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avrg: 12D miR HR13_24
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Results for Nr1i3
Z-value: 2.28
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Transcription factors associated with Nr1i3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nr1i3 | mm10_v2_chr1_+_171214013_171214045 | -0.75 | 7.3e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_-_128206346 Show fit | 4.19 |
ENSMUST00000033049.7
|
cytochrome c oxidase subunit VIa polypeptide 2 |
|
| chr6_-_5256226 Show fit | 3.99 |
ENSMUST00000125686.1
ENSMUST00000031773.2 |
paraoxonase 3 |
|
| chr6_+_90619241 Show fit | 3.46 |
ENSMUST00000032177.8
|
solute carrier family 41, member 3 |
|
| chr7_-_101864093 Show fit | 2.90 |
ENSMUST00000106981.1
|
folate receptor 1 (adult) |
|
| chr11_+_68556186 Show fit | 2.88 |
ENSMUST00000053211.6
|
major facilitator superfamily domain containing 6-like |
|
| chr16_+_5007306 Show fit | 2.75 |
ENSMUST00000178155.2
ENSMUST00000184256.1 ENSMUST00000185147.1 |
small integral membrane protein 22 |
|
| chr16_+_5007283 Show fit | 2.62 |
ENSMUST00000184439.1
|
small integral membrane protein 22 |
|
| chr4_-_19922599 Show fit | 2.40 |
ENSMUST00000029900.5
|
ATPase, H+ transporting, lysosomal V0 subunit D2 |
|
| chr15_-_66560997 Show fit | 2.28 |
ENSMUST00000048372.5
|
transmembrane protein 71 |
|
| chr11_+_69964758 Show fit | 2.08 |
ENSMUST00000108597.1
ENSMUST00000060651.5 ENSMUST00000108596.1 |
claudin 7 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nr1i3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.2 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.5 | 5.2 | GO:0060974 | cell migration involved in heart formation(GO:0060974) |
| 0.3 | 4.6 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.2 | 4.4 | GO:0032463 | negative regulation of protein homooligomerization(GO:0032463) |
| 1.3 | 4.0 | GO:0009804 | coumarin metabolic process(GO:0009804) phenylpropanoid catabolic process(GO:0046271) |
| 0.1 | 3.8 | GO:0007035 | vacuolar acidification(GO:0007035) |
| 0.3 | 3.7 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 1.1 | 3.2 | GO:0071846 | actin filament debranching(GO:0071846) |
| 0.5 | 2.9 | GO:0002835 | negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838) |
| 0.0 | 2.7 | GO:0007608 | sensory perception of smell(GO:0007608) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 27.8 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 4.8 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.0 | 3.9 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.2 | 3.7 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.3 | 3.5 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.1 | 2.9 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.2 | 2.4 | GO:0033179 | proton-transporting V-type ATPase, V0 domain(GO:0033179) |
| 0.0 | 2.4 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.2 | 2.2 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
| 0.0 | 2.2 | GO:0032420 | stereocilium(GO:0032420) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.4 | 4.4 | GO:0051870 | methotrexate binding(GO:0051870) |
| 0.1 | 4.1 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.7 | 4.0 | GO:0004064 | arylesterase activity(GO:0004064) |
| 0.1 | 4.0 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.1 | 3.3 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.3 | 3.2 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.2 | 3.1 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.0 | 3.0 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.2 | 2.9 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.5 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 3.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 3.3 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.1 | 3.2 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 3.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 3.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 3.0 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.1 | 2.4 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.1 | 2.3 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.0 | 2.1 | PID IL1 PATHWAY | IL1-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.6 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.2 | 6.4 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.2 | 4.1 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.1 | 3.7 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.1 | 3.6 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.1 | 3.3 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 2.6 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.1 | 2.5 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.1 | 2.0 | REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS | Genes involved in Nucleotide-like (purinergic) receptors |
| 0.1 | 2.0 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |