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avrg: GFI1 WT vs 36n/n vs KD
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Results for Smad3
Z-value: 7.71
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Transcription factors associated with Smad3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Smad3 | mm39_v1_chr9_-_63619251_63619276 | 0.86 | 6.5e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_+_23765546 Show fit | 27.78 |
ENSMUST00000102968.3
|
H4 clustered histone 4 |
|
| chr13_+_23940964 Show fit | 24.16 |
ENSMUST00000102965.4
|
H4 clustered histone 2 |
|
| chr13_+_23715220 Show fit | 23.60 |
ENSMUST00000102972.6
|
H4 clustered histone 8 |
|
| chr13_+_22220000 Show fit | 19.20 |
ENSMUST00000110455.4
|
H2B clustered histone 12 |
|
| chr13_-_23735822 Show fit | 19.06 |
ENSMUST00000102971.2
|
H4 clustered histone 6 |
|
| chr13_+_22227359 Show fit | 18.84 |
ENSMUST00000110452.2
|
H2B clustered histone 11 |
|
| chr3_-_96170627 Show fit | 18.50 |
ENSMUST00000171473.3
|
H4 clustered histone 14 |
|
| chr13_+_22017906 Show fit | 17.81 |
ENSMUST00000180288.2
|
H2B clustered histone 24 |
|
| chr13_+_23718038 Show fit | 16.51 |
ENSMUST00000073261.3
|
H2A clustered histone 10 |
|
| chr13_-_21934675 Show fit | 16.29 |
ENSMUST00000102983.2
|
H4 clustered histone 12 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Smad3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.9 | GO:0019236 | response to pheromone(GO:0019236) |
| 1.4 | 5.5 | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) |
| 0.2 | 5.5 | GO:0075522 | IRES-dependent viral translational initiation(GO:0075522) |
| 0.4 | 3.8 | GO:0030321 | transepithelial chloride transport(GO:0030321) |
| 0.0 | 3.5 | GO:0016579 | protein deubiquitination(GO:0016579) |
| 0.2 | 3.0 | GO:0034242 | negative regulation of syncytium formation by plasma membrane fusion(GO:0034242) |
| 0.2 | 3.0 | GO:0010572 | positive regulation of platelet activation(GO:0010572) |
| 0.3 | 2.8 | GO:0045048 | protein insertion into ER membrane(GO:0045048) |
| 0.7 | 2.7 | GO:0021691 | cerebellar Purkinje cell layer maturation(GO:0021691) |
| 0.3 | 2.0 | GO:0021633 | optic nerve structural organization(GO:0021633) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 7.5 | GO:0070822 | Sin3-type complex(GO:0070822) |
| 1.8 | 5.5 | GO:0005967 | mitochondrial pyruvate dehydrogenase complex(GO:0005967) |
| 0.0 | 4.9 | GO:0044306 | neuron projection terminus(GO:0044306) |
| 0.0 | 3.0 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 3.0 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.1 | 2.0 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.1 | 1.9 | GO:0070938 | contractile ring(GO:0070938) |
| 0.1 | 1.9 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 1.7 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 1.6 | GO:0060170 | ciliary membrane(GO:0060170) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.0 | GO:0005550 | pheromone binding(GO:0005550) |
| 1.4 | 5.5 | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740) |
| 0.4 | 5.5 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 0.0 | 4.7 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 1.0 | 3.8 | GO:0015065 | uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553) |
| 0.2 | 3.0 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.1 | 2.7 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.0 | 2.7 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.1 | 2.6 | GO:0005351 | sugar:proton symporter activity(GO:0005351) |
| 0.1 | 2.0 | GO:0015271 | outward rectifier potassium channel activity(GO:0015271) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 3.0 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.0 | 1.9 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 1.5 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 0.0 | 1.0 | PID ILK PATHWAY | Integrin-linked kinase signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 5.5 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.0 | 5.5 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.2 | 3.8 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.1 | 3.7 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 3.0 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 2.0 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 1.9 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 1.5 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.0 | 0.6 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 0.4 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |