Motif ID: ELF1,2,4.p2

Z-value: 3.557


Transcription factors associated with ELF1,2,4.p2:

Gene SymbolEntrez IDGene Name
Elf1 13709 E74-like factor 1
Elf2 69257 E74-like factor 2
Elf4 56501 E74-like factor 4 (ets domain transcription factor)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Elf1chr14_+_798809520.802.8e-41Click!
Elf2chr3_-_511299080.721.6e-30Click!
Elf4chrX_-_458163080.485.5e-12Click!


Activity profile for motif ELF1,2,4.p2.

activity profile for motif ELF1,2,4.p2


Sorted Z-values histogram for motif ELF1,2,4.p2

Sorted Z-values for motif ELF1,2,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ELF1,2,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_73367455 41.375 NM_153138
Wipf1
WAS/WASL interacting protein family, member 1
chr8_+_72332573 37.251 NM_198101
Gmip
Gem-interacting protein
chr9_+_107885355 35.134 NM_177090
Cdh29
Uba7
cadherin-like 29
ubiquitin-like modifier activating enzyme 7
chr7_+_50692442 33.118 NM_024253
Nkg7
natural killer cell group 7 sequence
chr4_-_123427465 31.214 NM_023423
Akirin1
akirin 1
chrX_-_90877453 29.872 NM_008892
Pola1
polymerase (DNA directed), alpha 1
chr16_+_48994292 29.248 NM_172616
C330027C09Rik
RIKEN cDNA C330027C09 gene
chr11_+_117061031 29.133 Sept9
septin 9
chr16_-_19983049 28.924 NM_183390
Klhl6
kelch-like 6 (Drosophila)
chr6_-_87788752 28.750 NM_133934
Isy1
ISY1 splicing factor homolog (S. cerevisiae)
chr6_+_117856781 28.570 NM_001166430
NM_001166431
NM_133834
Hnrnpf


heterogeneous nuclear ribonucleoprotein F


chr9_-_32348863 28.493 NM_008026
Fli1
Friend leukemia integration 1
chr2_-_25052245 28.309 NM_146115
A830007P12Rik
RIKEN cDNA A830007P12 gene
chr15_+_78730168 27.759 NM_009164
Sh3bp1
SH3-domain binding protein 1
chr6_+_119429620 27.539 NM_133940
Fbxl14
F-box and leucine-rich repeat protein 14
chr12_-_32893074 27.460 NM_001146201
NM_020272
NM_001146200
Pik3cg


phosphoinositide-3-kinase, catalytic, gamma polypeptide


chr1_+_89110855 27.412 Eif4e2
eukaryotic translation initiation factor 4E member 2
chr7_-_133512962 27.046 NM_010689
Lat
linker for activation of T cells
chr8_+_86479405 26.879 NM_024184
Asf1b
ASF1 anti-silencing function 1 homolog B (S. cerevisiae)
chr6_-_87788729 26.727 Isy1
ISY1 splicing factor homolog (S. cerevisiae)
chr9_+_20820403 26.401 NM_010493
Icam1
intercellular adhesion molecule 1
chr7_+_134234872 26.248 NM_178901
AI467606
expressed sequence AI467606
chr6_+_42300005 26.032 Zyx
zyxin
chr11_-_79894401 25.975 NM_018776
Crlf3
cytokine receptor-like factor 3
chr3_+_95463691 25.431 Mcl1
myeloid cell leukemia sequence 1
chr17_+_35331446 25.377 NM_008518
Ltb
lymphotoxin B
chrX_+_93291377 24.853 NM_010833
Msn
moesin
chr3_+_95032637 24.811 Cdc42se1
CDC42 small effector 1
chr1_-_20793592 24.418 Mcm3
minichromosome maintenance deficient 3 (S. cerevisiae)
chr6_+_17015159 24.406 Tes
testis derived transcript
chr7_-_85992096 23.798 NM_029585
Det1
de-etiolated homolog 1 (Arabidopsis)
chr17_+_45692647 23.672 NM_008690
Nfkbie
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr2_-_25052129 22.986 A830007P12Rik
RIKEN cDNA A830007P12 gene
chr6_+_117867280 22.654 NM_001166427
Hnrnpf
heterogeneous nuclear ribonucleoprotein F
chr14_+_75576599 22.320 Lcp1
lymphocyte cytosolic protein 1
chr3_+_115591053 22.241 NM_027193
Dph5
DPH5 homolog (S. cerevisiae)
chr3_+_95032685 22.093 NM_172395
NM_001038708
Cdc42se1

CDC42 small effector 1

chr11_+_87569075 22.079 A430104N18Rik
RIKEN cDNA A430104N18 gene
chr4_+_108520389 22.010 NM_029571
Kti12
KTI12 homolog, chromatin associated (S. cerevisiae)
chr4_-_63064369 21.904 NM_001045514
Akna
AT-hook transcription factor
chr19_+_9016335 21.800 NM_011842
Mta2
metastasis-associated gene family, member 2
chr17_+_35187185 21.764 NM_033444
Clic1
chloride intracellular channel 1
chr19_+_6085096 21.726 NM_026410
Cdca5
cell division cycle associated 5
chr7_-_142908061 21.602 NM_001081117
Mki67
antigen identified by monoclonal antibody Ki 67
chr5_-_108153337 21.508 NM_010278
Gfi1
growth factor independent 1
chr12_-_88541151 21.084 NM_001033475
Tmed8
transmembrane emp24 domain containing 8
chr1_+_173319048 20.888 NM_001005508
Arhgap30
Rho GTPase activating protein 30
chr1_-_54983211 20.834 NM_001081433
Ankrd44
ankyrin repeat domain 44
chr13_+_34094742 20.823 NM_009068
Ripk1
receptor (TNFRSF)-interacting serine-threonine kinase 1
chr3_+_106285556 20.681 Dennd2d
DENN/MADD domain containing 2D
chr10_+_126760748 20.414 NM_146011
Arhgap9
Rho GTPase activating protein 9
chr11_-_99016390 20.288 NM_007719
Ccr7
chemokine (C-C motif) receptor 7
chr2_+_5766079 20.202 NM_016918
Nudt5
nudix (nucleoside diphosphate linked moiety X)-type motif 5
chr11_-_121090513 19.978 NM_144832
BC017643
cDNA sequence BC017643
chr6_+_17015148 19.930 NM_207176
Tes
testis derived transcript
chr16_+_36935029 19.900 NM_008225
Hcls1
hematopoietic cell specific Lyn substrate 1
chr7_+_149646740 19.755 NM_001136071
Lsp1
lymphocyte specific 1
chr11_-_70468019 19.679 Pfn1
profilin 1
chr8_-_107788478 19.623 NM_001033161
Tradd
TNFRSF1A-associated via death domain
chr12_+_87027595 19.608 NM_016767
Batf
basic leucine zipper transcription factor, ATF-like
chr10_+_87609736 19.293 NM_027191
Nup37
nucleoporin 37
chr14_-_55725370 19.276 NM_007455
Ap1g2
adaptor protein complex AP-1, gamma 2 subunit
chr7_-_90803895 19.137 Il16
interleukin 16
chr7_+_25688004 19.007 NM_001130150
NM_001130151
NM_001130153
NM_008488
Arhgef1



Rho guanine nucleotide exchange factor (GEF) 1



chr1_-_54983048 18.962 Ankrd44
ankyrin repeat domain 44
chr1_-_37947185 18.890 Mitd1
MIT, microtubule interacting and transport, domain containing 1
chr2_-_120229789 18.879 NM_001110496
NM_001110497
NM_173734
Tmem87a


transmembrane protein 87A


chr2_-_23011403 18.853 NM_025979
Mastl
microtubule associated serine/threonine kinase-like
chr3_-_89222140 18.844 NM_016904
Cks1b
CDC28 protein kinase 1b
chr16_-_18812064 18.648 NM_009862
Cdc45
cell division cycle 45 homolog (S. cerevisiae)
chr13_+_34094217 18.545 Ripk1
receptor (TNFRSF)-interacting serine-threonine kinase 1
chr8_-_26212614 18.478 Plekha2
pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2
chr2_+_156665812 18.443 NM_173396
Tgif2
TGFB-induced factor homeobox 2
chr3_-_135354500 18.401 NM_008689
Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105
chr12_+_103521355 18.388 Rin3
Ras and Rab interactor 3
chr3_+_87650676 18.258 NM_001025571
NM_021309
Sh2d2a

SH2 domain protein 2A

chr10_+_87609768 18.210 NM_028334
Nup37
nucleoporin 37
chr18_+_70727897 18.116 NM_010773
Mbd2
methyl-CpG binding domain protein 2
chr17_-_71351465 18.053 2900073G15Rik
RIKEN cDNA 2900073G15 gene
chr8_-_83538732 17.940 NM_027554
Usp38
ubiquitin specific peptidase 38
chr2_+_118752232 17.903 NM_028117
Chst14
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14
chr19_-_5661634 17.871 Sipa1
signal-induced proliferation associated gene 1
chr8_-_26212588 17.669 Plekha2
pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2
chr10_-_92773778 17.567 NM_013508
Elk3
ELK3, member of ETS oncogene family
chr10_-_117229719 17.564 NM_134010
Nup107
nucleoporin 107
chr18_-_35900005 17.541 NM_028261
Tmem173
transmembrane protein 173
chr3_-_99966292 17.535 NM_175552
Wdr3
WD repeat domain 3
chr7_-_133848235 17.252 NM_009898
Coro1a
coronin, actin binding protein 1A
chr2_-_60800904 17.197 Rbms1
RNA binding motif, single stranded interacting protein 1
chr19_+_9004106 17.188 NM_144872
Eml3
echinoderm microtubule associated protein like 3
chr11_+_117060974 17.145 NM_001113486
Sept9
septin 9
chr5_+_46061125 17.130 NM_019438
Ncapg
non-SMC condensin I complex, subunit G
chr19_+_25073995 17.121 NM_028785
Dock8
dedicator of cytokinesis 8
chr7_+_149646716 17.099 Lsp1
lymphocyte specific 1
chr8_+_109960256 17.090 NM_025830
Wwp2
WW domain containing E3 ubiquitin protein ligase 2
chr15_-_54921986 17.019 NM_183089
Dscc1
defective in sister chromatid cohesion 1 homolog (S. cerevisiae)
chr8_-_86265035 17.008 NM_001163029
NM_001163030
NM_001163031
NM_011925
Cd97



CD97 antigen



chr17_-_86544514 16.840 NM_030133
Srbd1
S1 RNA binding domain 1
chr12_+_103521406 16.770 Rin3
Ras and Rab interactor 3
chr12_+_103521251 16.760 NM_177620
Rin3
Ras and Rab interactor 3
chr1_-_37947226 16.745 NM_026913
Mitd1
MIT, microtubule interacting and transport, domain containing 1
chr11_+_72774709 16.716 Atp2a3
ATPase, Ca++ transporting, ubiquitous
chr6_+_48689045 16.696 NM_008376
NM_175860
Gimap1

GTPase, IMAP family member 1

chr4_-_45333366 16.621 NM_025513
Exosc3
exosome component 3
chr1_+_154613763 16.617 Arpc5
actin related protein 2/3 complex, subunit 5
chr11_-_70468061 16.598 Pfn1
profilin 1
chr2_+_90936845 16.558 NM_011355
Sfpi1
SFFV proviral integration 1
chr4_-_106812064 16.543 2210012G02Rik
RIKEN cDNA 2210012G02 gene
chr8_+_97541591 16.497 NM_173036
Gpr97
G protein-coupled receptor 97
chr19_+_38129500 16.448 NM_028293
NM_001164362
NM_028760
Cep55


centrosomal protein 55


chr17_-_71351523 16.436 2900073G15Rik
RIKEN cDNA 2900073G15 gene
chr19_+_9016466 16.384 Mta2
metastasis-associated gene family, member 2
chr6_+_120314116 16.318 NM_145997
Kdm5a
lysine (K)-specific demethylase 5A
chr14_-_121778143 16.317 Stk24
serine/threonine kinase 24 (STE20 homolog, yeast)
chr1_+_66747396 16.177 NM_025683
Rpe
ribulose-5-phosphate-3-epimerase
chr8_+_87225390 16.116 Lyl1
lymphoblastomic leukemia 1
chr5_+_31216131 16.093 NM_133918
Emilin1
elastin microfibril interfacer 1
chr15_-_34372832 16.049 NM_009083
NM_001163485
Rpl30

ribosomal protein L30

chr3_-_107949028 16.019 NM_010306
Gnai3
guanine nucleotide binding protein (G protein), alpha inhibiting 3
chr7_-_134185894 15.990 Kif22
kinesin family member 22
chr8_+_87225355 15.925 NM_008535
Lyl1
lymphoblastomic leukemia 1
chr14_+_70499874 15.897 NM_021328
Bin3
bridging integrator 3
chr2_-_163575826 15.680 NM_007398
Ada
adenosine deaminase
chr11_+_72774670 15.663 NM_001163336
NM_001163337
NM_016745
Atp2a3


ATPase, Ca++ transporting, ubiquitous


chr4_-_122563074 15.613 NM_007598
Cap1
CAP, adenylate cyclase-associated protein 1 (yeast)
chr4_-_118109775 15.595 NM_023223
Cdc20
cell division cycle 20 homolog (S. cerevisiae)
chr9_-_50425561 15.504 NM_001134902
NM_212449
AU019823

expressed sequence AU019823

chr16_-_16073490 15.476 2310008H04Rik
RIKEN cDNA 2310008H04 gene
chr3_+_87734217 15.464 NM_177663
Isg20l2
interferon stimulated exonuclease gene 20-like 2
chr2_-_60800963 15.425 Rbms1
RNA binding motif, single stranded interacting protein 1
chr7_+_134439804 15.354 NM_008400
Itgal
integrin alpha L
chr1_-_33726582 15.307 NM_008922
Prim2
DNA primase, p58 subunit
chr14_-_21212709 15.298 NM_025440
Mrps16
mitochondrial ribosomal protein S16
chr3_-_135354151 15.241 Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105
chr13_-_101545800 15.191 NM_021886
Cenph
centromere protein H
chr13_-_93962125 15.162 NM_133905
Papd4
PAP associated domain containing 4
chr14_+_62950904 15.160 NM_026001
Rnaseh2b
ribonuclease H2, subunit B
chr10_-_80962400 15.151 S1pr4
sphingosine-1-phosphate receptor 4
chr17_+_74927634 15.117 NM_007566
Birc6
baculoviral IAP repeat-containing 6
chr17_+_64950988 15.075 NM_008549
Man2a1
mannosidase 2, alpha 1
chr7_+_133572567 15.050 Rabep2
rabaptin, RAB GTPase binding effector protein 2
chr6_+_133985717 15.004 NM_007961
Etv6
ets variant gene 6 (TEL oncogene)
chr15_+_98860321 14.980 NM_009448
Tuba1c
tubulin, alpha 1C
chr14_-_121778399 14.601 NM_145465
Stk24
serine/threonine kinase 24 (STE20 homolog, yeast)
chr6_+_133985988 14.591 Etv6
ets variant gene 6 (TEL oncogene)
chr15_+_78813524 14.568 Triobp
TRIO and F-actin binding protein
chr8_-_125005680 14.551


chr18_-_10181789 14.539 NM_009071
Rock1
Rho-associated coiled-coil containing protein kinase 1
chr2_-_126501173 14.416 NM_010249
NM_207669
Gabpb1

GA repeat binding protein, beta 1

chr11_+_61466766 14.401 Grap
GRB2-related adaptor protein
chr8_+_74743673 14.394 Fam32a
family with sequence similarity 32, member A
chr7_-_148286422 14.393 NM_023059
Sigirr
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr5_+_34678976 14.343 NM_011278
Rnf4
ring finger protein 4
chr19_+_4192077 14.305 NM_031868
Ppp1ca
protein phosphatase 1, catalytic subunit, alpha isoform
chr16_-_23127779 14.278 NM_145480
Rfc4
replication factor C (activator 1) 4
chr8_+_86239094 14.107 NM_197982
Ddx39
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39
chr15_-_5193681 13.994 NM_001136079
NM_008965
Ptger4

prostaglandin E receptor 4 (subtype EP4)

chr8_+_86239131 13.944 Ddx39
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39
chr6_+_39331379 13.899 NM_011226
Rab19
RAB19, member RAS oncogene family
chr5_-_123350242 13.886 NM_013910
Kdm2b
lysine (K)-specific demethylase 2B
chr10_-_92773579 13.883 Elk3
ELK3, member of ETS oncogene family
chr5_+_140807854 13.834 NM_008637
Nudt1
nudix (nucleoside diphosphate linked moiety X)-type motif 1
chr13_-_59924405 13.812 NM_153538
Zcchc6
zinc finger, CCHC domain containing 6
chrX_+_45499599 13.780 NM_028773
Sash3
SAM and SH3 domain containing 3
chr3_+_84470113 13.751 NM_177260
Tmem154
transmembrane protein 154
chr6_+_42299820 13.734 NM_011777
Zyx
zyxin
chr5_+_53981453 13.710 NM_009035
NM_001080927
Rbpj

recombination signal binding protein for immunoglobulin kappa J region

chr17_-_71351775 13.705 NM_026064
2900073G15Rik
RIKEN cDNA 2900073G15 gene
chr16_-_30587549 13.642 NM_178069
Lsg1
large subunit GTPase 1 homolog (S. cerevisiae)
chr8_+_74743620 13.633 NM_026455
Fam32a
family with sequence similarity 32, member A
chrX_+_46048180 13.610 NM_173376
Rbmx2
RNA binding motif protein, X-linked 2
chr18_+_36919868 13.554 NM_026464
Wdr55
WD repeat domain 55
chr11_+_32433265 13.542 NM_009288
Stk10
serine/threonine kinase 10
chr11_+_61466797 13.526 NM_027817
Grap
GRB2-related adaptor protein
chr10_+_4522597 13.515 NM_175374
Mtrf1l
mitochondrial translational release factor 1-like
chr1_-_140071818 13.416 NM_001111316
NM_011210
Ptprc

protein tyrosine phosphatase, receptor type, C

chr17_-_35137799 13.393 D17H6S56E-5
DNA segment, Chr 17, human D6S56E 5
chr8_+_73796512 13.349 NM_001142322
NM_001142323
NM_015742
Myo9b


myosin IXb


chr19_-_45824047 13.275 NM_008723
Npm3
nucleoplasmin 3
chr19_+_5568016 13.267 Gm962
predicted gene 962
chr14_+_55502433 13.247 Bcl2l2
BCL2-like 2
chr3_+_84470230 13.243 Tmem154
transmembrane protein 154
chr2_+_70893791 13.224 NM_001165980
NM_001165981
NM_001165982
NM_198005
Dcaf17



DDB1 and CUL4 associated factor 17



chr3_-_115710131 13.123 NM_023214
Slc30a7
solute carrier family 30 (zinc transporter), member 7
chr3_-_51081286 13.119 Elf2
E74-like factor 2
chr19_+_55328128 13.098 Acsl5
acyl-CoA synthetase long-chain family member 5
chr16_+_10412017 13.089 NM_011955
Nubp1
nucleotide binding protein 1
chr15_+_12134833 13.062 NM_172958
Mtmr12
myotubularin related protein 12
chr7_-_87679873 13.050 NM_007550
NM_001042527
Blm

Bloom syndrome, RecQ helicase-like

chr15_-_97923632 13.022 NM_144851
Senp1
SUMO1/sentrin specific peptidase 1
chr3_-_107948968 12.968 Gnai3
guanine nucleotide binding protein (G protein), alpha inhibiting 3
chr6_-_56654667 12.901 NM_025520
Lsm5
LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr16_-_55822217 12.887 NM_001159394
Nfkbiz
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr4_+_118293403 12.828 NM_026932
Ebna1bp2
EBNA1 binding protein 2
chr6_-_8209105 12.752 Rpa3
replication protein A3
chr3_-_58329639 12.683 Serp1
stress-associated endoplasmic reticulum protein 1
chr2_-_26758315 12.654 NM_009298
Surf6
surfeit gene 6
chr3_-_84386546 12.586 NM_001081093
Arfip1
ADP-ribosylation factor interacting protein 1
chr11_-_93747039 12.580 NM_001013375
Utp18
UTP18, small subunit (SSU) processome component, homolog (yeast)
chr11_-_120852609 12.542 NM_027874
NM_139059
Csnk1d

casein kinase 1, delta


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.61 7.30e-122 GO:0044260 cellular macromolecule metabolic process
1.53 2.66e-106 GO:0043170 macromolecule metabolic process
1.78 1.92e-93 GO:0010467 gene expression
1.75 4.89e-92 GO:0090304 nucleic acid metabolic process
1.42 3.55e-91 GO:0044237 cellular metabolic process
1.64 2.31e-83 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.39 2.12e-81 GO:0044238 primary metabolic process
1.56 2.32e-72 GO:0034641 cellular nitrogen compound metabolic process
1.72 3.48e-72 GO:0016070 RNA metabolic process
1.33 4.36e-69 GO:0008152 metabolic process
1.53 5.58e-68 GO:0006807 nitrogen compound metabolic process
1.68 3.16e-66 GO:0034645 cellular macromolecule biosynthetic process
1.67 1.13e-65 GO:0009059 macromolecule biosynthetic process
1.52 8.64e-53 GO:0044249 cellular biosynthetic process
1.48 2.93e-51 GO:0060255 regulation of macromolecule metabolic process
1.46 1.19e-49 GO:0031323 regulation of cellular metabolic process
1.50 1.35e-49 GO:0009058 biosynthetic process
1.42 1.55e-47 GO:0019222 regulation of metabolic process
1.45 1.61e-47 GO:0080090 regulation of primary metabolic process
1.51 5.53e-44 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.52 1.72e-43 GO:0010468 regulation of gene expression
1.50 2.05e-42 GO:0051171 regulation of nitrogen compound metabolic process
1.53 4.53e-42 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.57 6.73e-42 GO:0044267 cellular protein metabolic process
1.51 2.46e-41 GO:0010556 regulation of macromolecule biosynthetic process
2.23 1.49e-40 GO:0006396 RNA processing
1.53 5.22e-39 GO:0051252 regulation of RNA metabolic process
1.47 5.28e-37 GO:0031326 regulation of cellular biosynthetic process
1.52 5.29e-37 GO:0006355 regulation of transcription, DNA-dependent
1.46 9.25e-37 GO:0009889 regulation of biosynthetic process
1.59 3.43e-34 GO:0032774 RNA biosynthetic process
1.58 7.84e-34 GO:0006351 transcription, DNA-dependent
1.44 3.32e-31 GO:0019538 protein metabolic process
1.63 4.82e-31 GO:0006996 organelle organization
2.31 8.76e-30 GO:0016071 mRNA metabolic process
2.46 2.96e-29 GO:0006412 translation
1.82 2.71e-28 GO:0007049 cell cycle
1.39 4.34e-28 GO:0071840 cellular component organization or biogenesis
1.46 1.13e-27 GO:0071841 cellular component organization or biogenesis at cellular level
2.39 4.86e-27 GO:0006397 mRNA processing
2.40 6.14e-26 GO:0008380 RNA splicing
1.95 3.92e-22 GO:0006259 DNA metabolic process
1.35 1.51e-21 GO:0016043 cellular component organization
1.11 1.51e-20 GO:0009987 cellular process
1.40 8.48e-20 GO:0071842 cellular component organization at cellular level
2.49 1.38e-19 GO:0022613 ribonucleoprotein complex biogenesis
1.82 1.92e-19 GO:0022402 cell cycle process
2.01 2.46e-19 GO:0000278 mitotic cell cycle
1.87 7.15e-19 GO:0051276 chromosome organization
2.40 1.93e-18 GO:0071843 cellular component biogenesis at cellular level
1.95 7.72e-18 GO:0006974 response to DNA damage stimulus
1.61 1.10e-17 GO:0002376 immune system process
1.33 1.22e-17 GO:0048518 positive regulation of biological process
1.50 1.46e-17 GO:0010604 positive regulation of macromolecule metabolic process
1.42 7.79e-17 GO:0043412 macromolecule modification
1.49 1.13e-16 GO:0031325 positive regulation of cellular metabolic process
1.89 1.16e-16 GO:0022403 cell cycle phase
1.34 1.25e-16 GO:0048522 positive regulation of cellular process
1.46 4.27e-16 GO:0009893 positive regulation of metabolic process
1.68 4.17e-15 GO:0033554 cellular response to stress
1.97 5.83e-15 GO:0016568 chromatin modification
1.93 9.83e-15 GO:0002520 immune system development
2.58 1.01e-14 GO:0042254 ribosome biogenesis
1.53 4.07e-14 GO:0044085 cellular component biogenesis
1.40 4.33e-14 GO:0006464 protein modification process
2.14 5.31e-14 GO:0000087 M phase of mitotic cell cycle
1.92 1.19e-13 GO:0048534 hemopoietic or lymphoid organ development
2.13 2.40e-13 GO:0000280 nuclear division
2.13 2.40e-13 GO:0007067 mitosis
2.82 3.90e-13 GO:0006414 translational elongation
2.08 8.52e-13 GO:0048285 organelle fission
1.88 1.08e-12 GO:0000279 M phase
1.95 1.76e-12 GO:0006281 DNA repair
1.49 4.01e-12 GO:0010605 negative regulation of macromolecule metabolic process
2.29 1.07e-11 GO:0006260 DNA replication
1.85 1.43e-11 GO:0051301 cell division
1.91 1.77e-11 GO:0030097 hemopoiesis
2.14 2.54e-11 GO:0016570 histone modification
2.13 2.66e-11 GO:0016569 covalent chromatin modification
1.79 3.20e-11 GO:0006325 chromatin organization
1.45 7.95e-11 GO:0009892 negative regulation of metabolic process
1.30 1.02e-10 GO:0048523 negative regulation of cellular process
1.29 1.06e-10 GO:0048519 negative regulation of biological process
1.47 1.10e-10 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.47 1.23e-10 GO:0031324 negative regulation of cellular metabolic process
1.49 1.75e-10 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.60 1.94e-10 GO:0006364 rRNA processing
1.49 2.14e-10 GO:0010557 positive regulation of macromolecule biosynthetic process
1.48 2.86e-10 GO:0051173 positive regulation of nitrogen compound metabolic process
1.98 4.19e-10 GO:0034660 ncRNA metabolic process
1.46 4.77e-10 GO:0031328 positive regulation of cellular biosynthetic process
1.49 8.14e-10 GO:0010628 positive regulation of gene expression
1.67 8.89e-10 GO:0051726 regulation of cell cycle
2.52 1.23e-09 GO:0016072 rRNA metabolic process
1.99 1.25e-09 GO:0046649 lymphocyte activation
1.51 1.35e-09 GO:0045893 positive regulation of transcription, DNA-dependent
1.51 1.42e-09 GO:0051254 positive regulation of RNA metabolic process
1.40 1.55e-09 GO:0033036 macromolecule localization
1.44 4.11e-09 GO:0009891 positive regulation of biosynthetic process
1.80 5.31e-09 GO:0001775 cell activation
2.20 6.56e-09 GO:0051251 positive regulation of lymphocyte activation
1.85 1.07e-08 GO:0045321 leukocyte activation
1.42 1.09e-08 GO:0051641 cellular localization
1.33 1.35e-08 GO:0048583 regulation of response to stimulus
2.37 2.42e-08 GO:0007059 chromosome segregation
2.11 2.72e-08 GO:0002696 positive regulation of leukocyte activation
1.51 2.98e-08 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.80 3.55e-08 GO:0018193 peptidyl-amino acid modification
1.50 4.80e-08 GO:0051172 negative regulation of nitrogen compound metabolic process
1.99 6.51e-08 GO:0034470 ncRNA processing
1.52 8.44e-08 GO:0006915 apoptosis
2.06 9.02e-08 GO:0050867 positive regulation of cell activation
1.40 1.82e-07 GO:0008104 protein localization
2.18 1.90e-07 GO:0030098 lymphocyte differentiation
1.31 2.04e-07 GO:0006950 response to stress
1.47 2.63e-07 GO:0010558 negative regulation of macromolecule biosynthetic process
1.89 2.90e-07 GO:0051249 regulation of lymphocyte activation
1.48 2.94e-07 GO:0016265 death
1.50 2.99e-07 GO:0012501 programmed cell death
1.51 5.99e-07 GO:0002682 regulation of immune system process
1.47 6.28e-07 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.43 8.67e-07 GO:0045184 establishment of protein localization
1.46 9.43e-07 GO:0008219 cell death
1.41 1.68e-06 GO:0051649 establishment of localization in cell
1.43 1.78e-06 GO:0015031 protein transport
1.38 2.28e-06 GO:0032268 regulation of cellular protein metabolic process
1.53 2.56e-06 GO:0009792 embryo development ending in birth or egg hatching
1.54 2.59e-06 GO:0043009 chordate embryonic development
1.48 2.70e-06 GO:0046907 intracellular transport
1.43 2.76e-06 GO:0031327 negative regulation of cellular biosynthetic process
1.96 3.22e-06 GO:0002521 leukocyte differentiation
2.30 3.29e-06 GO:0043543 protein acylation
2.52 3.41e-06 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.52 3.41e-06 GO:0000398 nuclear mRNA splicing, via spliceosome
1.42 3.83e-06 GO:0009890 negative regulation of biosynthetic process
1.60 3.92e-06 GO:0002684 positive regulation of immune system process
1.78 4.02e-06 GO:0002694 regulation of leukocyte activation
1.81 4.10e-06 GO:0010564 regulation of cell cycle process
1.68 4.24e-06 GO:0001701 in utero embryonic development
1.45 4.85e-06 GO:0010629 negative regulation of gene expression
2.49 6.12e-06 GO:0000375 RNA splicing, via transesterification reactions
2.49 6.12e-06 GO:0016573 histone acetylation
2.06 6.73e-06 GO:0048872 homeostasis of number of cells
2.20 6.92e-06 GO:0071156 regulation of cell cycle arrest
1.46 7.85e-06 GO:0051253 negative regulation of RNA metabolic process
2.22 9.24e-06 GO:0050870 positive regulation of T cell activation
2.37 1.08e-05 GO:0006473 protein acetylation
2.18 1.54e-05 GO:0018205 peptidyl-lysine modification
1.46 1.82e-05 GO:0045892 negative regulation of transcription, DNA-dependent
2.42 1.87e-05 GO:0006475 internal protein amino acid acetylation
2.42 1.87e-05 GO:0018393 internal peptidyl-lysine acetylation
1.47 1.89e-05 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.38 2.13e-05 GO:0022607 cellular component assembly
1.73 2.28e-05 GO:0050865 regulation of cell activation
2.31 2.95e-05 GO:0006403 RNA localization
2.38 3.19e-05 GO:0018394 peptidyl-lysine acetylation
1.28 3.53e-05 GO:0065009 regulation of molecular function
1.38 3.86e-05 GO:0009790 embryo development
1.84 7.35e-05 GO:0006730 one-carbon metabolic process
2.29 9.96e-05 GO:0050657 nucleic acid transport
2.29 9.96e-05 GO:0050658 RNA transport
2.29 9.96e-05 GO:0051236 establishment of RNA localization
2.20 1.31e-04 GO:0032946 positive regulation of mononuclear cell proliferation
1.32 1.32e-04 GO:0051246 regulation of protein metabolic process
1.33 1.39e-04 GO:0010941 regulation of cell death
1.93 1.59e-04 GO:0042110 T cell activation
1.33 1.69e-04 GO:0043067 regulation of programmed cell death
1.51 1.72e-04 GO:0044265 cellular macromolecule catabolic process
1.33 1.78e-04 GO:0042981 regulation of apoptosis
2.53 1.82e-04 GO:0050871 positive regulation of B cell activation
1.87 2.69e-04 GO:0050863 regulation of T cell activation
2.20 2.73e-04 GO:0042113 B cell activation
2.17 2.92e-04 GO:0050671 positive regulation of lymphocyte proliferation
1.48 3.03e-04 GO:0070727 cellular macromolecule localization
2.15 3.09e-04 GO:0070665 positive regulation of leukocyte proliferation
2.13 3.23e-04 GO:0000075 cell cycle checkpoint
1.88 3.96e-04 GO:0051169 nuclear transport
1.89 4.12e-04 GO:0006913 nucleocytoplasmic transport
1.48 4.30e-04 GO:0080134 regulation of response to stress
1.42 5.32e-04 GO:0071844 cellular component assembly at cellular level
1.47 5.89e-04 GO:0034613 cellular protein localization
1.62 6.44e-04 GO:0001817 regulation of cytokine production
1.33 6.97e-04 GO:0042127 regulation of cell proliferation
1.28 7.00e-04 GO:0009966 regulation of signal transduction
1.36 7.12e-04 GO:0031399 regulation of protein modification process
2.68 7.47e-04 GO:0043966 histone H3 acetylation
2.20 8.26e-04 GO:0050864 regulation of B cell activation
1.83 9.18e-04 GO:0051052 regulation of DNA metabolic process
1.92 9.48e-04 GO:0032944 regulation of mononuclear cell proliferation
2.26 1.01e-03 GO:0010212 response to ionizing radiation
2.26 1.01e-03 GO:0022618 ribonucleoprotein complex assembly
1.96 1.04e-03 GO:0030099 myeloid cell differentiation
2.01 1.07e-03 GO:0006310 DNA recombination
1.56 1.08e-03 GO:0051098 regulation of binding
1.89 1.26e-03 GO:0006366 transcription from RNA polymerase II promoter
1.44 1.37e-03 GO:0009057 macromolecule catabolic process
2.23 1.60e-03 GO:0051028 mRNA transport
2.20 1.73e-03 GO:0071826 ribonucleoprotein complex subunit organization
1.27 1.73e-03 GO:0050790 regulation of catalytic activity
1.89 1.78e-03 GO:0070663 regulation of leukocyte proliferation
1.90 1.85e-03 GO:0050670 regulation of lymphocyte proliferation
1.22 2.44e-03 GO:0048513 organ development
1.97 3.08e-03 GO:0051325 interphase
2.07 3.09e-03 GO:0030217 T cell differentiation
1.98 3.13e-03 GO:0051329 interphase of mitotic cell cycle
2.03 3.16e-03 GO:0015931 nucleobase, nucleoside, nucleotide and nucleic acid transport
1.78 4.13e-03 GO:0006457 protein folding
1.96 4.41e-03 GO:0043414 macromolecule methylation
1.59 4.98e-03 GO:0010608 posttranscriptional regulation of gene expression
1.15 6.12e-03 GO:0032502 developmental process
1.16 6.85e-03 GO:0048856 anatomical structure development
1.86 7.10e-03 GO:0032259 methylation
2.20 7.60e-03 GO:0006302 double-strand break repair
1.34 8.68e-03 GO:0006468 protein phosphorylation
1.28 8.75e-03 GO:0006796 phosphate metabolic process
1.31 9.10e-03 GO:0016310 phosphorylation
2.28 9.26e-03 GO:0042102 positive regulation of T cell proliferation
1.36 9.79e-03 GO:0043933 macromolecular complex subunit organization
1.28 1.05e-02 GO:0006793 phosphorus metabolic process
1.37 1.10e-02 GO:0065003 macromolecular complex assembly
1.43 1.12e-02 GO:0051247 positive regulation of protein metabolic process
2.33 1.19e-02 GO:0030218 erythrocyte differentiation
2.33 1.19e-02 GO:0031570 DNA integrity checkpoint
2.33 1.19e-02 GO:0045621 positive regulation of lymphocyte differentiation
1.34 1.49e-02 GO:0070887 cellular response to chemical stimulus
2.39 1.49e-02 GO:0006261 DNA-dependent DNA replication
1.56 1.72e-02 GO:0051101 regulation of DNA binding
1.31 1.88e-02 GO:0048584 positive regulation of response to stimulus
1.43 1.97e-02 GO:0032270 positive regulation of cellular protein metabolic process
2.57 2.02e-02 GO:0000819 sister chromatid segregation
1.75 2.14e-02 GO:0001819 positive regulation of cytokine production
1.44 2.15e-02 GO:0006955 immune response
2.40 2.15e-02 GO:0030183 B cell differentiation
2.40 2.15e-02 GO:0045582 positive regulation of T cell differentiation
1.40 2.16e-02 GO:0071310 cellular response to organic substance
1.16 2.32e-02 GO:0048731 system development
1.47 2.34e-02 GO:0031401 positive regulation of protein modification process
2.34 2.50e-02 GO:0000077 DNA damage checkpoint
1.29 2.56e-02 GO:2000026 regulation of multicellular organismal development
1.30 2.59e-02 GO:0044093 positive regulation of molecular function
2.01 2.79e-02 GO:0045619 regulation of lymphocyte differentiation
1.35 2.80e-02 GO:0016192 vesicle-mediated transport
1.26 2.88e-02 GO:0050793 regulation of developmental process
1.37 2.96e-02 GO:0008284 positive regulation of cell proliferation
2.16 3.57e-02 GO:0034101 erythrocyte homeostasis
1.48 3.89e-02 GO:0030163 protein catabolic process
1.48 3.89e-02 GO:0070647 protein modification by small protein conjugation or removal
2.07 3.95e-02 GO:0006352 transcription initiation, DNA-dependent
3.08 4.21e-02 GO:0045577 regulation of B cell differentiation

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.31 5.37e-139 GO:0005622 intracellular
1.32 1.10e-136 GO:0044424 intracellular part
1.61 4.70e-134 GO:0005634 nucleus
1.34 5.56e-115 GO:0043226 organelle
1.38 1.35e-114 GO:0043227 membrane-bounded organelle
1.34 3.07e-114 GO:0043229 intracellular organelle
1.38 1.61e-113 GO:0043231 intracellular membrane-bounded organelle
1.93 1.68e-87 GO:0044428 nuclear part
1.82 1.72e-64 GO:0070013 intracellular organelle lumen
1.81 4.18e-64 GO:0043233 organelle lumen
1.88 6.69e-64 GO:0031981 nuclear lumen
1.80 7.73e-63 GO:0031974 membrane-enclosed lumen
1.47 8.33e-62 GO:0044446 intracellular organelle part
1.45 4.87e-60 GO:0044422 organelle part
1.24 1.84e-44 GO:0005737 cytoplasm
1.44 5.05e-43 GO:0032991 macromolecular complex
1.85 1.84e-40 GO:0005654 nucleoplasm
2.23 2.68e-37 GO:0030529 ribonucleoprotein complex
1.48 4.29e-34 GO:0043228 non-membrane-bounded organelle
1.48 4.29e-34 GO:0043232 intracellular non-membrane-bounded organelle
1.09 2.47e-27 GO:0005623 cell
1.09 2.47e-27 GO:0044464 cell part
1.81 6.63e-24 GO:0044451 nucleoplasm part
2.82 6.21e-22 GO:0005681 spliceosomal complex
1.35 1.31e-21 GO:0043234 protein complex
1.94 2.85e-21 GO:0005694 chromosome
2.02 3.33e-20 GO:0005730 nucleolus
1.48 7.24e-20 GO:0005829 cytosol
1.94 1.60e-19 GO:0044427 chromosomal part
1.19 8.76e-16 GO:0044444 cytoplasmic part
2.97 1.03e-14 GO:0071013 catalytic step 2 spliceosome
2.14 9.17e-11 GO:0005840 ribosome
1.98 6.99e-10 GO:0000228 nuclear chromosome
2.04 1.01e-09 GO:0044454 nuclear chromosome part
1.93 5.29e-09 GO:0000785 chromatin
2.03 6.53e-07 GO:0016604 nuclear body
2.54 9.19e-07 GO:0000123 histone acetyltransferase complex
1.85 2.31e-06 GO:0005635 nuclear envelope
1.96 1.11e-05 GO:0000775 chromosome, centromeric region
2.37 4.45e-05 GO:0000792 heterochromatin
2.07 4.76e-05 GO:0000793 condensed chromosome
2.39 9.22e-05 GO:0034708 methyltransferase complex
2.39 9.22e-05 GO:0035097 histone methyltransferase complex
2.51 1.28e-04 GO:0016363 nuclear matrix
2.04 1.44e-04 GO:0000790 nuclear chromatin
2.53 1.81e-04 GO:0022626 cytosolic ribosome
1.32 5.77e-04 GO:0012505 endomembrane system
2.27 5.96e-04 GO:0034399 nuclear periphery
2.72 7.37e-04 GO:0022627 cytosolic small ribosomal subunit
1.86 1.35e-03 GO:0044445 cytosolic part
2.33 1.61e-03 GO:0015935 small ribosomal subunit
2.00 1.81e-03 GO:0000776 kinetochore
2.40 2.90e-03 GO:0005643 nuclear pore
2.93 3.39e-03 GO:0005689 U12-type spliceosomal complex
1.83 3.59e-03 GO:0005819 spindle
1.49 3.80e-03 GO:0005667 transcription factor complex
2.61 5.48e-03 GO:0005657 replication fork
1.96 7.53e-03 GO:0016585 chromatin remodeling complex
1.20 1.02e-02 GO:0005856 cytoskeleton
2.67 1.09e-02 GO:0000781 chromosome, telomeric region
2.01 1.62e-02 GO:0016591 DNA-directed RNA polymerase II, holoenzyme
1.59 2.29e-02 GO:0031252 cell leading edge
2.80 2.92e-02 GO:0015030 Cajal body
1.51 3.00e-02 GO:0005815 microtubule organizing center
1.54 3.11e-02 GO:0005813 centrosome
2.39 3.12e-02 GO:0015934 large ribosomal subunit
2.08 3.31e-02 GO:0016607 nuclear speck
1.31 4.85e-02 GO:0015630 microtubule cytoskeleton

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.68 2.45e-73 GO:0003676 nucleic acid binding
1.22 1.38e-62 GO:0005488 binding
2.06 4.12e-42 GO:0003723 RNA binding
1.54 5.95e-31 GO:0003677 DNA binding
1.25 1.25e-27 GO:0005515 protein binding
1.44 5.55e-25 GO:0000166 nucleotide binding
1.42 5.17e-15 GO:0030554 adenyl nucleotide binding
1.38 6.20e-15 GO:0035639 purine ribonucleoside triphosphate binding
1.43 6.28e-15 GO:0005524 ATP binding
1.37 1.53e-14 GO:0017076 purine nucleotide binding
1.42 1.59e-14 GO:0032559 adenyl ribonucleotide binding
1.37 4.31e-14 GO:0032555 purine ribonucleotide binding
1.37 4.89e-14 GO:0032553 ribonucleotide binding
1.47 6.93e-11 GO:0030528 transcription regulator activity
2.71 2.34e-10 GO:0008026 ATP-dependent helicase activity
2.71 2.34e-10 GO:0070035 purine NTP-dependent helicase activity
1.16 6.65e-10 GO:0003824 catalytic activity
2.23 2.78e-09 GO:0004386 helicase activity
2.29 4.24e-09 GO:0003735 structural constituent of ribosome
1.75 1.06e-08 GO:0008134 transcription factor binding
1.74 1.28e-08 GO:0016564 transcription repressor activity
1.32 1.57e-07 GO:0008270 zinc ion binding
1.28 2.20e-07 GO:0016740 transferase activity
2.32 3.36e-07 GO:0008135 translation factor activity, nucleic acid binding
1.97 7.96e-07 GO:0008168 methyltransferase activity
1.95 1.10e-06 GO:0016741 transferase activity, transferring one-carbon groups
2.00 2.38e-06 GO:0004518 nuclease activity
1.17 6.85e-06 GO:0046872 metal ion binding
1.17 1.18e-05 GO:0043167 ion binding
1.17 1.56e-05 GO:0043169 cation binding
1.38 3.91e-05 GO:0001071 nucleic acid binding transcription factor activity
1.38 3.91e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
1.25 4.65e-05 GO:0046914 transition metal ion binding
1.75 5.93e-05 GO:0043566 structure-specific DNA binding
1.33 7.21e-05 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.56 9.38e-05 GO:0016563 transcription activator activity
1.38 3.34e-04 GO:0043565 sequence-specific DNA binding
1.69 3.53e-04 GO:0003682 chromatin binding
2.41 4.88e-04 GO:0004527 exonuclease activity
2.05 5.23e-04 GO:0047485 protein N-terminus binding
2.31 6.55e-04 GO:0003743 translation initiation factor activity
1.60 1.43e-03 GO:0000988 protein binding transcription factor activity
1.60 1.56e-03 GO:0000989 transcription factor binding transcription factor activity
1.84 2.19e-03 GO:0016853 isomerase activity
1.58 2.54e-03 GO:0003712 transcription cofactor activity
1.30 2.60e-03 GO:0019899 enzyme binding
1.44 2.94e-03 GO:0060589 nucleoside-triphosphatase regulator activity
2.83 3.37e-03 GO:0003678 DNA helicase activity
1.35 3.56e-03 GO:0017111 nucleoside-triphosphatase activity
2.39 3.58e-03 GO:0004812 aminoacyl-tRNA ligase activity
2.39 3.58e-03 GO:0016875 ligase activity, forming carbon-oxygen bonds
2.39 3.58e-03 GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds
1.33 7.95e-03 GO:0016462 pyrophosphatase activity
1.33 8.10e-03 GO:0016817 hydrolase activity, acting on acid anhydrides
1.36 9.58e-03 GO:0019904 protein domain specific binding
1.84 9.98e-03 GO:0016779 nucleotidyltransferase activity
1.32 1.10e-02 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.92 1.82e-02 GO:0004519 endonuclease activity
1.70 1.91e-02 GO:0003713 transcription coactivator activity
1.40 2.00e-02 GO:0030695 GTPase regulator activity
1.51 2.07e-02 GO:0019901 protein kinase binding
1.16 2.93e-02 GO:0016787 hydrolase activity
1.27 3.02e-02 GO:0016301 kinase activity
1.56 3.18e-02 GO:0010843 promoter binding
1.44 3.81e-02 GO:0008047 enzyme activator activity
1.48 3.90e-02 GO:0016887 ATPase activity
1.53 4.15e-02 GO:0042623 ATPase activity, coupled
1.48 4.42e-02 GO:0005083 small GTPase regulator activity