ISMARA results: Gfi1

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avrg: GFI1 WT vs 36n/n vs KD

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Results for Gfi1_Gfi1b

Z-value: 2.11

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Transcription factors associated with Gfi1_Gfi1b

Gene Symbol	Gene ID	Gene Info
Gfi1 Ensembl NCBI MGI UniProt	ENSMUSG00000029275.19	growth factor independent 1 transcription repressor
Gfi1b Ensembl NCBI MGI UniProt	ENSMUSG00000026815.15	growth factor independent 1B

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Gfi1b	mm39_v1_chr2_-_28511941_28511994	0.42	4.8e-01	Click!
Gfi1	mm39_v1_chr5_-_107873883_107873905	0.05	9.4e-01	Click!

Activity profile of Gfi1_Gfi1b motif

Sorted Z-values of Gfi1_Gfi1b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr13_+_23947641 Show fit	5.89	ENSMUST00000055770.4	H1f1 Ensembl NCBI MGI UniProt Show fit	H1.1 linker histone, cluster member
chr13_-_23946359 Show fit	5.69	ENSMUST00000091701.3	H3c1 Ensembl NCBI MGI UniProt Show fit	H3 clustered histone 1
chr13_-_23806530 Show fit	3.57	ENSMUST00000062045.4	H1f4 Ensembl NCBI MGI UniProt Show fit	H1.4 linker histone, cluster member
chr13_+_23755551 Show fit	3.33	ENSMUST00000079251.8	H2bc8 Ensembl NCBI MGI UniProt Show fit	H2B clustered histone 8
chr13_+_21901791 Show fit	2.18	ENSMUST00000188775.2	H3c10 Ensembl NCBI MGI UniProt Show fit	H3 clustered histone 10
chr13_-_23755374 Show fit	2.11	ENSMUST00000102969.6	H2ac8 Ensembl NCBI MGI UniProt Show fit	H2A clustered histone 8
chr3_+_54268523 Show fit	1.59	ENSMUST00000117373.8 ENSMUST00000107985.10 ENSMUST00000073012.13 ENSMUST00000081564.13	Postn Ensembl NCBI MGI UniProt Show fit	periostin, osteoblast specific factor
chr13_-_21967540 Show fit	1.44	ENSMUST00000189457.2	H3c11 Ensembl NCBI MGI UniProt Show fit	H3 clustered histone 11
chr12_-_99529767 Show fit	1.32	ENSMUST00000176928.3 ENSMUST00000223484.2	Foxn3 Ensembl NCBI MGI UniProt Show fit	forkhead box N3
chr7_+_24408662 Show fit	1.25	ENSMUST00000206826.2 ENSMUST00000051714.9	Lypd10 Ensembl NCBI MGI UniProt Show fit	Ly6/PLAUR domain containing 10

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Gfi1_Gfi1b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.8	GO:0097094	craniofacial suture morphogenesis(GO:0097094)
0.4	1.6	GO:1904207	regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.2	1.6	GO:0045919	positive regulation of cytolysis(GO:0045919)
0.0	1.4	GO:0001523	retinoid metabolic process(GO:0001523)
0.0	1.1	GO:0046329	negative regulation of JNK cascade(GO:0046329)
0.1	0.8	GO:0032911	negative regulation of transforming growth factor beta1 production(GO:0032911)
0.1	0.8	GO:0007527	adult somatic muscle development(GO:0007527)
0.1	0.8	GO:1904378	maintenance of unfolded protein(GO:0036506) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.1	0.8	GO:0051096	positive regulation of helicase activity(GO:0051096)
0.1	0.8	GO:0044828	negative regulation by host of viral genome replication(GO:0044828)

Showing 1 to 10 of 125 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.8	GO:0031594	neuromuscular junction(GO:0031594)
0.3	0.8	GO:0002944	cyclin K-CDK12 complex(GO:0002944) cyclin K-CDK13 complex(GO:0002945)
0.0	0.8	GO:0031527	filopodium membrane(GO:0031527)
0.1	0.7	GO:0072379	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.1	0.7	GO:0042613	MHC class II protein complex(GO:0042613)
0.1	0.7	GO:1990909	Wnt signalosome(GO:1990909)
0.0	0.6	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.5	GO:0032591	dendritic spine membrane(GO:0032591)
0.0	0.5	GO:0043196	varicosity(GO:0043196)
0.0	0.5	GO:0001891	phagocytic cup(GO:0001891)

Showing 1 to 10 of 46 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.6	GO:0001851	complement component C3b binding(GO:0001851)
0.0	1.5	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.0	1.5	GO:0017048	Rho GTPase binding(GO:0017048)
0.0	1.1	GO:0004745	retinol dehydrogenase activity(GO:0004745)
0.0	1.1	GO:1990381	ubiquitin-specific protease binding(GO:1990381)
0.0	0.9	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.0	0.7	GO:0017166	vinculin binding(GO:0017166)
0.0	0.7	GO:0070840	dynein complex binding(GO:0070840)
0.0	0.6	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.6	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624)

Showing 1 to 10 of 65 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
2.3	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.7	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.4	PID ARF 3PATHWAY	Arf1 pathway
0.3	PID S1P S1P4 PATHWAY	S1P4 pathway
0.2	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.1	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.1	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Showing 1 to 7 of 7 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.6	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	0.9	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.1	0.7	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.0	0.7	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.0	0.5	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.5	REACTOME TRAFFICKING OF AMPA RECEPTORS	Genes involved in Trafficking of AMPA receptors
0.0	0.4	REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0	0.4	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.0	0.4	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.1	0.3	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway

Showing 1 to 10 of 20 entries

Results for Gfi1_Gfi1b

Z-value: 2.11

Motif logo

Transcription factors associated with Gfi1_Gfi1b

Activity-expression correlation:

Activity profile of Gfi1_Gfi1b motif

Sorted Z-values of Gfi1_Gfi1b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Gfi1_Gfi1b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: