Project
avrg: GFI1 WT vs 36n/n vs KD
Navigation
Downloads
Results for Hcfc1_Six5_Smarcc2_Zfp143
Z-value: 7.30
Motif logo
Transcription factors associated with Hcfc1_Six5_Smarcc2_Zfp143
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSMUSG00000031386.15 | host cell factor C1 | |
| ENSMUSG00000040841.6 | sine oculis-related homeobox 5 | |
| ENSMUSG00000025369.16 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 | |
| ENSMUSG00000061079.15 | zinc finger protein 143 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hcfc1 | mm39_v1_chrX_-_73009933_73009982 | -0.88 | 5.0e-02 | Click! |
| Smarcc2 | mm39_v1_chr10_+_128295159_128295197 | -0.85 | 7.1e-02 | Click! |
| Six5 | mm39_v1_chr7_+_18828519_18828558 | -0.76 | 1.3e-01 | Click! |
| Zfp143 | mm39_v1_chr7_+_109660887_109660950 | 0.11 | 8.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_134123631 Show fit | 3.47 |
ENSMUST00000105869.9
|
platelet-activating factor acetylhydrolase 2 |
|
| chr18_-_42395207 Show fit | 3.23 |
ENSMUST00000097590.5
|
leucyl-tRNA synthetase |
|
| chr5_+_31350607 Show fit | 3.21 |
ENSMUST00000201535.4
|
sorting nexin 17 |
|
| chr3_-_89009153 Show fit | 3.15 |
ENSMUST00000199668.3
ENSMUST00000196709.5 |
farnesyl diphosphate synthetase |
|
| chr7_+_115692530 Show fit | 3.13 |
ENSMUST00000032899.12
ENSMUST00000106608.8 ENSMUST00000106607.2 |
RIKEN cDNA 1110004F10 gene |
|
| chr11_-_117764258 Show fit | 3.00 |
ENSMUST00000033230.8
|
threonine aldolase 1 |
|
| chr16_-_75563645 Show fit | 2.99 |
ENSMUST00000114244.2
ENSMUST00000046283.16 |
heat shock protein 70 family, member 13 |
|
| chr1_-_60137294 Show fit | 2.90 |
ENSMUST00000141417.3
ENSMUST00000122038.8 |
WD repeat domain 12 |
|
| chr7_+_127344942 Show fit | 2.77 |
ENSMUST00000189562.7
ENSMUST00000186116.7 |
F-box and leucine-rich repeat protein 19 |
|
| chr11_+_95557783 Show fit | 2.62 |
ENSMUST00000125172.8
ENSMUST00000036374.6 |
prohibitin |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hcfc1_Six5_Smarcc2_Zfp143
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 10.1 | GO:0030423 | targeting of mRNA for destruction involved in RNA interference(GO:0030423) |
| 0.5 | 6.2 | GO:0000463 | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) |
| 0.2 | 5.9 | GO:1990126 | retrograde transport, endosome to plasma membrane(GO:1990126) |
| 1.4 | 5.7 | GO:0045338 | farnesyl diphosphate metabolic process(GO:0045338) |
| 0.2 | 5.6 | GO:0032968 | positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968) |
| 0.5 | 5.4 | GO:0046826 | negative regulation of protein export from nucleus(GO:0046826) |
| 0.5 | 5.2 | GO:0036481 | intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036481) |
| 0.4 | 5.1 | GO:1902902 | negative regulation of autophagosome assembly(GO:1902902) |
| 1.6 | 4.9 | GO:0006429 | leucyl-tRNA aminoacylation(GO:0006429) |
| 0.1 | 4.8 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 17.7 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.1 | 13.6 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.6 | 6.8 | GO:0070578 | micro-ribonucleoprotein complex(GO:0035068) RISC-loading complex(GO:0070578) |
| 0.1 | 6.8 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.7 | 6.2 | GO:0070545 | PeBoW complex(GO:0070545) |
| 0.0 | 5.7 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.9 | 5.5 | GO:0070449 | elongin complex(GO:0070449) |
| 0.3 | 5.0 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.5 | 4.7 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 0.1 | 4.6 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.4 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 9.4 | GO:0008233 | peptidase activity(GO:0008233) |
| 0.0 | 8.3 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.9 | 6.8 | GO:0070883 | pre-miRNA binding(GO:0070883) |
| 1.7 | 6.6 | GO:0004337 | dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337) |
| 0.1 | 6.4 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
| 0.1 | 5.9 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 5.6 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 5.3 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 1.6 | 4.9 | GO:0004823 | glutamine-tRNA ligase activity(GO:0004819) leucine-tRNA ligase activity(GO:0004823) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.4 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.1 | 5.1 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.1 | 3.4 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 3.4 | PID P73PATHWAY | p73 transcription factor network |
| 0.1 | 3.0 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.1 | 2.3 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 2.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 2.3 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 2.2 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.1 | 1.8 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.6 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.3 | 7.9 | REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A | Genes involved in APC-Cdc20 mediated degradation of Nek2A |
| 0.1 | 7.9 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.3 | 7.2 | REACTOME MICRORNA MIRNA BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |
| 0.2 | 6.6 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.3 | 6.2 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.2 | 6.1 | REACTOME RNA POL I TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.2 | 5.6 | REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY | Genes involved in Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| 0.1 | 5.4 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 0.2 | 5.2 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |