Motif ID: EGR1..3.p2

Z-value: 2.355


Transcription factors associated with EGR1..3.p2:

Gene SymbolEntrez IDGene Name
Egr1 13653 early growth response 1
Egr2 13654 early growth response 2
Egr3 13655 early growth response 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Egr1chr18_+_350208670.503.7e-13Click!
Egr2chr10_+_670006130.146.1e-02Click!
Egr3chr14_+_70477115-0.045.7e-01Click!


Activity profile for motif EGR1..3.p2.

activity profile for motif EGR1..3.p2


Sorted Z-values histogram for motif EGR1..3.p2

Sorted Z-values for motif EGR1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EGR1..3.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_151235861 61.133 NM_001081557
NM_001195565
 Camta1

calmodulin binding transcription activator 1

chr11_-_5965555 41.392 Camk2b
calcium/calmodulin-dependent protein kinase II, beta
chr10_-_108447894 40.889 Syt1
synaptotagmin I
chr10_-_108447996 40.326 Syt1
synaptotagmin I
chr10_-_108448003 38.921 Syt1
synaptotagmin I
chrX_+_5624820 37.099 Nudt11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr12_+_109572514 35.377 NM_010010
 Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chrX_-_70905062 34.767 NM_012040
 Pnck
pregnancy upregulated non-ubiquitously expressed CaM kinase
chr10_-_108447674 32.662 NM_009306
 Syt1
synaptotagmin I
chr11_+_119804400 32.337 NM_001037754
NM_001037755
NM_130862
 Baiap2


brain-specific angiogenesis inhibitor 1-associated protein 2


chr9_-_53822931 31.956 Elmod1
ELMO domain containing 1
chr11_-_5965544 31.512 Camk2b
calcium/calmodulin-dependent protein kinase II, beta
chr3_+_28162135 31.461 NM_001163007
NM_001163008
NM_001163009
NM_026910
 Tnik



TRAF2 and NCK interacting kinase



chr9_-_53823107 31.312 NM_177769
 Elmod1
ELMO domain containing 1
chr18_+_35020867 30.714 Egr1
early growth response 1
chr8_-_126957835 30.473 NM_171824
 Pgbd5
piggyBac transposable element derived 5
chrX_-_70905384 29.935 Pnck
pregnancy upregulated non-ubiquitously expressed CaM kinase
chr17_+_25945986 29.680 NM_001164225
 Fbxl16
F-box and leucine-rich repeat protein 16
chr15_-_75397243 28.051 NM_001135688
 Ly6h
lymphocyte antigen 6 complex, locus H
chrX_-_20498021 27.913 NM_001110780
NM_013680
 Syn1

synapsin I


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 199 entries
Enrichment   P-value GO Accession GO Term
4.35 2.85e-07 GO:0048168 regulation of neuronal synaptic plasticity
4.20 4.21e-04 GO:0007628 adult walking behavior
4.20 1.01e-03 GO:0048169 regulation of long-term neuronal synaptic plasticity
4.06 1.04e-02 GO:0035249 synaptic transmission, glutamatergic
3.70 8.33e-03 GO:0014075 response to amine stimulus
3.46 5.70e-03 GO:0021954 central nervous system neuron development
3.33 5.56e-03 GO:0007269 neurotransmitter secretion
3.33 5.56e-03 GO:0007270 nerve-nerve synaptic transmission
3.17 8.43e-06 GO:0048167 regulation of synaptic plasticity
3.17 4.30e-02 GO:0010243 response to organic nitrogen
2.94 8.31e-03 GO:0032412 regulation of ion transmembrane transporter activity
2.90 1.83e-02 GO:0050808 synapse organization
2.80 8.82e-05 GO:0034765 regulation of ion transmembrane transport
2.80 2.10e-02 GO:0022898 regulation of transmembrane transporter activity
2.79 5.07e-03 GO:0008344 adult locomotory behavior
2.79 8.14e-03 GO:0017157 regulation of exocytosis
2.78 1.98e-03 GO:0001505 regulation of neurotransmitter levels
2.75 2.80e-02 GO:0070588 calcium ion transmembrane transport
2.71 1.44e-02 GO:0032409 regulation of transporter activity
2.61 1.82e-06 GO:0007626 locomotory behavior

Gene overrepresentation in compartment category:

Showing 1 to 20 of 82 entries
Enrichment   P-value GO Accession GO Term
5.42 6.57e-04 GO:0005891 voltage-gated calcium channel complex
5.17 4.48e-02 GO:0071565 nBAF complex
4.65 3.95e-02 GO:0030125 clathrin vesicle coat
4.65 3.95e-02 GO:0048786 presynaptic active zone
4.26 5.20e-03 GO:0034704 calcium channel complex
4.06 3.48e-06 GO:0042734 presynaptic membrane
4.06 8.30e-06 GO:0043198 dendritic shaft
3.81 7.82e-04 GO:0008287 protein serine/threonine phosphatase complex
3.79 1.12e-10 GO:0044309 neuron spine
3.68 1.63e-09 GO:0043197 dendritic spine
3.67 3.03e-03 GO:0044304 main axon
3.43 4.29e-09 GO:0014069 postsynaptic density
3.36 4.05e-02 GO:0030672 synaptic vesicle membrane
3.31 6.61e-05 GO:0030665 clathrin coated vesicle membrane
3.13 1.50e-02 GO:0030118 clathrin coat
3.12 1.70e-08 GO:0008021 synaptic vesicle
3.11 1.16e-26 GO:0030425 dendrite
3.02 1.14e-10 GO:0033267 axon part
3.00 3.28e-06 GO:0044306 neuron projection terminus
2.92 3.50e-05 GO:0043679 axon terminus

Gene overrepresentation in function category:

Showing 1 to 20 of 72 entries
Enrichment   P-value GO Accession GO Term
4.59 4.26e-04 GO:0005245 voltage-gated calcium channel activity
4.06 1.95e-04 GO:0035254 glutamate receptor binding
4.06 3.85e-02 GO:0035255 ionotropic glutamate receptor binding
2.73 1.49e-07 GO:0022843 voltage-gated cation channel activity
2.56 8.36e-04 GO:0030165 PDZ domain binding
2.44 5.59e-03 GO:0005249 voltage-gated potassium channel activity
2.35 1.64e-06 GO:0005244 voltage-gated ion channel activity
2.35 1.64e-06 GO:0022832 voltage-gated channel activity
2.33 6.73e-03 GO:0017016 Ras GTPase binding
2.31 1.02e-03 GO:0005516 calmodulin binding
2.29 5.08e-03 GO:0031267 small GTPase binding
2.23 3.59e-03 GO:0051020 GTPase binding
2.17 1.26e-05 GO:0005096 GTPase activator activity
2.16 5.01e-08 GO:0022836 gated channel activity
2.10 2.89e-06 GO:0005083 small GTPase regulator activity
2.09 2.28e-10 GO:0030695 GTPase regulator activity
2.07 2.68e-10 GO:0060589 nucleoside-triphosphatase regulator activity
2.06 3.08e-04 GO:0019787 small conjugating protein ligase activity
2.04 1.19e-03 GO:0004842 ubiquitin-protein ligase activity
2.01 2.26e-04 GO:0016881 acid-amino acid ligase activity