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avrg: GFI1 WT vs 36n/n vs KD
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Results for Hdx
Z-value: 7.44
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Transcription factors associated with Hdx
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hdx | mm39_v1_chrX_-_110606766_110606834 | 0.61 | 2.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_+_3017408 Show fit | 32.90 |
ENSMUST00000099049.4
|
predicted gene 10719 |
|
| chr9_+_3023547 Show fit | 28.89 |
ENSMUST00000099046.4
|
predicted gene 10718 |
|
| chr9_+_3005126 Show fit | 23.05 |
ENSMUST00000179881.2
|
predicted gene 11168 |
|
| chr9_+_3034599 Show fit | 22.21 |
ENSMUST00000178641.2
|
predicted gene, 17535 |
|
| chr9_+_3000922 Show fit | 22.08 |
ENSMUST00000151376.3
|
predicted gene 10722 |
|
| chr9_+_3027439 Show fit | 19.69 |
ENSMUST00000179982.2
ENSMUST00000177875.8 |
predicted gene 10717 |
|
| chr9_+_3032001 Show fit | 19.61 |
ENSMUST00000099056.4
ENSMUST00000179839.8 |
predicted gene 10717 |
|
| chr9_+_3025417 Show fit | 19.38 |
ENSMUST00000075573.7
|
predicted gene 10717 |
|
| chr9_+_3015654 Show fit | 18.39 |
ENSMUST00000099050.4
|
predicted gene 10720 |
|
| chr9_+_3018753 Show fit | 16.64 |
ENSMUST00000179272.2
|
predicted gene 10719 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hdx
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 12.9 | GO:0045919 | positive regulation of cytolysis(GO:0045919) |
| 0.1 | 8.0 | GO:0019236 | response to pheromone(GO:0019236) |
| 0.4 | 4.3 | GO:0002441 | histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553) |
| 0.3 | 3.3 | GO:0002002 | regulation of angiotensin levels in blood(GO:0002002) |
| 0.9 | 2.6 | GO:0038161 | prolactin signaling pathway(GO:0038161) |
| 0.0 | 2.1 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.1 | 1.8 | GO:0042761 | fatty acid elongation(GO:0030497) very long-chain fatty acid biosynthetic process(GO:0042761) |
| 0.6 | 1.7 | GO:0070563 | negative regulation of vitamin D receptor signaling pathway(GO:0070563) |
| 0.0 | 1.6 | GO:0006400 | tRNA modification(GO:0006400) |
| 0.0 | 1.5 | GO:0031571 | mitotic G1 DNA damage checkpoint(GO:0031571) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.1 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 2.7 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 2.5 | GO:0000922 | spindle pole(GO:0000922) |
| 0.0 | 2.2 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.1 | 1.5 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.1 | 1.3 | GO:0005861 | troponin complex(GO:0005861) |
| 0.1 | 1.3 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.0 | 1.2 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.1 | 0.4 | GO:0036501 | UFD1-NPL4 complex(GO:0036501) |
| 0.0 | 0.1 | GO:0061474 | phagolysosome membrane(GO:0061474) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.3 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 1.8 | 12.9 | GO:0001851 | complement component C3b binding(GO:0001851) |
| 0.1 | 8.1 | GO:0005550 | pheromone binding(GO:0005550) |
| 0.4 | 4.3 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) |
| 0.1 | 3.7 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.0 | 2.6 | GO:0017046 | peptide hormone binding(GO:0017046) |
| 0.0 | 2.6 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.1 | 2.0 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.4 | 1.8 | GO:0102344 | 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345) |
| 0.5 | 1.6 | GO:0008192 | RNA guanylyltransferase activity(GO:0008192) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.6 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.0 | 1.5 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 0.8 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 12.9 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.2 | 4.4 | REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS | Genes involved in Nucleotide-like (purinergic) receptors |
| 0.1 | 2.6 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.1 | 2.0 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.1 | 1.0 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.0 | 0.8 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 0.5 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.0 | 0.4 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.0 | 0.3 | REACTOME ACYL CHAIN REMODELLING OF PI | Genes involved in Acyl chain remodelling of PI |