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avrg: GFI1 WT vs 36n/n vs KD
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Results for Bptf
Z-value: 5.06
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Transcription factors associated with Bptf
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Bptf | mm39_v1_chr11_-_107022748_107022781 | -0.78 | 1.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_+_87685032 Show fit | 3.66 |
ENSMUST00000121303.8
|
myeloperoxidase |
|
| chr5_-_121045568 Show fit | 3.34 |
ENSMUST00000080322.8
|
2'-5' oligoadenylate synthetase 1A |
|
| chr11_+_87684548 Show fit | 2.93 |
ENSMUST00000143021.9
|
myeloperoxidase |
|
| chr9_+_98873831 Show fit | 2.52 |
ENSMUST00000185472.2
|
Fas apoptotic inhibitory molecule |
|
| chr19_+_12775938 Show fit | 2.46 |
ENSMUST00000025601.8
|
leupaxin |
|
| chr14_-_65830463 Show fit | 2.40 |
ENSMUST00000225355.2
ENSMUST00000022609.7 |
elongator acetyltransferase complex subunit 3 |
|
| chr12_-_75678092 Show fit | 2.39 |
ENSMUST00000238938.2
|
ribosomal protein, large P2, pseudogene 1 |
|
| chr14_+_55129950 Show fit | 2.34 |
ENSMUST00000140691.8
|
poly(A) binding protein, nuclear 1 |
|
| chr4_-_150994083 Show fit | 2.34 |
ENSMUST00000105674.8
ENSMUST00000105673.8 |
Parkinson disease (autosomal recessive, early onset) 7 |
|
| chr12_-_90705212 Show fit | 2.33 |
ENSMUST00000082432.6
|
deiodinase, iodothyronine, type II |
Network of associatons between targets according to the STRING database.
First level regulatory network of Bptf
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 6.6 | GO:0002149 | hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149) |
| 0.1 | 5.6 | GO:0030490 | maturation of SSU-rRNA(GO:0030490) |
| 1.2 | 4.7 | GO:0034309 | enzyme active site formation via L-cysteine sulfinic acid(GO:0018323) primary alcohol biosynthetic process(GO:0034309) cellular response to glyoxal(GO:0036471) glycolate biosynthetic process(GO:0046295) negative regulation of TRAIL-activated apoptotic signaling pathway(GO:1903122) regulation of pyrroline-5-carboxylate reductase activity(GO:1903167) positive regulation of pyrroline-5-carboxylate reductase activity(GO:1903168) regulation of tyrosine 3-monooxygenase activity(GO:1903176) positive regulation of tyrosine 3-monooxygenase activity(GO:1903178) L-dopa metabolic process(GO:1903184) L-dopa biosynthetic process(GO:1903185) glyoxal metabolic process(GO:1903189) regulation of L-dopa biosynthetic process(GO:1903195) positive regulation of L-dopa biosynthetic process(GO:1903197) regulation of L-dopa decarboxylase activity(GO:1903198) positive regulation of L-dopa decarboxylase activity(GO:1903200) positive regulation of cellular amino acid biosynthetic process(GO:2000284) |
| 1.0 | 4.0 | GO:1901421 | positive regulation of response to alcohol(GO:1901421) |
| 0.2 | 3.9 | GO:0001731 | formation of translation preinitiation complex(GO:0001731) |
| 0.0 | 3.7 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 0.1 | 3.4 | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771) |
| 0.5 | 3.1 | GO:0006556 | S-adenosylmethionine biosynthetic process(GO:0006556) |
| 0.1 | 3.1 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) |
| 0.4 | 3.0 | GO:0060332 | positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 30.2 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 8.3 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.4 | 7.6 | GO:0042582 | primary lysosome(GO:0005766) azurophil granule(GO:0042582) |
| 0.0 | 6.0 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 5.9 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 5.0 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.2 | 4.1 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.1 | 4.1 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 3.8 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 3.8 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.0 | GO:0004601 | peroxidase activity(GO:0004601) |
| 1.2 | 4.7 | GO:0036470 | tyrosine 3-monooxygenase activator activity(GO:0036470) L-dopa decarboxylase activator activity(GO:0036478) |
| 0.0 | 4.5 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 4.1 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 4.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.3 | 3.9 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.1 | 3.9 | GO:0030515 | snoRNA binding(GO:0030515) |
| 0.0 | 3.8 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 3.7 | GO:0042393 | histone binding(GO:0042393) |
| 0.2 | 3.6 | GO:0010314 | phosphatidylinositol-5-phosphate binding(GO:0010314) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 7.3 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.1 | 4.6 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 4.6 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.0 | 3.5 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.1 | 3.1 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.1 | 3.1 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.1 | 2.6 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 2.5 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.0 | 2.4 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.1 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.1 | 5.0 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 0.1 | 4.8 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.2 | 4.4 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.1 | 4.3 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.2 | 4.2 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.2 | 4.1 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.1 | 4.0 | REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | Genes involved in Transferrin endocytosis and recycling |
| 0.1 | 3.7 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 3.6 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |