Motif ID: EP300.p2

Z-value: 1.066


Transcription factors associated with EP300.p2:

Gene SymbolEntrez IDGene Name
Ep300 328572 E1A binding protein p300

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ep300chr15_+_81416643-0.424.6e-09Click!


Activity profile for motif EP300.p2.

activity profile for motif EP300.p2


Sorted Z-values histogram for motif EP300.p2

Sorted Z-values for motif EP300.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EP300.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_121426422 15.275 NM_010171
 F3
coagulation factor III
chr2_+_32780021 8.437


chr7_+_69493148 8.359 NM_010882
 Ndn
necdin
chr9_-_20781133 5.907 S1pr2
sphingosine-1-phosphate receptor 2
chr10_-_58684199 5.880 Sept10
septin 10
chr9_-_20781206 5.570 NM_010333
 S1pr2
sphingosine-1-phosphate receptor 2
chr10_+_58684631 5.245 NM_172939
 Ankrd57
ankyrin repeat domain 57
chr1_-_82287990 5.083 NM_010570
 Irs1
insulin receptor substrate 1
chr1_-_79855177 5.061 Serpine2
serine (or cysteine) peptidase inhibitor, clade E, member 2
chrX_+_33652066 5.009 NM_133990
 Il13ra1
interleukin 13 receptor, alpha 1
chr2_+_164312023 4.967 Dbndd2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr4_+_104829963 4.784 Ppap2b
phosphatidic acid phosphatase type 2B
chr7_-_149838254 4.459 Igf2
insulin-like growth factor 2
chr12_-_102988596 4.400


chr1_-_79855209 4.381 Serpine2
serine (or cysteine) peptidase inhibitor, clade E, member 2
chr3_-_27609279 4.355 NM_173182
 Fndc3b
fibronectin type III domain containing 3B
chr4_+_45985143 4.151 Tdrd7
tudor domain containing 7
chr2_-_91489909 4.137 NM_001033451
 Zfp408
zinc finger protein 408
chr2_+_91096960 4.038 NM_030880
 Pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr10_-_58684594 4.000 NM_001024910
NM_001024911
 Sept10

septin 10


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 131 entries
Enrichment   P-value GO Accession GO Term
3.64 2.40e-02 GO:0006888 ER to Golgi vesicle-mediated transport
3.35 1.06e-02 GO:0043242 negative regulation of protein complex disassembly
3.07 1.34e-02 GO:0043244 regulation of protein complex disassembly
2.96 4.18e-02 GO:0043401 steroid hormone mediated signaling pathway
2.77 1.03e-02 GO:0051494 negative regulation of cytoskeleton organization
2.73 1.37e-02 GO:0071383 cellular response to steroid hormone stimulus
2.65 3.81e-02 GO:0009755 hormone-mediated signaling pathway
2.54 3.33e-04 GO:0048193 Golgi vesicle transport
2.21 1.80e-02 GO:0043410 positive regulation of MAPKKK cascade
2.20 5.30e-04 GO:0051493 regulation of cytoskeleton organization
2.14 7.12e-03 GO:0042692 muscle cell differentiation
2.04 1.17e-03 GO:0044087 regulation of cellular component biogenesis
1.94 7.14e-03 GO:0071495 cellular response to endogenous stimulus
1.90 1.70e-10 GO:0046907 intracellular transport
1.90 3.85e-02 GO:0032870 cellular response to hormone stimulus
1.84 5.51e-03 GO:0045664 regulation of neuron differentiation
1.83 1.02e-08 GO:0016192 vesicle-mediated transport
1.82 3.45e-02 GO:0032880 regulation of protein localization
1.79 1.05e-02 GO:0048568 embryonic organ development
1.79 3.12e-02 GO:0061061 muscle structure development

Gene overrepresentation in compartment category:

Showing 1 to 20 of 56 entries
Enrichment   P-value GO Accession GO Term
2.60 1.84e-02 GO:0030117 membrane coat
2.60 1.84e-02 GO:0048475 coated membrane
2.53 2.41e-03 GO:0014069 postsynaptic density
2.43 1.66e-05 GO:0019717 synaptosome
2.05 2.27e-03 GO:0045211 postsynaptic membrane
1.99 2.79e-07 GO:0044456 synapse part
1.99 3.09e-03 GO:0031252 cell leading edge
1.90 2.78e-02 GO:0030135 coated vesicle
1.86 2.52e-08 GO:0045202 synapse
1.81 7.37e-05 GO:0044297 cell body
1.75 8.39e-04 GO:0043025 neuronal cell body
1.75 4.01e-03 GO:0015629 actin cytoskeleton
1.70 1.26e-02 GO:0030425 dendrite
1.69 4.97e-07 GO:0030054 cell junction
1.68 1.36e-02 GO:0048471 perinuclear region of cytoplasm
1.68 1.94e-02 GO:0044431 Golgi apparatus part
1.62 3.65e-02 GO:0005743 mitochondrial inner membrane
1.61 9.21e-05 GO:0043005 neuron projection
1.61 4.54e-03 GO:0031966 mitochondrial membrane
1.60 4.12e-03 GO:0005740 mitochondrial envelope

Gene overrepresentation in function category:

Showing 1 to 14 of 14 entries
Enrichment   P-value GO Accession GO Term
2.39 2.70e-02 GO:0008017 microtubule binding
2.25 6.02e-03 GO:0015631 tubulin binding
1.94 1.67e-10 GO:0008092 cytoskeletal protein binding
1.94 4.39e-05 GO:0046982 protein heterodimerization activity
1.83 4.16e-04 GO:0003779 actin binding
1.66 6.53e-03 GO:0032403 protein complex binding
1.62 3.33e-06 GO:0046983 protein dimerization activity
1.53 2.50e-02 GO:0042803 protein homodimerization activity
1.44 6.98e-03 GO:0001071 nucleic acid binding transcription factor activity
1.44 6.98e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.40 1.91e-03 GO:0005102 receptor binding
1.40 1.33e-02 GO:0019899 enzyme binding
1.39 1.47e-31 GO:0005515 protein binding
1.20 2.07e-25 GO:0005488 binding