0.2	GO:0070459	prolactin secretion(GO:0070459)
0.1	0.4	GO:0042095	interferon-gamma biosynthetic process(GO:0042095)
0.1	1.1	GO:0045653	negative regulation of megakaryocyte differentiation(GO:0045653)
0.1	0.5	GO:1900042	positive regulation of interleukin-2 secretion(GO:1900042)
0.1	0.2	GO:0090126	protein complex assembly involved in synapse maturation(GO:0090126)
0.1	2.4	GO:0007212	dopamine receptor signaling pathway(GO:0007212)
0.1	1.3	GO:0032620	interleukin-17 production(GO:0032620)
0.1	0.2	GO:0044333	Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.1	0.1	GO:0021524	visceral motor neuron differentiation(GO:0021524)
0.1	0.6	GO:1902902	negative regulation of autophagosome assembly(GO:1902902)
0.1	0.2	GO:0014809	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1	0.2	GO:1903237	negative regulation of leukocyte tethering or rolling(GO:1903237)
0.1	0.2	GO:1904457	positive regulation of neuronal action potential(GO:1904457)
0.1	0.2	GO:1900020	regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.0	0.2	GO:0035608	protein deglutamylation(GO:0035608) protein side chain deglutamylation(GO:0035610)
0.0	0.1	GO:0036022	limb joint morphogenesis(GO:0036022) embryonic skeletal limb joint morphogenesis(GO:0036023)
0.0	0.1	GO:1902202	regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.0	0.2	GO:1902037	negative regulation of hematopoietic stem cell differentiation(GO:1902037)
0.0	0.2	GO:0070164	negative regulation of adiponectin secretion(GO:0070164)
0.0	0.3	GO:0032483	regulation of Rab protein signal transduction(GO:0032483)
0.0	0.1	GO:0006553	lysine metabolic process(GO:0006553)
0.0	0.5	GO:0098532	histone H3-K27 trimethylation(GO:0098532)
0.0	0.3	GO:0060842	arterial endothelial cell differentiation(GO:0060842)
0.0	0.1	GO:0002727	natural killer cell cytokine production(GO:0002370) regulation of natural killer cell cytokine production(GO:0002727) positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.0	0.5	GO:0043011	myeloid dendritic cell differentiation(GO:0043011)
0.0	0.1	GO:0097527	necroptotic signaling pathway(GO:0097527)
0.0	0.4	GO:0042126	nitrate metabolic process(GO:0042126)
0.0	2.7	GO:0006687	glycosphingolipid metabolic process(GO:0006687)
0.0	6.7	GO:0016052	carbohydrate catabolic process(GO:0016052)
0.0	0.3	GO:0044375	regulation of peroxisome size(GO:0044375)
0.0	0.3	GO:0045409	negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.0	0.4	GO:0060923	cardiac muscle cell fate commitment(GO:0060923)
0.0	0.3	GO:1904220	regulation of serine C-palmitoyltransferase activity(GO:1904220)
0.0	0.2	GO:0038094	Fc-gamma receptor signaling pathway(GO:0038094)
0.0	0.3	GO:2000252	negative regulation of feeding behavior(GO:2000252)
0.0	0.2	GO:0044336	canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336)
0.0	0.3	GO:0015808	L-alanine transport(GO:0015808)
0.0	0.7	GO:0032291	central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291) long-chain fatty acid biosynthetic process(GO:0042759)
0.0	0.8	GO:0006516	glycoprotein catabolic process(GO:0006516)
0.0	0.6	GO:0016540	protein autoprocessing(GO:0016540)
0.0	0.2	GO:0038018	Wnt receptor catabolic process(GO:0038018)
0.0	0.2	GO:0060022	hard palate development(GO:0060022)
0.0	0.4	GO:2000406	positive regulation of T cell migration(GO:2000406)
0.0	0.4	GO:0098543	detection of bacterium(GO:0016045) detection of other organism(GO:0098543)
0.0	0.4	GO:0030432	peristalsis(GO:0030432)
0.0	0.1	GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.0	0.3	GO:1902083	negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0	0.6	GO:0046485	ether lipid metabolic process(GO:0046485)
0.0	0.2	GO:0046501	protoporphyrinogen IX metabolic process(GO:0046501)
0.0	0.4	GO:0006968	cellular defense response(GO:0006968)
0.0	0.2	GO:0039019	pronephric nephron development(GO:0039019)
0.0	0.1	GO:1904879	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.0	0.2	GO:0060124	positive regulation of growth hormone secretion(GO:0060124)
0.0	0.2	GO:0051694	pointed-end actin filament capping(GO:0051694)
0.0	0.1	GO:1903225	negative regulation of endodermal cell differentiation(GO:1903225)
0.0	0.3	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.5	GO:0030238	male sex determination(GO:0030238)
0.0	0.1	GO:0097343	ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026)
0.0	0.2	GO:0006663	platelet activating factor biosynthetic process(GO:0006663)
0.0	0.2	GO:1902856	negative regulation of nonmotile primary cilium assembly(GO:1902856)
0.0	0.5	GO:1901841	regulation of high voltage-gated calcium channel activity(GO:1901841)
0.0	0.1	GO:0061428	peptidyl-aspartic acid hydroxylation(GO:0042264) negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.0	0.1	GO:0032815	negative regulation of natural killer cell activation(GO:0032815)
0.0	0.2	GO:0072086	proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081) specification of loop of Henle identity(GO:0072086)
0.0	0.1	GO:1904565	response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.0	0.7	GO:0061462	protein localization to lysosome(GO:0061462)
0.0	0.1	GO:0015712	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0	0.2	GO:0031274	positive regulation of pseudopodium assembly(GO:0031274)
0.0	0.3	GO:0030277	maintenance of gastrointestinal epithelium(GO:0030277)
0.0	0.3	GO:0007252	I-kappaB phosphorylation(GO:0007252)
0.0	0.1	GO:0019676	ammonia assimilation cycle(GO:0019676)
0.0	0.9	GO:0010107	potassium ion import(GO:0010107)
0.0	0.3	GO:0031584	activation of phospholipase D activity(GO:0031584)
0.0	0.1	GO:0006011	UDP-glucose metabolic process(GO:0006011)
0.0	0.2	GO:0003406	retinal pigment epithelium development(GO:0003406)
0.0	0.3	GO:0090435	protein localization to nuclear envelope(GO:0090435)
0.0	0.4	GO:0031953	negative regulation of protein autophosphorylation(GO:0031953)
0.0	0.4	GO:1903025	regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.0	0.3	GO:0021796	cerebral cortex regionalization(GO:0021796)
0.0	0.3	GO:0030853	negative regulation of granulocyte differentiation(GO:0030853)
0.0	0.6	GO:0090200	positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.0	0.5	GO:0030574	collagen catabolic process(GO:0030574)
0.0	0.9	GO:0043392	negative regulation of DNA binding(GO:0043392)
0.0	0.2	GO:1901223	negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.0	0.1	GO:0042695	thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.0	0.2	GO:0034975	protein folding in endoplasmic reticulum(GO:0034975)
0.0	0.1	GO:0000715	nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.0	0.1	GO:0070966	nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0	0.4	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.3	GO:0070266	necroptotic process(GO:0070266)
0.0	0.4	GO:1903541	regulation of exosomal secretion(GO:1903541) positive regulation of exosomal secretion(GO:1903543)
0.0	0.4	GO:0042789	mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.0	0.3	GO:0015812	gamma-aminobutyric acid secretion(GO:0014051) gamma-aminobutyric acid transport(GO:0015812)
0.0	0.1	GO:0090038	negative regulation of protein kinase C signaling(GO:0090038)
0.0	0.6	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0	0.1	GO:0032379	positive regulation of intracellular lipid transport(GO:0032379) positive regulation of intracellular sterol transport(GO:0032382) positive regulation of intracellular cholesterol transport(GO:0032385) lipid hydroperoxide transport(GO:1901373)
0.0	0.2	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0	0.4	GO:0060670	branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0	0.1	GO:1900003	regulation of serine-type endopeptidase activity(GO:1900003) negative regulation of serine-type endopeptidase activity(GO:1900004) regulation of serine-type peptidase activity(GO:1902571) negative regulation of serine-type peptidase activity(GO:1902572)
0.0	0.0	GO:0003199	endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.0	0.1	GO:0018101	protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.0	0.3	GO:0002347	response to tumor cell(GO:0002347)
0.0	0.5	GO:0016578	histone deubiquitination(GO:0016578)
0.0	0.1	GO:0061193	taste bud development(GO:0061193)
0.0	0.1	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.0	0.1	GO:0002232	leukocyte chemotaxis involved in inflammatory response(GO:0002232) regulation of NAD(P)H oxidase activity(GO:0033860) phagosome acidification(GO:0090383) negative regulation of neutrophil migration(GO:1902623)
0.0	0.2	GO:0032534	regulation of microvillus assembly(GO:0032534)
0.0	0.7	GO:0061098	positive regulation of protein tyrosine kinase activity(GO:0061098)
0.0	0.5	GO:0032011	ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0	0.1	GO:0035989	tendon development(GO:0035989)
0.0	0.2	GO:1904424	regulation of GTP binding(GO:1904424)
0.0	0.2	GO:0007190	activation of adenylate cyclase activity(GO:0007190)
0.0	0.4	GO:0008053	mitochondrial fusion(GO:0008053)
0.0	0.1	GO:1905051	regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053)
0.0	0.2	GO:0090527	actin filament reorganization(GO:0090527)
0.0	0.1	GO:0001712	ectodermal cell fate commitment(GO:0001712)
0.0	0.2	GO:0051231	spindle elongation(GO:0051231)
0.0	0.3	GO:0001833	inner cell mass cell proliferation(GO:0001833)
0.0	0.1	GO:2000659	regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.0	0.1	GO:0051612	negative regulation of neurotransmitter uptake(GO:0051581) negative regulation of serotonin uptake(GO:0051612)
0.0	0.1	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.3	GO:0006465	signal peptide processing(GO:0006465)
0.0	0.1	GO:0030240	skeletal muscle thin filament assembly(GO:0030240)
0.0	0.0	GO:1904732	regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959)
0.0	0.2	GO:0051601	exocyst localization(GO:0051601)
0.0	0.5	GO:0051642	centrosome localization(GO:0051642)
0.0	0.1	GO:0036265	RNA (guanine-N7)-methylation(GO:0036265)
0.0	0.2	GO:0098719	sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0	0.1	GO:0007343	egg activation(GO:0007343)
0.0	0.2	GO:0015937	coenzyme A biosynthetic process(GO:0015937)
0.0	0.2	GO:0035067	negative regulation of histone acetylation(GO:0035067)
0.0	0.1	GO:2001166	regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.0	0.7	GO:0000271	polysaccharide biosynthetic process(GO:0000271)
0.0	0.1	GO:0045721	negative regulation of gluconeogenesis(GO:0045721)
0.0	0.7	GO:0001919	regulation of receptor recycling(GO:0001919)
0.0	0.1	GO:0031848	protection from non-homologous end joining at telomere(GO:0031848)
0.0	0.1	GO:0070495	regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.0	0.1	GO:0006983	ER overload response(GO:0006983)
0.0	0.1	GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0	0.1	GO:0009816	defense response, incompatible interaction(GO:0009814) defense response to bacterium, incompatible interaction(GO:0009816) regulation of defense response to bacterium, incompatible interaction(GO:1902477)
0.0	0.2	GO:0046337	phosphatidylethanolamine metabolic process(GO:0046337)
0.0	1.9	GO:0042098	T cell proliferation(GO:0042098)
0.0	0.3	GO:0019731	antibacterial humoral response(GO:0019731)
0.0	0.1	GO:1902035	positive regulation of hematopoietic stem cell proliferation(GO:1902035)
0.0	0.1	GO:0045836	positive regulation of meiotic nuclear division(GO:0045836)
0.0	0.1	GO:1903608	protein localization to cytoplasmic stress granule(GO:1903608)
0.0	0.2	GO:0046069	cGMP catabolic process(GO:0046069)
0.0	0.0	GO:0019478	aspartate catabolic process(GO:0006533) D-amino acid catabolic process(GO:0019478)
0.0	0.1	GO:0046851	negative regulation of bone resorption(GO:0045779) negative regulation of bone remodeling(GO:0046851)
0.0	0.1	GO:2000576	regulation of microtubule motor activity(GO:2000574) positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0	0.3	GO:0070306	lens fiber cell differentiation(GO:0070306)
0.0	0.2	GO:0070831	basement membrane assembly(GO:0070831)
0.0	0.2	GO:0042088	T-helper 1 type immune response(GO:0042088)
0.0	0.4	GO:0046854	phosphatidylinositol phosphorylation(GO:0046854)
0.0	0.0	GO:0002314	germinal center B cell differentiation(GO:0002314)
0.0	0.6	GO:0007218	neuropeptide signaling pathway(GO:0007218)
0.0	0.1	GO:0014883	transition between fast and slow fiber(GO:0014883)
0.0	0.2	GO:0042572	retinol metabolic process(GO:0042572)
0.0	0.0	GO:1900226	negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.7	3.3	GO:1990111	spermatoproteasome complex(GO:1990111)
0.6	8.5	GO:0020003	symbiont-containing vacuole(GO:0020003)
0.4	1.8	GO:0097169	AIM2 inflammasome complex(GO:0097169)
0.4	3.2	GO:0042825	TAP complex(GO:0042825)
0.3	1.7	GO:1990462	omegasome(GO:1990462)
0.2	2.5	GO:0042612	MHC class I protein complex(GO:0042612)
0.2	1.4	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.2	0.7	GO:0033185	dolichol-phosphate-mannose synthase complex(GO:0033185)
0.2	1.0	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.2	1.3	GO:0033269	internode region of axon(GO:0033269)
0.1	0.7	GO:1990037	Lewy body core(GO:1990037)
0.1	1.1	GO:0070369	beta-catenin-TCF7L2 complex(GO:0070369)
0.1	0.6	GO:0043202	lysosomal lumen(GO:0043202)
0.1	0.9	GO:0045098	type III intermediate filament(GO:0045098)
0.1	2.0	GO:0043196	varicosity(GO:0043196)
0.1	0.3	GO:1990696	USH2 complex(GO:1990696)
0.1	0.4	GO:0072557	IPAF inflammasome complex(GO:0072557)
0.1	1.3	GO:0033391	chromatoid body(GO:0033391)
0.1	0.8	GO:0043020	NADPH oxidase complex(GO:0043020)
0.1	0.2	GO:0042584	chromaffin granule membrane(GO:0042584)
0.1	0.9	GO:0042611	MHC protein complex(GO:0042611)
0.1	0.4	GO:0071986	Ragulator complex(GO:0071986)
0.1	0.4	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1	0.6	GO:1990712	HFE-transferrin receptor complex(GO:1990712)
0.1	1.2	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.1	1.5	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.1	0.7	GO:0043083	synaptic cleft(GO:0043083)
0.1	0.4	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.7	GO:0044754	autolysosome(GO:0044754)
0.0	0.2	GO:0034751	aryl hydrocarbon receptor complex(GO:0034751)
