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GSE80451: E.coli grown aerobically and anaerobically

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Results for PurR

Z-value: 2.93

Transcription factors associated with PurR

Gene Symbol Gene ID Gene Info
purR
purR PurR transcriptional repressor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
purR0.922.5e-02Click!

Activity profile of PurR motif

Sorted Z-values of PurR motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
purEK 11.25
purK
purE
N5-carboxyaminoimidazole ribonucleotide synthetase
N5-carboxyaminoimidazole ribonucleotide mutase
glyA 7.61
glyA
serine hydroxymethyltransferase
pyrC 7.48
pyrC
dihydroorotase
purA 7.17
purA
adenylosuccinate synthetase
purC 7.08
purC
phosphoribosylaminoimidazole-succinocarboxamide synthase
purL 5.45
purL
phosphoribosylformylglycinamide synthetase
prs 5.38
prs
ribose-phosphate diphosphokinase
carAB 4.55
carB
carA
carbamoyl phosphate synthetase, β chain
carbamoyl phosphate synthetase, α chain
cvpA-purF-ubiX 4.45
cvpA
purF
ubiX
membrane protein required for colicin V production
amidophosphoribosyl transferase
3-octaprenyl-4-hydroxybenzoate carboxy-lyase partner protein
gcvTHP 3.19
gcvH
gcvP
gcvT
glycine cleavage system H protein
glycine decarboxylase
aminomethyltransferase
codBA 3.09
codB
codA
cytosine transporter
cytosine deaminase
hflD-purB 2.92
purB
hflD
adenylosuccinate lyase
lysogenization regulator
purMN 2.80
purN
purM
phosphoribosylglycinamide formyltransferase 1
phosphoribosylformylglycinamide cyclo-ligase
guaBA 2.65
guaB
guaA
IMP dehydrogenase
GMP synthetase
purHD 2.03
purH
purD
AICAR transformylase/IMP cyclohydrolase
phosphoribosylamine-glycine ligase
purR 1.59
purR
PurR transcriptional repressor

Network of associatons between targets according to the STRING database.

First level regulatory network of PurR

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 12.6 GO:0046040 IMP metabolic process(GO:0046040)
2.7 10.8 GO:0006544 glycine metabolic process(GO:0006544) glycine catabolic process(GO:0006546)
2.6 2.6 GO:1901070 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037) guanosine-containing compound biosynthetic process(GO:1901070)
2.0 9.9 GO:0019856 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
1.8 5.4 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
1.2 8.1 GO:0006164 purine nucleotide biosynthetic process(GO:0006164)
1.0 3.1 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208) pyrimidine nucleobase transport(GO:0015855)
0.5 7.1 GO:0033014 tetrapyrrole metabolic process(GO:0033013) tetrapyrrole biosynthetic process(GO:0033014)
0.1 2.9 GO:0009408 response to heat(GO:0009408)
0.0 2.8 GO:0006974 cellular response to DNA damage stimulus(GO:0006974)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 3.2 GO:1990204 oxidoreductase complex(GO:1990204)
0.1 54.5 GO:0005829 cytosol(GO:0005829)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 12.7 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
2.5 12.4 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
1.9 7.5 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
1.1 25.5 GO:0016879 ligase activity, forming carbon-nitrogen bonds(GO:0016879)
1.1 5.4 GO:0042301 phosphate ion binding(GO:0042301)
1.0 3.1 GO:0015205 pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205)
1.0 2.9 GO:0016842 amidine-lyase activity(GO:0016842)
0.5 3.2 GO:0031405 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638) lipoic acid binding(GO:0031405)
0.4 4.4 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.4 1.6 GO:0001141 transcriptional repressor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding(GO:0001141) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)