Motif ID: ATF6.p2

Z-value: 1.638


Transcription factors associated with ATF6.p2:

Gene SymbolEntrez IDGene Name
Atf6 226641 activating transcription factor 6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf6chr1_-_1727978660.055.3e-01Click!


Activity profile for motif ATF6.p2.

activity profile for motif ATF6.p2


Sorted Z-values histogram for motif ATF6.p2

Sorted Z-values for motif ATF6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF6.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_128519295 22.655 Kcnk1
potassium channel, subfamily K, member 1
chr6_+_4455686 21.974 NM_007743
 Col1a2
collagen, type I, alpha 2
chr1_-_71699671 21.890 NM_010233
 Fn1
fibronectin 1
chr7_-_52347489 19.419 NM_026555
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr7_-_52347012 19.206 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr12_+_110779204 19.002 Meg3
maternally expressed 3
chr5_+_144165615 18.313 Kdelr2
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
chr15_+_79346819 17.731 NM_134090
 Kdelr3
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
chr4_-_11313886 17.029 NM_194055
 Esrp1
epithelial splicing regulatory protein 1
chr8_+_128519001 16.113 NM_008430
 Kcnk1
potassium channel, subfamily K, member 1
chr7_-_52722144 15.645 NM_007527
 Bax
BCL2-associated X protein
chr5_+_144165482 15.598 NM_025841
 Kdelr2
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
chr6_-_101327849 15.437 NM_018884
 Pdzrn3
PDZ domain containing RING finger 3
chr5_+_65361309 15.204 NM_026667
 Fam114a1
family with sequence similarity 114, member A1
chr6_-_118429262 14.512 Zfp9
zinc finger protein 9
chr6_-_118429289 14.163 NM_011763
 Zfp9
zinc finger protein 9
chr8_-_67171481 14.159 Cpe
carboxypeptidase E
chr14_+_55050437 13.789 NM_008608
 Mmp14
matrix metallopeptidase 14 (membrane-inserted)
chr11_+_3414983 13.668 Selm
selenoprotein M
chr11_+_3414884 13.621 Selm
selenoprotein M

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 120 entries
Enrichment   P-value GO Accession GO Term
15.89 7.24e-05 GO:0048200 Golgi transport vesicle coating
15.89 7.24e-05 GO:0048205 COPI coating of Golgi vesicle
15.13 1.25e-05 GO:0048199 vesicle targeting, to, from or within Golgi
14.44 1.91e-04 GO:0048194 Golgi vesicle budding
12.02 2.28e-05 GO:0006901 vesicle coating
11.35 1.14e-02 GO:0006891 intra-Golgi vesicle-mediated transport
10.21 1.40e-04 GO:0006900 membrane budding
10.09 8.74e-04 GO:0006903 vesicle targeting
9.35 8.94e-03 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER
7.26 1.64e-02 GO:0051650 establishment of vesicle localization
6.59 1.08e-02 GO:0006888 ER to Golgi vesicle-mediated transport
6.40 1.32e-03 GO:0051648 vesicle localization
6.13 6.63e-03 GO:0034976 response to endoplasmic reticulum stress
5.93 8.63e-12 GO:0048193 Golgi vesicle transport
5.27 1.51e-03 GO:0045666 positive regulation of neuron differentiation
4.16 2.51e-02 GO:0001841 neural tube formation
3.68 3.53e-03 GO:0021915 neural tube development
2.98 2.28e-14 GO:0016192 vesicle-mediated transport
2.93 2.20e-02 GO:0060537 muscle tissue development
2.90 1.74e-09 GO:0034613 cellular protein localization

Gene overrepresentation in compartment category:

Showing 1 to 20 of 46 entries
Enrichment   P-value GO Accession GO Term
15.13 1.78e-02 GO:0000421 autophagic vacuole membrane
11.35 1.80e-03 GO:0030663 COPI coated vesicle membrane
10.59 5.04e-04 GO:0030137 COPI-coated vesicle
10.32 2.06e-02 GO:0030126 COPI vesicle coat
7.04 9.20e-04 GO:0030120 vesicle coat
6.11 3.37e-02 GO:0030660 Golgi-associated vesicle membrane
5.67 7.80e-04 GO:0005798 Golgi-associated vesicle
4.39 4.75e-03 GO:0030117 membrane coat
4.39 4.75e-03 GO:0048475 coated membrane
4.22 3.37e-03 GO:0030662 coated vesicle membrane
3.33 1.37e-04 GO:0000139 Golgi membrane
3.28 9.93e-05 GO:0030135 coated vesicle
3.06 1.65e-07 GO:0044431 Golgi apparatus part
2.89 6.62e-03 GO:0030659 cytoplasmic vesicle membrane
2.80 1.05e-02 GO:0044433 cytoplasmic vesicle part
2.76 8.67e-03 GO:0012506 vesicle membrane
2.51 3.93e-04 GO:0048471 perinuclear region of cytoplasm
2.44 1.48e-15 GO:0005783 endoplasmic reticulum
2.08 4.52e-08 GO:0005794 Golgi apparatus
2.04 1.81e-03 GO:0016023 cytoplasmic membrane-bounded vesicle

Gene overrepresentation in function category:

Showing 1 to 20 of 24 entries
Enrichment   P-value GO Accession GO Term
22.70 4.07e-02 GO:0046923 ER retention sequence binding
12.61 8.51e-03 GO:0019789 SUMO ligase activity
5.24 1.84e-02 GO:0005097 Rab GTPase activator activity
3.66 6.07e-03 GO:0008135 translation factor activity, nucleic acid binding
3.51 3.54e-02 GO:0005099 Ras GTPase activator activity
2.86 1.77e-02 GO:0003924 GTPase activity
2.65 9.65e-03 GO:0019787 small conjugating protein ligase activity
2.53 3.05e-03 GO:0019901 protein kinase binding
2.44 2.45e-02 GO:0016881 acid-amino acid ligase activity
2.30 1.04e-05 GO:0019904 protein domain specific binding
2.27 5.01e-03 GO:0005525 GTP binding
2.24 3.50e-03 GO:0032403 protein complex binding
2.19 3.13e-02 GO:0019900 kinase binding
2.17 1.32e-02 GO:0019001 guanyl nucleotide binding
2.17 1.32e-02 GO:0032561 guanyl ribonucleotide binding
1.97 2.15e-04 GO:0046983 protein dimerization activity
1.91 4.35e-02 GO:0042803 protein homodimerization activity
1.90 1.03e-04 GO:0019899 enzyme binding
1.87 6.20e-04 GO:0042802 identical protein binding
1.76 2.08e-03 GO:0030528 transcription regulator activity