ISMARA results: Sox18

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avrg: GFI1 WT vs 36n/n vs KD

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Results for Sox18_Sox12

Z-value: 3.69

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Transcription factors associated with Sox18_Sox12

Gene Symbol	Gene ID	Gene Info
Sox18 Ensembl NCBI MGI UniProt	ENSMUSG00000046470.6	SRY (sex determining region Y)-box 18
Sox12 Ensembl NCBI MGI UniProt	ENSMUSG00000051817.9	SRY (sex determining region Y)-box 12

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Sox12	mm39_v1_chr2_-_152239966_152239997	-0.67	2.2e-01	Click!
Sox18	mm39_v1_chr2_-_181313415_181313438	0.33	5.9e-01	Click!

Activity profile of Sox18_Sox12 motif

Sorted Z-values of Sox18_Sox12 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_-_86528739 Show fit	5.22	ENSMUST00000214141.2	Olfr1087 Ensembl NCBI MGI UniProt Show fit	olfactory receptor 1087
chr13_+_21938258 Show fit	4.42	ENSMUST00000091709.3	H2bc15 Ensembl NCBI MGI UniProt Show fit	H2B clustered histone 15
chr9_+_20193647 Show fit	3.91	ENSMUST00000071725.4 ENSMUST00000212983.3	Olfr39 Ensembl NCBI MGI UniProt Show fit	olfactory receptor 39
chr2_+_87404246 Show fit	3.76	ENSMUST00000213315.2 ENSMUST00000214773.2	Olfr1129 Ensembl NCBI MGI UniProt Show fit	olfactory receptor 1129
chr19_-_13126896 Show fit	3.12	ENSMUST00000213493.2	Olfr1459 Ensembl NCBI MGI UniProt Show fit	olfactory receptor 1459
chr13_+_23930717 Show fit	3.05	ENSMUST00000099703.5	H2bc3 Ensembl NCBI MGI UniProt Show fit	H2B clustered histone 3
chr9_-_39161290 Show fit	2.85	ENSMUST00000213472.2	Olfr1537 Ensembl NCBI MGI UniProt Show fit	olfactory receptor 1537
chr6_-_57340712 Show fit	2.81	ENSMUST00000228156.2 ENSMUST00000227186.2 ENSMUST00000228294.2 ENSMUST00000228342.2	Vmn1r17 Ensembl NCBI MGI UniProt Show fit	vomeronasal 1 receptor 17
chr5_+_146769700 Show fit	2.74	ENSMUST00000035983.12	Rpl21 Ensembl NCBI MGI UniProt Show fit	ribosomal protein L21
chr2_-_88947627 Show fit	2.62	ENSMUST00000217635.2 ENSMUST00000143255.3 ENSMUST00000213404.2	Olfr1221 Ensembl NCBI MGI UniProt Show fit	olfactory receptor 1221

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox18_Sox12

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	60.2	GO:0007608	sensory perception of smell(GO:0007608)
0.1	5.3	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0	4.8	GO:0019236	response to pheromone(GO:0019236)
0.0	3.4	GO:0007606	sensory perception of chemical stimulus(GO:0007606)
0.0	3.0	GO:0042773	ATP synthesis coupled electron transport(GO:0042773)
0.4	2.6	GO:1903054	negative regulation of extracellular matrix organization(GO:1903054)
0.4	2.4	GO:0071492	cellular response to UV-A(GO:0071492)
0.3	2.4	GO:0045919	positive regulation of cytolysis(GO:0045919)
0.7	2.2	GO:0008628	hormone-mediated apoptotic signaling pathway(GO:0008628)
0.0	2.2	GO:0030010	establishment of cell polarity(GO:0030010)

Showing 1 to 10 of 82 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.6	GO:0070469	respiratory chain(GO:0070469)
0.0	2.7	GO:0043204	perikaryon(GO:0043204)
0.2	2.6	GO:0031258	lamellipodium membrane(GO:0031258)
0.0	2.6	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.0	2.5	GO:0005903	brush border(GO:0005903)
0.1	2.0	GO:0017119	Golgi transport complex(GO:0017119)
0.1	2.0	GO:0034451	centriolar satellite(GO:0034451)
0.0	1.9	GO:0032420	stereocilium(GO:0032420)
0.6	1.8	GO:0044317	rod spherule(GO:0044317)
0.0	1.6	GO:0005814	centriole(GO:0005814)

Showing 1 to 10 of 37 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	38.0	GO:0004984	olfactory receptor activity(GO:0004984)
0.1	33.8	GO:0005549	odorant binding(GO:0005549)
0.2	5.8	GO:0050136	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0	2.8	GO:0005518	collagen binding(GO:0005518)
0.0	2.8	GO:0008238	exopeptidase activity(GO:0008238)
0.1	2.5	GO:0004993	G-protein coupled serotonin receptor activity(GO:0004993)
0.0	2.3	GO:0030971	receptor tyrosine kinase binding(GO:0030971)
0.7	2.2	GO:0038052	RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1	2.2	GO:0070016	armadillo repeat domain binding(GO:0070016)
0.2	1.7	GO:0001851	complement component C3b binding(GO:0001851)

Showing 1 to 10 of 46 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.7	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.1	2.6	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.1	2.2	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.0	1.7	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.0	1.0	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0	0.8	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.0	0.7	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	0.5	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network

Showing 1 to 8 of 8 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.8	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.0	2.7	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.2	2.4	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	2.0	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
0.0	1.2	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.0	1.2	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.4	1.1	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.1	1.1	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.0	1.1	REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1	0.8	REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Presynaptic nicotinic acetylcholine receptors

Showing 1 to 10 of 23 entries

Results for Sox18_Sox12

Z-value: 3.69

Motif logo

Transcription factors associated with Sox18_Sox12

Activity-expression correlation:

Activity profile of Sox18_Sox12 motif

Sorted Z-values of Sox18_Sox12 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox18_Sox12

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: