Motif ID: CEBPA,B_DDIT3.p2

Z-value: 1.384


Transcription factors associated with CEBPA,B_DDIT3.p2:

Gene SymbolEntrez IDGene Name
Cebpa 12606 CCAAT/enhancer binding protein (C/EBP), alpha
Cebpb 12608 CCAAT/enhancer binding protein (C/EBP), beta
Ddit3 13198 DNA-damage inducible transcript 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Cebpbchr2_+_1675144600.591.8e-18Click!
Cebpachr7_+_359043100.531.2e-14Click!
Ddit3chr10_+_1267278460.018.9e-01Click!


Activity profile for motif CEBPA,B_DDIT3.p2.

activity profile for motif CEBPA,B_DDIT3.p2


Sorted Z-values histogram for motif CEBPA,B_DDIT3.p2

Sorted Z-values for motif CEBPA,B_DDIT3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of CEBPA,B_DDIT3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_+_51710846 32.236 Rnase4
ribonuclease, RNase A family 4
chr18_-_36886375 31.312 Cd14
CD14 antigen
chr7_-_133768983 26.307 NM_019738
Nupr1
nuclear protein 1
chr7_+_138087002 24.580 Htra1
HtrA serine peptidase 1
chr4_+_63005581 24.302 NM_008768
Orm1
orosomucoid 1
chr2_+_145686480 23.427 Rin2
Ras and Rab interactor 2
chr18_-_36886051 23.367 Cd14
CD14 antigen
chr18_-_36886307 20.860 NM_009841
Cd14
CD14 antigen
chr2_+_145685882 20.830 Rin2
Ras and Rab interactor 2
chr3_+_66023808 18.647 NM_008987
Ptx3
pentraxin related gene
chr3_+_66023884 18.633 Ptx3
pentraxin related gene
chr13_+_49639799 18.020 NM_001172481
NM_025711
Aspn

asporin

chr2_+_145686377 17.721 Rin2
Ras and Rab interactor 2
chr3_+_19857053 17.562 NM_001042611
NM_007752
Cp

ceruloplasmin

chr1_-_71642303 16.627 Fn1
fibronectin 1
chr9_-_48413097 14.708 Nnmt
nicotinamide N-methyltransferase
chr7_-_128217980 14.240 NM_030691
Igsf6
immunoglobulin superfamily, member 6
chr1_+_82313187 13.975 Rhbdd1
rhomboid domain containing 1
chr10_+_59763520 13.959 Psap
prosaposin
chr1_+_82313139 13.225 NM_029777
Rhbdd1
rhomboid domain containing 1
chr9_-_48413181 12.600 NM_010924
Nnmt
nicotinamide N-methyltransferase
chr7_+_31561419 11.197 NM_028618
Dmkn
dermokine
chr13_+_49639847 11.161 Aspn
asporin
chr2_-_129196855 10.211 NM_008361
Il1b
interleukin 1 beta
chr1_+_59543450 9.822


chr17_+_57498108 9.650 NM_010130
Emr1
EGF-like module containing, mucin-like, hormone receptor-like sequence 1
chr11_-_99354449 9.473 Krt23
keratin 23
chr11_-_99354417 9.191 NM_033373
Krt23
keratin 23
chr2_-_152169650 8.942 NM_175093
Trib3
tribbles homolog 3 (Drosophila)
chr2_+_119176963 8.073 NM_026929
Chac1
ChaC, cation transport regulator-like 1 (E. coli)
chr16_-_23029138 8.013 Kng2
kininogen 2
chr7_-_116688776 7.895 St5
suppression of tumorigenicity 5
chr2_+_119177025 7.456 Chac1
ChaC, cation transport regulator-like 1 (E. coli)
chr16_+_22892112 7.350 NM_013465
Ahsg
alpha-2-HS-glycoprotein
chr11_-_55209320 7.263 Sparc
secreted acidic cysteine rich glycoprotein
chr16_+_22892156 7.202 Ahsg
alpha-2-HS-glycoprotein
chr11_-_120504978 6.750 NM_144795
Pycr1
pyrroline-5-carboxylate reductase 1
chr16_+_22892125 6.746 Ahsg
alpha-2-HS-glycoprotein
chr11_-_75236012 6.663 Serpinf1
serine (or cysteine) peptidase inhibitor, clade F, member 1
chr11_-_83462722 6.496 NM_011337
Ccl3
chemokine (C-C motif) ligand 3
chr2_+_14151018 6.493 NM_008625
Mrc1
mannose receptor, C type 1
chr16_-_38433223 6.482 NM_134102
Pla1a
phospholipase A1 member A
chr8_-_108660711 6.350 Esrp2
epithelial splicing regulatory protein 2
chr1_-_39634096 6.016 NM_001033135
Rnf149
ring finger protein 149
chr11_+_16808929 5.929 Egfr
epidermal growth factor receptor
chr19_-_36194284 5.901 NM_013468
Ankrd1
ankyrin repeat domain 1 (cardiac muscle)
chr3_+_93123668 5.867 NM_133698
Hrnr
hornerin
chr14_+_44680318 5.809 NM_007895
NM_001012766
NM_017388
BC151093
Ear2
Ear12
Ear3
cDNA sequence BC151093
eosinophil-associated, ribonuclease A family, member 2
eosinophil-associated, ribonuclease A family, member 12
eosinophil-associated, ribonuclease A family, member 3
chr14_+_102237708 5.767 Lmo7
LIM domain only 7
chr13_-_74832039 5.709 Cast
calpastatin
chr12_+_81979727 5.633 4933426M11Rik
RIKEN cDNA 4933426M11 gene
chr6_+_115372083 5.607 NM_011146
Pparg
peroxisome proliferator activated receptor gamma
chr14_-_44397257 5.358 NM_007894
Ear1
eosinophil-associated, ribonuclease A family, member 1
chr3_-_129035406 5.308 NM_007934
Enpep
glutamyl aminopeptidase
chr7_+_26682681 4.964 NM_009999
Cyp2b10
cytochrome P450, family 2, subfamily b, polypeptide 10
chr16_-_23029075 4.943 Kng2
kininogen 2
chr13_-_37142112 4.769 NM_001166391
F13a1
coagulation factor XIII, A1 subunit
chr3_+_19857375 4.713 Cp
ceruloplasmin
chr18_-_64676160 4.677 NM_001142950
NM_027350
Nars

asparaginyl-tRNA synthetase

chr18_-_64676144 4.593 Nars
asparaginyl-tRNA synthetase
chr8_-_108660736 4.588 NM_176838
Esrp2
epithelial splicing regulatory protein 2
chr5_-_5265981 4.493 Cdk14
cyclin-dependent kinase 14
chr7_+_26682646 4.456 Cyp2b10
cytochrome P450, family 2, subfamily b, polypeptide 10
chr11_+_3931731 4.414 NM_146013
Sec14l4
SEC14-like 4 (S. cerevisiae)
chr1_+_74421706 4.317 NM_013612
Slc11a1
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
chr10_-_36855292 4.248 Marcks
myristoylated alanine rich protein kinase C substrate
chr19_-_3929736 4.225 Aldh3b1
aldehyde dehydrogenase 3 family, member B1
chr15_-_58046380 3.938 Fbxo32
F-box protein 32
chr11_-_75236085 3.920 NM_011340
Serpinf1
serine (or cysteine) peptidase inhibitor, clade F, member 1
chr11_-_99250663 3.909 NM_010660
Krt10
keratin 10
chrX_-_73088288 3.894 NM_001166454
Pls3
plastin 3 (T-isoform)
chr19_-_3929715 3.817 NM_026316
Aldh3b1
aldehyde dehydrogenase 3 family, member B1
chr9_-_100386803 3.787 NM_001033543
Il20rb
interleukin 20 receptor beta
chr9_+_92502076 3.605


chr11_-_75236018 3.551 Serpinf1
serine (or cysteine) peptidase inhibitor, clade F, member 1
chr7_+_35905996 3.460 Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
chr14_-_37862119 3.350 NM_021340
Rgr
retinal G protein coupled receptor
chr18_-_43952520 3.278 NM_001033280
Gm94
predicted gene 94
chr7_-_140179678 3.019 Ctbp2
C-terminal binding protein 2
chr17_+_75784448 2.968 Ltbp1
latent transforming growth factor beta binding protein 1
chr1_-_137335507 2.926 Nav1
neuron navigator 1
chr18_-_64676090 2.849 Nars
asparaginyl-tRNA synthetase
chr6_-_131197295 2.736 NM_001170851
NM_008462
Klra2

killer cell lectin-like receptor, subfamily A, member 2

chr12_-_103056971 2.715 Fbln5
fibulin 5
chr2_+_24200925 2.651 Il1rn
interleukin 1 receptor antagonist
chr6_-_87759747 2.631 NM_133717
Rab43
RAB43, member RAS oncogene family
chr3_+_146260100 2.624 NM_009474
Uox
urate oxidase
chr9_-_7932402 2.608 Yap1
yes-associated protein 1
chr1_-_133173495 2.603 Ikbke
inhibitor of kappaB kinase epsilon
chr8_+_48907496 2.575 NM_001111318
Cldn24
claudin 22-like
chr7_+_27542160 2.557 NM_007814
Cyp2b19
cytochrome P450, family 2, subfamily b, polypeptide 19
chr19_+_8893890 2.553 NM_001081196
Hnrnpul2
heterogeneous nuclear ribonucleoprotein U-like 2
chr13_-_53076251 2.550 NM_017373
Nfil3
nuclear factor, interleukin 3, regulated
chr16_-_23029154 2.372 NM_001102409
NM_001102410
NM_201375
Kng2


kininogen 2


chr4_+_55362949 2.350 Rad23b
RAD23b homolog (S. cerevisiae)
chr7_+_28390872 2.161 NM_007434
Akt2
thymoma viral proto-oncogene 2
chr4_+_53556496 2.081 Slc44a1
solute carrier family 44, member 1
chr19_+_45089665 2.048 NM_145503
NM_001130525
Lzts2

leucine zipper, putative tumor suppressor 2

chr4_+_154936480 1.994 NM_138671
Nadk
NAD kinase
chr6_-_82724366 1.924 NM_013820
Hk2
hexokinase 2
chr19_+_56798916 1.917 Adrb1
adrenergic receptor, beta 1
chr19_+_46206383 1.869 NM_007703
Elovl3
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3
chr6_+_141634834 1.868


chr9_+_5308846 1.853 NM_007609
Casp4
caspase 4, apoptosis-related cysteine peptidase
chr9_+_107982741 1.764 NM_008243
Mst1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr8_-_40727989 1.737 NM_001113326
NM_031195
Msr1

macrophage scavenger receptor 1

chr8_+_96910392 1.660 NM_022331
Herpud1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr16_-_16073490 1.642 2310008H04Rik
RIKEN cDNA 2310008H04 gene
chrX_+_106290703 1.563 NM_019989
Sh3bgrl
SH3-binding domain glutamic acid-rich protein like
chr2_+_25508637 1.560 NM_033145
Lcn8
lipocalin 8
chr3_+_121234528 1.519 A530020G20Rik
RIKEN cDNA A530020G20 gene
chr12_-_105013969 1.512 Serpina1a
Serpina1b
serine (or cysteine) peptidase inhibitor, clade A, member 1A
serine (or cysteine) preptidase inhibitor, clade A, member 1B
chr12_-_82068951 1.498 Slc10a1
solute carrier family 10 (sodium/bile acid cotransporter family), member 1
chr2_+_138104219 1.496 NM_145534
Btbd3
BTB (POZ) domain containing 3
chr12_-_86097486 1.471


chr11_+_108256590 1.469 NM_013475
Apoh
apolipoprotein H
chr8_+_113557991 1.441 Aars
alanyl-tRNA synthetase
chr3_-_131047840 1.402 NM_028943
Sgms2
sphingomyelin synthase 2
chr16_+_23058492 1.324 Kng1
kininogen 1
chr14_+_51575810 1.315 NM_001123371
Pnp2
purine-nucleoside phosphorylase 2
chr8_-_95624574 1.311


chrX_-_137908516 1.308 Col4a6
collagen, type IV, alpha 6
chr5_+_119214935 1.306 Med13l
mediator complex subunit 13-like
chr15_-_103140868 1.293 NM_030720
Gpr84
G protein-coupled receptor 84
chr17_-_45797425 1.289 Tmem63b
transmembrane protein 63b
chr2_+_172219293 1.284 NM_001033538
NM_001080820
Cass4

Cas scaffolding protein family member 4

chr16_+_23058457 1.282 Kng1
kininogen 1
chr14_+_76245031 1.277 NM_009429
Tpt1
tumor protein, translationally-controlled 1
chr5_-_104406406 1.265 NM_001163486
NM_198030
Hsd17b13

hydroxysteroid (17-beta) dehydrogenase 13

chr3_-_90499611 1.185 NM_009114
S100a9
S100 calcium binding protein A9 (calgranulin B)
chr2_-_60560659 1.175 NM_001159564
Itgb6
integrin beta 6
chr2_+_24132788 1.172 NM_019451
Il1f5
interleukin 1 family, member 5 (delta)
chr11_+_57822347 1.152 NM_028451
Larp1
La ribonucleoprotein domain family, member 1
chr2_+_174167172 1.148 Gnas
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
chr14_-_69273768 1.145 NM_001048175
NM_010082
NM_183366
Adam28


a disintegrin and metallopeptidase domain 28


chrX_+_132781054 1.143 Wbp5
WW domain binding protein 5
chr12_-_103057259 1.142 NM_011812
Fbln5
fibulin 5
chr10_+_80646662 1.069 NM_007828
Dapk3
death-associated protein kinase 3
chr8_+_3665753 1.060 NM_026985
1810033B17Rik
RIKEN cDNA 1810033B17 gene
chr15_-_76137667 1.060 NM_153122
Oplah
5-oxoprolinase (ATP-hydrolysing)
chr11_-_87639611 1.031 NM_080420
Lpo
lactoperoxidase
chr10_-_121063321 0.981 NM_001081056
Xpot
exportin, tRNA (nuclear export receptor for tRNAs)
chr11_+_93905443 0.974 Spag9
sperm associated antigen 9
chr1_+_40281924 0.961 NM_008362
Il1r1
interleukin 1 receptor, type I
chr14_+_76245115 0.956 Tpt1
tumor protein, translationally-controlled 1
chr4_-_132066370 0.947 NM_144907
Sesn2
sestrin 2
chr10_-_67741461 0.912 NM_023598
Arid5b
AT rich interactive domain 5B (MRF1-like)
chr14_+_51781934 0.886 NM_019398
Ear5
eosinophil-associated, ribonuclease A family, member 5
chr11_+_93905557 0.873 Spag9
sperm associated antigen 9
chr15_-_101510717 0.840 NM_010669
Krt6b
keratin 6B
chr1_-_182160174 0.835 Psen2
presenilin 2
chr7_+_74792295 0.821 NM_001168475
NM_001168476
NM_001168477
NM_025905
Ttc23



tetratricopeptide repeat domain 23



chr19_+_30307417 0.819 Mbl2
mannose-binding lectin (protein C) 2
chr9_+_124016886 0.818 NM_009915
Ccr2
chemokine (C-C motif) receptor 2
chr8_+_113557763 0.801 NM_146217
Aars
alanyl-tRNA synthetase
chr14_+_76245136 0.775 Tpt1
tumor protein, translationally-controlled 1
chr7_+_86058650 0.774 NM_020583
Isg20
interferon-stimulated protein
chr5_-_4104331 0.772 Cyp51
cytochrome P450, family 51
chr11_-_106077627 0.757 Ccdc47
coiled-coil domain containing 47
chr10_+_115254308 0.732 NM_001168679
NM_001168680
NM_146010
Tspan8


tetraspanin 8


chr5_-_115086269 0.726 Trpv4
transient receptor potential cation channel, subfamily V, member 4
chr7_-_135349828 0.701 NM_009943
Cox6a2
cytochrome c oxidase, subunit VI a, polypeptide 2
chr9_-_20619426 0.688 NM_016919
Col5a3
collagen, type V, alpha 3
chr10_-_4752710 0.646 NM_026793
Myct1
myc target 1
chr5_-_121822213 0.635 Trafd1
TRAF type zinc finger domain containing 1
chr1_+_91351435 0.621 Agap1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr15_-_83263181 0.616 NM_001159510
NM_011862
Pacsin2

protein kinase C and casein kinase substrate in neurons 2

chr15_-_12479631 0.593 Pdzd2
PDZ domain containing 2
chr3_+_84470113 0.587 NM_177260
Tmem154
transmembrane protein 154
chr17_+_56154918 0.587 Mpnd
MPN domain containing
chr6_-_125112509 0.538 Gapdh
Gm5523
Gm10481
glyceraldehyde-3-phosphate dehydrogenase
glyceraldehyde-3-phosphate dehydrogenase pseudogene
glyceraldehyde-3-phosphate dehydrogenase pseudogene
chr8_+_107257897 0.522 NM_001190330
NM_133960
Ces2a

carboxylesterase 2A

chr4_-_100854453 0.513 Jak1
Janus kinase 1
chr10_-_116675736 0.512 NM_029906
9530003J23Rik
RIKEN cDNA 9530003J23 gene
chr2_-_121890678 0.497 Spg11
spastic paraplegia 11
chr12_+_89131277 0.492 NM_001177574
Gm2022
predicted pseudogene 2022
chrX_-_160696001 0.485 NM_009759
Bmx
BMX non-receptor tyrosine kinase
chr11_+_67051530 0.474 NM_010855
Myh4
myosin, heavy polypeptide 4, skeletal muscle
chr5_-_4104696 0.470 NM_020010
Cyp51
cytochrome P450, family 51
chr9_+_110322311 0.468 NM_008694
Ngp
neutrophilic granule protein
chr6_-_115568804 0.445 Raf1
v-raf-leukemia viral oncogene 1
chr5_+_93522440 0.426 NM_001009818
Sept11
septin 11
chr15_+_9265318 0.408 Ugt3a2
UDP glycosyltransferases 3 family, polypeptide A2
chr6_-_92484838 0.400 NM_001134459
Prickle2
prickle homolog 2 (Drosophila)
chr1_+_172163001 0.397 NM_001033499
Sh2d1b2
SH2 domain protein 1B2
chr2_-_30816439 0.358


chr16_+_92292580 0.343 NM_134110
Kcne2
potassium voltage-gated channel, Isk-related subfamily, gene 2
chr15_+_9265343 0.337 NM_144845
Ugt3a2
UDP glycosyltransferases 3 family, polypeptide A2
chr5_-_54098762 0.333 NM_009827
Cckar
cholecystokinin A receptor
chr10_-_116675657 0.331 9530003J23Rik
RIKEN cDNA 9530003J23 gene
chr8_+_83017933 0.325 NM_010369
Gypa
glycophorin A
chr1_-_64167818 0.323 Klf7
Kruppel-like factor 7 (ubiquitous)
chr13_-_108516475 0.297 Zswim6
zinc finger, SWIM domain containing 6
chr9_+_21639937 0.282 NM_001080940
Gm6484
predicted gene 6484
chr6_-_141895265 0.269 Slco1a1
solute carrier organic anion transporter family, member 1a1
chr14_+_70945119 0.260 Reep4
receptor accessory protein 4
chr11_+_78059452 0.248 Sdf2
stromal cell derived factor 2
chr10_+_126727846 0.246 NM_007837
Ddit3
DNA-damage inducible transcript 3
chr1_+_91351373 0.240 NM_001037136
NM_178119
Agap1

ArfGAP with GTPase domain, ankyrin repeat and PH domain 1

chr5_+_93112640 0.238 Shroom3
shroom family member 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
8.20 1.14e-07 GO:0006954 inflammatory response
5.46 2.01e-06 GO:0009611 response to wounding
4.72 2.11e-05 GO:0080134 regulation of response to stress
3.95 7.02e-04 GO:0006952 defense response
2.44 9.33e-04 GO:0006950 response to stress
14.80 2.71e-03 GO:0002526 acute inflammatory response
19.39 4.75e-03 GO:0006953 acute-phase response
11.04 1.54e-02 GO:0045444 fat cell differentiation
2.24 1.68e-02 GO:0048583 regulation of response to stimulus
5.17 2.34e-02 GO:0072507 divalent inorganic cation homeostasis

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.41 3.94e-05 GO:0005576 extracellular region
3.06 5.32e-05 GO:0044421 extracellular region part
3.27 2.70e-04 GO:0005615 extracellular space

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
10.86 1.70e-02 GO:0002020 protease binding
27.14 2.87e-02 GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters