ISMARA results: Pou1f1

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avrg: GFI1 WT vs 36n/n vs KD

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Results for Pou1f1

Z-value: 6.76

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Transcription factors associated with Pou1f1

Gene Symbol	Gene ID	Gene Info
Pou1f1 Ensembl NCBI MGI UniProt	ENSMUSG00000004842.19	POU domain, class 1, transcription factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Pou1f1	mm39_v1_chr16_+_65317389_65317434	0.96	8.5e-03	Click!

Activity profile of Pou1f1 motif

Sorted Z-values of Pou1f1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_+_87610895 Show fit	12.13	ENSMUST00000215394.2	Olfr152 Ensembl NCBI MGI UniProt Show fit	olfactory receptor 152
chr13_+_23728222 Show fit	9.97	ENSMUST00000075558.5	H3c7 Ensembl NCBI MGI UniProt Show fit	H3 clustered histone 7
chr2_+_85820648 Show fit	8.86	ENSMUST00000216807.2	Olfr1031 Ensembl NCBI MGI UniProt Show fit	olfactory receptor 1031
chr2_+_87609827 Show fit	8.83	ENSMUST00000105210.3	Olfr152 Ensembl NCBI MGI UniProt Show fit	olfactory receptor 152
chr14_-_51045182 Show fit	8.23	ENSMUST00000227614.2	Ccnb1ip1 Ensembl NCBI MGI UniProt Show fit	cyclin B1 interacting protein 1
chr13_-_23746543 Show fit	7.56	ENSMUST00000105107.2	H3c6 Ensembl NCBI MGI UniProt Show fit	H3 clustered histone 6
chr7_-_103113358 Show fit	6.82	ENSMUST00000214347.2	Olfr607 Ensembl NCBI MGI UniProt Show fit	olfactory receptor 607
chr13_-_23727549 Show fit	6.52	ENSMUST00000224359.2	H2bc9 Ensembl NCBI MGI UniProt Show fit	H2B clustered histone 9
chr19_+_13560875 Show fit	6.30	ENSMUST00000208104.3 ENSMUST00000216014.3 ENSMUST00000216369.2 ENSMUST00000217451.3 ENSMUST00000215567.3	Olfr1484 Ensembl NCBI MGI UniProt Show fit	olfactory receptor 1484
chr7_-_85065128 Show fit	5.68	ENSMUST00000171213.3 ENSMUST00000233336.2	Vmn2r69 Ensembl NCBI MGI UniProt Show fit	vomeronasal 2, receptor 69

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Pou1f1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	241.1	GO:0007606	sensory perception of chemical stimulus(GO:0007606)
0.3	86.9	GO:0050907	detection of chemical stimulus involved in sensory perception(GO:0050907)
0.3	38.9	GO:0019236	response to pheromone(GO:0019236)
0.3	12.6	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.4	7.2	GO:0051026	chiasma assembly(GO:0051026)
0.1	3.9	GO:0042773	ATP synthesis coupled electron transport(GO:0042773)
0.1	3.2	GO:0034587	piRNA metabolic process(GO:0034587)
0.6	2.9	GO:0050902	leukocyte adhesive activation(GO:0050902)
0.3	2.7	GO:0086023	adrenergic receptor signaling pathway involved in heart process(GO:0086023)
0.8	2.4	GO:0032685	negative regulation of granulocyte macrophage colony-stimulating factor production(GO:0032685)

Showing 1 to 10 of 172 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	280.5	GO:0016021	integral component of membrane(GO:0016021)
0.0	6.0	GO:0000795	synaptonemal complex(GO:0000795)
0.1	5.9	GO:0070469	respiratory chain(GO:0070469)
0.2	2.9	GO:0001931	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.2	2.1	GO:0000812	Swr1 complex(GO:0000812)
0.1	2.1	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
0.1	1.9	GO:0030140	trans-Golgi network transport vesicle(GO:0030140)
0.3	1.8	GO:0071547	piP-body(GO:0071547)
0.2	1.6	GO:0072557	IPAF inflammasome complex(GO:0072557)
0.0	1.6	GO:0030667	secretory granule membrane(GO:0030667)

Showing 1 to 10 of 56 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	204.2	GO:0004984	olfactory receptor activity(GO:0004984)
0.2	110.1	GO:0005549	odorant binding(GO:0005549)
0.3	34.9	GO:0005550	pheromone binding(GO:0005550)
0.2	6.5	GO:0050136	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2	4.0	GO:0016503	pheromone receptor activity(GO:0016503)
0.0	3.1	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3	2.7	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.2	2.5	GO:1990405	protein antigen binding(GO:1990405)
0.1	2.5	GO:0004623	phospholipase A2 activity(GO:0004623)
0.6	2.4	GO:0015057	thrombin receptor activity(GO:0015057)

Showing 1 to 10 of 111 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.4	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0	2.8	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.0	2.6	PID NOTCH PATHWAY	Notch signaling pathway
0.1	2.4	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.0	2.2	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.1	1.6	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.0	1.5	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	1.3	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.0	1.3	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.1	1.2	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway

Showing 1 to 10 of 17 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.5	REACTOME ACYL CHAIN REMODELLING OF PS	Genes involved in Acyl chain remodelling of PS
0.0	3.2	REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS	Genes involved in Class A/1 (Rhodopsin-like receptors)
0.0	3.1	REACTOME CIRCADIAN CLOCK	Genes involved in Circadian Clock
0.0	2.2	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.1	2.0	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.0	1.8	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1	1.7	REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS	Genes involved in Nucleotide-like (purinergic) receptors
0.0	1.7	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.1	1.6	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.1	1.5	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism

Showing 1 to 10 of 46 entries

Results for Pou1f1

Z-value: 6.76

Motif logo

Transcription factors associated with Pou1f1

Activity-expression correlation:

Activity profile of Pou1f1 motif

Sorted Z-values of Pou1f1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Pou1f1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: