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avrg: GFI1 WT vs 36n/n vs KD
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Results for Ybx1_Nfya_Nfyb_Nfyc_Cebpz
Z-value: 6.87
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Transcription factors associated with Ybx1_Nfya_Nfyb_Nfyc_Cebpz
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSMUSG00000028639.15 | Y box protein 1 | |
| ENSMUSG00000023994.14 | nuclear transcription factor-Y alpha | |
| ENSMUSG00000020248.19 | nuclear transcription factor-Y beta | |
| ENSMUSG00000032897.18 | nuclear transcription factor-Y gamma | |
| ENSMUSG00000024081.10 | CCAAT/enhancer binding protein zeta |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Ybx1 | mm39_v1_chr4_-_119151717_119151801 | 0.96 | 7.9e-03 | Click! |
| Nfyb | mm39_v1_chr10_-_82599967_82599991 | 0.87 | 5.4e-02 | Click! |
| Cebpz | mm39_v1_chr17_-_79244460_79244504 | 0.54 | 3.5e-01 | Click! |
| Nfyc | mm39_v1_chr4_-_120672900_120672959 | 0.52 | 3.7e-01 | Click! |
| Nfya | mm39_v1_chr17_-_48716756_48716934 | -0.25 | 6.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Ybx1_Nfya_Nfyb_Nfyc_Cebpz
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.5 | GO:0016126 | sterol biosynthetic process(GO:0016126) |
| 0.3 | 9.4 | GO:0006743 | ubiquinone metabolic process(GO:0006743) |
| 0.3 | 8.0 | GO:1904874 | positive regulation of telomerase RNA localization to Cajal body(GO:1904874) |
| 0.8 | 7.2 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
| 1.4 | 6.8 | GO:0010877 | lipid transport involved in lipid storage(GO:0010877) |
| 0.4 | 6.7 | GO:0001731 | formation of translation preinitiation complex(GO:0001731) |
| 0.5 | 5.7 | GO:0090166 | Golgi disassembly(GO:0090166) |
| 0.3 | 5.5 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 0.0 | 5.4 | GO:0006457 | protein folding(GO:0006457) |
| 0.5 | 5.1 | GO:0016321 | female meiosis chromosome segregation(GO:0016321) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 54.6 | GO:0005739 | mitochondrion(GO:0005739) |
| 1.5 | 22.6 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.1 | 16.5 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 14.7 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.0 | 7.2 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.5 | 6.8 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.6 | 6.7 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.1 | 6.6 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.2 | 6.0 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.2 | 5.9 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.6 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.3 | 13.0 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.0 | 7.8 | GO:0042393 | histone binding(GO:0042393) |
| 0.3 | 7.7 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.5 | 7.4 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
| 1.2 | 7.2 | GO:0004656 | procollagen-proline 4-dioxygenase activity(GO:0004656) |
| 0.3 | 6.5 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.6 | 6.3 | GO:0004576 | oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.0 | 6.2 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 0.1 | 6.0 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.5 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.2 | 11.6 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.1 | 7.9 | PID P73PATHWAY | p73 transcription factor network |
| 0.2 | 7.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 6.9 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 6.2 | PID ATR PATHWAY | ATR signaling pathway |
| 0.2 | 5.1 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 4.7 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 4.5 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 4.2 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 24.9 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.2 | 15.8 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 10.1 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.3 | 8.6 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 0.8 | 8.4 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.1 | 8.1 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.4 | 7.9 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.3 | 7.8 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.5 | 6.4 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.1 | 6.1 | REACTOME G1 PHASE | Genes involved in G1 Phase |