Motif ID: E2F1..5.p2

Z-value: 6.191


Transcription factors associated with E2F1..5.p2:

Gene SymbolEntrez IDGene Name
E2f1 13555 E2F transcription factor 1
E2f2 242705 E2F transcription factor 2
E2f3 13557 E2F transcription factor 3
E2f4 104394 E2F transcription factor 4
E2f5 13559 E2F transcription factor 5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f1chr2_-_1543948640.691.3e-26Click!
E2f2chr4_+_1357286000.681.7e-26Click!
E2f3chr13_-_300779310.637.5e-22Click!
E2f4chr8_+_1078284910.531.8e-14Click!
E2f5chr3_+_14578783-0.027.5e-01Click!


Activity profile for motif E2F1..5.p2.

activity profile for motif E2F1..5.p2


Sorted Z-values histogram for motif E2F1..5.p2

Sorted Z-values for motif E2F1..5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of E2F1..5.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_25393083 205.825 NM_009104
 Rrm2
ribonucleotide reductase M2
chr10_-_68815606 190.395 NM_007659
 Cdk1
cyclin-dependent kinase 1
chr1_-_130256055 178.689 NM_008567
 Mcm6
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr15_-_57966551 170.642 NM_027435
 Atad2
ATPase family, AAA domain containing 2
chr8_+_77633426 170.047 NM_008566
 Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr10_+_110182506 159.597 NM_178609
 E2f7
E2F transcription factor 7
chr1_-_20810238 152.621 NM_008563
 Mcm3
minichromosome maintenance deficient 3 (S. cerevisiae)
chr10_-_20880559 148.266 NM_001198914
NM_010848
 Myb

myeloblastosis oncogene

chr5_-_138613028 146.050 NM_008568
 Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr8_+_125091889 138.459 NM_026014
 Cdt1
chromatin licensing and DNA replication factor 1
chr2_+_72314235 134.555 NM_025866
 Cdca7
cell division cycle associated 7
chr11_+_98769122 126.897 Cdc6
cell division cycle 6 homolog (S. cerevisiae)
chr13_-_21925343 122.491 NM_178185
NM_001177544
 Hist1h2ah
Hist1h2ap
Hist1h2ai
Hist1h2ao
histone cluster 1, H2ah
histone cluster 1, H2ap
histone cluster 1, H2ai
histone cluster 1, H2ao
chr6_-_88848650 116.296 NM_008564
 Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr11_+_98769162 115.939 NM_001025779
 Cdc6
cell division cycle 6 homolog (S. cerevisiae)
chr13_-_21879086 111.341 NM_178184
 Hist1h2an
histone cluster 1, H2an
chr13_-_22134795 106.518 NM_178186
 Hist1h2ag
Hist1h2ai
histone cluster 1, H2ag
histone cluster 1, H2ai
chr10_+_127669118 104.620 NM_001136082
NM_001164080
NM_001164081
 Timeless


timeless homolog (Drosophila)


chr2_-_157030236 103.984 NM_001139516
NM_011249
 Rbl1

retinoblastoma-like 1 (p107)

chr10_+_127669154 103.485 Timeless
timeless homolog (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 160 entries
Enrichment   P-value GO Accession GO Term
18.42 1.97e-02 GO:0019985 translesion synthesis
16.57 8.61e-08 GO:0006270 DNA-dependent DNA replication initiation
15.07 4.51e-07 GO:0071897 DNA biosynthetic process
13.15 2.04e-02 GO:0000731 DNA synthesis involved in DNA repair
12.28 6.83e-05 GO:2000104 negative regulation of DNA-dependent DNA replication
11.84 1.41e-05 GO:0090329 regulation of DNA-dependent DNA replication
11.05 1.00e-02 GO:0000084 S phase of mitotic cell cycle
11.05 1.00e-02 GO:0006268 DNA unwinding involved in replication
10.05 2.10e-02 GO:0051320 S phase
9.69 2.87e-05 GO:0006297 nucleotide-excision repair, DNA gap filling
8.29 8.81e-04 GO:0007062 sister chromatid cohesion
7.37 1.18e-02 GO:0032392 DNA geometric change
7.21 2.20e-08 GO:0006261 DNA-dependent DNA replication
6.82 2.13e-29 GO:0006260 DNA replication
6.82 1.76e-03 GO:0033261 regulation of S phase
6.31 3.67e-04 GO:0008156 negative regulation of DNA replication
5.84 3.20e-04 GO:0043966 histone H3 acetylation
4.93 4.31e-04 GO:0006289 nucleotide-excision repair
4.87 1.33e-03 GO:0051053 negative regulation of DNA metabolic process
4.72 9.25e-06 GO:0006473 protein acetylation

Gene overrepresentation in compartment category:

Showing 1 to 20 of 53 entries
Enrichment   P-value GO Accession GO Term
18.42 1.66e-04 GO:0042555 MCM complex
11.05 1.56e-03 GO:0005652 nuclear lamina
10.23 1.74e-02 GO:0035098 ESC/E(Z) complex
7.48 1.55e-06 GO:0005657 replication fork
6.91 4.48e-02 GO:0043596 nuclear replication fork
6.79 1.37e-02 GO:0031519 PcG protein complex
4.68 5.91e-05 GO:0000792 heterochromatin
4.60 2.31e-06 GO:0071013 catalytic step 2 spliceosome
4.60 7.48e-05 GO:0000123 histone acetyltransferase complex
4.39 2.26e-02 GO:0016605 PML body
4.37 5.29e-07 GO:0000790 nuclear chromatin
4.37 8.43e-04 GO:0034708 methyltransferase complex
4.37 8.43e-04 GO:0035097 histone methyltransferase complex
4.26 1.54e-09 GO:0005681 spliceosomal complex
3.99 5.58e-03 GO:0034399 nuclear periphery
3.98 2.19e-08 GO:0016604 nuclear body
3.97 3.17e-11 GO:0044454 nuclear chromosome part
3.87 2.64e-05 GO:0000793 condensed chromosome
3.86 2.38e-12 GO:0000785 chromatin
3.83 6.67e-12 GO:0000228 nuclear chromosome

Gene overrepresentation in function category:

Showing 1 to 20 of 45 entries
Enrichment   P-value GO Accession GO Term
16.11 5.26e-06 GO:0070888 E-box binding
7.62 6.85e-06 GO:0003887 DNA-directed DNA polymerase activity
6.91 2.56e-05 GO:0034061 DNA polymerase activity
4.79 9.07e-04 GO:0003697 single-stranded DNA binding
3.79 5.17e-11 GO:0043566 structure-specific DNA binding
3.63 4.74e-10 GO:0003682 chromatin binding
3.56 1.12e-03 GO:0003714 transcription corepressor activity
3.44 2.25e-02 GO:0042393 histone binding
3.27 7.60e-05 GO:0003690 double-stranded DNA binding
3.10 1.41e-10 GO:0008134 transcription factor binding
2.98 2.45e-02 GO:0016779 nucleotidyltransferase activity
2.72 1.94e-04 GO:0000975 regulatory region DNA binding
2.72 1.94e-04 GO:0001067 regulatory region nucleic acid binding
2.72 1.94e-04 GO:0044212 transcription regulatory region DNA binding
2.58 9.99e-42 GO:0003677 DNA binding
2.58 2.94e-04 GO:0003712 transcription cofactor activity
2.56 3.25e-04 GO:0000989 transcription factor binding transcription factor activity
2.54 1.50e-15 GO:0001071 nucleic acid binding transcription factor activity
2.54 1.50e-15 GO:0003700 sequence-specific DNA binding transcription factor activity
2.53 4.33e-04 GO:0000988 protein binding transcription factor activity