Motif ID: AUUGCAC

Z-value: 0.841


Mature miRNA associated with seed AUUGCAC:

NamemiRBase Accession
mmu-miR-25 MIMAT0000652
mmu-miR-32 MIMAT0000654
mmu-miR-363-3p MIMAT0000708
mmu-miR-367 MIMAT0003181
mmu-miR-92a MIMAT0000539
mmu-miR-92b MIMAT0004899



Activity profile for motif AUUGCAC.

activity profile for motif AUUGCAC


Sorted Z-values histogram for motif AUUGCAC

Sorted Z-values for motif AUUGCAC



Network of associatons between targets according to the STRING database.



First level regulatory network of AUUGCAC

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_55545337 12.954 NM_010637
Klf4
Kruppel-like factor 4 (gut)
chr18_-_64820573 10.471 NM_001001488
Atp8b1
ATPase, class I, type 8B, member 1
chr5_-_66489416 10.093 NM_139065
Rbm47
RNA binding motif protein 47
chr8_+_74842931 9.322 NM_008452
Klf2
Kruppel-like factor 2 (lung)
chr7_+_35904310 9.189 NM_007678
Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
chr16_-_45844409 8.794 NM_153412
Phldb2
pleckstrin homology-like domain, family B, member 2
chr5_-_66543123 8.684 NM_001127382
Rbm47
RNA binding motif protein 47
chr5_-_66542161 8.252 NM_178446
Rbm47
RNA binding motif protein 47
chr16_+_24721940 8.247 NM_001145954
Lpp
LIM domain containing preferred translocation partner in lipoma
chr16_+_24393435 7.833 NM_178665
Lpp
LIM domain containing preferred translocation partner in lipoma
chr6_+_88674398 7.540 NM_001166249
NM_011844
Mgll

monoglyceride lipase

chr7_-_150646883 7.315 NM_001161624
NM_009876
Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr16_+_37777075 7.087 NM_008047
Fstl1
follistatin-like 1
chr17_+_64950988 6.962 NM_008549
Man2a1
mannosidase 2, alpha 1
chr5_+_120120671 6.890 NM_011535
NM_198052
Tbx3

T-box 3

chr17_+_83614611 6.493 NM_134117
Pkdcc
protein kinase domain containing, cytoplasmic
chr1_-_135975681 6.460 NM_007570
Btg2
B-cell translocation gene 2, anti-proliferative
chr6_+_34659440 6.276 NM_145575
Cald1
caldesmon 1
chr9_+_65478364 6.274 NM_028030
Rbpms2
RNA binding protein with multiple splicing 2
chr7_+_36119255 6.242 NM_027897
Rhpn2
rhophilin, Rho GTPase binding protein 2
chr15_+_102820969 5.807 NM_010466
Hoxc8
homeobox C8
chr6_-_137597616 5.559 NM_007945
Eps8
epidermal growth factor receptor pathway substrate 8
chr9_+_35018704 5.515 NM_026130
Srpr
signal recognition particle receptor ('docking protein')
chr3_+_121656136 5.483 NM_172525
Arhgap29
Rho GTPase activating protein 29
chr17_-_31992708 5.465 NM_010831
Sik1
salt inducible kinase 1
chr17_-_71202829 5.413 NM_001164074
Tgif1
TGFB-induced factor homeobox 1
chr10_+_21714471 5.303 NM_011361
Sgk1
serum/glucocorticoid regulated kinase 1
chr17_-_71200462 5.267 NM_009372
Tgif1
TGFB-induced factor homeobox 1
chr9_+_95538038 5.241 NM_029620
Pcolce2
procollagen C-endopeptidase enhancer 2
chr17_-_43013320 5.106 NM_009847
Cd2ap
CD2-associated protein
chr4_+_97444312 5.042 NM_001122953
NM_010905
Nfia

nuclear factor I/A

chr17_-_71201055 4.967 NM_001164075
Tgif1
TGFB-induced factor homeobox 1
chr16_+_24448176 4.953 NM_001145952
Lpp
LIM domain containing preferred translocation partner in lipoma
chr17_-_71196116 4.947 NM_001164077
Tgif1
TGFB-induced factor homeobox 1
chr4_+_97248556 4.872 NM_001122952
Nfia
D130039L10Rik
nuclear factor I/A
RIKEN cDNA D130039L10 gene
chr6_+_108778633 4.853 NM_138677
Edem1
ER degradation enhancer, mannosidase alpha-like 1
chr10_+_21601968 4.748 NM_001161845
Sgk1
serum/glucocorticoid regulated kinase 1
chr18_+_11052464 4.731 NM_010258
Gata6
GATA binding protein 6
chr18_+_58038278 4.723 NM_009194
Slc12a2
solute carrier family 12, member 2
chr10_+_21712008 4.655 NM_001161849
Sgk1
serum/glucocorticoid regulated kinase 1
chr2_+_79475581 4.643 NM_080558
Ssfa2
sperm specific antigen 2
chr7_+_119822831 4.591 NM_001166584
NM_009346
Tead1

TEA domain family member 1

chr17_-_71199129 4.589 NM_001164076
Tgif1
TGFB-induced factor homeobox 1
chr8_+_28196312 4.575 NM_054044
Gpr124
G protein-coupled receptor 124
chr10_+_21705909 4.549 NM_001161848
Sgk1
serum/glucocorticoid regulated kinase 1
chr9_-_63869857 4.469 NM_008542
Smad6
MAD homolog 6 (Drosophila)
chr3_-_27609279 4.432 NM_173182
Fndc3b
fibronectin type III domain containing 3B
chr10_+_21713669 4.408 NM_001161850
Sgk1
serum/glucocorticoid regulated kinase 1
chr18_+_56591785 4.378 NM_026240
Gramd3
GRAM domain containing 3
chr2_-_173102033 4.338 NM_022995
Pmepa1
prostate transmembrane protein, androgen induced 1
chr10_+_21698470 4.334 NM_001161847
Sgk1
serum/glucocorticoid regulated kinase 1
chr13_+_81022644 4.280 NM_001042591
Arrdc3
arrestin domain containing 3
chr12_+_25257147 4.245 NM_001161406
Grhl1
grainyhead-like 1 (Drosophila)
chr2_-_12223518 4.236 NM_001001309
Itga8
integrin alpha 8
chr4_-_104782444 3.924 NM_178143
Prkaa2
protein kinase, AMP-activated, alpha 2 catalytic subunit
chr7_+_117771170 3.918 NM_009627
Adm
adrenomedullin
chr3_+_95462640 3.900 NM_008562
Mcl1
myeloid cell leukemia sequence 1
chr12_+_35731853 3.893 NM_001014973
Snx13
sorting nexin 13
chr19_-_47538898 3.871 NM_001164717
NM_008018
Sh3pxd2a

SH3 and PX domains 2A

chr11_-_103273956 3.845 NM_183034
Plekhm1
pleckstrin homology domain containing, family M (with RUN domain) member 1
chr1_+_9788206 3.782 NM_133220
NM_177547
Sgk3

serum/glucocorticoid regulated kinase 3

chr3_-_79371600 3.760 NM_001162999
Fnip2
folliculin interacting protein 2
chr4_-_119094957 3.712 NM_026494
Ppcs
phosphopantothenoylcysteine synthetase
chr12_+_25265583 3.636 NM_145890
Grhl1
grainyhead-like 1 (Drosophila)
chr12_+_113052385 3.603 NM_026752
Zfyve21
zinc finger, FYVE domain containing 21
chr2_+_35477498 3.543 NM_001114124
Dab2ip
disabled homolog 2 (Drosophila) interacting protein
chr2_+_103810274 3.525 NM_001142335
NM_008505
Lmo2

LIM domain only 2

chr14_-_122138082 3.452 NM_001128307
NM_001128308
Dock9

dedicator of cytokinesis 9

chr3_-_131047840 3.430 NM_028943
Sgms2
sphingomyelin synthase 2
chr11_+_49607656 3.417 NM_013529
Gfpt2
glutamine fructose-6-phosphate transaminase 2
chr3_+_41367672 3.414 NM_001130185
Phf17
PHD finger protein 17
chr2_-_26359261 3.316 NM_008714
Notch1
Notch gene homolog 1 (Drosophila)
chr3_+_41367304 3.302 NM_172303
Phf17
PHD finger protein 17
chr13_+_44826121 3.263 NM_021878
Jarid2
jumonji, AT rich interactive domain 2
chr9_-_41932371 3.158 NM_011436
Sorl1
sortilin-related receptor, LDLR class A repeats-containing
chr7_+_119902897 3.128 NM_001166585
Tead1
TEA domain family member 1
chr1_-_51972816 3.125 NM_001161817
NM_010863
Myo1b

myosin IB

chr15_+_78939343 3.070 NM_177461
Micall1
microtubule associated monoxygenase, calponin and LIM domain containing -like 1
chr2_+_35547418 3.051 NM_001001602
Dab2ip
disabled homolog 2 (Drosophila) interacting protein
chr15_+_102236709 3.051 NM_013672
Sp1
trans-acting transcription factor 1
chr15_-_103197178 3.015 NM_010577
Itga5
integrin alpha 5 (fibronectin receptor alpha)
chrX_+_103222548 2.958 NM_001109757
NM_009726
Atp7a

ATPase, Cu++ transporting, alpha polypeptide

chr16_+_56477956 2.896 NM_001014399
NM_001014422
NM_001014423
NM_001014424
NM_178790
Abi3bp




ABI gene family, member 3 (NESH) binding protein




chr7_-_26601526 2.882 NM_028775
Cyp2s1
cytochrome P450, family 2, subfamily s, polypeptide 1
chr7_+_52825672 2.870 NM_009737
Bcat2
branched chain aminotransferase 2, mitochondrial
chrX_-_9046362 2.844 NM_007807
Cybb
cytochrome b-245, beta polypeptide
chr2_+_33071451 2.828 NM_011923
Angptl2
angiopoietin-like 2
chr13_-_54789548 2.789 NM_001146027
Rnf44
ring finger protein 44
chr14_-_122097583 2.755 NM_001081039
Dock9
dedicator of cytokinesis 9
chr12_+_3806955 2.741 NM_007872
Dnmt3a
DNA methyltransferase 3A
chr4_-_82151180 2.724 NM_001113209
NM_001113210
NM_008687
Nfib


nuclear factor I/B


chr2_+_74529947 2.681 NM_013554
Hoxd10
homeobox D10
chr4_+_155186568 2.670 NM_207678
Ccnl2
cyclin L2
chr14_-_58364879 2.668 NM_015771
Lats2
large tumor suppressor 2
chr13_-_54789148 2.666 NM_001146025
NM_001146026
NM_134064
Rnf44


ring finger protein 44


chr6_-_98978185 2.652 NM_001197322
Foxp1
forkhead box P1
chr2_+_127951773 2.627 NM_009754
NM_207680
NM_207681
Bcl2l11


BCL2-like 11 (apoptosis facilitator)


chr10_-_120913138 2.598 NM_138956
Rassf3
Ras association (RalGDS/AF-6) domain family member 3
chr5_-_108304062 2.592 NM_007964
Evi5
ecotropic viral integration site 5
chr2_+_103809709 2.591 NM_001142336
Lmo2
LIM domain only 2
chr11_-_21270779 2.589 NM_139297
Ugp2
UDP-glucose pyrophosphorylase 2
chr2_+_35413977 2.580 NM_001114125
Dab2ip
disabled homolog 2 (Drosophila) interacting protein
chr18_-_21810868 2.560 NM_001081403
Klhl14
kelch-like 14 (Drosophila)
chr7_-_75893927 2.556 NM_001042592
NM_025549
Arrdc4

arrestin domain containing 4

chr11_+_53164267 2.535 NM_033565
Aff4
AF4/FMR2 family, member 4
chr1_+_9838330 2.534 NM_001037759
Sgk3
serum/glucocorticoid regulated kinase 3
chr13_-_104124527 2.505 NM_175171
Mast4
microtubule associated serine/threonine kinase family member 4
chr13_-_115248924 2.480 NM_008046
Fst
follistatin
chr6_-_99216494 2.437 NM_001197321
Foxp1
forkhead box P1
chr2_-_84555162 2.406 NM_144887
Zdhhc5
zinc finger, DHHC domain containing 5
chr9_-_26613989 2.377 NM_153803
Glb1l2
galactosidase, beta 1-like 2
chr2_-_143836838 2.372 NM_024281
NM_133626
Rrbp1

ribosome binding protein 1

chr11_+_72420705 2.361 NM_025985
Ube2g1
ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans)
chr17_-_24787217 2.348 NM_023055
Slc9a3r2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr3_+_116215963 2.344 NM_010022
Dbt
dihydrolipoamide branched chain transacylase E2
chr10_-_117283020 2.338 NM_024457
Rap1b
RAS related protein 1b
chr2_+_172171015 2.336 NM_025912
2010011I20Rik
RIKEN cDNA 2010011I20 gene
chrX_+_70728939 2.328 NM_007542
Bgn
biglycan
chrX_+_20265590 2.326 NM_011049
Cdk16
cyclin-dependent kinase 16
chr2_+_103798150 2.318 NM_001142337
Lmo2
LIM domain only 2
chr6_+_15135505 2.286 NM_212435
Foxp2
forkhead box P2
chr13_-_43576328 2.246 NM_019930
Ranbp9
RAN binding protein 9
chr11_+_94072732 2.233 NM_009427
Tob1
transducer of ErbB-2.1
chr11_-_75236085 2.228 NM_011340
Serpinf1
serine (or cysteine) peptidase inhibitor, clade F, member 1
chr5_+_30890386 2.221 NM_010608
Kcnk3
potassium channel, subfamily K, member 3
chr3_+_41368801 2.192 NM_001130186
Phf17
PHD finger protein 17
chr5_+_111308801 2.188 NM_024477
Ttc28
tetratricopeptide repeat domain 28
chr3_+_41359653 2.186 NM_001130184
Phf17
PHD finger protein 17
chr15_+_25552273 2.168 NM_019472
Myo10
myosin X
chr4_+_124479785 2.163 NM_008636
Mtf1
metal response element binding transcription factor 1
chr12_-_45311020 2.140 NM_013760
Dnajb9
DnaJ (Hsp40) homolog, subfamily B, member 9
chr4_-_154596628 2.139 NM_011385
Ski
ski sarcoma viral oncogene homolog (avian)
chr13_+_45485106 2.136 NM_153789
NM_181043
Mylip

myosin regulatory light chain interacting protein

chr6_+_14851348 2.113 NM_053242
Foxp2
forkhead box P2
chr6_-_99385338 2.101 NM_053202
Foxp1
forkhead box P1
chr13_+_94827750 2.043 NM_172589
Lhfpl2
lipoma HMGIC fusion partner-like 2
chr5_+_43624701 2.040 NM_001177379
NM_175937
Cpeb2

cytoplasmic polyadenylation element binding protein 2

chr12_+_34642516 2.040 NM_011658
Twist1
twist homolog 1 (Drosophila)
chr15_+_37162790 2.038 NM_026496
Grhl2
grainyhead-like 2 (Drosophila)
chr4_-_46614726 2.035 NM_001164804
Coro2a
coronin, actin binding protein 2A
chr2_-_44968728 2.020 NM_015753
Zeb2
zinc finger E-box binding homeobox 2
chr19_+_16207300 2.008 NM_008139
Gnaq
guanine nucleotide binding protein, alpha q polypeptide
chr14_-_35315715 2.001 NM_009758
Bmpr1a
bone morphogenetic protein receptor, type 1A
chr13_-_99585403 1.931 NM_172591
Fcho2
FCH domain only 2
chr9_-_108166059 1.929 NM_010017
Dag1
dystroglycan 1
chr14_+_31292750 1.925 NM_133761
Dcp1a
DCP1 decapping enzyme homolog A (S. cerevisiae)
chr10_-_59414516 1.884 NM_029083
Ddit4
DNA-damage-inducible transcript 4
chr4_+_62876389 1.881 NM_025685
Col27a1
collagen, type XXVII, alpha 1
chr10_+_69707965 1.822 NM_025807
Slc16a9
solute carrier family 16 (monocarboxylic acid transporters), member 9
chr17_+_88840048 1.822 NM_180974
Foxn2
forkhead box N2
chr5_+_32438843 1.820 NM_008037
Fosl2
fos-like antigen 2
chr19_+_38911056 1.815 NM_145952
Tbc1d12
TBC1D12: TBC1 domain family, member 12
chr7_+_138009310 1.790 NM_133942
Plekha1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr12_+_3426883 1.778 NM_172421
Asxl2
additional sex combs like 2 (Drosophila)
chr5_-_121038602 1.777 NM_145853
Tpcn1
two pore channel 1
chrX_-_72376117 1.777 NM_008621
Mpp1
membrane protein, palmitoylated
chr2_+_83564553 1.772 NM_008402
Itgav
integrin alpha V
chr6_-_39675456 1.765 NM_139294
Braf
Braf transforming gene
chr14_-_122196929 1.672 NM_134074
Dock9
dedicator of cytokinesis 9
chr3_+_108087046 1.667 NM_019972
Sort1
sortilin 1
chr18_+_69505374 1.662 NM_001083967
Tcf4
transcription factor 4
chr2_+_62502329 1.658 NM_145523
Gca
grancalcin
chr5_+_28397902 1.613 NM_153526
Insig1
insulin induced gene 1
chr4_+_85699818 1.611 NM_029967
Adamtsl1
ADAMTS-like 1
chr5_+_140267449 1.576 NM_010757
Mafk
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)
chr10_+_114822009 1.550 NM_001033261
Zfc3h1
zinc finger, C3H1-type containing
chr5_+_136470670 1.539 NM_023742
Dtx2
deltex 2 homolog (Drosophila)
chr14_+_45970767 1.535 NM_019637
Styx
serine/threonine/tyrosine interaction protein
chr12_+_72932064 1.526 NM_026102
NM_172464
Daam1

