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avrg: 2D miR_HR1_12
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Results for Irf2_Irf1_Irf8_Irf9_Irf7
Z-value: 2.20
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Transcription factors associated with Irf2_Irf1_Irf8_Irf9_Irf7
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSMUSG00000031627.7 | interferon regulatory factor 2 | |
| ENSMUSG00000018899.10 | interferon regulatory factor 1 | |
| ENSMUSG00000041515.3 | interferon regulatory factor 8 | |
| ENSMUSG00000002325.8 | interferon regulatory factor 9 | |
| ENSMUSG00000025498.8 | interferon regulatory factor 7 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Irf2 | mm10_v2_chr8_+_46739745_46739791 | -0.52 | 8.2e-02 | Click! |
| Irf1 | mm10_v2_chr11_+_53770458_53770509 | 0.45 | 1.4e-01 | Click! |
| Irf8 | mm10_v2_chr8_+_120736352_120736385 | -0.43 | 1.6e-01 | Click! |
| Irf7 | mm10_v2_chr7_-_141266415_141266481 | 0.33 | 3.0e-01 | Click! |
| Irf9 | mm10_v2_chr14_+_55604550_55604579 | -0.15 | 6.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Irf2_Irf1_Irf8_Irf9_Irf7
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.6 | GO:0051607 | defense response to virus(GO:0051607) |
| 0.3 | 9.8 | GO:0042832 | defense response to protozoan(GO:0042832) |
| 0.0 | 6.7 | GO:0016052 | carbohydrate catabolic process(GO:0016052) |
| 0.4 | 5.9 | GO:0002483 | antigen processing and presentation of endogenous peptide antigen(GO:0002483) |
| 0.9 | 4.5 | GO:0009597 | detection of virus(GO:0009597) |
| 1.4 | 4.3 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 0.3 | 3.8 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 0.2 | 2.8 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.1 | 2.7 | GO:2001275 | positive regulation of glucose import in response to insulin stimulus(GO:2001275) |
| 0.0 | 2.7 | GO:0006687 | glycosphingolipid metabolic process(GO:0006687) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 8.5 | GO:0020003 | symbiont-containing vacuole(GO:0020003) |
| 0.0 | 5.3 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.7 | 3.3 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.0 | 3.3 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.4 | 3.2 | GO:0042825 | TAP complex(GO:0042825) |
| 0.0 | 3.2 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 3.0 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 2.6 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.2 | 2.5 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.1 | 2.0 | GO:0043196 | varicosity(GO:0043196) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.2 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.9 | 6.3 | GO:0004556 | alpha-amylase activity(GO:0004556) |
| 0.1 | 6.2 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.0 | 5.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.5 | 5.4 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.4 | 4.7 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.5 | 3.2 | GO:0046978 | TAP1 binding(GO:0046978) TAP2 binding(GO:0046979) |
| 0.6 | 2.8 | GO:0031849 | olfactory receptor binding(GO:0031849) |
| 0.1 | 2.7 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.4 | 2.3 | GO:0060698 | endoribonuclease inhibitor activity(GO:0060698) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.0 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.1 | 3.3 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 3.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 2.6 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.0 | 2.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 2.0 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 2.0 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 2.0 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.1 | 1.9 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 1.8 | ST G ALPHA S PATHWAY | G alpha s Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 15.0 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.3 | 6.0 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.1 | 2.2 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.1 | 1.9 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.2 | 1.8 | REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.5 | 1.6 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.1 | 1.6 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.1 | 1.6 | REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.0 | 1.6 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.1 | 1.5 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |