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avrg: GFI1 WT vs 36n/n vs KD
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Results for Max_Mycn
Z-value: 6.37
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Transcription factors associated with Max_Mycn
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Mycn | mm39_v1_chr12_-_12990584_12990617 | 0.74 | 1.5e-01 | Click! |
| Max | mm39_v1_chr12_-_77008799_77008832 | -0.61 | 2.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Max_Mycn
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 10.8 | GO:0010288 | response to lead ion(GO:0010288) |
| 0.8 | 10.7 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
| 3.0 | 8.9 | GO:1990117 | release of matrix enzymes from mitochondria(GO:0032976) B cell receptor apoptotic signaling pathway(GO:1990117) |
| 0.2 | 7.9 | GO:0006400 | tRNA modification(GO:0006400) |
| 0.1 | 7.0 | GO:0016925 | protein sumoylation(GO:0016925) |
| 1.3 | 6.7 | GO:0019919 | peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919) |
| 0.7 | 6.7 | GO:0009162 | deoxyribonucleoside monophosphate metabolic process(GO:0009162) |
| 0.1 | 6.6 | GO:0006414 | translational elongation(GO:0006414) |
| 0.5 | 6.4 | GO:0000463 | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) |
| 0.6 | 6.1 | GO:0019244 | lactate biosynthetic process from pyruvate(GO:0019244) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 80.7 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.1 | 30.4 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.0 | 11.4 | GO:0005730 | nucleolus(GO:0005730) |
| 1.4 | 10.8 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 3.0 | 8.9 | GO:0097144 | BAX complex(GO:0097144) |
| 0.2 | 8.6 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.1 | 7.8 | GO:0034399 | nuclear periphery(GO:0034399) |
| 0.1 | 7.7 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.3 | 7.0 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.8 | 6.7 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.6 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.3 | 13.6 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.1 | 12.7 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.4 | 11.6 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.2 | 9.6 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.5 | 9.0 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.9 | 8.9 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.2 | 8.3 | GO:0000049 | tRNA binding(GO:0000049) |
| 0.6 | 7.2 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 0.3 | 7.0 | GO:0030515 | snoRNA binding(GO:0030515) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 32.9 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.8 | 15.9 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.4 | 8.4 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.2 | 6.8 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.1 | 5.6 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 5.5 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.2 | 4.2 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.1 | 4.1 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 3.4 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 3.0 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 19.8 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.1 | 15.2 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.1 | 12.5 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.5 | 12.3 | REACTOME PYRUVATE METABOLISM | Genes involved in Pyruvate metabolism |
| 0.3 | 10.2 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.2 | 10.1 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.2 | 9.7 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 8.5 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 0.3 | 8.2 | REACTOME RNA POL I TRANSCRIPTION INITIATION | Genes involved in RNA Polymerase I Transcription Initiation |
| 0.3 | 7.7 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |