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avrg: GFI1 WT vs 36n/n vs KD
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Results for Creb1
Z-value: 4.73
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Transcription factors associated with Creb1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Creb1 | mm39_v1_chr1_+_64572050_64572059 | -0.96 | 8.0e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Creb1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 8.3 | GO:0080120 | CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120) |
| 0.1 | 6.9 | GO:0032981 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.1 | 4.1 | GO:0032543 | mitochondrial translation(GO:0032543) |
| 0.5 | 3.5 | GO:0045716 | positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716) |
| 0.1 | 3.3 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.6 | 3.2 | GO:1990928 | response to amino acid starvation(GO:1990928) |
| 0.2 | 3.0 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.3 | 2.9 | GO:0060011 | Sertoli cell proliferation(GO:0060011) |
| 0.7 | 2.8 | GO:0001306 | age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571) |
| 0.9 | 2.6 | GO:0034473 | U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.6 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.1 | 6.1 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.2 | 5.5 | GO:0000178 | exosome (RNase complex)(GO:0000178) |
| 0.0 | 5.0 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.2 | 4.0 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.1 | 4.0 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 4.0 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.0 | 3.5 | GO:0043679 | axon terminus(GO:0043679) |
| 0.4 | 3.2 | GO:0005851 | eukaryotic translation initiation factor 2 complex(GO:0005850) eukaryotic translation initiation factor 2B complex(GO:0005851) |
| 0.2 | 2.9 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.4 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 9.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 5.5 | GO:0003724 | RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) |
| 0.1 | 4.2 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 4.0 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.3 | 3.5 | GO:1990715 | mRNA CDS binding(GO:1990715) |
| 0.1 | 3.0 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.1 | 3.0 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
| 0.1 | 2.9 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.0 | 2.9 | GO:0004497 | monooxygenase activity(GO:0004497) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.5 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 2.2 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.1 | 1.8 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 1.8 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 1.5 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 0.9 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 0.8 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 0.7 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.1 | 0.6 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 0.6 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.1 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.2 | 3.2 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.0 | 3.1 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.2 | 2.6 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 0.1 | 2.5 | REACTOME RNA POL I TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.1 | 2.2 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.0 | 2.0 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.1 | 1.8 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 1.8 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 1.7 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |