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avrg: 2D miR_HR1_12
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Results for Tfdp1_Wt1_Egr2
Z-value: 8.17
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Transcription factors associated with Tfdp1_Wt1_Egr2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tfdp1 | mm10_v2_chr8_+_13339656_13339674 | 0.90 | 5.7e-05 | Click! |
| Egr2 | mm10_v2_chr10_+_67535493_67535583 | 0.66 | 2.0e-02 | Click! |
| Wt1 | mm10_v2_chr2_+_105127200_105127222 | 0.37 | 2.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Tfdp1_Wt1_Egr2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 60.8 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.9 | 37.8 | GO:0021680 | cerebellar Purkinje cell layer development(GO:0021680) |
| 1.0 | 34.6 | GO:0045746 | negative regulation of Notch signaling pathway(GO:0045746) |
| 1.0 | 32.1 | GO:0006284 | base-excision repair(GO:0006284) |
| 1.1 | 27.1 | GO:0006978 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978) |
| 4.1 | 24.5 | GO:0031536 | positive regulation of exit from mitosis(GO:0031536) |
| 0.6 | 24.3 | GO:1902808 | positive regulation of cell cycle G1/S phase transition(GO:1902808) |
| 0.3 | 24.1 | GO:0051225 | spindle assembly(GO:0051225) |
| 2.3 | 23.5 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 6.9 | 20.6 | GO:0032877 | positive regulation of DNA endoreduplication(GO:0032877) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 112.3 | GO:0005730 | nucleolus(GO:0005730) |
| 0.4 | 58.4 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.2 | 42.2 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.3 | 39.3 | GO:0000775 | chromosome, centromeric region(GO:0000775) |
| 0.3 | 31.9 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 2.0 | 30.7 | GO:0042555 | MCM complex(GO:0042555) |
| 0.5 | 30.6 | GO:0005643 | nuclear pore(GO:0005643) |
| 3.7 | 29.4 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.4 | 28.6 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.5 | 27.8 | GO:0005844 | polysome(GO:0005844) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 87.0 | GO:0003723 | RNA binding(GO:0003723) |
| 0.5 | 79.8 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.5 | 36.8 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.4 | 33.6 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 1.1 | 31.3 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.9 | 30.7 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 1.0 | 30.5 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.2 | 28.2 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.1 | 27.0 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.3 | 26.8 | GO:0101005 | thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 105.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 1.3 | 62.6 | PID AURORA B PATHWAY | Aurora B signaling |
| 1.2 | 56.0 | PID ATR PATHWAY | ATR signaling pathway |
| 1.1 | 51.4 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.7 | 50.3 | PID E2F PATHWAY | E2F transcription factor network |
| 3.1 | 49.8 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.4 | 36.9 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.5 | 34.3 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.6 | 33.8 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.8 | 25.1 | PID FANCONI PATHWAY | Fanconi anemia pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 68.8 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 2.3 | 67.1 | REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 2.6 | 66.8 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.7 | 39.9 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.2 | 35.4 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.5 | 31.3 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 3.8 | 30.1 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 1.1 | 29.5 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.9 | 28.5 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 0.5 | 28.1 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |