Project

GSE80451: E.coli grown aerobically and anaerobically

Navigation
Downloads

Results for H-NS

Z-value: 0.98

Transcription factors associated with H-NS

Gene Symbol Gene ID Gene Info
hns
hns DNA-binding transcriptional dual regulator H-NS

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hns-0.866.1e-02Click!

Activity profile of H-NS motif

Sorted Z-values of H-NS motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
rrsC-gltU-rrlC-rrfC 3.25
rrlC
gltU
rrfC
rrsC
rrlC 23S ribosomal RNA
tRNAgltU
rrfC 5S ribosomal RNA
rrsC 16S ribosomal RNA
rrsD-ileU-alaU-rrlD-rrfD-thrV-rrfF 3.24
rrlD
ileU
alaU
thrV
rrfF
rrsD
rrfD
rrlD 23S ribosomal RNA
tRNAileU
tRNAalaU
tRNAthrV
rrfF 5S ribosomal RNA
rrsD 16S ribosomal RNA
rrfD 5S ribosomal RNA
rrsG-gltW-rrlG-rrfG 3.21
rrlG
gltW
rrfG
rrsG
rrlG 23S ribosomal RNA
tRNAgltW
rrfG 5S ribosomal RNA
rrsG 16S ribosomal RNA
rrsB-gltT-rrlB-rrfB 3.21
rrlB
gltT
rrfB
rrsB
rrlB 23S ribosomal RNA
tRNAgltT
rrfB 5S ribosomal RNA
rrsB 16S ribosomal RNA
rrsH-ileV-alaV-rrlH-rrfH 3.12
rrlH
rrfH
rrsH
ileV
alaV
rrlH 23S ribosomal RNA
rrfH 5S ribosomal RNA
rrsH 16S ribosomal RNA
tRNAileV
tRNAalaV
fimB 1.79
fimB
regulator for fimA
hchA 1.62
hchA
amino acid deglycase Hsp31
cspA 1.50
cspA
CspA DNA-binding transcriptional activator
asr 0.91
asr
acid shock protein
cmoM-mukFEB 0.90
cmoM
mukB
mukF
mukE
tRNA cmo5U34 methyltransferase
cell division protein involved in chromosome partitioning
Ca2+-binding protein involved in chromosome partitioning
protein involved in chromosome partitioning
fimE 0.89
fimE
regulator for fimA
flhDC 0.85
flhC
flhD
FlhC transcriptional dual regulator
FlhD transcriptional dual regulator
relA-mazEF 0.75
mazE
relA
mazF
MazE antitoxin of the MazF-MazE toxin-antitoxin system
GDP pyrophosphokinase/GTP pyrophosphokinase
MazF toxin of the MazF-MazE toxin-antitoxin system that exhibits ribonuclease activity
bglGFB 0.61
bglB
bglG
bglF
6-phospho-β-glucosidase B; cryptic
BglG transcriptional antiterminator
BglF
csiD-lhgO-gabDTP 0.58
gabD
lhgO
gabP
csiD
gabT
succinate-semialdehyde dehydrogenase (NADP+)
L-2-hydroxyglutarate oxidase
4-aminobutyrate:H+ symporter
predicted protein
4-aminobutyrate aminotransferase
leuO 0.55
leuO
LeuO DNA-binding transcriptional dual regulator
hdfR 0.55
hdfR
HdfR DNA-binding transcriptional dual regulator
adiY 0.54
adiY
AdiY DNA-binding transcriptional activator
cysPUWAM 0.53
cysU
cysM
cysW
cysA
cysP
sulfate / thiosulfate ABC transporter - membrane subunit
cysteine synthase B
sulfate / thiosulfate ABC transporter - membrane subunit
sulfate / thiosulfate ABC transporter - ATP binding subunit
sulfate / thiosulfate ABC transporter - periplasmic binding protein CysP
appY 0.50
appY
AppY DNA-binding transcriptional activator
gadX 0.48
gadX
GadX DNA-binding transcriptional dual regulator
nrdDG 0.45
nrdD
nrdG
anaerobic ribonucleoside-triphosphate reductase
anaerobic ribonucleoside-triphosphate reductase-activating protein
proVWX 0.45
proX
proW
proV
glycine betaine / proline ABC transporter - periplasmic binding protein
glycine betaine / proline ABC transporter - membrane subunit
glycine betaine / proline ABC transporter - ATP binding subunit
gspAB 0.40
gspB
gspA
calcium-binding protein required for initiation of chromosome replication
general secretory pathway component, cryptic
bglG 0.39
bglG
BglG transcriptional antiterminator
evgAS 0.38
evgA
evgS
EvgA transcriptional activator
EvgS sensory histidine kinase
gadE-mdtEF 0.31
mdtF
mdtE
gadE
MdtEF-TolC multidrug efflux pump - permease subunit
MdtEF-TolC multidrug efflux pump - membrane fusion protein
GadE DNA-binding transcriptional activator
gadXW 0.30
gadW
gadX
GadW DNA-binding transcriptional dual regulator
GadX DNA-binding transcriptional dual regulator
adiA 0.23
adiA
arginine decarboxylase, degradative
yjjP 0.22
yjjP
predicted inner membrane structural protein
gadAX 0.20
gadX
gadA
GadX DNA-binding transcriptional dual regulator
glutamate decarboxylase A subunit
hisJQMP 0.14
hisM
hisP
hisQ
hisJ
lysine/arginine/ornithine ABC transporter / histidine ABC transporter - membrane subunit
lysine / arginine / ornithine ABC transporter / histidine ABC transporter - ATP binding subunit
lysine / arginine / ornithine ABC transporter / histidine ABC transporter - membrane subunit
histidine ABC transporter - periplasmic binding protein
hdeAB-yhiD 0.12
yhiD
hdeB
hdeA
inner membrane protein YhiD
HdeB monomer
HdeA monomer, chaperone active form
gspCDEFGHIJKLMO 0.11
gspC
gspF
gspG
gspD
gspE
gspJ
gspK
gspH
gspI
gspO
gspL
gspM
putative protein secretion protein for export
putative protein secretion protein for export
putative protein secretion protein for export
putative protein secretion protein for export
putative protein secretion protein for export
putative protein secretion protein for export
putative protein secretion protein for export
putative protein secretion protein for export
putative protein secretion protein for export
leader peptidase, integral membrane protein
putative protein secretion protein for export
putative protein secretion protein
galETK 0.11
galT
galE
galK
galactose-1-phosphate uridylyltransferase
UDP-glucose 4-epimerase
galactokinase
nirBDC-cysG 0.09
nirD
cysG
nirC
nirB
nitrite reductase, small subunit
siroheme synthase subunit
nitrite transporter NirC
nitrite reductase, large subunit
galETKM 0.09
galT
galE
galM
galK
galactose-1-phosphate uridylyltransferase
UDP-glucose 4-epimerase
galactose-1-epimerase
galactokinase
nhaAR 0.08
nhaA
nhaR
Na+:H+ antiporter NhaA
NhaR transcriptional activator
hlyE 0.06
hlyE
hemolysin E
cadBA 0.06
cadA
cadB
lysine decarboxylase 1
lysine:cadaverine antiporter
yjjQ-bglJ 0.04
bglJ
yjjQ
BglJ DNA-binding transcriptional regulator
YjjQ DNA-binding transcriptional repressor
lacZYA 0.03
lacA
lacY
lacZ
galactoside O-acetyltransferase
lactose / melibiose:H+ symporter LacY
β-galactosidase
ilvIH 0.01
ilvI
ilvH
acetolactate synthase / acetohydroxybutanoate synthase, catalytic subunit
acetolactate synthase / acetohydroxybutanoate synthase, regulatory subunit

Network of associatons between targets according to the STRING database.

