ISMARA results: Pou2f2

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avrg: GFI1 WT vs 36n/n vs KD

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Results for Pou2f2_Pou3f1

Z-value: 7.07

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Transcription factors associated with Pou2f2_Pou3f1

Gene Symbol	Gene ID	Gene Info
Pou2f2 Ensembl NCBI MGI UniProt	ENSMUSG00000008496.20	POU domain, class 2, transcription factor 2
Pou3f1 Ensembl NCBI MGI UniProt	ENSMUSG00000090125.4	POU domain, class 3, transcription factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Pou3f1	mm39_v1_chr4_+_124550600_124550600	0.95	1.2e-02	Click!
Pou2f2	mm39_v1_chr7_-_24831892_24831937	0.62	2.7e-01	Click!

Activity profile of Pou2f2_Pou3f1 motif

Sorted Z-values of Pou2f2_Pou3f1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr13_+_23930717 Show fit	38.78	ENSMUST00000099703.5	H2bc3 Ensembl NCBI MGI UniProt Show fit	H2B clustered histone 3
chr13_-_23758370 Show fit	20.98	ENSMUST00000105106.2	H2bc7 Ensembl NCBI MGI UniProt Show fit	H2B clustered histone 7
chr3_-_96128196 Show fit	20.35	ENSMUST00000090782.4	H2ac20 Ensembl NCBI MGI UniProt Show fit	H2A clustered histone 20
chr3_+_96177010 Show fit	19.31	ENSMUST00000051089.4 ENSMUST00000177113.2	Gm42743 Ensembl NCBI MGI UniProt Show fit H2bc18 Ensembl NCBI MGI UniProt Show fit	predicted gene 42743 H2B clustered histone 18
chr13_+_23868175 Show fit	19.02	ENSMUST00000018246.6	H2bc4 Ensembl NCBI MGI UniProt Show fit	H2B clustered histone 4
chr13_+_22220000 Show fit	18.13	ENSMUST00000110455.4	H2bc12 Ensembl NCBI MGI UniProt Show fit	H2B clustered histone 12
chr3_+_96152813 Show fit	18.07	ENSMUST00000078756.7 ENSMUST00000090779.4	H2ac18 Ensembl NCBI MGI UniProt Show fit Gm20634 Ensembl NCBI MGI UniProt Show fit	H2A clustered histone 18 predicted gene 20634
chr13_+_21906214 Show fit	17.73	ENSMUST00000224651.2	H2bc14 Ensembl NCBI MGI UniProt Show fit	H2B clustered histone 14
chr13_+_22227359 Show fit	17.63	ENSMUST00000110452.2	H2bc11 Ensembl NCBI MGI UniProt Show fit	H2B clustered histone 11
chr3_-_96147592 Show fit	17.39	ENSMUST00000074976.8	H2ac19 Ensembl NCBI MGI UniProt Show fit	H2A clustered histone 19

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Pou2f2_Pou3f1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	10.3	GO:0051865	protein autoubiquitination(GO:0051865)
1.5	7.7	GO:1904059	regulation of locomotor rhythm(GO:1904059)
1.7	5.1	GO:0032741	positive regulation of interleukin-18 production(GO:0032741)
0.7	4.9	GO:0055095	lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096)
1.1	4.6	GO:2000872	positive regulation of progesterone secretion(GO:2000872)
0.2	4.3	GO:0014049	positive regulation of glutamate secretion(GO:0014049)
0.5	3.8	GO:0007527	adult somatic muscle development(GO:0007527)
0.0	3.8	GO:0045576	mast cell activation(GO:0045576)
0.0	3.1	GO:0060325	face morphogenesis(GO:0060325)
0.2	2.9	GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)

Showing 1 to 10 of 76 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.3	GO:0005604	basement membrane(GO:0005604)
0.0	5.3	GO:0043195	terminal bouton(GO:0043195)
0.9	5.1	GO:0036019	endolysosome(GO:0036019)
0.2	4.9	GO:0042627	chylomicron(GO:0042627)
0.1	3.9	GO:0070938	contractile ring(GO:0070938)
0.3	2.4	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0	2.1	GO:0032420	stereocilium(GO:0032420)
0.0	1.9	GO:0000777	condensed chromosome kinetochore(GO:0000777)
0.0	1.9	GO:0005913	cell-cell adherens junction(GO:0005913)
0.0	1.8	GO:0043596	nuclear replication fork(GO:0043596)

Showing 1 to 10 of 30 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	10.1	GO:0030674	protein binding, bridging(GO:0030674)
0.0	9.8	GO:0016887	ATPase activity(GO:0016887)
0.1	5.8	GO:0019003	GDP binding(GO:0019003)
1.0	5.7	GO:0045322	unmethylated CpG binding(GO:0045322)
0.0	4.8	GO:0008017	microtubule binding(GO:0008017)
0.1	4.5	GO:1990841	promoter-specific chromatin binding(GO:1990841)
0.2	4.3	GO:0004806	triglyceride lipase activity(GO:0004806)
0.1	3.8	GO:0017166	vinculin binding(GO:0017166)
0.1	3.5	GO:0004386	helicase activity(GO:0004386)
0.6	2.5	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)

Showing 1 to 10 of 48 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.7	PID RAS PATHWAY	Regulation of Ras family activation
0.1	5.0	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	4.5	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	2.0	PID NOTCH PATHWAY	Notch signaling pathway
0.0	1.7	ST GA12 PATHWAY	G alpha 12 Pathway
0.1	1.5	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.1	1.4	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.0	1.4	PID ALK1 PATHWAY	ALK1 signaling events
0.0	1.4	PID IL4 2PATHWAY	IL4-mediated signaling events
0.0	1.3	PID CASPASE PATHWAY	Caspase cascade in apoptosis

Showing 1 to 10 of 19 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	5.8	REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.4	5.1	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.2	4.9	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.4	4.3	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.1	3.8	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	3.2	REACTOME TOLL RECEPTOR CASCADES	Genes involved in Toll Receptor Cascades
0.0	2.5	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.1	2.1	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.1	2.0	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	1.8	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels

Showing 1 to 10 of 20 entries

Results for Pou2f2_Pou3f1

Z-value: 7.07

Motif logo

Transcription factors associated with Pou2f2_Pou3f1

Activity-expression correlation:

Activity profile of Pou2f2_Pou3f1 motif

Sorted Z-values of Pou2f2_Pou3f1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Pou2f2_Pou3f1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: