Motif ID: ADNP_IRX_SIX_ZHX.p2

Z-value: 1.583


Transcription factors associated with ADNP_IRX_SIX_ZHX.p2:

Gene SymbolEntrez IDGene Name
Adnp 11538 activity-dependent neuroprotective protein
Irx4 50916 Iroquois related homeobox 4 (Drosophila)
Irx5 54352 Iroquois related homeobox 5 (Drosophila)
Six2 20472 sine oculis-related homeobox 2 homolog (Drosophila)
Six5 20475 sine oculis-related homeobox 5 homolog (Drosophila)
Zhx1 22770 zinc fingers and homeoboxes 1
Zhx2 387609 zinc fingers and homeoboxes 2
Zhx3 320799 zinc fingers and homeoboxes 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zhx1chr15_-_57907735-0.199.1e-03Click!
Adnpchr2_-_168032561-0.138.2e-02Click!
Six2chr17_-_860875860.121.2e-01Click!
Six5chr7_+_19679892,
chr7_+_19680105
0.111.3e-01Click!
Irx4chr13_+_73397944-0.063.8e-01Click!
Zhx2chr15_+_575262120.054.8e-01Click!
Zhx3chr2_-_160698705-0.027.4e-01Click!
Irx5chr8_+_94881694,
chr8_+_94881868
-0.019.0e-01Click!


Activity profile for motif ADNP_IRX_SIX_ZHX.p2.

activity profile for motif ADNP_IRX_SIX_ZHX.p2


Sorted Z-values histogram for motif ADNP_IRX_SIX_ZHX.p2

Sorted Z-values for motif ADNP_IRX_SIX_ZHX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ADNP_IRX_SIX_ZHX.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_54839147 28.941 Znrf2
zinc and ring finger 2
chr4_+_116265582 23.105 Gpbp1l1
GC-rich promoter binding protein 1-like 1
chr6_-_51413182 21.811 Hnrnpa2b1
heterogeneous nuclear ribonucleoprotein A2/B1
chr1_+_89951985 21.365 NM_201641
Ugt1a10
UDP glycosyltransferase 1 family, polypeptide A10
chr10_-_117252126 20.140


chr1_-_30920095 18.730 NM_001081080
Phf3
PHD finger protein 3
chr1_+_6720087 17.973 NM_173868
St18
suppression of tumorigenicity 18
chr1_+_6720153 17.825 St18
suppression of tumorigenicity 18
chr7_-_80686630 17.675 NM_001081345
Chd2
chromodomain helicase DNA binding protein 2
chr4_+_98697606 17.510 NM_013913
Angptl3
angiopoietin-like 3
chr5_-_66000506 17.095 B230308N11Rik
RIKEN cDNA B230308N11 gene
chr6_-_68967061 17.070


chr7_+_138712015 14.664 Bub3
budding uninhibited by benzimidazoles 3 homolog (S. cerevisiae)
chr6_+_134874663 13.835 Cdkn1b
cyclin-dependent kinase inhibitor 1B
chr4_+_132753616 13.440


chrX_-_159402493 12.252 NM_009789
S100g
S100 calcium binding protein G
chr1_+_45402907 12.143 Col3a1
collagen, type III, alpha 1
chr13_-_29045399 12.068 NM_009238
Sox4
SRY-box containing gene 4
chr5_-_87997908 11.920 Sult1d1
sulfotransferase family 1D, member 1
chr1_-_167865030 11.908 NM_198933
NM_198934
Pou2f1

POU domain, class 2, transcription factor 1


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 63 entries
Enrichment   P-value GO Accession GO Term
3.71 3.75e-02 GO:0006959 humoral immune response
2.48 8.52e-03 GO:0048545 response to steroid hormone stimulus
2.36 1.32e-02 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
2.30 1.59e-02 GO:0008202 steroid metabolic process
2.10 7.82e-03 GO:0001501 skeletal system development
1.92 2.72e-02 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.82 1.17e-05 GO:0045893 positive regulation of transcription, DNA-dependent
1.82 9.21e-04 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.79 2.57e-05 GO:0051254 positive regulation of RNA metabolic process
1.77 3.77e-02 GO:0043066 negative regulation of apoptosis
1.75 1.09e-05 GO:0010557 positive regulation of macromolecule biosynthetic process
1.73 2.73e-02 GO:0051094 positive regulation of developmental process
1.70 2.46e-04 GO:0010628 positive regulation of gene expression
1.69 4.65e-05 GO:0031328 positive regulation of cellular biosynthetic process
1.68 2.49e-04 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.68 1.28e-03 GO:0048584 positive regulation of response to stimulus
1.67 7.46e-05 GO:0009891 positive regulation of biosynthetic process
1.67 2.57e-04 GO:0051173 positive regulation of nitrogen compound metabolic process
1.64 2.25e-04 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.63 4.23e-03 GO:0009790 embryo development

Gene overrepresentation in compartment category:

Showing 1 to 15 of 15 entries
Enrichment   P-value GO Accession GO Term
2.12 1.58e-04 GO:0005792 microsome
2.07 3.44e-04 GO:0042598 vesicular fraction
1.87 1.98e-02 GO:0005667 transcription factor complex
1.63 1.56e-03 GO:0005615 extracellular space
1.53 2.02e-03 GO:0044421 extracellular region part
1.47 9.95e-06 GO:0005576 extracellular region
1.35 3.61e-02 GO:0005829 cytosol
1.32 4.18e-02 GO:0044428 nuclear part
1.25 7.37e-06 GO:0005634 nucleus
1.15 6.06e-04 GO:0043227 membrane-bounded organelle
1.14 1.23e-03 GO:0043231 intracellular membrane-bounded organelle
1.12 3.54e-04 GO:0044424 intracellular part
1.12 2.36e-03 GO:0043226 organelle
1.12 6.26e-03 GO:0043229 intracellular organelle
1.11 3.51e-04 GO:0005622 intracellular

Gene overrepresentation in function category:

Showing 1 to 16 of 16 entries
Enrichment   P-value GO Accession GO Term
4.10 4.95e-03 GO:0043498 cell surface binding
2.57 6.66e-03 GO:0004497 monooxygenase activity
2.27 4.30e-02 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
2.15 1.18e-02 GO:0000975 regulatory region DNA binding
2.15 1.18e-02 GO:0001067 regulatory region nucleic acid binding
2.15 1.18e-02 GO:0044212 transcription regulatory region DNA binding
2.05 3.48e-09 GO:0043565 sequence-specific DNA binding
2.03 1.24e-03 GO:0016564 transcription repressor activity
1.99 1.17e-09 GO:0001071 nucleic acid binding transcription factor activity
1.99 1.17e-09 GO:0003700 sequence-specific DNA binding transcription factor activity
1.85 2.47e-02 GO:0016563 transcription activator activity
1.77 5.31e-07 GO:0030528 transcription regulator activity
1.55 1.00e-07 GO:0003677 DNA binding
1.43 2.45e-07 GO:0003676 nucleic acid binding
1.22 2.86e-05 GO:0005515 protein binding
1.14 8.00e-07 GO:0005488 binding