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avrg: GFI1 WT vs 36n/n vs KD
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Results for Zfx_Zfp711
Z-value: 6.99
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Transcription factors associated with Zfx_Zfp711
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Zfx | mm39_v1_chrX_-_93166992_93167018 | 0.46 | 4.3e-01 | Click! |
| Zfp711 | mm39_v1_chrX_+_111510223_111510223 | -0.07 | 9.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_-_85414220 Show fit | 3.12 |
ENSMUST00000238449.2
ENSMUST00000238687.2 |
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing |
|
| chr5_-_115257336 Show fit | 3.08 |
ENSMUST00000031524.11
|
acyl-Coenzyme A dehydrogenase, short chain |
|
| chr7_+_142606476 Show fit | 3.04 |
ENSMUST00000037941.10
|
CD81 antigen |
|
| chr6_+_52691204 Show fit | 2.98 |
ENSMUST00000138040.8
ENSMUST00000129660.2 |
Tax1 (human T cell leukemia virus type I) binding protein 1 |
|
| chr8_-_123939480 Show fit | 2.68 |
ENSMUST00000000759.9
|
charged multivesicular body protein 1A |
|
| chr15_-_4008913 Show fit | 2.61 |
ENSMUST00000022791.9
|
F-box protein 4 |
|
| chr18_-_10030017 Show fit | 2.60 |
ENSMUST00000116669.2
ENSMUST00000092096.14 |
ubiquitin specific peptidase 14 |
|
| chr8_+_85696453 Show fit | 2.36 |
ENSMUST00000125893.8
|
peroxiredoxin 2 |
|
| chr9_+_72569628 Show fit | 2.30 |
ENSMUST00000034740.15
|
neural precursor cell expressed, developmentally down-regulated 4 |
|
| chr8_+_85696695 Show fit | 2.29 |
ENSMUST00000164807.2
|
peroxiredoxin 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Zfx_Zfp711
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 8.4 | GO:0002536 | respiratory burst involved in inflammatory response(GO:0002536) |
| 0.1 | 7.0 | GO:0006414 | translational elongation(GO:0006414) |
| 0.1 | 6.7 | GO:0010257 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.1 | 6.0 | GO:0030071 | regulation of mitotic metaphase/anaphase transition(GO:0030071) |
| 0.3 | 5.7 | GO:0000338 | protein deneddylation(GO:0000338) |
| 0.3 | 5.6 | GO:0001731 | formation of translation preinitiation complex(GO:0001731) |
| 0.1 | 5.6 | GO:0016126 | sterol biosynthetic process(GO:0016126) |
| 0.1 | 5.1 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.3 | 4.9 | GO:1904869 | protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) |
| 0.2 | 4.9 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 76.0 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.1 | 28.3 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 23.2 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 13.5 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.2 | 10.5 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 10.2 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.1 | 8.7 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 8.4 | GO:0000313 | organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761) |
| 0.2 | 8.2 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 7.9 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 22.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.8 | 12.3 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 0.1 | 11.7 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.0 | 10.4 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 8.5 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.1 | 7.8 | GO:0070035 | ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035) |
| 0.1 | 7.0 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.3 | 6.3 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.4 | 6.1 | GO:0046977 | TAP binding(GO:0046977) |
| 0.2 | 5.9 | GO:0003746 | translation elongation factor activity(GO:0003746) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.9 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.3 | 8.6 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.2 | 7.6 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 7.1 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.2 | 5.4 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.1 | 4.9 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 4.5 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.2 | 4.4 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.1 | 4.2 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.2 | 4.0 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 31.3 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.2 | 19.1 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.3 | 16.9 | REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 | Genes involved in SCF-beta-TrCP mediated degradation of Emi1 |
| 0.1 | 14.4 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 9.5 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.2 | 7.7 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.1 | 7.7 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.2 | 7.0 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.2 | 6.6 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.3 | 6.5 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |