Motif ID: EN1,2.p2

Z-value: 1.285


Transcription factors associated with EN1,2.p2:

Gene SymbolEntrez IDGene Name
En1 13798 engrailed 1
En2 13799 engrailed 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
En1chr1_+_122499031-0.145.4e-02Click!
En2chr5_+_284922350.018.8e-01Click!


Activity profile for motif EN1,2.p2.

activity profile for motif EN1,2.p2


Sorted Z-values histogram for motif EN1,2.p2

Sorted Z-values for motif EN1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EN1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_129776837 21.284 Prkcb
protein kinase C, beta
chr19_-_41406744 12.478 Pik3ap1
phosphoinositide-3-kinase adaptor protein 1
chr11_-_83462722 11.858 NM_011337
Ccl3
chemokine (C-C motif) ligand 3
chr6_-_87446228 11.243 NM_175476
Arhgap25
Rho GTPase activating protein 25
chr12_+_99506844 10.084 NM_008152
Gpr65
G-protein coupled receptor 65
chr7_-_27724396 9.436 NM_001101467
Cyp2a22
cytochrome P450, family 2, subfamily a, polypeptide 22
chr2_-_126968325 8.872 NM_001163528
Itpripl1
inositol 1,4,5-triphosphate receptor interacting protein-like 1
chr9_+_88851757 8.510 NM_009742
Bcl2a1a
B-cell leukemia/lymphoma 2 related protein A1a
chr6_+_83293435 8.466 Mobkl1b
MOB1, Mps One Binder kinase activator-like 1B (yeast)
chr7_+_52257572 8.369


chr7_+_52965052 8.340 Dbp
D site albumin promoter binding protein
chr1_+_174628164 8.160 NM_007768
Crp
C-reactive protein, pentraxin-related
chr2_-_129196855 7.982 NM_008361
Il1b
interleukin 1 beta
chr19_+_29446941 7.870 Cd274
CD274 antigen
chr19_-_34952328 7.744 Pank1
pantothenate kinase 1
chr18_-_77870871 7.697 2310007O11Rik
RIKEN cDNA 2310007O11 gene
chr8_+_41837561 7.472 NM_011781
Adam25
a disintegrin and metallopeptidase domain 25 (testase 2)
chr17_+_87762817 7.427 Ttc7
tetratricopeptide repeat domain 7
chr14_-_56143027 7.298 NM_008736
Nrl
neural retina leucine zipper gene
chr14_+_45607785 7.104 NM_008964
Ptger2
prostaglandin E receptor 2 (subtype EP2)
chr16_-_58928469 7.063 NM_146999
Olfr181
olfactory receptor 181
chr5_-_121262512 7.009 NM_033541
Oas1c
2'-5' oligoadenylate synthetase 1C
chrX_+_104344792 6.934 NM_001122595
A630033H20Rik
RIKEN cDNA A630033H20 gene
chr14_-_56143799 6.923 NM_001136074
Nrl
neural retina leucine zipper gene
chr3_-_81779636 6.705 NM_019911
Tdo2
tryptophan 2,3-dioxygenase
chr19_-_34952377 6.605 NM_023792
Pank1
pantothenate kinase 1
chr8_+_72426082 6.517 NM_032004
Tssk6
testis-specific serine kinase 6
chr19_-_41068625 6.513 Blnk
B-cell linker
chr5_-_73143979 6.484 NM_001122754
Txk
TXK tyrosine kinase
chr7_-_53970378 6.483 Saa3
serum amyloid A 3
chr9_-_88626434 6.436 Bcl2a1d
B-cell leukemia/lymphoma 2 related protein A1d
chr2_+_79547936 6.389 NM_172420
Ppp1r1c
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr19_-_11698132 6.335 NM_013516
Ms4a2
membrane-spanning 4-domains, subfamily A, member 2
chr5_-_73127743 6.256 NM_013698
Txk
TXK tyrosine kinase
chr13_+_4190423 6.086 NM_013778
Akr1c13
aldo-keto reductase family 1, member C13
chr19_-_41069024 6.029 NM_008528
Blnk
B-cell linker
chr14_-_51766415 5.785 NM_011271
Rnase1
ribonuclease, RNase A family, 1 (pancreatic)
chr1_+_87918516 5.687 NM_001122732
NM_027029
NM_027300
NM_028647
Spata3



spermatogenesis associated 3



chr1_-_65109982 5.669 NM_007776
Crygd
crystallin, gamma D
chr11_-_99997241 5.650 NM_008469
Krt15
keratin 15
chrX_-_98463514 5.636 NM_013563
Il2rg
interleukin 2 receptor, gamma chain
chr11_-_99982808 5.551 NM_010662
Krt13
keratin 13
chr9_+_39201377 5.530 NM_001011812
Olfr951
olfactory receptor 951
chr2_+_121276592 5.477 Serf2
small EDRK-rich factor 2
chr4_+_32504409 5.463 NM_001109661
Bach2
BTB and CNC homology 2
chr11_-_77538789 5.440 NM_009965
Cryba1
crystallin, beta A1
chr10_-_53638995 5.423 Man1a
mannosidase 1, alpha
chr7_+_27620354 5.413 NM_007812
Cyp2a5
cytochrome P450, family 2, subfamily a, polypeptide 5
chr10_+_128143313 5.403 NM_021882
Pmel
premelanosome protein
chr16_-_38800293 5.386 NM_178924
Upk1b
uroplakin 1B
chr1_-_80661844 5.268 Dock10
dedicator of cytokinesis 10
chrX_+_70962097 5.241 Abcd1
ATP-binding cassette, sub-family D (ALD), member 1
chr19_-_11340591 5.237 NM_007641
Ms4a1
membrane-spanning 4-domains, subfamily A, member 1
chrX_+_104344265 5.166 NM_001122596
A630033H20Rik
RIKEN cDNA A630033H20 gene
chr11_+_49058980 5.148 Mgat1
mannoside acetylglucosaminyltransferase 1
chr7_+_29222465 5.137 NM_022024
Gmfg
glia maturation factor, gamma
chr7_-_126666995 5.125 NM_027943
Pdilt
protein disulfide isomerase-like, testis expressed
chr6_+_39331379 5.075 NM_011226
Rab19
RAB19, member RAS oncogene family
chr8_+_107572489 4.936 NM_001164681
NM_198672
Ces3a

carboxylesterase 3A

chr5_-_86947601 4.892 NM_177162
9930032O22Rik
RIKEN cDNA 9930032O22 gene
chr8_-_107784507 4.819 Tradd
TNFRSF1A-associated via death domain
chr1_-_173537404 4.669 NM_008534
Ly9
lymphocyte antigen 9
chr5_-_104406333 4.656 Hsd17b13
hydroxysteroid (17-beta) dehydrogenase 13
chr17_-_34134101 4.611 H2-K1
histocompatibility 2, K1, K region
chr17_-_34424623 4.525 NM_010378
H2-Aa
histocompatibility 2, class II antigen A, alpha
chr11_-_99236216 4.512 NM_027574
Krt28
keratin 28
chr7_+_27620380 4.510 Cyp2a4
Cyp2a5
cytochrome P450, family 2, subfamily a, polypeptide 4
cytochrome P450, family 2, subfamily a, polypeptide 5
chr16_+_90220986 4.506 NM_011434
Sod1
superoxide dismutase 1, soluble
chr6_-_115684968 4.492 NM_001168259
Tmem40
transmembrane protein 40
chr13_+_103483611 4.464 NM_008533
Cd180
CD180 antigen
chr6_+_89926164 4.458 NM_053229
Vmn1r46
vomeronasal 1 receptor 46
chr14_-_51815597 4.438 NM_007449
Ang2
angiogenin, ribonuclease A family, member 2
chr9_-_109751959 4.407 NM_009921
Camp
cathelicidin antimicrobial peptide
chr16_+_59148654 4.373 NM_146998
Olfr195
olfactory receptor 195
chr11_-_100957861 4.355


chr15_+_3230053 4.348


chr3_+_94736974 4.347 Selenbp1
selenium binding protein 1
chr2_+_14151018 4.335 NM_008625
Mrc1
mannose receptor, C type 1
chr11_-_95703752 4.298 NM_025659
NM_001163464
Abi3

ABI gene family, member 3

chr1_+_74421706 4.298 NM_013612
Slc11a1
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
chr16_+_17898729 4.290 NM_009436
Tssk2
testis-specific serine kinase 2
chr19_-_46747463 4.075 NM_007809
Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
chr17_-_85082214 3.969 NM_031884
Abcg5
ATP-binding cassette, sub-family G (WHITE), member 5
chr9_-_110959315 3.965 Ccrl2
chemokine (C-C motif) receptor-like 2
chr3_+_137949734 3.947 Adh1
alcohol dehydrogenase 1 (class I)
chr17_+_34052312 3.872


chr17_-_85082309 3.863 Abcg5
ATP-binding cassette, sub-family G (WHITE), member 5
chr17_-_34134309 3.801 H2-K1
histocompatibility 2, K1, K region
chr4_+_115845976 3.749 NM_001099295
1700042G07Rik
RIKEN cDNA 1700042G07 gene
chr8_-_44784840 3.730 NM_001079931
Adam34
Gm5347
a disintegrin and metallopeptidase domain 34
predicted gene 5347
chr9_-_88626613 3.708 NM_007536
Bcl2a1d
B-cell leukemia/lymphoma 2 related protein A1d
chr16_+_20128178 3.684 Klhl24
kelch-like 24 (Drosophila)
chr11_-_99016390 3.657 NM_007719
Ccr7
chemokine (C-C motif) receptor 7
chr4_+_130469048 3.653 Laptm5
lysosomal-associated protein transmembrane 5
chr6_-_128776236 3.640 NM_030599
Klrb1b
killer cell lectin-like receptor subfamily B member 1B
chr7_+_27092187 3.632 NM_009997
Cyp2a4
cytochrome P450, family 2, subfamily a, polypeptide 4
chr10_-_80131318 3.629 Mknk2
MAP kinase-interacting serine/threonine kinase 2
chr1_+_154622471 3.628


chr17_+_13208071 3.525 Sod2
superoxide dismutase 2, mitochondrial
chr6_-_130287518 3.501 NM_010648
Klra3
killer cell lectin-like receptor, subfamily A, member 3
chr10_-_111434231 3.487 Glipr1
GLI pathogenesis-related 1 (glioma)
chr16_-_30258448 3.472


chr5_-_92776027 3.468 Cxcl10
chemokine (C-X-C motif) ligand 10
chr6_-_129422702 3.460 NM_020008
Clec7a
C-type lectin domain family 7, member a
chr9_+_89094190 3.402 Bcl2a1a
B-cell leukemia/lymphoma 2 related protein A1a
chr2_-_17918493 3.388 NM_026627
H2afb1
H2A histone family, member B1
chr11_+_87895626 3.381 Vezf1
vascular endothelial zinc finger 1
chr16_-_48772068 3.357 NM_198297
Trat1
T cell receptor associated transmembrane adaptor 1
chr17_+_12571494 3.348 Plg
plasminogen
chr14_+_56372605 3.312 2610027L16Rik
RIKEN cDNA 2610027L16 gene
chr12_+_34000269 3.249 Atxn7l1
ataxin 7-like 1
chr7_+_27814096 3.240 NM_133657
Cyp2a12
cytochrome P450, family 2, subfamily a, polypeptide 12
chr17_+_48594225 3.229 NM_152823
Unc5cl
unc-5 homolog C (C. elegans)-like
chr5_+_88408469 3.220 NM_027631
4931407G18Rik
RIKEN cDNA 4931407G18 gene
chr5_-_115119973 3.216 Gltp
glycolipid transfer protein
chrX_+_70962057 3.161 Abcd1
ATP-binding cassette, sub-family D (ALD), member 1
chr3_+_138078450 3.143 NM_011996
Adh4
alcohol dehydrogenase 4 (class II), pi polypeptide
chr9_+_108411809 3.123 NM_001168270
Qars
glutaminyl-tRNA synthetase
chr10_+_127691272 3.067 Apon
apolipoprotein N
chr6_-_125186982 3.043 NM_001033126
NM_001042564
Cd27

CD27 antigen

chr9_+_4309898 3.036 Kbtbd3
kelch repeat and BTB (POZ) domain containing 3
chr16_+_20548675 3.020 NM_013852
Abcf3
ATP-binding cassette, sub-family F (GCN20), member 3
chr15_+_4677207 3.019 NM_016704
C6
complement component 6
chr1_-_146024404 3.007 NM_153171
Rgs13
regulator of G-protein signaling 13
chr11_-_117630476 3.006 Tmc6
transmembrane channel-like gene family 6
chr5_-_121337533 3.005 NM_011852
Oas1g
2'-5' oligoadenylate synthetase 1G
chr16_+_36935029 3.002 NM_008225
Hcls1
hematopoietic cell specific Lyn substrate 1
chr11_-_99199267 2.966 NM_001033397
Krt26
keratin 26
chr19_+_10788964 2.950


chr14_-_47896531 2.947 NM_172598
Wdhd1
WD repeat and HMG-box DNA binding protein 1
chr6_-_119305193 2.944 Adipor2
adiponectin receptor 2
chr3_-_123375305 2.938 NM_031186
Ndst3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr9_-_110959702 2.902 NM_017466
Ccrl2
chemokine (C-C motif) receptor-like 2
chr2_+_92223074 2.886 NM_183112
1700029I15Rik
RIKEN cDNA 1700029I15 gene
chr2_-_126969008 2.870 NM_001163527
Itpripl1
inositol 1,4,5-triphosphate receptor interacting protein-like 1
chr19_-_29095519 2.856


chr3_-_86803173 2.855 NM_007639
Cd1d1
CD1d1 antigen
chr17_+_25503264 2.842 NM_010781
Tpsb2
tryptase beta 2
chr14_+_21513864 2.805


chr7_-_51787440 2.801 NM_019866
Spib
Spi-B transcription factor (Spi-1/PU.1 related)
chr1_+_173144142 2.800 Nr1i3
nuclear receptor subfamily 1, group I, member 3
chr10_+_111602731 2.791 NM_178278
Caps2
calcyphosphine 2
chr13_-_93346126 2.789 NM_030237
Spz1
spermatogenic leucine zipper 1
chr11_+_95703598 2.772 NM_023121
Gngt2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
chr4_+_147976641 2.765 NM_001003893
NM_010767
Masp2

mannan-binding lectin serine peptidase 2

chr5_-_124315478 2.761 NM_030701
Niacr1
niacin receptor 1
chrX_-_5897723 2.740 NM_009757
Bmp15
bone morphogenetic protein 15
chr10_-_24647173 2.725 Arg1
arginase, liver
chr5_-_92682184 2.688 NM_011148
Ppef2
protein phosphatase, EF hand calcium-binding domain 2
chr13_-_21384553 2.685 NM_010343
Gpx5
glutathione peroxidase 5
chr17_+_12571455 2.678 NM_008877
Plg
plasminogen
chr3_+_54943959 2.638 NM_177203
A730037C10Rik
RIKEN cDNA A730037C10 gene
chr3_-_58984006 2.635 NM_032399
Gpr87
G protein-coupled receptor 87
chr2_-_26314921 2.600 Notch1
Notch gene homolog 1 (Drosophila)
chr6_+_15750966 2.593 Mdfic
MyoD family inhibitor domain containing
chr11_+_105836521 2.589 NM_009598
Ace
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
chr8_-_44613490 2.579 NM_001009547
Adam26b
a disintegrin and metallopeptidase domain 26B
chr14_-_31756446 2.576 NM_008406
Itih1
inter-alpha trypsin inhibitor, heavy chain 1
chr13_-_4149873 2.562 NM_134066
Akr1c18
aldo-keto reductase family 1, member C18
chr15_+_84155149 2.558 NM_022321
Parvg
parvin, gamma
chr15_+_78156227 2.528 NM_007780
Csf2rb
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chr4_+_48064119 2.509 NM_015743
Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr9_-_44611033 2.494 NM_138951
Ttc36
tetratricopeptide repeat domain 36
chr7_-_5148348 2.483 NM_030740
Vmn1r56
vomeronasal 1 receptor 56
chr6_+_57531124 2.478 Herc6
hect domain and RLD 6
chr11_-_72609306 2.469 NM_001024926
Cyb5d2
cytochrome b5 domain containing 2
chr2_+_25312352 2.469 Clic3
chloride intracellular channel 3
chr11_-_69619087 2.464 NM_001033433
Tmem102
transmembrane protein 102
chr2_-_103105045 2.458 Ehf
ets homologous factor
chr14_-_47896464 2.447 Wdhd1
WD repeat and HMG-box DNA binding protein 1
chr5_-_66472208 2.436 Rbm47
RNA binding motif protein 47
chr10_-_117732093 2.410 NM_054079
Iltifb
interleukin 10-related T cell-derived inducible factor beta
chr16_-_58872973 2.406 NM_146993
NM_146996
Olfr176
Olfr177
olfactory receptor 176
olfactory receptor 177
chr7_-_147174332 2.369 Adam8
a disintegrin and metallopeptidase domain 8
chr7_-_127813763 2.363 NM_001040137
NM_001040136
Pdzd9

PDZ domain containing 9

chr9_-_123883398 2.345 NM_009912
Ccr1
chemokine (C-C motif) receptor 1
chr1_-_175157322 2.339 NM_010184
Fcer1a
Fc receptor, IgE, high affinity I, alpha polypeptide
chr14_+_56590264 2.326 NM_001024714
Cma2
chymase 2, mast cell
chr14_+_56188462 2.317


chr3_-_135988955 2.309 NM_001033350
Bank1
B-cell scaffold protein with ankyrin repeats 1
chr9_-_80359017 2.304 NM_022016
Impg1
interphotoreceptor matrix proteoglycan 1
chr10_+_127691166 2.277 NM_133996
Apon
apolipoprotein N
chr4_+_147415297 2.261 NM_001161798
Mthfr
5,10-methylenetetrahydrofolate reductase
chr14_+_32481114 2.260 Btd
biotinidase
chr4_-_106472351 2.255 NM_025590
Acot11
acyl-CoA thioesterase 11
chr6_-_129335520 2.254 NM_027709
Clec12b
C-type lectin domain family 12, member B
chr2_+_25312358 2.238 NM_027085
Clic3
chloride intracellular channel 3
chr7_-_111042984 2.233 NM_013617
Olfr64
olfactory receptor 64
chr4_-_19849712 2.231 NM_175406
Atp6v0d2
ATPase, H+ transporting, lysosomal V0 subunit D2
chr3_+_59729135 2.229 NM_177661
C130079G13Rik
RIKEN cDNA C130079G13 gene
chr6_+_41488583 2.207


chr17_+_35610430 2.205 H2-Q10
histocompatibility 2, Q region locus 10
chr14_-_64162562 2.204 Mtmr9
myotubularin related protein 9
chr2_+_30122256 2.197 Phyhd1
phytanoyl-CoA dioxygenase domain containing 1
chr3_-_20174589 2.183 NM_029706
Cpb1
carboxypeptidase B1 (tissue)
chr17_+_34335139 2.171 NM_010724
Psmb8
proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)
chr6_+_142246944 2.166 NM_010491
Iapp
islet amyloid polypeptide
chr3_+_90472990 2.165 NM_013650
S100a8
S100 calcium binding protein A8 (calgranulin A)
chr16_+_45224449 2.154 NM_001037719
NM_177584
Btla

B and T lymphocyte associated

chr14_+_47896669 2.154 NM_080843
Socs4
suppressor of cytokine signaling 4

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
3.56 3.02e-06 GO:0006954 inflammatory response
2.59 1.10e-04 GO:0009611 response to wounding
1.95 2.00e-04 GO:0002376 immune system process
2.29 4.46e-04 GO:0006952 defense response
15.08 1.36e-03 GO:0042447 hormone catabolic process
8.08 1.59e-03 GO:0006953 acute-phase response
1.60 1.65e-03 GO:0042221 response to chemical stimulus
5.11 2.17e-03 GO:0019748 secondary metabolic process
2.05 5.19e-03 GO:0002682 regulation of immune system process
5.71 1.30e-02 GO:0002526 acute inflammatory response

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.88 4.27e-10 GO:0005576 extracellular region
2.20 1.68e-06 GO:0005615 extracellular space
3.05 1.00e-04 GO:0009897 external side of plasma membrane
1.82 3.66e-04 GO:0044421 extracellular region part
2.12 2.05e-03 GO:0009986 cell surface

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
2.09 2.62e-02 GO:0008289 lipid binding
2.65 4.82e-02 GO:0005125 cytokine activity