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avrg: GFI1 WT vs 36n/n vs KD
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Results for Nrf1
Z-value: 9.42
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Transcription factors associated with Nrf1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nrf1 | mm39_v1_chr6_+_30047968_30048048 | 0.56 | 3.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nrf1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.5 | GO:0006457 | protein folding(GO:0006457) |
| 0.9 | 13.0 | GO:1903405 | protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) |
| 1.9 | 11.7 | GO:0045905 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 1.4 | 11.1 | GO:0017198 | N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920) |
| 0.2 | 8.5 | GO:0032981 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.1 | 8.4 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 1.0 | 7.3 | GO:0045585 | regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585) |
| 0.7 | 7.2 | GO:0019659 | glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661) |
| 0.2 | 7.1 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) |
| 0.7 | 6.5 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 43.9 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.7 | 13.0 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 1.0 | 11.6 | GO:0031415 | NatA complex(GO:0031415) |
| 0.2 | 11.1 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.3 | 9.5 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.2 | 9.4 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 8.3 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 8.0 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.3 | 7.6 | GO:0046930 | pore complex(GO:0046930) |
| 1.2 | 7.5 | GO:0097226 | sperm mitochondrial sheath(GO:0097226) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 20.0 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.4 | 14.9 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.7 | 12.1 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.1 | 11.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.4 | 11.1 | GO:1990190 | peptide-glutamate-N-acetyltransferase activity(GO:1990190) |
| 0.1 | 8.6 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 8.0 | GO:0051015 | actin filament binding(GO:0051015) |
| 1.1 | 7.5 | GO:0002135 | CTP binding(GO:0002135) |
| 0.7 | 7.2 | GO:0015288 | porin activity(GO:0015288) |
| 0.7 | 7.2 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 16.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.4 | 9.6 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.2 | 7.9 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.1 | 7.7 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 7.6 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 4.9 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 4.5 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 4.1 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.1 | 4.1 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 3.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 13.0 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.4 | 11.9 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.1 | 10.7 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.4 | 9.6 | REACTOME PYRUVATE METABOLISM | Genes involved in Pyruvate metabolism |
| 0.2 | 8.7 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 7.9 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.4 | 7.8 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.0 | 7.5 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 7.2 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.1 | 6.9 | REACTOME TRANSLATION | Genes involved in Translation |