0.0	0.3	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.0	0.6	GO:0044322	endoplasmic reticulum quality control compartment(GO:0044322)
0.0	0.3	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.0	0.5	GO:0008024	cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.0	2.6	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.0	0.3	GO:0030870	Mre11 complex(GO:0030870)
0.0	0.1	GO:0005588	collagen type V trimer(GO:0005588)
0.0	0.2	GO:0097443	sorting endosome(GO:0097443)
0.0	1.5	GO:0055038	recycling endosome membrane(GO:0055038)
0.0	1.0	GO:0071782	endoplasmic reticulum tubular network(GO:0071782)
0.0	0.6	GO:0017119	Golgi transport complex(GO:0017119)
0.0	0.2	GO:0044316	cone cell pedicle(GO:0044316)
0.0	0.4	GO:0033270	paranode region of axon(GO:0033270)
0.0	0.1	GO:1990257	piccolo-bassoon transport vesicle(GO:1990257)
0.0	1.1	GO:0048770	melanosome(GO:0042470) pigment granule(GO:0048770)
0.0	5.3	GO:0005923	bicellular tight junction(GO:0005923)
0.0	0.3	GO:0030688	preribosome, small subunit precursor(GO:0030688)
0.0	0.3	GO:0005787	signal peptidase complex(GO:0005787)
0.0	0.5	GO:0000124	SAGA complex(GO:0000124)
0.0	0.4	GO:0035631	CD40 receptor complex(GO:0035631)
0.0	1.3	GO:0005637	nuclear inner membrane(GO:0005637)
0.0	0.6	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.5	GO:0005640	nuclear outer membrane(GO:0005640)
0.0	3.0	GO:0016363	nuclear matrix(GO:0016363)
0.0	0.3	GO:0042587	glycogen granule(GO:0042587)
0.0	3.3	GO:0045111	intermediate filament cytoskeleton(GO:0045111)
0.0	0.2	GO:0016012	sarcoglycan complex(GO:0016012)
0.0	1.2	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.0	0.2	GO:0002177	manchette(GO:0002177)
0.0	1.8	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	0.1	GO:0097165	nuclear stress granule(GO:0097165)
0.0	0.3	GO:0097542	ciliary tip(GO:0097542)
0.0	0.1	GO:0016939	kinesin II complex(GO:0016939)
0.0	0.2	GO:0070695	FHF complex(GO:0070695)
0.0	0.1	GO:0043527	tRNA methyltransferase complex(GO:0043527)
0.0	0.4	GO:0030014	CCR4-NOT complex(GO:0030014)
0.0	0.2	GO:0036056	filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0	0.4	GO:0005666	DNA-directed RNA polymerase III complex(GO:0005666)
0.0	0.2	GO:0097197	tetraspanin-enriched microdomain(GO:0097197)
0.0	0.1	GO:0005861	troponin complex(GO:0005861)
0.0	0.3	GO:0005922	connexon complex(GO:0005922)
0.0	0.1	GO:0031211	serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0	0.1	GO:0071942	XPC complex(GO:0071942)
0.0	0.2	GO:0045179	apical cortex(GO:0045179)
0.0	0.9	GO:0009925	basal plasma membrane(GO:0009925)
0.0	0.2	GO:0042599	lamellar body(GO:0042599)
0.0	1.4	GO:0005811	lipid particle(GO:0005811)
0.0	0.0	GO:0046691	intracellular canaliculus(GO:0046691)
0.0	0.1	GO:0001533	cornified envelope(GO:0001533)
0.0	0.1	GO:0035749	myelin sheath adaxonal region(GO:0035749)
0.0	0.4	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.0	0.0	GO:0043540	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.0	0.1	GO:0097441	basilar dendrite(GO:0097441)
0.0	0.1	GO:0045293	mRNA editing complex(GO:0045293)
0.0	3.2	GO:0098852	lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0	0.2	GO:0005662	DNA replication factor A complex(GO:0005662)
0.0	0.2	GO:0072546	ER membrane protein complex(GO:0072546)
0.0	0.4	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.6	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.0	0.0	GO:0030981	cortical microtubule cytoskeleton(GO:0030981)
0.0	0.1	GO:0001520	outer dense fiber(GO:0001520)
0.0	1.0	GO:0036126	sperm flagellum(GO:0036126)
0.0	0.2	GO:0031105	septin complex(GO:0031105)
0.0	0.5	GO:0031901	early endosome membrane(GO:0031901)
0.0	0.6	GO:0005776	autophagosome(GO:0005776)
0.0	0.1	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.0	0.2	GO:0031527	filopodium membrane(GO:0031527)
0.0	0.5	GO:0005719	nuclear euchromatin(GO:0005719)
0.0	0.6	GO:0010008	endosome membrane(GO:0010008)
0.0	0.1	GO:0033503	HULC complex(GO:0033503)
0.0	0.4	GO:0031201	SNARE complex(GO:0031201)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.9	6.3	GO:0004556	alpha-amylase activity(GO:0004556)
0.7	2.0	GO:0016824	hydrolase activity, acting on acid halide bonds(GO:0016824) hydrolase activity, acting on acid halide bonds, in C-halide compounds(GO:0019120) alkylhalidase activity(GO:0047651)
0.6	2.8	GO:0031849	olfactory receptor binding(GO:0031849)
0.5	5.4	GO:0001730	2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.5	3.2	GO:0046978	TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
0.4	0.8	GO:0030881	beta-2-microglobulin binding(GO:0030881)
0.4	2.3	GO:0060698	endoribonuclease inhibitor activity(GO:0060698)
0.4	1.1	GO:0009041	uridylate kinase activity(GO:0009041)
0.4	4.7	GO:0050700	CARD domain binding(GO:0050700)
0.3	1.4	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.3	0.8	GO:0050479	glyceryl-ether monooxygenase activity(GO:0050479)
0.3	1.4	GO:0004839	ubiquitin activating enzyme activity(GO:0004839)
0.2	0.7	GO:0042015	interleukin-20 binding(GO:0042015)
0.2	1.5	GO:0032027	myosin light chain binding(GO:0032027)
0.2	1.6	GO:0016936	galactoside binding(GO:0016936)
0.2	1.7	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.2	1.5	GO:0019763	immunoglobulin receptor activity(GO:0019763)
0.2	0.9	GO:0004850	uridine phosphorylase activity(GO:0004850)
0.2	0.5	GO:0005118	sevenless binding(GO:0005118)
0.2	0.5	GO:0070052	collagen V binding(GO:0070052)
0.2	0.7	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.2	1.3	GO:0032051	clathrin light chain binding(GO:0032051)
0.1	0.4	GO:0070401	NADP+ binding(GO:0070401)
0.1	0.6	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
0.1	0.9	GO:0045340	mercury ion binding(GO:0045340)
0.1	1.4	GO:0031730	CCR5 chemokine receptor binding(GO:0031730)
0.1	1.7	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.1	0.1	GO:1903135	cupric ion binding(GO:1903135)
0.1	0.8	GO:0008381	mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1	0.5	GO:0070976	TIR domain binding(GO:0070976)
0.1	0.5	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1	1.2	GO:0008329	signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.1	0.4	GO:0098809	nitrite reductase activity(GO:0098809)
0.1	0.5	GO:0016823	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.1	0.5	GO:0008859	exoribonuclease II activity(GO:0008859)
0.1	0.3	GO:0005302	hydrogen:amino acid symporter activity(GO:0005280) L-tyrosine transmembrane transporter activity(GO:0005302)
0.1	0.4	GO:0004483	mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
0.1	2.7	GO:0042605	peptide antigen binding(GO:0042605)
0.1	0.4	GO:0004977	melanocortin receptor activity(GO:0004977)
0.1	1.1	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1	0.7	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
0.1	0.3	GO:0004974	leukotriene receptor activity(GO:0004974)
0.1	1.1	GO:0005041	low-density lipoprotein receptor activity(GO:0005041)
0.1	0.8	GO:0031419	cobalamin binding(GO:0031419)
0.1	0.3	GO:0031752	D5 dopamine receptor binding(GO:0031752)
0.1	1.3	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1	0.3	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)
0.1	0.3	GO:0097322	7SK snRNA binding(GO:0097322)
0.1	0.3	GO:0001733	galactosylceramide sulfotransferase activity(GO:0001733)
0.1	0.2	GO:0036004	GAF domain binding(GO:0036004)
0.1	0.3	GO:0034714	type III transforming growth factor beta receptor binding(GO:0034714)
0.1	0.2	GO:0004967	glucagon receptor activity(GO:0004967)
0.1	0.5	GO:0051430	corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1	0.6	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.1	0.4	GO:0004028	3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.1	6.2	GO:0003725	double-stranded RNA binding(GO:0003725)
0.1	0.2	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.1	2.3	GO:0005035	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1	0.6	GO:0003909	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.1	0.5	GO:0035662	Toll-like receptor 4 binding(GO:0035662)
0.1	0.3	GO:0003844	1,4-alpha-glucan branching enzyme activity(GO:0003844)
0.1	0.4	GO:0042296	ISG15 transferase activity(GO:0042296)
0.1	0.7	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.1	0.3	GO:0089720	caspase binding(GO:0089720)
0.1	0.2	GO:0004060	arylamine N-acetyltransferase activity(GO:0004060)
0.1	0.3	GO:0045131	pre-mRNA branch point binding(GO:0045131)
0.1	1.6	GO:0001848	complement binding(GO:0001848)
0.1	0.2	GO:0032129	histone deacetylase activity (H3-K9 specific)(GO:0032129) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969)
0.1	1.3	GO:0070628	proteasome binding(GO:0070628)
0.1	0.8	GO:0050308	sugar-phosphatase activity(GO:0050308)
0.1	1.4	GO:0005521	lamin binding(GO:0005521)
0.1	0.9	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.1	0.2	GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.1	0.3	GO:0005166	neurotrophin p75 receptor binding(GO:0005166)
0.1	0.2	GO:0005042	netrin receptor activity(GO:0005042)
0.1	0.3	GO:0048019	receptor antagonist activity(GO:0048019)
0.1	1.6	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
0.0	0.2	GO:0031852	mu-type opioid receptor binding(GO:0031852)
0.0	0.1	GO:0004619	bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0	1.1	GO:0045295	gamma-catenin binding(GO:0045295)
0.0	0.5	GO:0043495	protein anchor(GO:0043495)
0.0	0.2	GO:0072345	NAADP-sensitive calcium-release channel activity(GO:0072345)
0.0	1.0	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.0	0.5	GO:0070403	NAD+ binding(GO:0070403)
0.0	0.2	GO:0005223	intracellular cGMP activated cation channel activity(GO:0005223)
0.0	1.8	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.2	GO:0061628	H3K27me3 modified histone binding(GO:0061628)
0.0	0.4	GO:0090599	alpha-glucosidase activity(GO:0090599)
0.0	0.6	GO:0004679	AMP-activated protein kinase activity(GO:0004679)
0.0	0.1	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.1	GO:0047961	glycine N-acyltransferase activity(GO:0047961)
0.0	2.1	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0	0.1	GO:0008176	tRNA (guanine-N7-)-methyltransferase activity(GO:0008176)
0.0	0.1	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.1	GO:0015526	hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0	5.6	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	0.1	GO:0005171	hepatocyte growth factor receptor binding(GO:0005171)
0.0	0.2	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.9	GO:0005242	inward rectifier potassium channel activity(GO:0005242)
0.0	0.1	GO:0016454	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	0.4	GO:0035925	mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0	0.1	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.8	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.4	GO:0031996	thioesterase binding(GO:0031996)
0.0	0.3	GO:0042609	CD4 receptor binding(GO:0042609)
0.0	0.4	GO:0046703	natural killer cell lectin-like receptor binding(GO:0046703)
0.0	0.2	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0	0.2	GO:0035368	selenocysteine insertion sequence binding(GO:0035368)
0.0	0.2	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0	0.3	GO:0003958	NADPH-hemoprotein reductase activity(GO:0003958)
0.0	0.1	GO:0016880	acid-ammonia (or amide) ligase activity(GO:0016880)
0.0	0.5	GO:0004806	triglyceride lipase activity(GO:0004806)
0.0	0.7	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.2	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.6	GO:0071855	neuropeptide receptor binding(GO:0071855)
0.0	0.4	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.2	GO:0061578	Lys63-specific deubiquitinase activity(GO:0061578)
0.0	0.2	GO:0019158	fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0	7.2	GO:0003924	GTPase activity(GO:0003924)
0.0	1.6	GO:0019843	rRNA binding(GO:0019843)
0.0	0.2	GO:0047498	calcium-dependent phospholipase A2 activity(GO:0047498)
0.0	1.0	GO:0050699	WW domain binding(GO:0050699)
0.0	1.4	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	0.5	GO:0017091	AU-rich element binding(GO:0017091)
0.0	0.3	GO:0044548	S100 protein binding(GO:0044548)
0.0	0.1	GO:0071532	ankyrin repeat binding(GO:0071532)
0.0	0.8	GO:0005158	insulin receptor binding(GO:0005158)
0.0	0.1	GO:0003692	left-handed Z-DNA binding(GO:0003692) double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.1	GO:1904121	propanoyl-CoA C-acyltransferase activity(GO:0033814) propionyl-CoA C2-trimethyltridecanoyltransferase activity(GO:0050632) phosphatidylethanolamine transporter activity(GO:1904121)
0.0	0.3	GO:0098505	G-rich strand telomeric DNA binding(GO:0098505)
0.0	0.4	GO:0001056	RNA polymerase III activity(GO:0001056)
0.0	0.3	GO:0005243	gap junction channel activity(GO:0005243)
0.0	0.1	GO:0004792	thiosulfate sulfurtransferase activity(GO:0004792)
0.0	1.2	GO:0016836	hydro-lyase activity(GO:0016836)
0.0	0.1	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.6	GO:0071889	14-3-3 protein binding(GO:0071889)
0.0	0.3	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.0	1.4	GO:0043621	protein self-association(GO:0043621)
0.0	0.1	GO:0086056	voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0	0.1	GO:0035727	lysophosphatidic acid binding(GO:0035727)
0.0	0.1	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.0	0.1	GO:0005169	neurotrophin TRKB receptor binding(GO:0005169)
0.0	0.2	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.0	GO:0004945	angiotensin type II receptor activity(GO:0004945)
0.0	0.4	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.5	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	1.4	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.0	0.1	GO:0005008	hepatocyte growth factor-activated receptor activity(GO:0005008)
0.0	0.6	GO:0030552	cAMP binding(GO:0030552)
0.0	0.2	GO:0042288	MHC class I protein binding(GO:0042288)
0.0	0.2	GO:0015386	potassium:proton antiporter activity(GO:0015386)
0.0	1.3	GO:0046906	heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.0	0.6	GO:0043531	ADP binding(GO:0043531)
0.0	0.2	GO:0016634	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.0	0.1	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0	0.2	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.4	GO:0001671	ATPase activator activity(GO:0001671)
0.0	0.1	GO:0005093	Rab GDP-dissociation inhibitor activity(GO:0005093)
0.0	0.2	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.1	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0	0.1	GO:0004661	protein geranylgeranyltransferase activity(GO:0004661)
0.0	0.2	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.0	0.2	GO:0022889	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	0.3	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0	0.3	GO:0005452	inorganic anion exchanger activity(GO:0005452)
0.0	0.1	GO:0008494	translation activator activity(GO:0008494)
0.0	1.2	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0	0.0	GO:0003884	D-amino-acid oxidase activity(GO:0003884)
0.0	0.0	GO:1903136	cuprous ion binding(GO:1903136)
0.0	0.1	GO:0016208	AMP binding(GO:0016208)
0.0	0.1	GO:0035312	5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0	0.0	GO:0008147	structural constituent of bone(GO:0008147)
0.0	0.1	GO:0022842	leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
0.0	0.1	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.1	GO:0051400	BH domain binding(GO:0051400)
0.0	0.3	GO:0004602	glutathione peroxidase activity(GO:0004602)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	2.6	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.1	1.8	ST G ALPHA S PATHWAY	G alpha s Pathway
0.1	1.6	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.1	0.8	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1	5.0	PID IL12 2PATHWAY	IL12-mediated signaling events
0.1	2.0	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.1	0.5	PID IL27 PATHWAY	IL27-mediated signaling events
0.1	1.9	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.1	0.6	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.1	1.3	PID CONE PATHWAY	Visual signal transduction: Cones
0.1	3.3	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	0.6	PID TRAIL PATHWAY	TRAIL signaling pathway
0.0	1.1	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.0	1.1	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.0	0.4	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	2.0	PID IL4 2PATHWAY	IL4-mediated signaling events
0.0	0.6	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.0	0.2	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	0.4	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.0	0.4	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.0	0.3	PID S1P S1P4 PATHWAY	S1P4 pathway
0.0	0.7	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.0	0.5	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.0	0.8	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.0	0.3	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.0	0.4	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	1.1	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.0	0.4	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0	2.0	SIG PIP3 SIGNALING IN CARDIAC MYOCTES	Genes related to PIP3 signaling in cardiac myocytes
0.0	0.6	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.0	0.6	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.0	0.2	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0	0.0	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.0	0.4	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.0	3.3	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	2.5	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0	0.4	PID ARF6 PATHWAY	Arf6 signaling events
0.0	0.2	PID IL3 PATHWAY	IL3-mediated signaling events
0.0	0.3	SIG CHEMOTAXIS	Genes related to chemotaxis
0.0	0.5	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.0	0.1	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	0.4	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	0.4	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.0	0.2	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.0	0.4	PID ENDOTHELIN PATHWAY	Endothelins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	1.6	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.3	6.0	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.3	15.0	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.2	1.8	REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON	Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.1	1.9	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.1	1.5	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.1	1.4	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.1	1.4	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.1	1.1	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.1	2.2	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1	1.6	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1	1.6	REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.1	1.1	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.1	0.5	REACTOME DEFENSINS	Genes involved in Defensins
0.1	0.1	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
0.0	0.3	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0	0.9	REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS	Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.0	0.3	REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES	Genes involved in p75NTR recruits signalling complexes
0.0	0.7	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0	0.3	REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	Genes involved in Thromboxane signalling through TP receptor
0.0	1.5	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.0	1.6	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0	0.6	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0	1.4	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	0.8	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	0.9	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0	0.5	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.0	0.9	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.0	1.0	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0	0.3	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.0	1.2	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	1.2	REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0	0.9	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.0	0.5	REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0	0.6	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0	0.3	REACTOME EICOSANOID LIGAND BINDING RECEPTORS	Genes involved in Eicosanoid ligand-binding receptors
0.0	0.4	REACTOME GLUCAGON TYPE LIGAND RECEPTORS	Genes involved in Glucagon-type ligand receptors
0.0	1.1	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.2	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.0	0.2	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.0	1.0	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	1.1	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0	0.2	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.0	0.2	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0	0.2	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0	0.2	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.0	0.2	REACTOME FGFR4 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR4 ligand binding and activation
0.0	0.6	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.0	0.3	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0	0.3	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.0	0.1	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.0	0.4	REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	Genes involved in Synthesis of PIPs at the Golgi membrane
0.0	0.4	REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0	0.3	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.5	REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS	Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0	0.7	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0	0.3	REACTOME ACYL CHAIN REMODELLING OF PI	Genes involved in Acyl chain remodelling of PI
0.0	0.3	REACTOME RNA POL III CHAIN ELONGATION	Genes involved in RNA Polymerase III Chain Elongation
0.0	1.1	REACTOME GLUCOSE METABOLISM	Genes involved in Glucose metabolism
0.0	0.9	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.0	0.1	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	0.2	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.0	0.1	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0	0.5	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.0	0.1	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0	0.5	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
0.0	0.5	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.0	0.2	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	0.2	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling

Results for Irf2_Irf1_Irf8_Irf9_Irf7

Z-value: 2.20

Motif logo

Transcription factors associated with Irf2_Irf1_Irf8_Irf9_Irf7

Activity-expression correlation:

Activity profile of Irf2_Irf1_Irf8_Irf9_Irf7 motif

Sorted Z-values of Irf2_Irf1_Irf8_Irf9_Irf7 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf2_Irf1_Irf8_Irf9_Irf7

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: