Motif ID: ATF5_CREB3.p2

Z-value: 1.770


Transcription factors associated with ATF5_CREB3.p2:

Gene SymbolEntrez IDGene Name
Atf5 107503 activating transcription factor 5
Creb3 12913 cAMP responsive element binding protein 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf5chr7_-_52068757,
chr7_-_52068446		-0.191.1e-02Click!
Creb3chr4_+_43575487-0.073.5e-01Click!


Activity profile for motif ATF5_CREB3.p2.

activity profile for motif ATF5_CREB3.p2


Sorted Z-values histogram for motif ATF5_CREB3.p2

Sorted Z-values for motif ATF5_CREB3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF5_CREB3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_83936038 72.380 Sult4a1
sulfotransferase family 4A, member 1
chr2_+_136539202 47.976 Snap25
synaptosomal-associated protein 25
chr1_-_79436564 47.839 NM_009129
 Scg2
secretogranin II
chr2_+_132607398 41.586 Chgb
chromogranin B
chr2_+_132607408 41.174 Chgb
chromogranin B
chr2_+_136539143 40.206 NM_011428
 Snap25
synaptosomal-associated protein 25
chr2_+_132607432 39.936 Chgb
chromogranin B
chr8_-_73011217 36.145 NM_182991
 Tmem59l
transmembrane protein 59-like
chr15_+_101097276 31.286 NM_010444
 Nr4a1
nuclear receptor subfamily 4, group A, member 1
chr12_+_110779204 30.996 Meg3
maternally expressed 3
chr3_-_117063317 30.865 D3Bwg0562e
DNA segment, Chr 3, Brigham & Women's Genetics 0562 expressed
chr8_+_73278577 29.630 NM_001166399
NM_009001
 Rab3a

RAB3A, member RAS oncogene family

chr3_-_117063090 27.855 D3Bwg0562e
DNA segment, Chr 3, Brigham & Women's Genetics 0562 expressed
chr13_+_58909254 27.182 Ntrk2
neurotrophic tyrosine kinase, receptor, type 2
chr2_+_177876710 27.129 Phactr3
phosphatase and actin regulator 3
chr2_+_177876635 26.159 NM_028806
 Phactr3
phosphatase and actin regulator 3
chr1_+_63319842 25.763 NM_028673
 Zdbf2
zinc finger, DBF-type containing 2
chr13_+_13876570 25.341 Gng4
guanine nucleotide binding protein (G protein), gamma 4
chr18_+_35020859 25.303 NM_007913
 Egr1
early growth response 1
chr13_+_58909168 24.035 NM_001025074
 Ntrk2
neurotrophic tyrosine kinase, receptor, type 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 112 entries
Enrichment   P-value GO Accession GO Term
15.10 4.56e-02 GO:0008090 retrograde axon cargo transport
5.66 2.98e-02 GO:0010970 microtubule-based transport
5.66 2.98e-02 GO:0030705 cytoskeleton-dependent intracellular transport
4.87 4.57e-02 GO:0006888 ER to Golgi vesicle-mediated transport
4.32 2.76e-02 GO:0048489 synaptic vesicle transport
3.54 2.69e-05 GO:0048193 Golgi vesicle transport
2.75 3.16e-02 GO:0006184 GTP catabolic process
2.55 3.02e-04 GO:0009203 ribonucleoside triphosphate catabolic process
2.53 2.63e-04 GO:0009261 ribonucleotide catabolic process
2.51 7.07e-04 GO:0007409 axonogenesis
2.49 7.94e-04 GO:0009207 purine ribonucleoside triphosphate catabolic process
2.47 6.85e-04 GO:0009143 nucleoside triphosphate catabolic process
2.46 1.12e-03 GO:0009146 purine nucleoside triphosphate catabolic process
2.44 1.40e-03 GO:0009154 purine ribonucleotide catabolic process
2.33 1.60e-04 GO:0009259 ribonucleotide metabolic process
2.31 1.49e-04 GO:0070647 protein modification by small protein conjugation or removal
2.31 1.04e-03 GO:0009199 ribonucleoside triphosphate metabolic process
2.31 2.62e-03 GO:0072523 purine-containing compound catabolic process
2.31 2.90e-03 GO:0048812 neuron projection morphogenesis
2.31 3.81e-03 GO:0006195 purine nucleotide catabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 61 entries
Enrichment   P-value GO Accession GO Term
6.71 3.60e-03 GO:0030658 transport vesicle membrane
5.73 4.85e-04 GO:0030120 vesicle coat
5.23 1.10e-02 GO:0030660 Golgi-associated vesicle membrane
3.88 1.88e-04 GO:0030662 coated vesicle membrane
3.37 1.87e-08 GO:0030135 coated vesicle
3.20 6.77e-04 GO:0008021 synaptic vesicle
3.00 3.47e-05 GO:0030136 clathrin-coated vesicle
2.88 4.53e-02 GO:0044306 neuron projection terminus
2.86 6.71e-04 GO:0033267 axon part
2.61 1.09e-03 GO:0044433 cytoplasmic vesicle part
2.60 1.81e-03 GO:0030659 cytoplasmic vesicle membrane
2.56 3.31e-06 GO:0030424 axon
2.55 1.19e-02 GO:0019717 synaptosome
2.53 1.38e-03 GO:0012506 vesicle membrane
2.48 2.80e-02 GO:0005681 spliceosomal complex
2.40 9.54e-07 GO:0044456 synapse part
2.31 4.30e-02 GO:0000139 Golgi membrane
2.29 3.22e-04 GO:0005874 microtubule
2.28 1.41e-04 GO:0030425 dendrite
2.26 3.97e-03 GO:0005815 microtubule organizing center

Gene overrepresentation in function category:

Showing 1 to 19 of 19 entries
Enrichment   P-value GO Accession GO Term
4.72 1.58e-02 GO:0019888 protein phosphatase regulator activity
3.02 2.12e-02 GO:0031072 heat shock protein binding
2.09 2.93e-02 GO:0016791 phosphatase activity
1.92 2.16e-02 GO:0005525 GTP binding
1.74 6.41e-04 GO:0003723 RNA binding
1.73 2.39e-03 GO:0016462 pyrophosphatase activity
1.72 2.83e-03 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.72 3.00e-03 GO:0016817 hydrolase activity, acting on acid anhydrides
1.66 2.02e-02 GO:0017111 nucleoside-triphosphatase activity
1.53 6.79e-08 GO:0000166 nucleotide binding
1.51 1.37e-05 GO:0035639 purine ribonucleoside triphosphate binding
1.50 2.62e-05 GO:0017076 purine nucleotide binding
1.49 3.27e-05 GO:0032555 purine ribonucleotide binding
1.49 3.40e-05 GO:0032553 ribonucleotide binding
1.42 1.94e-02 GO:0005524 ATP binding
1.40 2.39e-02 GO:0030554 adenyl nucleotide binding
1.40 2.90e-02 GO:0032559 adenyl ribonucleotide binding
1.38 2.67e-14 GO:0005515 protein binding
1.21 3.56e-14 GO:0005488 binding