Motif ID: EOMES.p2

Z-value: 1.104


Transcription factors associated with EOMES.p2:

Gene SymbolEntrez IDGene Name
Eomes 13813 eomesodermin homolog (Xenopus laevis)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Eomeschr9_+_1183873060.351.0e-06Click!


Activity profile for motif EOMES.p2.

activity profile for motif EOMES.p2


Sorted Z-values histogram for motif EOMES.p2

Sorted Z-values for motif EOMES.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EOMES.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_38754568 21.044 Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chrX_+_38754480 19.442 NM_016886
Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chrX_+_38754605 15.061 Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr17_-_90436488 13.807 Nrxn1
neurexin I
chrX_+_38754658 12.976 Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr1_-_75250520 11.320 Ptprn
protein tyrosine phosphatase, receptor type, N
chr5_+_19413335 10.137 NM_001170745
NM_015823
Magi2

membrane associated guanylate kinase, WW and PDZ domain containing 2

chr8_-_126957835 10.087 NM_171824
Pgbd5
piggyBac transposable element derived 5
chrX_+_133200982 9.595 Tceal3
transcription elongation factor A (SII)-like 3
chr7_-_4498168 9.418 NM_016908
Syt5
synaptotagmin V
chr1_-_135972341 9.149


chr7_-_107806887 8.773 NM_001163183
NM_001163184
NM_001163185
Plekhb1


pleckstrin homology domain containing, family B (evectins) member 1


chr3_-_115955629 8.711 Gpr88
G-protein coupled receptor 88
chrX_+_133200913 8.412 NM_001029978
Tceal3
transcription elongation factor A (SII)-like 3
chr2_+_121134843 8.359 Mtap1a
microtubule-associated protein 1 A
chr1_-_136229504 8.326 NM_001144855
Ppfia4
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
chr15_-_44584003 8.287 NM_178765
Sybu
syntabulin (syntaxin-interacting)
chr12_+_71008808 8.194 Atl1
atlastin GTPase 1
chr6_+_114081227 8.056 NM_172890
Slc6a11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr4_+_48058102 7.955 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chrX_-_147091911 7.884 NM_001002272
NM_019548
Tro

trophinin

chr3_+_55265811 7.878 Dclk1
doublecortin-like kinase 1
chr12_+_110783786 7.557 Meg3
maternally expressed 3
chr11_+_69154265 7.519 A030009H04Rik
RIKEN cDNA A030009H04 gene
chr12_+_89961317 7.518 NM_001198587
Nrxn3
neurexin III
chr10_+_122701051 7.465 NM_182807
Fam19a2
family with sequence similarity 19, member A2
chr12_-_42212538 7.329 Lrrn3
leucine rich repeat protein 3, neuronal
chr15_+_103333554 7.325 NM_008800
Pde1b
phosphodiesterase 1B, Ca2+-calmodulin dependent
chr1_-_166368439 7.286 Atp1b1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr17_+_8436671 7.161 NM_001190334
NM_001190335
NM_001190336
NM_001190337
Ccr6



chemokine (C-C motif) receptor 6



chr9_+_89804612 7.146 NM_001039655
NM_011245
Rasgrf1

RAS protein-specific guanine nucleotide-releasing factor 1

chr3_+_75361454 7.104 NM_009250
Serpini1
serine (or cysteine) peptidase inhibitor, clade I, member 1
chr12_-_4344470 7.093 Ncoa1
nuclear receptor coactivator 1
chr18_+_61123204 7.011 NM_009792
Camk2a
calcium/calmodulin-dependent protein kinase II alpha
chr15_+_103333440 6.991 Pde1b
phosphodiesterase 1B, Ca2+-calmodulin dependent
chr14_+_70857227 6.908 NM_145981
Phyhip
phytanoyl-CoA hydroxylase interacting protein
chr10_+_98453513 6.818 Atp2b1
ATPase, Ca++ transporting, plasma membrane 1
chr2_+_181287207 6.793 Dnajc5
DnaJ (Hsp40) homolog, subfamily C, member 5
chr12_+_110783593 6.613 Meg3
maternally expressed 3
chr4_-_126427788 6.410 Ncdn
neurochondrin
chr9_-_26816373 6.269 Vps26b
vacuolar protein sorting 26 homolog B (yeast)
chr9_+_75159201 6.099 NM_010313
Gnb5
guanine nucleotide binding protein (G protein), beta 5
chr6_-_87483228 6.075 NM_001037727
Arhgap25
Rho GTPase activating protein 25
chrX_+_45976982 6.056 NM_001166450
Slc25a14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr6_+_115189004 5.969 Syn2
synapsin II
chr14_+_56130147 5.939 NM_009947
Cpne6
copine VI
chr15_-_75397601 5.885 NM_011837
Ly6h
lymphocyte antigen 6 complex, locus H
chr9_-_26815760 5.840 Vps26b
vacuolar protein sorting 26 homolog B (yeast)
chr8_-_4259126 5.785 NM_183315
Ctxn1
cortexin 1
chr9_+_21742717 5.766 NM_144935
BC018242
cDNA sequence BC018242
chr14_-_70923865 5.723 NM_011359
Sftpc
surfactant associated protein C
chr1_-_134287712 5.578 NM_178874
Tmcc2
transmembrane and coiled-coil domains 2
chr3_+_55265654 5.566 NM_001111051
NM_001111052
NM_001195539
NM_001195540
Dclk1



doublecortin-like kinase 1



chrX_+_39855629 5.536 NM_011364
Sh2d1a
SH2 domain protein 1A
chr6_+_79969636 5.519 NM_178731
Lrrtm4
leucine rich repeat transmembrane neuronal 4
chr6_-_24905939 5.518 NM_177013
Tmem229a
transmembrane protein 229A
chr7_+_26052714 5.485 Cic
capicua homolog (Drosophila)
chr7_-_25772525 5.468 Atp1a3
ATPase, Na+/K+ transporting, alpha 3 polypeptide
chrX_+_102318792 5.387 Magee1
melanoma antigen, family E, 1
chr9_-_40812668 5.383 NM_019465
Crtam
cytotoxic and regulatory T cell molecule
chr7_+_27542160 5.328 NM_007814
Cyp2b19
cytochrome P450, family 2, subfamily b, polypeptide 19
chr5_-_73143979 5.267 NM_001122754
Txk
TXK tyrosine kinase
chr17_+_24641034 5.261 Caskin1
CASK interacting protein 1
chr2_-_91773029 5.249


chr14_-_9142289 5.214 NM_183187
Fam107a
family with sequence similarity 107, member A
chr3_-_81878554 5.211 NM_001161796
NM_017469
Gucy1b3

guanylate cyclase 1, soluble, beta 3

chr17_-_51965912 5.131 NM_001163631
Satb1
special AT-rich sequence binding protein 1
chr1_+_183282758 5.077 NM_001160211
NM_001160212
NM_028408
Cnih3


cornichon homolog 3 (Drosophila)


chr11_-_83881811 5.074 NM_019819
Dusp14
dual specificity phosphatase 14
chr6_-_98877291 4.978


chr2_-_12933305 4.877 C1ql3
C1q-like 3
chr5_-_123183537 4.869 Camkk2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chrX_+_104479684 4.860 NM_001177782
Gpr174
G protein-coupled receptor 174
chr5_+_138187303 4.742 Tsc22d4
TSC22 domain family, member 4
chr7_+_19469999 4.678 NM_009402
Pglyrp1
peptidoglycan recognition protein 1
chr14_+_52513284 4.628 NM_001039676
Slc39a2
solute carrier family 39 (zinc transporter), member 2
chr17_+_8435390 4.607 NM_009835
Ccr6
chemokine (C-C motif) receptor 6
chr15_-_95358578 4.584 Nell2
NEL-like 2 (chicken)
chr1_+_87804443 4.505 Itm2c
integral membrane protein 2C
chr6_-_127075853 4.502 Ccnd2
cyclin D2
chr5_-_23835349 4.499 Kcnh2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr16_-_31314534 4.494 NM_007470
Apod
apolipoprotein D
chr2_+_121692687 4.417 NM_177054
NM_199038
Casc4

cancer susceptibility candidate 4

chr10_+_117878101 4.404 NM_008337
Ifng
interferon gamma
chr2_-_33743465 4.299 NM_175184
Fam125b
family with sequence similarity 125, member B
chr7_-_81429262 4.298 Slco3a1
solute carrier organic anion transporter family, member 3a1
chr1_-_172487240 4.283 NM_027528
Nos1ap
nitric oxide synthase 1 (neuronal) adaptor protein
chr17_+_74898763 4.213 Yipf4
Yip1 domain family, member 4
chr11_-_6328316 4.209


chr11_+_23978110 4.195 Bcl11a
B-cell CLL/lymphoma 11A (zinc finger protein)
chr18_+_37644674 4.140 NM_053142
Pcdhb17
protocadherin beta 17
chrX_+_45976650 4.123 NM_011398
Slc25a14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr11_+_100437204 4.090 NM_001146318
Cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
chr7_+_112574425 4.070 Cckbr
cholecystokinin B receptor
chr14_+_61351770 4.028 Spata13
spermatogenesis associated 13
chr16_-_67621054 4.009 NM_001145977
NM_178721
Cadm2

cell adhesion molecule 2

chr16_+_20695034 3.942 NM_133778
Fam131a
family with sequence similarity 131, member A
chr15_+_80453912 3.904 NM_010815
Grap2
GRB2-related adaptor protein 2
chr2_-_56967331 3.893 NM_013613
Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr3_+_64913564 3.871 NM_010597
Kcnab1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr14_-_57744057 3.865 NM_008128
Gjb6
gap junction protein, beta 6
chr9_-_123587923 3.786 NM_139142
Slc6a20a
solute carrier family 6 (neurotransmitter transporter), member 20A
chr8_-_55606109 3.738 Spcs3
signal peptidase complex subunit 3 homolog (S. cerevisiae)
chr14_+_84843366 3.692 NM_001013753
Pcdh17
protocadherin 17
chr8_+_84239098 3.541 NM_001024617
Inpp4b
inositol polyphosphate-4-phosphatase, type II
chr13_-_108516475 3.536 Zswim6
zinc finger, SWIM domain containing 6
chr17_-_35838974 3.412 NM_001198831
Ddr1
discoidin domain receptor family, member 1
chr17_-_57217861 3.384 NM_153551
Dennd1c
DENN/MADD domain containing 1C
chr7_-_31663995 3.382 NM_009845
Cd22
CD22 antigen
chr12_+_110806715 3.376 Meg3
maternally expressed 3
chr17_-_35838818 3.338 Ddr1
discoidin domain receptor family, member 1
chr12_+_3891743 3.337 NM_153743
Dnmt3a
DNA methyltransferase 3A
chr4_-_129250806 3.321 NM_001162433
Lck
lymphocyte protein tyrosine kinase
chr4_+_102432943 3.306 NM_144906
Sgip1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr18_+_45719732 3.279 NM_080465
Kcnn2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chrX_+_156411885 3.274 Sh3kbp1
SH3-domain kinase binding protein 1
chr1_-_184246785 3.268 Fbxo28
F-box protein 28
chr14_-_66211842 3.262 NM_028811
Elp3
elongation protein 3 homolog (S. cerevisiae)
chr1_+_174271338 3.249 NM_001039484
Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr6_-_116666759 3.230 NM_178768
Tmem72
transmembrane protein 72
chr8_-_124999921 3.224 NM_001033142
Rnf166
ring finger protein 166
chr14_-_55735114 3.217 NM_177049
Jph4
junctophilin 4
chr18_+_45719101 3.213 Kcnn2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr1_-_162281701 3.185 NM_001038621
Rabgap1l
RAB GTPase activating protein 1-like
chr3_-_94386590 3.134 NM_001082484
NM_029721
Snx27

sorting nexin family member 27

chr7_-_52622323 3.121


chr17_+_21520684 3.059 NM_172486
Zfp677
zinc finger protein 677
chr3_-_117063090 3.048 D3Bwg0562e
DNA segment, Chr 3, Brigham & Women's Genetics 0562 expressed
chr15_-_95358306 3.030 Nell2
NEL-like 2 (chicken)
chr5_+_138187390 3.009 Tsc22d4
TSC22 domain family, member 4
chr1_-_174259356 3.009 NM_008429
Kcnj9
potassium inwardly-rectifying channel, subfamily J, member 9
chr7_-_108729674 2.988 NM_019915
Art2a-ps
Art2b
ADP-ribosyltransferase 2a, pseudogene
ADP-ribosyltransferase 2b
chrX_-_98615554 2.952 NM_001177988
NM_019831
Zmym3

zinc finger, MYM-type 3

chr16_-_17406406 2.945 NM_001001983
Pi4ka
phosphatidylinositol 4-kinase, catalytic, alpha polypeptide
chr3_+_108163704 2.942 Sort1
sortilin 1
chr10_+_90038471 2.931 NM_001177397
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr11_+_23980676 2.929 NM_001159290
Bcl11a
B-cell CLL/lymphoma 11A (zinc finger protein)
chr14_-_68742863 2.909 Nefm
neurofilament, medium polypeptide
chr2_-_57034164 2.900 BB557941
expressed sequence BB557941
chr2_+_164648185 2.888 NM_028028
Zswim1
zinc finger, SWIM domain containing 1
chrX_+_160346948 2.880 NM_026887
Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr6_+_39523866 2.875 NM_178873
Adck2
aarF domain containing kinase 2
chr6_-_60778740 2.844 NM_001042451
Snca
synuclein, alpha
chr17_+_37210011 2.830 Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chr4_-_153531656 2.826


chr3_-_32884000 2.811 NM_001163517
Pex5l
peroxisomal biogenesis factor 5-like
chr3_-_75360749 2.802 Pdcd10
programmed cell death 10
chr7_+_129815257 2.796 NM_019430
Cacng3
calcium channel, voltage-dependent, gamma subunit 3
chr7_-_147268150 2.794 NM_001190386
Caly
calcyon neuron-specific vesicular protein
chr16_-_48772068 2.791 NM_198297
Trat1
T cell receptor associated transmembrane adaptor 1
chr2_+_143371807 2.774 NM_008792
Pcsk2
proprotein convertase subtilisin/kexin type 2
chr16_-_94509462 2.770 NM_139145
Hlcs
holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)
chr17_-_29374656 2.761 NM_153166
Cpne5
copine V
chr2_-_129525512 2.750 Pdyn
prodynorphin
chr4_+_5726856 2.747 Fam110b
family with sequence similarity 110, member B
chr7_-_90803895 2.744 Il16
interleukin 16
chr11_+_78139476 2.707 Aldoc
aldolase C, fructose-bisphosphate
chr11_-_106163120 2.693 NM_008117
Gh
growth hormone
chr18_+_45719464 2.671 Kcnn2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr1_+_37426061 2.668 NM_172971
Inpp4a
inositol polyphosphate-4-phosphatase, type I
chr16_-_28445276 2.667 NM_183064
Fgf12
fibroblast growth factor 12
chr7_+_97278722 2.648 NM_146194
Picalm
phosphatidylinositol binding clathrin assembly protein
chr4_+_126800830 2.639 Zmym6
zinc finger, MYM-type 6
chr16_-_19983049 2.630 NM_183390
Klhl6
kelch-like 6 (Drosophila)
chr9_-_49311823 2.561 Ncam1
neural cell adhesion molecule 1
chr5_-_124028994 2.537 Clip1
CAP-GLY domain containing linker protein 1
chr4_+_147374850 2.531 NM_008725
Nppa
natriuretic peptide type A
chr2_+_164648495 2.530 Zswim1
zinc finger, SWIM domain containing 1
chr2_+_119000244 2.523 NM_001039223
Gm14137
predicted gene 14137
chr18_+_82644510 2.522 NM_001025245
NM_010777
Mbp

myelin basic protein

chr4_+_102432879 2.509 Sgip1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr1_+_89652645 2.509 NM_029846
Atg16l1
autophagy-related 16-like 1 (yeast)
chr12_+_30219769 2.477 NM_001093776
Myt1l
myelin transcription factor 1-like
chr2_+_124962427 2.475 NM_001162934
Ctxn2
cortexin 2
chr9_-_21822333 2.473 Elavl3
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)
chr17_-_36408313 2.469 NM_178281
Trim39
tripartite motif-containing 39
chr7_-_52494097 2.418 NM_007645
Cd37
CD37 antigen
chr12_+_101447480 2.418 Calm1
calmodulin 1
chr6_+_48597232 2.399 NM_001077410
NM_212486
Gimap8

GTPase, IMAP family member 8

chr10_+_4978808 2.392 Syne1
synaptic nuclear envelope 1
chr19_-_29887442 2.388 NM_177721
Ranbp6
RAN binding protein 6
chrX_+_140127827 2.378 NM_001195046
NM_001195047
Pak3

p21 protein (Cdc42/Rac)-activated kinase 3

chr2_+_172805342 2.374 NM_001083959
NM_001083960
NM_012046
Spo11


sporulation protein, meiosis-specific, SPO11 homolog (S. cerevisiae)


chr6_+_7505070 2.349 NM_009311
Tac1
tachykinin 1
chr19_-_7289788 2.346


chr1_+_6792987 2.339 St18
suppression of tumorigenicity 18
chr4_+_42963222 2.333 Dnajb5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr18_+_37644390 2.301 Pcdhb17
protocadherin beta 17
chr10_+_72119562 2.294 Zwint
ZW10 interactor
chr4_+_9196439 2.289 NM_028940
Clvs1
clavesin 1
chr2_-_25325248 2.287 NM_008963
Ptgds
prostaglandin D2 synthase (brain)
chr6_-_36761360 2.263 NM_008973
Ptn
pleiotrophin
chr13_+_33175971 2.249 NM_173052
Serpinb1b
serine (or cysteine) peptidase inhibitor, clade B, member 1b
chrX_+_45872593 2.234 NM_011228
Rab33a
RAB33A, member of RAS oncogene family
chr10_+_115614313 2.233 NM_001161839
NM_001161838
NM_001161840
Ptprr


protein tyrosine phosphatase, receptor type, R


chr16_+_93762803 2.225 Dopey2
dopey family member 2
chr16_-_5008915 2.218


chr7_-_85722668 2.213 NM_008746
NM_182809
Ntrk3

neurotrophic tyrosine kinase, receptor, type 3

chr2_-_12932442 2.205 NM_153155
C1ql3
C1q-like 3
chr17_-_24306262 2.201 NM_009729
Atp6v0c-ps2
Atp6v0c
ATPase, H+ transporting, lysosomal V0 subunit C, pseudogene 2
ATPase, H+ transporting, lysosomal V0 subunit C

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.92 3.94e-03 GO:0007154 cell communication
2.21 6.12e-03 GO:0007610 behavior

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.40 2.43e-08 GO:0043005 neuron projection
1.40 5.89e-06 GO:0005886 plasma membrane
1.39 9.01e-06 GO:0071944 cell periphery
2.27 1.01e-05 GO:0045202 synapse
1.78 2.08e-05 GO:0042995 cell projection
2.56 1.14e-04 GO:0030425 dendrite
2.38 2.36e-04 GO:0044456 synapse part
1.50 1.08e-03 GO:0044459 plasma membrane part
1.38 1.29e-03 GO:0043234 protein complex
1.57 6.35e-03 GO:0000267 cell fraction
1.13 6.64e-03 GO:0005622 intracellular
1.66 8.92e-03 GO:0005624 membrane fraction
1.63 1.17e-02 GO:0005626 insoluble fraction
2.13 1.17e-02 GO:0043025 neuronal cell body
2.10 1.32e-02 GO:0044297 cell body
1.87 1.47e-02 GO:0016023 cytoplasmic membrane-bounded vesicle
1.22 2.18e-02 GO:0005634 nucleus
1.81 2.64e-02 GO:0031988 membrane-bounded vesicle
2.59 3.05e-02 GO:0045211 postsynaptic membrane
7.35 3.10e-02 GO:0016010 dystrophin-associated glycoprotein complex
1.12 3.27e-02 GO:0044424 intracellular part
2.57 3.32e-02 GO:0044433 cytoplasmic vesicle part
2.16 4.69e-02 GO:0030424 axon

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.27 1.61e-04 GO:0005515 protein binding
1.13 5.79e-03 GO:0005488 binding