dishevelled associated activator of morphogenesis 1

chr1_+_7079000 1.485 NM_183028
Pcmtd1
protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1
chr7_-_4453210 1.484 NM_029834
Ppp1r12c
protein phosphatase 1, regulatory (inhibitor) subunit 12C
chr18_-_58369579 1.483 NM_010181
Fbn2
fibrillin 2
chr13_+_42147389 1.481 NM_007772
Hivep1
human immunodeficiency virus type I enhancer binding protein 1
chr8_+_36650839 1.480 NM_001081279
Mfhas1
malignant fibrous histiocytoma amplified sequence 1
chr9_+_96159123 1.474 NM_001184709
Tfdp2
transcription factor Dp 2
chr14_+_12386043 1.444 NM_008981
Ptprg
protein tyrosine phosphatase, receptor type, G
chr11_+_45869473 1.440 NM_009616
Adam19
a disintegrin and metallopeptidase domain 19 (meltrin beta)
chr4_-_76240202 1.438 NM_011211
Ptprd
protein tyrosine phosphatase, receptor type, D
chr15_-_38448923 1.435 NM_001102458
NM_018745
Azin1

antizyme inhibitor 1

chr5_+_139230946 1.432 NM_030565
Fam20c
family with sequence similarity 20, member C
chr5_-_151992724 1.418 NM_001163493
NM_146258
Stard13

StAR-related lipid transfer (START) domain containing 13

chr7_-_20147745 1.416 NM_199149
Lrrc68
leucine rich repeat containing 68
chr4_+_136025675 1.416 NM_024452
Luzp1
leucine zipper protein 1
chr1_+_95700522 1.415 NM_025454
Ing5
inhibitor of growth family, member 5
chr8_+_59799779 1.396 NM_010402
Hand2
heart and neural crest derivatives expressed transcript 2
chr4_-_75779379 1.389 NM_001014288
Ptprd
protein tyrosine phosphatase, receptor type, D
chr4_+_129138915 1.355 NM_133889
Bsdc1
BSD domain containing 1
chr4_-_136913576 1.349 NM_009861
Cdc42
cell division cycle 42 homolog (S. cerevisiae)
chr14_+_121434765 1.330 NM_134082
Farp1
FERM, RhoGEF (Arhgef) and pleckstrin domain protein 1 (chondrocyte-derived)
chr1_+_133867185 1.317 NM_145977
Slc45a3
solute carrier family 45, member 3
chr4_-_44181148 1.316 NM_001038993
Rnf38
ring finger protein 38
chr9_+_74800828 1.291 NM_001113283
BC031353
cDNA sequence BC031353
chr15_-_98748371 1.277 NM_029098
Lmbr1l
limb region 1 like
chr18_+_69504145 1.276 NM_013685
Tcf4
transcription factor 4
chr3_-_81949667 1.268 NM_021896
Gucy1a3
guanylate cyclase 1, soluble, alpha 3
chr4_-_135577545 1.258 NM_013736
Tceb3
transcription elongation factor B (SIII), polypeptide 3
chr4_-_133574655 1.251 NM_145833
Lin28a
lin-28 homolog A (C. elegans)
chr18_-_12394830 1.240 NM_008720
Npc1
Niemann Pick type C1
chr14_+_117324518 1.237 NM_001079844
NM_011821
Gpc6

glypican 6

chr9_+_74823917 1.224 NM_153584
BC031353
cDNA sequence BC031353

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.30 1.05e-18 GO:0031323 regulation of cellular metabolic process
2.16 1.00e-17 GO:0019222 regulation of metabolic process
2.26 1.76e-17 GO:0080090 regulation of primary metabolic process
2.21 2.36e-15 GO:0060255 regulation of macromolecule metabolic process
2.47 6.56e-15 GO:2000112 regulation of cellular macromolecule biosynthetic process
2.43 1.14e-14 GO:0010556 regulation of macromolecule biosynthetic process
2.51 2.29e-14 GO:0048519 negative regulation of biological process
2.38 3.27e-14 GO:0010468 regulation of gene expression
2.34 4.54e-14 GO:0009889 regulation of biosynthetic process
2.34 5.70e-14 GO:0031326 regulation of cellular biosynthetic process
2.57 7.52e-14 GO:0048523 negative regulation of cellular process
2.34 1.09e-13 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
3.58 1.64e-13 GO:0006357 regulation of transcription from RNA polymerase II promoter
2.31 2.22e-13 GO:0051171 regulation of nitrogen compound metabolic process
2.47 2.41e-13 GO:0006355 regulation of transcription, DNA-dependent
2.76 2.47e-13 GO:0006351 transcription, DNA-dependent
2.76 2.73e-13 GO:0032774 RNA biosynthetic process
2.42 8.27e-13 GO:0051252 regulation of RNA metabolic process
2.11 5.17e-11 GO:0044249 cellular biosynthetic process
2.26 6.55e-11 GO:0048522 positive regulation of cellular process
1.65 8.68e-11 GO:0044237 cellular metabolic process
2.06 1.32e-10 GO:0009058 biosynthetic process
3.65 1.37e-10 GO:0045893 positive regulation of transcription, DNA-dependent
3.50 1.60e-10 GO:0010628 positive regulation of gene expression
2.27 1.60e-10 GO:0034645 cellular macromolecule biosynthetic process
3.59 2.31e-10 GO:0051254 positive regulation of RNA metabolic process
2.25 2.56e-10 GO:0009059 macromolecule biosynthetic process
3.35 4.11e-10 GO:0010557 positive regulation of macromolecule biosynthetic process
3.09 4.64e-10 GO:0009892 negative regulation of metabolic process
1.79 5.03e-10 GO:0044260 cellular macromolecule metabolic process
2.13 5.81e-10 GO:0048518 positive regulation of biological process
1.52 9.18e-10 GO:0050794 regulation of cellular process
3.33 9.71e-10 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.79 1.14e-09 GO:0031325 positive regulation of cellular metabolic process
3.18 1.44e-09 GO:0031328 positive regulation of cellular biosynthetic process
2.71 1.48e-09 GO:0009893 positive regulation of metabolic process
2.80 1.76e-09 GO:0010604 positive regulation of macromolecule metabolic process
3.24 2.33e-09 GO:0051173 positive regulation of nitrogen compound metabolic process
1.49 2.58e-09 GO:0050789 regulation of biological process
3.12 2.93e-09 GO:0009891 positive regulation of biosynthetic process
1.59 3.05e-09 GO:0044238 primary metabolic process
3.10 3.70e-09 GO:0031324 negative regulation of cellular metabolic process
3.61 5.45e-09 GO:0010629 negative regulation of gene expression
1.46 6.94e-09 GO:0065007 biological regulation
5.04 7.88e-09 GO:0035295 tube development
3.02 1.55e-08 GO:0010605 negative regulation of macromolecule metabolic process
2.17 1.66e-08 GO:0016070 RNA metabolic process
3.70 1.96e-08 GO:0045892 negative regulation of transcription, DNA-dependent
3.50 2.72e-08 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
3.64 3.03e-08 GO:0051253 negative regulation of RNA metabolic process
3.40 3.21e-08 GO:0010558 negative regulation of macromolecule biosynthetic process
3.45 3.90e-08 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
3.44 4.26e-08 GO:0051172 negative regulation of nitrogen compound metabolic process
3.30 4.53e-08 GO:0009890 negative regulation of biosynthetic process
1.66 5.05e-08 GO:0043170 macromolecule metabolic process
3.72 6.28e-08 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
3.29 8.55e-08 GO:0031327 negative regulation of cellular biosynthetic process
1.90 1.49e-07 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.82 2.62e-07 GO:0006807 nitrogen compound metabolic process
3.10 2.96e-07 GO:0009790 embryo development
1.93 3.10e-07 GO:0007275 multicellular organismal development
2.52 3.64e-07 GO:0009653 anatomical structure morphogenesis
4.09 4.22e-07 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.28 4.51e-07 GO:0009987 cellular process
1.47 5.51e-07 GO:0008152 metabolic process
1.81 6.46e-07 GO:0034641 cellular nitrogen compound metabolic process
2.27 7.15e-07 GO:0048513 organ development
2.62 8.03e-07 GO:0009966 regulation of signal transduction
1.95 1.19e-06 GO:0090304 nucleic acid metabolic process
1.98 1.46e-06 GO:0010467 gene expression
7.61 1.59e-06 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
3.33 2.17e-06 GO:0009887 organ morphogenesis
1.84 2.17e-06 GO:0032502 developmental process
1.92 4.80e-06 GO:0048856 anatomical structure development
1.98 5.32e-06 GO:0048731 system development
3.35 3.50e-05 GO:0048646 anatomical structure formation involved in morphogenesis
3.79 6.78e-05 GO:0007389 pattern specification process
3.79 6.78e-05 GO:0048729 tissue morphogenesis
3.72 9.60e-05 GO:0009968 negative regulation of signal transduction
2.15 9.78e-05 GO:0048583 regulation of response to stimulus
3.55 1.22e-04 GO:0010648 negative regulation of cell communication
2.46 1.90e-04 GO:0050793 regulation of developmental process
3.44 2.18e-04 GO:0048598 embryonic morphogenesis
2.17 3.07e-04 GO:0023051 regulation of signaling
5.16 3.16e-04 GO:0060562 epithelial tube morphogenesis
4.52 3.35e-04 GO:0035239 tube morphogenesis
3.41 4.61e-04 GO:0023057 negative regulation of signaling
3.13 6.91e-04 GO:0048585 negative regulation of response to stimulus
3.36 1.06e-03 GO:0032583 regulation of gene-specific transcription
3.62 1.08e-03 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
8.69 1.10e-03 GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
5.44 1.10e-03 GO:0060541 respiratory system development
8.55 1.27e-03 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
2.01 1.39e-03 GO:0006464 protein modification process
2.43 1.57e-03 GO:0042127 regulation of cell proliferation
5.70 1.78e-03 GO:0030324 lung development
5.61 2.11e-03 GO:0030323 respiratory tube development
2.44 2.12e-03 GO:0009888 tissue development
3.95 2.27e-03 GO:0003002 regionalization
1.95 2.64e-03 GO:0043412 macromolecule modification
2.31 2.68e-03 GO:0051641 cellular localization
2.52 3.32e-03 GO:0045595 regulation of cell differentiation
3.81 3.61e-03 GO:0031329 regulation of cellular catabolic process
5.88 3.64e-03 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
3.10 3.99e-03 GO:0007417 central nervous system development
2.91 4.24e-03 GO:0072358 cardiovascular system development
2.91 4.24e-03 GO:0072359 circulatory system development
2.16 4.87e-03 GO:0007399 nervous system development
12.38 9.32e-03 GO:0030514 negative regulation of BMP signaling pathway
3.39 9.55e-03 GO:0009894 regulation of catabolic process
3.22 1.09e-02 GO:0008285 negative regulation of cell proliferation
9.31 1.17e-02 GO:0030510 regulation of BMP signaling pathway
2.59 1.32e-02 GO:0042325 regulation of phosphorylation
9.11 1.36e-02 GO:0030509 BMP signaling pathway
3.27 1.58e-02 GO:0007420 brain development
2.08 1.66e-02 GO:0033036 macromolecule localization
2.14 1.95e-02 GO:0010646 regulation of cell communication
3.34 2.09e-02 GO:0045596 negative regulation of cell differentiation
1.79 2.14e-02 GO:0030154 cell differentiation
3.48 2.20e-02 GO:0002009 morphogenesis of an epithelium
2.50 2.53e-02 GO:0019220 regulation of phosphate metabolic process
2.50 2.53e-02 GO:0051174 regulation of phosphorus metabolic process
8.22 2.74e-02 GO:0001889 liver development
5.25 2.81e-02 GO:0033673 negative regulation of kinase activity
8.06 3.12e-02 GO:0061008 hepaticobiliary system development
2.18 3.19e-02 GO:0032268 regulation of cellular protein metabolic process
2.15 3.20e-02 GO:0006796 phosphate metabolic process
2.14 3.34e-02 GO:0006793 phosphorus metabolic process
3.93 3.92e-02 GO:0032582 negative regulation of gene-specific transcription
9.71 4.08e-02 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
1.69 4.78e-02 GO:0044267 cellular protein metabolic process
2.23 4.80e-02 GO:0051649 establishment of localization in cell
2.90 4.85e-02 GO:0060429 epithelium development
1.73 4.92e-02 GO:0048869 cellular developmental process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.42 2.79e-13 GO:0044424 intracellular part
1.40 3.72e-13 GO:0005622 intracellular
1.71 1.11e-09 GO:0005634 nucleus
1.40 1.56e-08 GO:0043229 intracellular organelle
1.40 2.12e-08 GO:0043226 organelle
1.43 4.36e-08 GO:0043231 intracellular membrane-bounded organelle
1.43 5.30e-08 GO:0043227 membrane-bounded organelle
2.60 2.61e-06 GO:0005654 nucleoplasm
4.12 9.29e-06 GO:0005667 transcription factor complex
2.94 1.02e-05 GO:0044451 nucleoplasm part
2.21 1.41e-05 GO:0031981 nuclear lumen
1.17 2.72e-05 GO:0005623 cell
1.17 2.72e-05 GO:0044464 cell part
1.36 3.62e-05 GO:0005737 cytoplasm
2.03 8.69e-05 GO:0070013 intracellular organelle lumen
2.02 9.22e-05 GO:0043233 organelle lumen
1.98 1.74e-04 GO:0031974 membrane-enclosed lumen
1.66 1.42e-03 GO:0043234 protein complex
1.84 2.43e-03 GO:0044428 nuclear part
1.45 1.18e-02 GO:0044446 intracellular organelle part
1.42 2.47e-02 GO:0044422 organelle part
1.47 4.70e-02 GO:0032991 macromolecular complex

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.47 1.33e-17 GO:0005488 binding
1.77 1.17e-13 GO:0005515 protein binding
3.84 4.90e-13 GO:0001071 nucleic acid binding transcription factor activity
3.84 4.90e-13 GO:0003700 sequence-specific DNA binding transcription factor activity
3.34 2.57e-11 GO:0030528 transcription regulator activity
2.44 6.55e-10 GO:0003677 DNA binding
3.50 9.48e-09 GO:0043565 sequence-specific DNA binding
4.54 8.80e-08 GO:0016563 transcription activator activity
1.94 6.91e-07 GO:0003676 nucleic acid binding
10.16 5.30e-05 GO:0046332 SMAD binding
4.86 5.49e-05 GO:0010843 promoter binding
3.88 7.05e-05 GO:0008134 transcription factor binding
4.56 1.31e-04 GO:0000975 regulatory region DNA binding
4.56 1.31e-04 GO:0001067 regulatory region nucleic acid binding
4.56 1.31e-04 GO:0044212 transcription regulatory region DNA binding
4.42 4.36e-04 GO:0003682 chromatin binding
5.10 1.13e-03 GO:0003690 double-stranded DNA binding
3.66 1.20e-03 GO:0046982 protein heterodimerization activity
3.44 1.48e-03 GO:0016564 transcription repressor activity
4.21 1.71e-03 GO:0043566 structure-specific DNA binding
2.32 4.56e-03 GO:0016301 kinase activity
1.93 8.31e-03 GO:0008270 zinc ion binding
19.95 8.61e-03 GO:0048185 activin binding
5.55 8.99e-03 GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
2.34 1.06e-02 GO:0046983 protein dimerization activity
3.54 1.21e-02 GO:0000989 transcription factor binding transcription factor activity
2.12 1.36e-02 GO:0016772 transferase activity, transferring phosphorus-containing groups
3.49 1.38e-02 GO:0000988 protein binding transcription factor activity
1.80 1.50e-02 GO:0046914 transition metal ion binding
5.91 1.56e-02 GO:0003705 sequence-specific enhancer binding RNA polymerase II transcription factor activity
3.34 2.24e-02 GO:0019901 protein kinase binding
2.28 3.03e-02 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.64 3.71e-02 GO:0000166 nucleotide binding
25.65 3.90e-02 GO:0015924 mannosyl-oligosaccharide mannosidase activity
25.65 3.90e-02 GO:0034713 type I transforming growth factor beta receptor binding
2.68 4.06e-02 GO:0004674 protein serine/threonine kinase activity
3.30 4.50e-02 GO:0003712 transcription cofactor activity