First level regulatory network of H-NS

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.7 GO:0015074 DNA integration(GO:0015074)
0.5 1.6 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process to lactate(GO:0061727)
0.5 1.5 GO:0060567 negative regulation of protein complex disassembly(GO:0043242) negative regulation of DNA-templated transcription, termination(GO:0060567)
0.3 0.9 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.2 0.7 GO:0034035 guanosine tetraphosphate metabolic process(GO:0015969) purine ribonucleoside bisphosphate metabolic process(GO:0034035) ncRNA catabolic process(GO:0034661)
0.2 0.5 GO:0006535 cysteine biosynthetic process from serine(GO:0006535)
0.2 0.9 GO:0010043 response to zinc ion(GO:0010043)
0.1 0.6 GO:0006591 ornithine metabolic process(GO:0006591) arginine biosynthetic process via ornithine(GO:0042450)
0.1 0.2 GO:0006527 arginine catabolic process(GO:0006527)
0.1 0.5 GO:0019692 2'-deoxyribonucleotide biosynthetic process(GO:0009265) 2'-deoxyribonucleotide metabolic process(GO:0009394) deoxyribose phosphate metabolic process(GO:0019692) deoxyribose phosphate biosynthetic process(GO:0046385)
0.1 0.5 GO:0072337 modified amino acid transport(GO:0072337)
0.1 0.3 GO:0051453 regulation of pH(GO:0006885) cellular monovalent inorganic cation homeostasis(GO:0030004) regulation of cellular pH(GO:0030641) regulation of intracellular pH(GO:0051453) monovalent inorganic cation homeostasis(GO:0055067)
0.1 0.2 GO:1903401 L-lysine transmembrane transport(GO:1903401)
0.1 0.5 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.0 0.6 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 0.3 GO:0010447 response to acidic pH(GO:0010447)
0.0 0.1 GO:0015707 nitrite transport(GO:0015707)
0.0 0.1 GO:0009405 pathogenesis(GO:0009405)
0.0 0.3 GO:0006855 drug transmembrane transport(GO:0006855)
0.0 0.1 GO:0071806 protein transmembrane transport(GO:0071806)
0.0 0.7 GO:0051254 positive regulation of transcription, DNA-templated(GO:0045893) positive regulation of RNA metabolic process(GO:0051254) positive regulation of RNA biosynthetic process(GO:1902680) positive regulation of nucleic acid-templated transcription(GO:1903508)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0005694 chromosome(GO:0005694) chromosomal part(GO:0044427)
0.1 0.7 GO:0005618 cell wall(GO:0005618)
0.0 1.1 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190) ATPase dependent transmembrane transport complex(GO:0098533) ATPase complex(GO:1904949)
0.0 0.1 GO:0005576 extracellular region(GO:0005576)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.5 GO:0001070 RNA binding transcription factor activity(GO:0001070) transcription antitermination factor activity, RNA binding(GO:0001072)
0.3 0.9 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.2 0.7 GO:0008728 GTP diphosphokinase activity(GO:0008728) guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity(GO:0008893) diphosphoric monoester hydrolase activity(GO:0016794)
0.2 0.6 GO:0008706 6-phospho-beta-glucosidase activity(GO:0008706)
0.2 0.6 GO:0004777 succinate-semialdehyde dehydrogenase (NAD+) activity(GO:0004777)
0.2 0.5 GO:0005275 amine transmembrane transporter activity(GO:0005275) transmembrane receptor activity(GO:0099600)
0.2 1.1 GO:0001216 transcriptional activator activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding(GO:0001140) bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding(GO:0001216)
0.1 0.4 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1 0.5 GO:0080146 L-cysteine desulfhydrase activity(GO:0080146)
0.1 0.1 GO:0051087 chaperone binding(GO:0051087)
0.1 0.2 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
0.0 1.4 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 0.1 GO:0004325 ferrochelatase activity(GO:0004325) nitrite transmembrane transporter activity(GO:0015113)
0.0 0.3 GO:0015238 drug transmembrane transporter activity(GO:0015238)
0.0 0.4 GO:0000155 phosphorelay sensor kinase activity(GO:0000155) protein histidine kinase activity(GO:0004673)
0.0 1.1 GO:0001071 nucleic acid binding transcription factor activity(GO:0001071)
0.0 0.2 GO:0016831 carboxy-lyase activity(GO:0016831)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways