Motif ID: CUCCCAA

Z-value: 0.908


Mature miRNA associated with seed CUCCCAA:

NamemiRBase Accession
mmu-miR-150 MIMAT0000160
mmu-miR-5127 MIMAT0020638



Activity profile for motif CUCCCAA.

activity profile for motif CUCCCAA


Sorted Z-values histogram for motif CUCCCAA

Sorted Z-values for motif CUCCCAA



Network of associatons between targets according to the STRING database.



First level regulatory network of CUCCCAA

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_103014374 7.212 NM_173781
Rab6b
RAB6B, member RAS oncogene family
chr2_-_53937785 4.979 NM_023396
Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr5_+_113919352 4.861 NM_177292
Wscd2
WSC domain containing 2
chr2_-_148558110 4.858 NM_019632
Napb
N-ethylmaleimide sensitive fusion protein attachment protein beta
chr4_-_151851574 4.751 NM_010598
Kcnab2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr8_+_4493404 4.655 NM_026058
Lass4
LAG1 homolog, ceramide synthase 4
chr11_-_108205199 4.640 NM_011101
Prkca
protein kinase C, alpha
chr9_+_107838164 4.565 NM_145621
Camkv
CaM kinase-like vesicle-associated
chr7_+_147020072 4.241 NM_177469
Gpr123
G protein-coupled receptor 123
chr4_-_57003214 4.147 NM_001142965
6430704M03Rik
RIKEN cDNA 6430704M03 gene
chr2_+_163264188 4.012 NM_144891
Gdap1l1
ganglioside-induced differentiation-associated protein 1-like 1
chr1_+_160292470 3.895 NM_007495
Astn1
astrotactin 1
chr7_+_129432585 3.881 NM_008855
Prkcb
protein kinase C, beta
chr2_+_158201373 3.815 NM_175692
Snhg11
small nucleolar RNA host gene 11
chr9_+_74918979 3.754 NM_010864
Myo5a
myosin VA
chr15_-_78136032 3.750 NM_007781
Csf2rb2
colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)
chr17_+_4995073 3.639 NM_001085355
Arid1b
AT rich interactive domain 1B (SWI-like)
chr5_-_108978950 3.468 NM_007756
Cplx1
complexin 1
chr6_-_122692754 3.432 NM_011401
Slc2a3
solute carrier family 2 (facilitated glucose transporter), member 3
chr2_+_106535757 3.401 NM_029837
Mpped2
metallophosphoesterase domain containing 2
chr9_+_107199019 3.383 NM_009895
Cish
cytokine inducible SH2-containing protein
chr11_-_70501586 3.366 NM_001190376
NM_001190378
NM_001190379
NM_178116
Camta2



calmodulin binding transcription activator 2



chr1_-_134539434 3.341 NM_001160316
Nfasc
neurofascin
chr4_+_135451278 3.327 NM_009924
Cnr2
cannabinoid receptor 2 (macrophage)
chr4_-_86876328 3.318 NM_172426
Slc24a2
solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
chr5_-_8622882 3.298 NM_198620
Rundc3b
RUN domain containing 3B
chr7_-_116925058 3.292 NM_020610
Nrip3
nuclear receptor interacting protein 3
chr15_+_103333554 3.142 NM_008800
Pde1b
phosphodiesterase 1B, Ca2+-calmodulin dependent
chrX_+_7455387 3.014 NM_138606
Pim2
proviral integration site 2
chr1_-_134603848 2.961 NM_001160318
Nfasc
neurofascin
chr8_-_122099088 2.946 NM_175185
Hsdl1
hydroxysteroid dehydrogenase like 1
chr3_+_34548916 2.934 NM_011443
Sox2
SRY-box containing gene 2
chr18_+_39152776 2.932 NM_175164
Arhgap26
Rho GTPase activating protein 26
chr2_+_106533615 2.892 NM_001143683
Mpped2
metallophosphoesterase domain containing 2
chr19_-_4906607 2.865 NM_001033128
Bbs1
Bardet-Biedl syndrome 1 (human)
chr3_-_152003317 2.841 NM_001162375
NM_174868
Fam73a

family with sequence similarity 73, member A

chr6_+_83187368 2.829 NM_001166067
Slc4a5
solute carrier family 4, sodium bicarbonate cotransporter, member 5
chr2_+_150396150 2.824 NM_009977
Cst7
cystatin F (leukocystatin)
chr5_-_36925021 2.789 NM_133910
Tbc1d14
TBC1 domain family, member 14
chr2_-_104250490 2.646 NM_001033347
D430041D05Rik
RIKEN cDNA D430041D05 gene
chr4_+_130469187 2.642 NM_010686
Laptm5
lysosomal-associated protein transmembrane 5
chr2_-_118199046 2.570 NM_201367
Gpr176
G protein-coupled receptor 176
chr9_-_20264387 2.548 NM_011753
Zfp26
zinc finger protein 26
chr2_+_179777187 2.543 NM_178750
Ss18l1
synovial sarcoma translocation gene on chromosome 18-like 1
chr2_+_25733302 2.537 NM_175462
Kcnt1
potassium channel, subfamily T, member 1
chr2_-_37286367 2.516 NM_146253
Zbtb6
zinc finger and BTB domain containing 6
chr10_+_122115755 2.506 NM_001110218
NM_176919
Ppm1h

protein phosphatase 1H (PP2C domain containing)

chr11_-_69227176 2.492 NM_001017426
Kdm6b
KDM1 lysine (K)-specific demethylase 6B
chr1_-_134638361 2.488 NM_001160317
NM_182716
Nfasc

neurofascin

chr17_-_33897428 2.483 NM_008997
Rab11b
RAB11B, member RAS oncogene family
chr4_-_154772070 2.479 NM_008072
Gabrd
gamma-aminobutyric acid (GABA) A receptor, subunit delta
chr9_+_44925922 2.432 NM_001014761
Scn2b
sodium channel, voltage-gated, type II, beta
chr1_+_75476106 2.406 NM_177056
Tmem198
transmembrane protein 198
chr15_+_82105322 2.390 NM_011889
Sept3
septin 3
chr4_-_107973683 2.357 NM_001033634
Zyg11b
zyg-ll homolog B (C. elegans)
chr11_+_83223573 2.353 NM_001013386
Rasl10b
RAS-like, family 10, member B
chr6_-_126690651 2.341 NM_013568
Kcna6
potassium voltage-gated channel, shaker-related, subfamily, member 6
chr10_-_9620837 2.332 NM_001081344
Stxbp5
syntaxin binding protein 5 (tomosyn)
chr11_+_11586215 2.287 NM_001025597
NM_009578
Ikzf1

IKAROS family zinc finger 1

chr2_+_145068346 2.279 NM_053195
Slc24a3
solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
chr1_+_93437656 2.271 NM_023046
Asb1
ankyrin repeat and SOCS box-containing 1
chr1_+_93437120 2.270 NM_001039126
Asb1
ankyrin repeat and SOCS box-containing 1
chr5_-_108153337 2.266 NM_010278
Gfi1
growth factor independent 1
chr15_-_74583382 2.263 NM_011838
Lynx1
Ly6/neurotoxin 1
chr4_+_122860705 2.211 NM_174998
Hpcal4
hippocalcin-like 4
chr11_+_4136787 2.200 NM_001013365
Osm
oncostatin M
chr4_-_86873866 2.151 NM_001110240
Slc24a2
solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
chr17_-_56273265 2.137 NM_013662
Sema6b
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr5_-_121262512 2.130 NM_033541
Oas1c
2'-5' oligoadenylate synthetase 1C
chr4_+_155367019 2.128 NM_011341
Sdf4
stromal cell derived factor 4
chr2_+_24240916 2.100 NM_177611
Psd4
pleckstrin and Sec7 domain containing 4
chr5_+_30559138 2.077 NM_027652
Ept1
ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
chr17_-_43803963 2.077 NM_028711
Slc25a27
solute carrier family 25, member 27
chr5_-_73729789 2.076 NM_026950
Ociad2
OCIA domain containing 2
chr10_+_60760581 2.070 NM_011073
Prf1
perforin 1 (pore forming protein)
chr6_-_121423682 2.038 NM_001033354
Iqsec3
IQ motif and Sec7 domain 3
chr9_-_72339762 2.026 NM_009359
Tex9
testis expressed gene 9
chr9_-_44128228 2.015 NM_027909
C2cd2l
C2 calcium-dependent domain containing 2-like
chr10_+_127662893 2.014 NM_008600
Mip
major intrinsic protein of eye lens fiber
chr11_+_32433265 1.997 NM_009288
Stk10
serine/threonine kinase 10
chr11_-_114657186 1.989 NM_028055
Btbd17
BTB (POZ) domain containing 17
chr1_+_65233222 1.982 NM_011086
Pikfyve
phosphoinositide kinase, FYVE finger containing
chr10_+_4795808 1.976 NM_153399
Syne1
synaptic nuclear envelope 1
chr7_+_98239230 1.963 NM_011807
Dlg2
discs, large homolog 2 (Drosophila)
chr8_-_73987384 1.954 NM_022419
Abhd8
abhydrolase domain containing 8
chr11_-_114795651 1.952 NM_199221
Cd300lb
CD300 antigen like family member B
chr14_+_52730577 1.949 NM_001168515
NM_023879
Rpgrip1

retinitis pigmentosa GTPase regulator interacting protein 1

chr16_+_20695034 1.947 NM_133778
Fam131a
family with sequence similarity 131, member A
chrX_+_130829763 1.942 NM_026239
Tmem35
transmembrane protein 35
chr1_-_168339909 1.917 NM_001142948
NM_175170
Pogk

pogo transposable element with KRAB domain

chr6_+_47194393 1.894 NM_025771
Cntnap2
contactin associated protein-like 2
chr7_+_64845887 1.886 NM_001038701
Gabrb3
gamma-aminobutyric acid (GABA) A receptor, subunit beta 3
chr15_+_82129383 1.873 NM_029066
Wbp2nl
WBP2 N-terminal like
chr2_+_127073631 1.873 NM_175145
Tmem127
transmembrane protein 127
chr11_+_6963421 1.871 NM_009622
Adcy1
adenylate cyclase 1
chr3_-_95021614 1.868 NM_029885
NM_172512
Gabpb2

GA repeat binding protein, beta 2

chr10_+_74429876 1.867 NM_010311
Gnaz
guanine nucleotide binding protein, alpha z subunit
chr5_+_136293975 1.865 NM_021403
Srrm3
serine/arginine repetitive matrix 3
chr17_-_32946797 1.843 NM_183177
Zfp811
zinc finger protein 811
chr4_-_46579311 1.836 NM_178893
Coro2a
coronin, actin binding protein 2A
chr16_-_22657283 1.833 NM_138650
Dgkg
diacylglycerol kinase, gamma
chr6_-_142912908 1.830 NM_011374
St8sia1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr12_+_12268901 1.827 NM_001146119
NM_029758
Fam49a

family with sequence similarity 49, member A

chr15_-_91403685 1.812 NM_001033633
Slc2a13
solute carrier family 2 (facilitated glucose transporter), member 13
chr19_+_10652212 1.812 NM_201351
Cybasc3
cytochrome b, ascorbate dependent 3
chr6_+_45010040 1.810 NM_001004357
Cntnap2
contactin associated protein-like 2
chr7_-_116895708 1.808 NM_020050
Tmem9b
TMEM9 domain family, member B
chr16_-_55895391 1.807 NM_001134457
NM_001134494
Fam55c

family with sequence similarity 55, member C

chr11_-_119903061 1.792 NM_001198787
Aatk
apoptosis-associated tyrosine kinase
chr5_-_138181225 1.785 NM_175521
6430598A04Rik
RIKEN cDNA 6430598A04 gene
chr6_-_56319574 1.783 NM_001159955
NM_001159956
NM_001159957
Pde1c


phosphodiesterase 1C


chr9_-_69989285 1.782 NM_029784
Fam81a
family with sequence similarity 81, member A
chr17_-_36179615 1.778 NM_010397
NM_010399
H2-T22
H2-T9
histocompatibility 2, T region locus 22
histocompatibility 2, T region locus 9
chr12_+_75098739 1.762 NM_172804
Syt16
synaptotagmin XVI
chrX_+_159339512 1.760 NM_001168569
NM_001168571
NM_018737
Ctps2


cytidine 5'-triphosphate synthase 2


chrX_-_133527570 1.757 NM_001114179
Mcart6
mitochondrial carrier triple repeat 6
chr2_+_112106470 1.753 NM_133649
Slc12a6
solute carrier family 12, member 6
chrX_+_159339465 1.746 NM_001168568
Ctps2
cytidine 5'-triphosphate synthase 2
chr9_-_45077167 1.743 NM_008348
Il10ra
interleukin 10 receptor, alpha
chr15_-_88979923 1.741 NM_011161
Mapk11
mitogen-activated protein kinase 11
chrX_-_49034778 1.738 NM_001077202
Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr4_+_154335029 1.737 NM_010419
Hes5
hairy and enhancer of split 5 (Drosophila)
chr7_-_134164627 1.732 NM_001102563
Prrt2
proline-rich transmembrane protein 2
chr9_+_44048756 1.730 NM_001081369
Ccdc153
coiled-coil domain containing 153
chr7_-_19895354 1.718 NM_008036
Fosb
FBJ osteosarcoma oncogene B
chr17_+_71553920 1.705 NM_001164885
Lpin2
lipin 2
chr7_+_64846528 1.696 NM_008071
Gabrb3
gamma-aminobutyric acid (GABA) A receptor, subunit beta 3
chr3_-_96618414 1.686 NM_018767
Cd160
CD160 antigen
chr11_+_114751354 1.667 NM_170758
Cd300a
CD300A antigen
chr14_-_56143027 1.667 NM_008736
Nrl
neural retina leucine zipper gene
chr4_+_137806293 1.657 NM_001099631
Sh2d5
SH2 domain containing 5
chr15_-_66801198 1.653 NM_008681
Ndrg1
N-myc downstream regulated gene 1
chr19_+_46647844 1.645 NM_053196
Sfxn2
sideroflexin 2
chr7_+_53651811 1.628 NM_008421
NM_001112739
Kcnc1

potassium voltage gated channel, Shaw-related subfamily, member 1

chr14_-_63379948 1.623 NM_008715
Ints6
integrator complex subunit 6
chr11_-_115992196 1.612 NM_178802
Trim65
tripartite motif-containing 65
chr11_-_70034477 1.604 NM_172371
Slc16a13
solute carrier family 16 (monocarboxylic acid transporters), member 13
chr13_+_36059774 1.600 NM_029628
Ppp1r3g
protein phosphatase 1, regulatory (inhibitor) subunit 3G
chr2_+_3341402 1.599 NM_001110214
NM_146114
NM_175683
Dclre1c


DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)


chrX_+_63902456 1.599 NM_001161431
Slitrk2
SLIT and NTRK-like family, member 2
chr1_-_174136874 1.594 NM_011063
Pea15a
phosphoprotein enriched in astrocytes 15A
chr12_-_113749363 1.592 NM_178915
Tmem179
transmembrane protein 179
chr19_-_6932673 1.587 NM_001081291
Ccdc88b
coiled-coil domain containing 88B
chr6_-_56312803 1.583 NM_001159960
Pde1c
phosphodiesterase 1C
chr7_+_152082435 1.581 NM_008003
Fgf15
fibroblast growth factor 15
chr17_-_36258349 1.580 NM_010395
H2-T10
H2-T9
histocompatibility 2, T region locus 10
histocompatibility 2, T region locus 9
chr2_-_121176719 1.575 NM_178795
Ppip5k1
diphosphoinositol pentakisphosphate kinase 1
chr17_+_78599556 1.572 NM_015800
Crim1
cysteine rich transmembrane BMP regulator 1 (chordin like)
chr2_+_49921978 1.560 NM_177139
Lypd6
LY6/PLAUR domain containing 6
chrX_-_49033640 1.552 NM_015819
Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr12_+_3365102 1.551 NM_008445
Kif3c
kinesin family member 3C
chr17_-_36505355 1.546 NM_201608
H2-M10.3
histocompatibility 2, M region locus 10.3
chr4_+_151712739 1.524 NM_001081376
NM_029216
Chd5

chromodomain helicase DNA binding protein 5

chr9_+_108728650 1.518 NM_080437
Celsr3
cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
chr16_+_8513513 1.518 NM_001170978
NM_172961
Abat

4-aminobutyrate aminotransferase

chr4_+_125168074 1.515 NM_001081097
Grik3
glutamate receptor, ionotropic, kainate 3
chr11_-_107772661 1.514 NM_080644
Cacng5
calcium channel, voltage-dependent, gamma subunit 5
chr4_-_46662986 1.509 NM_198664
Tbc1d2
TBC1 domain family, member 2
chr5_-_139960431 1.504 NM_001159908
NM_133349
Zfand2a

zinc finger, AN1-type domain 2A

chr9_+_94570310 1.499 NM_177909
Slc9a9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr9_-_78435825 1.496 NM_172773
Slc17a5
solute carrier family 17 (anion/sugar transporter), member 5
chr13_-_47110187 1.486 NM_175340
Nhlrc1
NHL repeat containing 1
chr7_+_103359146 1.484 NM_011858
Odz4
odd Oz/ten-m homolog 4 (Drosophila)
chr7_+_152101004 1.481 NM_028184
Oraov1
oral cancer overexpressed 1
chr9_-_121767026 1.470 NM_019814
Higd1a
HIG1 domain family, member 1A
chr11_-_119908236 1.461 NM_001198785
NM_007377
Aatk

apoptosis-associated tyrosine kinase

chrX_+_149216463 1.444 NM_010951
Gpr143
G protein-coupled receptor 143
chr15_+_87455659 1.441 NM_134096
Fam19a5
family with sequence similarity 19, member A5
chr6_+_61130318 1.440 NM_001164316
NM_183310
Fam190a

family with sequence similarity 190, member A

chr7_-_150970404 1.435 NM_175534
Mrgpre
MAS-related GPR, member E
chr1_-_65003291 1.435 NM_001039493
Plekhm3
pleckstrin homology domain containing, family M, member 3
chr14_+_70857227 1.433 NM_145981
Phyhip
phytanoyl-CoA hydroxylase interacting protein
chr7_-_129125061 1.427 NM_001033318
Cog7
component of oligomeric golgi complex 7
chr16_+_45610535 1.424 NM_001159297
NM_008099
Gcet2

germinal center expressed transcript 2

chr2_+_112124767 1.417 NM_133648
Slc12a6
solute carrier family 12, member 6
chr18_+_36953553 1.408 NM_025594
Zmat2
zinc finger, matrin type 2
chr6_-_56312170 1.398 NM_001025568
NM_001159952
NM_001159953
NM_011054
Pde1c



phosphodiesterase 1C



chr6_+_137359231 1.394 NM_001164402
NM_001164403
Ptpro

protein tyrosine phosphatase, receptor type, O

chr5_+_123794456 1.392 NM_029850
Bcl7a
B-cell CLL/lymphoma 7A
chr15_-_102993714 1.390 NM_027885
Smug1
single-strand selective monofunctional uracil DNA glycosylase
chr4_+_32504409 1.388 NM_001109661
Bach2
BTB and CNC homology 2
chr6_-_112897259 1.386 NM_080448
Srgap3
SLIT-ROBO Rho GTPase activating protein 3
chr8_+_12949417 1.385 NM_001159485
NM_001159486
Mcf2l

