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avrg: GFI1 WT vs 36n/n vs KD
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Results for Id4
Z-value: 3.74
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Transcription factors associated with Id4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Id4 | mm39_v1_chr13_+_48414582_48414704 | 0.98 | 4.3e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Id4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.2 | GO:0031648 | protein destabilization(GO:0031648) |
| 0.3 | 3.5 | GO:0045631 | regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980) |
| 0.1 | 3.4 | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311) |
| 0.8 | 3.2 | GO:0072365 | regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072365) |
| 0.0 | 3.0 | GO:0060612 | adipose tissue development(GO:0060612) |
| 0.4 | 2.8 | GO:0090038 | negative regulation of protein kinase C signaling(GO:0090038) |
| 0.2 | 2.7 | GO:0033631 | cell-cell adhesion mediated by integrin(GO:0033631) |
| 0.1 | 2.7 | GO:1905145 | acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145) |
| 0.3 | 2.6 | GO:0032485 | regulation of Ral protein signal transduction(GO:0032485) |
| 0.5 | 2.5 | GO:0046878 | positive regulation of saliva secretion(GO:0046878) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.0 | GO:0030117 | membrane coat(GO:0030117) coated membrane(GO:0048475) |
| 0.0 | 5.6 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.1 | 5.5 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 4.4 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.1 | 4.3 | GO:0043034 | costamere(GO:0043034) |
| 0.5 | 4.1 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.1 | 3.6 | GO:0043596 | nuclear replication fork(GO:0043596) |
| 0.1 | 3.5 | GO:0005849 | mRNA cleavage factor complex(GO:0005849) |
| 0.0 | 3.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 3.1 | GO:0045095 | keratin filament(GO:0045095) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.7 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 7.3 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.1 | 4.7 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.0 | 4.2 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 3.8 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.1 | 3.4 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.0 | 3.2 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 2.9 | GO:0036459 | thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005) |
| 0.4 | 2.8 | GO:0030550 | acetylcholine receptor inhibitor activity(GO:0030550) |
| 0.1 | 2.8 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.8 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.1 | 4.9 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.1 | 4.4 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 4.3 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 4.0 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 3.1 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 0.0 | 2.5 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 2.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 2.1 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.0 | 2.1 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.7 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.1 | 4.6 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 3.2 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.1 | 3.0 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.1 | 2.9 | REACTOME ENOS ACTIVATION AND REGULATION | Genes involved in eNOS activation and regulation |
| 0.0 | 2.9 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 2.8 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 2.3 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.1 | 2.2 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 0.0 | 2.2 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |