ISMARA results: MraZ

Project

GSE80451: E.coli grown aerobically and anaerobically

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Results for MraZ

Z-value: 0.36

Transcription factors associated with MraZ

Gene Symbol	Gene ID	Gene Info
mraZ RegulonDB EcoCyc	mraZ	MraZ DNA-binding transcriptional repressor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
mraZ		0.93	2.2e-02	Click!

Activity profile of MraZ motif

Sorted Z-values of MraZ motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
mraZ-rsmH-ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC Show fit	0.67		murC RegulonDB EcoCyc Show fit mraZ RegulonDB EcoCyc Show fit ftsA RegulonDB EcoCyc Show fit mraY RegulonDB EcoCyc Show fit rsmH RegulonDB EcoCyc Show fit ftsL RegulonDB EcoCyc Show fit murD RegulonDB EcoCyc Show fit murE RegulonDB EcoCyc Show fit ftsI RegulonDB EcoCyc Show fit murG RegulonDB EcoCyc Show fit ftsW RegulonDB EcoCyc Show fit murF RegulonDB EcoCyc Show fit ftsQ RegulonDB EcoCyc Show fit lpxC RegulonDB EcoCyc Show fit ddlB RegulonDB EcoCyc Show fit ftsZ RegulonDB EcoCyc Show fit	UDP-N-acetylmuramate-alanine ligase MraZ DNA-binding transcriptional repressor essential cell division protein FtsA phospho-N-acetylmuramoyl-pentapeptide transferase 16S rRNA m⁴C1402 methyltransferase essential cell division protein FtsL UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase essential cell division protein FtsI; penicillin-binding protein 3 N-acetylglucosaminyl transferase essential cell division protein FtsW; lipid II flippase D-alanyl-D-alanine-adding enzyme essential cell division protein FtsQ UDP-3-O-acyl-N-acetylglucosamine deacetylase D-alanine-D-alanine ligase B essential cell division protein FtsZ
mioC Show fit	0.57		mioC RegulonDB EcoCyc Show fit	flavoprotein involved in biotin synthesis

Network of associatons between targets according to the STRING database.

First level regulatory network of MraZ

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0015835	peptidoglycan transport(GO:0015835)
0.1	0.6	GO:0009102	biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.7	GO:0032153	cell division site(GO:0032153)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0008658	acetylglucosaminyltransferase activity(GO:0008375) penicillin binding(GO:0008658) UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity(GO:0008759) phospho-N-acetylmuramoyl-pentapeptide-transferase activity(GO:0008963) peptidoglycan transporter activity(GO:0015647)
0.0	0.6	GO:0010181	FMN binding(GO:0010181)