mcf.2 transforming sequence-like

chr6_-_28084368 1.383 NM_008174
Grm8
glutamate receptor, metabotropic 8
chr5_-_105722663 1.382 NM_194336
Mpa2l
Gbp4
macrophage activation 2 like
guanylate binding protein 4
chr3_-_126646303 1.361 NM_001034168
Ank2
ankyrin 2, brain
chr18_-_25324465 1.359 NM_001142697
5730494M16Rik
RIKEN cDNA 5730494M16 gene
chr5_-_118694869 1.345 NM_172998
NM_001109902
Rnft2

ring finger protein, transmembrane 2

chr3_-_96633253 1.345 NM_001163496
NM_001163497
Cd160

CD160 antigen

chr11_-_16908631 1.341 NM_019549
Plek
pleckstrin
chr15_-_95359136 1.337 NM_016743
Nell2
NEL-like 2 (chicken)
chrX_-_133572810 1.335 NM_001082412
Mcart6
mitochondrial carrier triple repeat 6
chr7_-_135605026 1.321 NM_009383
Tial1
Tia1 cytotoxic granule-associated RNA binding protein-like 1
chr12_+_4082573 1.296 NM_153082
Dnajc27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr5_-_113739711 1.295 NM_001162965
NM_172718
Sgsm1

small G protein signaling modulator 1

chr15_-_97561769 1.292 NM_001168693
Endou
endonuclease, polyU-specific
chr6_-_124838150 1.288 NM_013488
Cd4
CD4 antigen
chr11_-_98190774 1.287 NM_010895
Neurod2
neurogenic differentiation 2
chrX_+_63906333 1.285 NM_198863
Slitrk2
SLIT and NTRK-like family, member 2
chr16_+_44347501 1.270 NM_144550
Spice1
spindle and centriole associated protein 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.45 2.05e-04 GO:0031323 regulation of cellular metabolic process
1.75 6.27e-04 GO:0023051 regulation of signaling
1.88 1.06e-03 GO:0035556 intracellular signal transduction
1.41 2.27e-03 GO:0080090 regulation of primary metabolic process
1.37 3.31e-03 GO:0019222 regulation of metabolic process
2.35 4.91e-03 GO:0060341 regulation of cellular localization
2.46 5.33e-03 GO:0007610 behavior
2.53 8.74e-03 GO:0051046 regulation of secretion
2.50 1.05e-02 GO:0019226 transmission of nerve impulse
2.50 1.05e-02 GO:0035637 multicellular organismal signaling
1.76 1.67e-02 GO:0010646 regulation of cell communication
1.42 2.62e-02 GO:0051171 regulation of nitrogen compound metabolic process
1.91 2.71e-02 GO:0051049 regulation of transport
2.22 4.00e-02 GO:0010648 negative regulation of cell communication
1.60 4.29e-02 GO:0065009 regulation of molecular function

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.54 4.21e-07 GO:0043005 neuron projection
2.96 2.70e-06 GO:0044456 synapse part
1.44 2.18e-05 GO:0071944 cell periphery
3.67 6.93e-05 GO:0045211 postsynaptic membrane
1.42 9.58e-05 GO:0005886 plasma membrane
2.36 1.22e-04 GO:0045202 synapse
2.92 1.64e-04 GO:0030424 axon
2.77 3.12e-04 GO:0030425 dendrite
2.50 1.07e-03 GO:0044297 cell body
2.54 1.16e-03 GO:0043025 neuronal cell body
1.77 1.27e-03 GO:0042995 cell projection
2.27 2.88e-03 GO:0044463 cell projection part
10.55 2.89e-03 GO:0005892 nicotinic acetylcholine-gated receptor-channel complex
3.20 1.77e-02 GO:0033267 axon part
2.74 4.29e-02 GO:0034702 ion channel complex

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
2.53 1.98e-04 GO:0030695 GTPase regulator activity
2.46 4.02e-04 GO:0060589 nucleoside-triphosphatase regulator activity
2.57 1.41e-02 GO:0005083 small GTPase regulator activity
2.73 1.89e-02 GO:0005096 GTPase activator activity
4.54 2.39e-02 GO:0030594 neurotransmitter receptor activity
10.05 3.36e-02 GO:0015464 acetylcholine receptor activity