Project
avrg: 2D miR_HR1_12
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Results for Mybl1
Z-value: 5.09
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Transcription factors associated with Mybl1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Mybl1 | mm10_v2_chr1_-_9700209_9700329 | 0.96 | 4.1e-07 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_118814195 Show fit | 9.50 |
ENSMUST00000110842.1
|
kinetochore-localized astrin/SPAG5 binding |
|
| chr2_+_118814237 Show fit | 8.54 |
ENSMUST00000028803.7
ENSMUST00000126045.1 |
kinetochore-localized astrin/SPAG5 binding |
|
| chr14_+_65806066 Show fit | 8.21 |
ENSMUST00000139644.1
|
PDZ binding kinase |
|
| chr2_+_118813995 Show fit | 8.03 |
ENSMUST00000134661.1
|
kinetochore-localized astrin/SPAG5 binding |
|
| chr4_-_118437331 Show fit | 7.55 |
ENSMUST00000006565.6
|
cell division cycle 20 |
|
| chrX_-_102157065 Show fit | 6.82 |
ENSMUST00000056904.2
|
excision repair cross-complementing rodent repair deficiency complementation group 6 like |
|
| chr14_+_46760526 Show fit | 5.70 |
ENSMUST00000067426.4
|
cyclin-dependent kinase inhibitor 3 |
|
| chr7_+_79660196 Show fit | 5.65 |
ENSMUST00000035977.7
|
TOPBP1-interacting checkpoint and replication regulator |
|
| chr6_+_124829540 Show fit | 5.56 |
ENSMUST00000150120.1
|
cell division cycle associated 3 |
|
| chr4_-_117182623 Show fit | 5.47 |
ENSMUST00000065896.2
|
kinesin family member 2C |
Network of associatons between targets according to the STRING database.
First level regulatory network of Mybl1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 26.1 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 0.0 | 19.6 | GO:0051301 | cell division(GO:0051301) |
| 0.2 | 14.4 | GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032435) |
| 0.1 | 8.0 | GO:0008637 | apoptotic mitochondrial changes(GO:0008637) |
| 1.9 | 7.5 | GO:0098763 | mitotic cell cycle phase(GO:0098763) |
| 0.2 | 7.3 | GO:0071427 | mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427) |
| 0.2 | 7.1 | GO:0006335 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
| 0.0 | 7.0 | GO:0000082 | G1/S transition of mitotic cell cycle(GO:0000082) |
| 0.7 | 5.7 | GO:0030174 | regulation of DNA-dependent DNA replication initiation(GO:0030174) |
| 0.9 | 5.6 | GO:0006452 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 31.5 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.1 | 11.1 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.1 | 9.1 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.4 | 9.0 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.1 | 9.0 | GO:0000776 | kinetochore(GO:0000776) |
| 0.2 | 8.3 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.7 | 8.0 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.0 | 7.9 | GO:0005730 | nucleolus(GO:0005730) |
| 0.1 | 6.1 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 1.7 | 5.2 | GO:1990423 | RZZ complex(GO:1990423) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.5 | 8.0 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 1.3 | 7.5 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 0.0 | 7.1 | GO:0004386 | helicase activity(GO:0004386) |
| 0.2 | 6.7 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.4 | 5.9 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.1 | 5.9 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 5.9 | GO:0042393 | histone binding(GO:0042393) |
| 1.1 | 5.6 | GO:0004768 | stearoyl-CoA 9-desaturase activity(GO:0004768) |
| 0.1 | 5.2 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 17.8 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.2 | 7.5 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.2 | 7.1 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.1 | 5.5 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 4.1 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.1 | 3.8 | PID FOXO PATHWAY | FoxO family signaling |
| 0.2 | 3.7 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 3.2 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 3.0 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.0 | 2.9 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 47.5 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.3 | 7.6 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.3 | 7.4 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 7.1 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 6.1 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 0.1 | 6.1 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.2 | 5.1 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.3 | 4.9 | REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX | Genes involved in Association of licensing factors with the pre-replicative complex |
| 0.1 | 4.8 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.1 | 4.7 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |