• All motifs sorted by activity significance
• All samples sorted alphabetically

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)

Motif ID: EBF1.p2

Z-value: 1.251

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr7_+_149628285	14.014	NM_009405	Tnni2	troponin I, skeletal, fast 2
chr12_-_102988510	13.517		Fbln5	fibulin 5
chrX_+_53984926	12.986	NM_010211	Fhl1	four and a half LIM domains 1
chrX_+_53985133	12.343	NM_001077361	Fhl1	four and a half LIM domains 1
chr10_+_75398317	12.218	NM_175329	Chchd10	coiled-coil-helix-coiled-coil-helix domain containing 10
chr11_-_32122236	10.040		Rhbdf1	rhomboid family 1 (Drosophila)
chr9_-_114753191	9.536	NM_027294	Cmtm8	CKLF-like MARVEL transmembrane domain containing 8
chr6_+_3953944	9.287	NM_025331	Gng11	guanine nucleotide binding protein (G protein), gamma 11
chr7_-_26262552	9.243	NM_001039185 NM_001039186 NM_001039187 NM_011926	Ceacam1	carcinoembryonic antigen-related cell adhesion molecule 1
chr6_+_3954259	9.161		Gng11	guanine nucleotide binding protein (G protein), gamma 11
chr19_+_25484006	9.153		Kank1	KN motif and ankyrin repeat domains 1
chr13_+_13529868	8.965	NM_010917	Nid1	nidogen 1
chr15_-_76853069	8.964	NM_001164048 NM_001164047	Mb	myoglobin
chr3_+_52845429	8.779	NM_175386	Lhfp	lipoma HMGIC fusion partner
chr3_+_52845510	8.772		Lhfp	lipoma HMGIC fusion partner
chr18_+_60963495	8.688	NM_001042605 NM_010545	Cd74	CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
chr2_+_25264823	8.658
chr15_-_34608458	8.654	NM_145469	Nipal2	NIPA-like domain containing 2
chr13_+_13529947	8.411		Nid1	nidogen 1
chr15_+_101933364	8.395	NM_153533	Tenc1	tensin like C1 domain-containing phosphatase
chr6_+_56782042	8.375	NM_012056	Fkbp9	FK506 binding protein 9
chr17_-_35018943	8.362		C2	complement component 2 (within H-2S)
chr7_+_149627709	8.286		Tnni2	troponin I, skeletal, fast 2
chr6_+_3954225	8.127		Gng11	guanine nucleotide binding protein (G protein), gamma 11
chr16_-_45844409	8.082	NM_153412	Phldb2	pleckstrin homology-like domain, family B, member 2
chr17_+_15080256	8.017		1600012H06Rik	RIKEN cDNA 1600012H06 gene
chr17_+_15080216	7.825		1600012H06Rik	RIKEN cDNA 1600012H06 gene
chr7_-_149838254	7.558		Igf2	insulin-like growth factor 2
chr15_-_76342209	7.459	NM_010046	Dgat1	diacylglycerol O-acyltransferase 1
chr13_+_13529902	7.348		Nid1	nidogen 1
chr8_+_71404491	7.307		Lpl	lipoprotein lipase
chr17_+_15080188	7.286	NM_001083880 NM_001083881 NM_001083882 NM_026451	1600012H06Rik	RIKEN cDNA 1600012H06 gene
chr10_-_70622370	7.228	NM_031397	Bicc1	bicaudal C homolog 1 (Drosophila)
chr2_-_125331264	7.190		Fbn1	fibrillin 1
chr1_-_74170987	7.160	NM_027884	Tns1	tensin 1
chr17_-_35019039	7.110	NM_013484	C2	complement component 2 (within H-2S)
chr1_+_92100572	6.995	NM_007722	Cxcr7	chemokine (C-X-C motif) receptor 7
chr13_+_13529923	6.928		Nid1	nidogen 1
chr17_+_44325518	6.833	NM_172621	Clic5	chloride intracellular channel 5
chr3_-_129035406	6.782	NM_007934	Enpep	glutamyl aminopeptidase
chr6_+_48634586	6.662		Gimap4	GTPase, IMAP family member 4
chr17_+_44325664	6.600		Clic5	chloride intracellular channel 5
chr11_-_102680467	6.399	NM_001159382	Gjc1	gap junction protein, gamma 1
chr5_+_93032108	6.370		Stbd1	starch binding domain 1
chr5_+_93032061	6.329	NM_175096	Stbd1	starch binding domain 1
chr16_+_95479164	6.183	NM_001039056 NM_001039057 NM_019664	Kcnj15	potassium inwardly-rectifying channel, subfamily J, member 15
chr15_-_78236262	6.171	NM_009437	Tst	thiosulfate sulfurtransferase, mitochondrial
chr11_-_3817574	6.159		Tcn2	transcobalamin 2
chr1_+_137737433	6.080	NM_001130176	Tnnt2	troponin T2, cardiac
chr2_+_164388211	6.049	NM_026323	Wfdc2	WAP four-disulfide core domain 2
chr15_-_34608600	6.033		Nipal2	NIPA-like domain containing 2
chr6_+_56782073	6.024		Fkbp9	FK506 binding protein 9
chr9_+_102910816	5.707	NM_033314	Slco2a1	solute carrier organic anion transporter family, member 2a1
chr18_+_36508277	5.570	NM_001081365	0610010O12Rik	RIKEN cDNA 0610010O12 gene
chr9_+_66006025	5.487	NM_010019	Dapk2	death-associated protein kinase 2
chr13_-_3917356	5.461	NM_019671	Net1	neuroepithelial cell transforming gene 1
chr9_+_95538150	5.408		Pcolce2	procollagen C-endopeptidase enhancer 2
chr11_+_50415579	5.388	NM_175643	Adamts2	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2
chr7_-_116760660	5.375	NM_001001326 NM_029811	St5	suppression of tumorigenicity 5
chr4_+_155213788	5.357	NM_024263	Mxra8	matrix-remodelling associated 8
chr6_+_88674398	5.326	NM_001166249 NM_011844	Mgll	monoglyceride lipase
chr9_-_63869857	5.302	NM_008542	Smad6	MAD homolog 6 (Drosophila)
chr14_-_41827037	5.266	NM_027464	5730469M10Rik	RIKEN cDNA 5730469M10 gene
chr9_+_95538038	5.265	NM_029620	Pcolce2	procollagen C-endopeptidase enhancer 2
chr11_-_72303293	5.251	NM_153060	Spns2	spinster homolog 2 (Drosophila)
chrX_+_96237919	5.233	NM_199018	Stard8	START domain containing 8
chr13_-_41942856	5.178	NM_175417 NM_001145875	9530008L14Rik	RIKEN cDNA 9530008L14 gene
chr15_-_89004279	5.177	NM_001159521	Plxnb2	plexin B2
chr8_+_71404452	5.130	NM_008509	Lpl	lipoprotein lipase
chr2_-_91864276	5.106	NM_011957	Creb3l1	cAMP responsive element binding protein 3-like 1
chr9_+_66006060	5.096		Dapk2	death-associated protein kinase 2
chr12_+_31597051	5.089		Sh3yl1	Sh3 domain YSC-like 1
chr3_+_122432075	5.045	NM_153422	Pde5a	phosphodiesterase 5A, cGMP-specific
chr2_-_125332107	4.648	NM_007993	Fbn1	fibrillin 1
chr6_+_86578225	4.617		Asprv1	aspartic peptidase, retroviral-like 1
chr15_-_100467247	4.602	NM_174992 NM_001033872	Smagp	small cell adhesion glycoprotein
chr5_-_140289167	4.593	NM_144914	Tmem184a	transmembrane protein 184a
chr11_-_32122259	4.538	NM_010117	Rhbdf1	rhomboid family 1 (Drosophila)
chr4_-_40800983	4.534		B4galt1	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
chr15_-_100467171	4.485		Smagp	small cell adhesion glycoprotein
chr3_+_118265066	4.422	NM_170778	Dpyd	dihydropyrimidine dehydrogenase
chr1_-_95532278	4.413	NM_021537	Stk25	serine/threonine kinase 25 (yeast)
chr12_-_106003060	4.381		Clmn	calmin
chr7_+_125740810	4.378	NM_001105252	Tmc5	transmembrane channel-like gene family 5
chr1_-_95532192	4.366		Stk25	serine/threonine kinase 25 (yeast)
chr15_-_101755120	4.311	NM_008475	Krt4	keratin 4
chr14_+_55059393	4.302		Mmp14	matrix metallopeptidase 14 (membrane-inserted)
chr16_+_24393435	4.290	NM_178665	Lpp	LIM domain containing preferred translocation partner in lipoma
chr10_+_18564876	4.285	NM_022032	Perp	PERP, TP53 apoptosis effector
chr12_-_58646914	4.280		Foxa1	forkhead box A1
chr7_-_51780003	4.266	NM_146189	Mybpc2	myosin binding protein C, fast-type
chr11_-_4060222	4.207	NM_001164620 NM_177616	Ccdc157	coiled-coil domain containing 157
chr2_+_123915670	4.198		Sema6d	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr2_+_10075169	4.174	NM_172471	Itih5	inter-alpha (globulin) inhibitor H5
chr1_-_99992145	4.173	NM_013626	Pam	peptidylglycine alpha-amidating monooxygenase
chr1_-_95531961	4.124		Stk25	serine/threonine kinase 25 (yeast)
chr7_-_106501584	4.123		Serpinh1	serine (or cysteine) peptidase inhibitor, clade H, member 1
chr14_+_20570444	4.106	NM_008695	Nid2	nidogen 2
chr14_+_55059217	4.102		Mmp14	matrix metallopeptidase 14 (membrane-inserted)
chr1_-_121970345	4.067	NM_019432	Tmem37	transmembrane protein 37
chr6_+_86578167	4.037	NM_026414	Asprv1	aspartic peptidase, retroviral-like 1
chr7_+_108470264	4.009		Stard10	START domain containing 10
chr16_+_23146631	3.995		Adipoq	adiponectin, C1Q and collagen domain containing
chr2_+_122591075	3.977	NM_001162503	Sqrdl	sulfide quinone reductase-like (yeast)
chr15_+_84550474	3.933	NM_001164627 NM_001164628 NM_028455	Arhgap8	Rho GTPase activating protein 8
chr9_-_8004559	3.928	NM_001171147 NM_009534	Yap1	yes-associated protein 1
chr4_-_137352181	3.928	NM_007431	Alpl	alkaline phosphatase, liver/bone/kidney
chr14_+_21526757	3.925	NM_027996	2310021P13Rik	RIKEN cDNA 2310021P13 gene
chr14_-_70605828	3.921		Sorbs3	sorbin and SH3 domain containing 3
chr6_+_48634576	3.920	NM_174990 NM_175048	Gimap4	GTPase, IMAP family member 4
chr11_+_84693721	3.906	NM_025414	Myo19	myosin XIX
chr10_-_6080145	3.904	NM_031185	Akap12	A kinase (PRKA) anchor protein (gravin) 12
chr1_-_121970308	3.869		Tmem37	transmembrane protein 37
chr1_+_161974815	3.859		4930523C07Rik	RIKEN cDNA 4930523C07 gene
chr11_-_116555897	3.858	NM_009180	St6galnac2	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
chr15_+_85566122	3.846	NM_011144	Ppara	peroxisome proliferator activated receptor alpha
chr9_+_98325217	3.767		Rbp1	retinol binding protein 1, cellular
chr4_+_154783298	3.701	NM_001166029 NM_177674	2010015L04Rik	RIKEN cDNA 2010015L04 gene
chr15_+_33012863	3.669	NM_018755 NM_176073	Pgcp	plasma glutamate carboxypeptidase
chr16_-_97832640	3.663		Tmprss2	transmembrane protease, serine 2
chr18_+_36526187	3.655		0610010O12Rik	RIKEN cDNA 0610010O12 gene
chr2_-_68310324	3.626		Stk39	serine/threonine kinase 39, STE20/SPS1 homolog (yeast)
chr9_-_119002573	3.612		Plcd1	phospholipase C, delta 1
chr6_-_30254273	3.607	NM_001170345 NM_001169576 NM_009459	Gm2058 Ube2h	predicted gene 2058 ubiquitin-conjugating enzyme E2H
