Motif ID: EN1,2.p2

Z-value: 1.285


Transcription factors associated with EN1,2.p2:

Gene SymbolEntrez IDGene Name
En1 13798 engrailed 1
En2 13799 engrailed 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
En1chr1_+_122499031-0.145.4e-02Click!
En2chr5_+_284922350.018.8e-01Click!


Activity profile for motif EN1,2.p2.

activity profile for motif EN1,2.p2


Sorted Z-values histogram for motif EN1,2.p2

Sorted Z-values for motif EN1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EN1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_129776837 21.284 Prkcb
protein kinase C, beta
chr19_-_41406744 12.478 Pik3ap1
phosphoinositide-3-kinase adaptor protein 1
chr11_-_83462722 11.858 NM_011337
 Ccl3
chemokine (C-C motif) ligand 3
chr6_-_87446228 11.243 NM_175476
 Arhgap25
Rho GTPase activating protein 25
chr12_+_99506844 10.084 NM_008152
 Gpr65
G-protein coupled receptor 65
chr7_-_27724396 9.436 NM_001101467
 Cyp2a22
cytochrome P450, family 2, subfamily a, polypeptide 22
chr2_-_126968325 8.872 NM_001163528
 Itpripl1
inositol 1,4,5-triphosphate receptor interacting protein-like 1
chr9_+_88851757 8.510 NM_009742
 Bcl2a1a
B-cell leukemia/lymphoma 2 related protein A1a
chr6_+_83293435 8.466 Mobkl1b
MOB1, Mps One Binder kinase activator-like 1B (yeast)
chr7_+_52257572 8.369


chr7_+_52965052 8.340 Dbp
D site albumin promoter binding protein
chr1_+_174628164 8.160 NM_007768
 Crp
C-reactive protein, pentraxin-related
chr2_-_129196855 7.982 NM_008361
 Il1b
interleukin 1 beta
chr19_+_29446941 7.870 Cd274
CD274 antigen
chr19_-_34952328 7.744 Pank1
pantothenate kinase 1
chr18_-_77870871 7.697 2310007O11Rik
RIKEN cDNA 2310007O11 gene
chr8_+_41837561 7.472 NM_011781
 Adam25
a disintegrin and metallopeptidase domain 25 (testase 2)
chr17_+_87762817 7.427 Ttc7
tetratricopeptide repeat domain 7
chr14_-_56143027 7.298 NM_008736
 Nrl
neural retina leucine zipper gene
chr14_+_45607785 7.104 NM_008964
 Ptger2
prostaglandin E receptor 2 (subtype EP2)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 10 of 10 entries
Enrichment   P-value GO Accession GO Term
15.08 1.36e-03 GO:0042447 hormone catabolic process
8.08 1.59e-03 GO:0006953 acute-phase response
5.71 1.30e-02 GO:0002526 acute inflammatory response
5.11 2.17e-03 GO:0019748 secondary metabolic process
3.56 3.02e-06 GO:0006954 inflammatory response
2.59 1.10e-04 GO:0009611 response to wounding
2.29 4.46e-04 GO:0006952 defense response
2.05 5.19e-03 GO:0002682 regulation of immune system process
1.95 2.00e-04 GO:0002376 immune system process
1.60 1.65e-03 GO:0042221 response to chemical stimulus

Gene overrepresentation in compartment category:

Showing 1 to 5 of 5 entries
Enrichment   P-value GO Accession GO Term
3.05 1.00e-04 GO:0009897 external side of plasma membrane
2.20 1.68e-06 GO:0005615 extracellular space
2.12 2.05e-03 GO:0009986 cell surface
1.88 4.27e-10 GO:0005576 extracellular region
1.82 3.66e-04 GO:0044421 extracellular region part

Gene overrepresentation in function category:

Showing 1 to 2 of 2 entries
Enrichment   P-value GO Accession GO Term
2.65 4.82e-02 GO:0005125 cytokine activity
2.09 2.62e-02 GO:0008289 lipid binding