chr3_-_57651409	3.601		Pfn2	profilin 2
chr17_+_34807445	3.568	NM_031176	Tnxb	tenascin XB
chr12_+_17888699	3.567		Gm9222	predicted gene 9222
chr18_-_60783946	3.564	NM_177340	Synpo	synaptopodin
chr1_-_166387998	3.544		Atp1b1	ATPase, Na+/K+ transporting, beta 1 polypeptide
chr10_-_36855668	3.526		Marcks	myristoylated alanine rich protein kinase C substrate
chr8_-_80248234	3.509		Ednra	endothelin receptor type A
chr16_+_23146608	3.506	NM_009605	Adipoq	adiponectin, C1Q and collagen domain containing
chr12_-_93087514	3.504	NM_001039089 NM_011344	Sel1l	sel-1 suppressor of lin-12-like (C. elegans)
chr4_+_111087610	3.503	NM_026279	Bend5	BEN domain containing 5
chr5_+_122550987	3.503	NM_010861	Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow
chr4_+_137476662	3.458		Ece1	endothelin converting enzyme 1
chr9_-_119002601	3.442	NM_019676	Plcd1	phospholipase C, delta 1
chr16_+_70314331	3.422	NM_028803	Gbe1	glucan (1,4-alpha-), branching enzyme 1
chrX_-_99839480	3.391	NM_008832 NM_173021	Phka1	phosphorylase kinase alpha 1
chr6_+_4471231	3.388		Col1a2	collagen, type I, alpha 2
chr15_+_78939343	3.340	NM_177461	Micall1	microtubule associated monoxygenase, calponin and LIM domain containing -like 1
chr13_-_23666058	3.340	NM_178195	Hist1h2bf	histone cluster 1, H2bf
chr13_-_24026024	3.332	NM_175663	Hist1h2ba	histone cluster 1, H2ba
chr1_+_78306890	3.324	NM_001004173	Sgpp2	sphingosine-1-phosphate phosphotase 2
chr2_-_164268672	3.301	NM_011521	Sdc4	syndecan 4
chr19_-_38199036	3.275		Rbp4	retinol binding protein 4, plasma
chr15_+_85566055	3.227		Ppara	peroxisome proliferator activated receptor alpha
chr10_-_74979949	3.222		1110038D17Rik	RIKEN cDNA 1110038D17 gene
chr16_-_24393527	3.202		1110054M08Rik	RIKEN cDNA 1110054M08 gene
chr15_+_33012972	3.147		Pgcp	plasma glutamate carboxypeptidase
chr16_-_84835213	3.146		Atp5j	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F
chr12_-_58647074	3.140	NM_008259	Foxa1	forkhead box A1
chr17_-_56249206	3.135	NM_020568	Plin4	perilipin 4
chr10_+_57514349	3.133	NM_020561	Smpdl3a	sphingomyelin phosphodiesterase, acid-like 3A
chr1_+_137715174	3.131	NM_133664	Lad1	ladinin
chr9_-_8004450	3.129		Yap1	yes-associated protein 1
chr4_+_102787069	3.090	NM_027696	Mier1	mesoderm induction early response 1 homolog (Xenopus laevis
chr10_-_74980017	3.072	NM_175133	1110038D17Rik	RIKEN cDNA 1110038D17 gene
chr13_+_38243146	3.042	NM_023842	Dsp	desmoplakin
chr9_+_43909852	3.017	NM_001190313 NM_145613 NM_001190314 NM_147126	C1qtnf5 Mfrp	C1q and tumor necrosis factor related protein 5 membrane-type frizzled-related protein
chr6_-_55124983	3.013	NM_009349	Inmt	indolethylamine N-methyltransferase
chr16_-_10313963	2.991		Emp2	epithelial membrane protein 2
chr5_+_103854200	2.977	NM_011204	Ptpn13	protein tyrosine phosphatase, non-receptor type 13
chr1_-_99991958	2.957		Pam	peptidylglycine alpha-amidating monooxygenase
chr3_+_101266000	2.955		Igsf3	immunoglobulin superfamily, member 3
chr1_+_7079042	2.949		Pcmtd1	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1
chr7_-_30033397	2.942		2200002D01Rik	RIKEN cDNA 2200002D01 gene
chr15_+_78939582	2.924		Micall1	microtubule associated monoxygenase, calponin and LIM domain containing -like 1
chr19_-_9003845	2.901	NM_009073	Rom1	rod outer segment membrane protein 1
chr1_+_161974651	2.898		4930523C07Rik	RIKEN cDNA 4930523C07 gene
chr10_+_23943322	2.882	NM_021509	Moxd1	monooxygenase, DBH-like 1
chr8_+_85814244	2.872	NM_009463	Ucp1	uncoupling protein 1 (mitochondrial, proton carrier)
chr4_-_40800995	2.869	NM_022305	B4galt1	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
chr4_-_153674160	2.852		Arhgef16	Rho guanine nucleotide exchange factor (GEF) 16
chr18_+_67503217	2.851	NM_007702	Cidea	cell death-inducing DNA fragmentation factor, alpha subunit-like effector A
chr14_+_66285263	2.821		Scara5	scavenger receptor class A, member 5 (putative)
chr5_+_124423632	2.819	NM_145070	Hip1r	huntingtin interacting protein 1 related
chr16_-_97832672	2.800		Tmprss2	transmembrane protease, serine 2
chr10_+_18564932	2.784		Perp	PERP, TP53 apoptosis effector
chr13_-_61006182	2.779	NM_026429	Tpbpb	trophoblast specific protein beta
chr17_+_47573557	2.775	NM_145489	AI661453	expressed sequence AI661453
chr10_+_58684631	2.774	NM_172939	Ankrd57	ankyrin repeat domain 57
chr16_-_18089085	2.772	NM_011172	Prodh	proline dehydrogenase
chr13_+_113254277	2.756	NM_010560	Il6st	interleukin 6 signal transducer
chr19_-_38199291	2.738	NM_011255	Rbp4	retinol binding protein 4, plasma
chr7_-_52071027	2.724	NM_030693	Atf5	activating transcription factor 5
chr17_-_86566816	2.705		Gm5817	predicted gene 5817
chr3_+_104667380	2.697		St7l	suppression of tumorigenicity 7-like
chr7_-_86887995	2.688		Pex11a	peroxisomal biogenesis factor 11 alpha
chr9_-_70504934	2.688	NM_172772	Fam63b	family with sequence similarity 63, member B
chr14_-_69903072	2.682	NM_026331	Slc25a37	solute carrier family 25, member 37
chr18_-_62339609	2.664	NM_007420	Adrb2	adrenergic receptor, beta 2
chr7_-_151924382	2.655	NM_178642	Ano1	anoctamin 1, calcium activated chloride channel
chr7_-_29157512	2.653	NM_001083912 NM_138752	Plekhg2	pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr15_+_99223622	2.640	NM_001171035	Tmbim6	transmembrane BAX inhibitor motif containing 6
chr10_-_53795485	2.638		Man1a	mannosidase 1, alpha
chr1_+_62750471	2.613		Nrp2	neuropilin 2
chr3_+_96361879	2.604	NM_001009935 NM_023719	Txnip	thioredoxin interacting protein
chr5_+_109123159	2.590	NM_001164259 NM_054071	Fgfrl1	fibroblast growth factor receptor-like 1
chr6_+_72306146	2.589		Tmem150a	transmembrane protein 150A

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
1.40	3.09e-05	GO:0048856	anatomical structure development
2.05	4.20e-05	GO:0005975	carbohydrate metabolic process
1.57	1.43e-04	GO:0009653	anatomical structure morphogenesis
1.59	4.33e-04	GO:0009966	regulation of signal transduction
1.68	6.27e-04	GO:0009888	tissue development
11.14	6.59e-04	GO:0030212	hyaluronan metabolic process
1.18	7.16e-04	GO:0008152	metabolic process
2.27	9.99e-04	GO:0007507	heart development
1.37	1.31e-03	GO:0048731	system development
1.33	1.61e-03	GO:0007275	multicellular organismal development
1.31	1.70e-03	GO:0051179	localization
1.31	1.82e-03	GO:0032502	developmental process
1.44	1.89e-03	GO:0048513	organ development
1.35	4.35e-03	GO:0048522	positive regulation of cellular process
1.47	5.04e-03	GO:0023051	regulation of signaling
1.83	6.37e-03	GO:0072358	cardiovascular system development
1.83	6.37e-03	GO:0072359	circulatory system development
3.22	6.49e-03	GO:0031589	cell-substrate adhesion
10.75	7.40e-03	GO:0032489	regulation of Cdc42 protein signal transduction
10.75	7.40e-03	GO:0043088	regulation of Cdc42 GTPase activity
1.31	8.41e-03	GO:0048518	positive regulation of biological process
3.64	1.21e-02	GO:0007160	cell-matrix adhesion
1.96	1.30e-02	GO:0044262	cellular carbohydrate metabolic process
1.58	1.48e-02	GO:0042127	regulation of cell proliferation
2.24	2.16e-02	GO:0030036	actin cytoskeleton organization
2.82	2.18e-02	GO:0032970	regulation of actin filament-based process
11.94	2.43e-02	GO:0043089	positive regulation of Cdc42 GTPase activity
1.52	3.02e-02	GO:0032879	regulation of localization
2.16	3.37e-02	GO:0030029	actin filament-based process
1.58	4.56e-02	GO:0006629	lipid metabolic process
1.16	4.72e-02	GO:0044238	primary metabolic process

Gene overrepresentation in compartment category:

Enrichment	P-value	GO Accession	GO Term
1.32	5.56e-20	GO:0005737	cytoplasm
1.19	1.30e-12	GO:0005622	intracellular
1.20	2.38e-12	GO:0044424	intracellular part
1.32	1.71e-10	GO:0044444	cytoplasmic part
1.32	7.30e-06	GO:0071944	cell periphery
2.59	8.75e-06	GO:0016323	basolateral plasma membrane
1.31	1.82e-05	GO:0005886	plasma membrane
1.17	8.07e-05	GO:0016020	membrane
1.08	1.33e-04	GO:0005623	cell
1.08	1.33e-04	GO:0044464	cell part
1.13	1.62e-03	GO:0043226	organelle
1.13	1.72e-03	GO:0043229	intracellular organelle
1.49	3.18e-03	GO:0000267	cell fraction
1.69	1.10e-02	GO:0044429	mitochondrial part
1.44	1.20e-02	GO:0031090	organelle membrane
1.35	1.33e-02	GO:0044459	plasma membrane part
1.51	1.89e-02	GO:0005624	membrane fraction
1.76	1.96e-02	GO:0005740	mitochondrial envelope
1.49	2.31e-02	GO:0005626	insoluble fraction
2.01	2.40e-02	GO:0045177	apical part of cell
1.12	2.84e-02	GO:0043227	membrane-bounded organelle
1.12	3.45e-02	GO:0043231	intracellular membrane-bounded organelle
2.90	3.56e-02	GO:0005925	focal adhesion
2.13	4.32e-02	GO:0016324	apical plasma membrane
1.59	4.39e-02	GO:0031967	organelle envelope
2.74	4.67e-02	GO:0030055	cell-substrate junction
1.73	4.74e-02	GO:0031966	mitochondrial membrane

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
1.28	7.43e-08	GO:0005515	protein binding
1.16	2.57e-07	GO:0005488	binding
2.29	3.49e-05	GO:0003779	actin binding
1.95	4.30e-05	GO:0008092	cytoskeletal protein binding
1.22	4.99e-04	GO:0003824	catalytic activity
2.62	2.61e-02	GO:0017124	SH3 domain binding
5.46	3.07e-02	GO:0001968	fibronectin binding
1.67	3.79e-02	GO:0019904	protein domain specific binding