Motif ID: ESRRA.p2

Z-value: 2.822


Transcription factors associated with ESRRA.p2:

Gene SymbolEntrez IDGene Name
Esrra 26379 estrogen related receptor, alpha

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Esrrachr19_-_69860370.372.3e-07Click!


Activity profile for motif ESRRA.p2.

activity profile for motif ESRRA.p2


Sorted Z-values histogram for motif ESRRA.p2

Sorted Z-values for motif ESRRA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESRRA.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_180891448 61.984 Eef1a2
eukaryotic translation elongation factor 1 alpha 2
chr19_-_43598949 58.446 NM_010324
 Got1
glutamate oxaloacetate transaminase 1, soluble
chr15_-_83936038 53.731 Sult4a1
sulfotransferase family 4A, member 1
chr12_+_110783593 52.262 Meg3
maternally expressed 3
chr7_-_148615247 48.880 NM_021316
 Cend1
cell cycle exit and neuronal differentiation 1
chr12_+_110783786 47.848 Meg3
maternally expressed 3
chr2_+_121183509 44.872 Ckmt1
creatine kinase, mitochondrial 1, ubiquitous
chr9_-_107571294 43.687 Slc38a3
solute carrier family 38, member 3
chr10_+_75398588 43.653 Chchd10
coiled-coil-helix-coiled-coil-helix domain containing 10
chr7_-_31840594 39.712 Fxyd1
FXYD domain-containing ion transport regulator 1
chr2_+_121184334 39.566 NM_009897
 Ckmt1
creatine kinase, mitochondrial 1, ubiquitous
chr7_-_31840647 39.110 NM_019503
NM_052992
 Fxyd1

FXYD domain-containing ion transport regulator 1

chr2_-_181049204 38.189 NM_009133
 Stmn3
stathmin-like 3
chr6_+_48487648 37.385 Atp6v0e2
ATPase, H+ transporting, lysosomal V0 subunit E2
chr15_-_83936183 37.123 NM_013873
 Sult4a1
sulfotransferase family 4A, member 1
chr6_+_48487567 36.151 NM_133764
 Atp6v0e2
ATPase, H+ transporting, lysosomal V0 subunit E2
chr6_-_142456402 35.512 NM_008492
 Ldhb
lactate dehydrogenase B
chr11_-_3995299 35.489 NM_026443
 Mtfp1
mitochondrial fission process 1
chr2_+_177876635 33.395 NM_028806
 Phactr3
phosphatase and actin regulator 3
chr12_+_103793130 32.860 NM_007693
 Chga
chromogranin A

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 52 entries
Enrichment   P-value GO Accession GO Term
13.92 2.71e-05 GO:0015985 energy coupled proton transport, down electrochemical gradient
13.92 2.71e-05 GO:0015986 ATP synthesis coupled proton transport
8.62 3.13e-03 GO:0046356 acetyl-CoA catabolic process
7.92 2.74e-02 GO:0006099 tricarboxylic acid cycle
7.27 3.64e-03 GO:0009109 coenzyme catabolic process
7.24 1.42e-02 GO:0009060 aerobic respiration
6.79 1.67e-04 GO:0006084 acetyl-CoA metabolic process
6.17 1.66e-02 GO:0051187 cofactor catabolic process
5.71 1.77e-10 GO:0022900 electron transport chain
5.50 4.58e-02 GO:0031110 regulation of microtubule polymerization or depolymerization
5.16 1.64e-03 GO:0006754 ATP biosynthetic process
5.11 7.15e-04 GO:0045333 cellular respiration
4.71 6.33e-16 GO:0006091 generation of precursor metabolites and energy
4.70 2.98e-02 GO:0006839 mitochondrial transport
4.39 1.13e-02 GO:0009206 purine ribonucleoside triphosphate biosynthetic process
4.38 2.63e-02 GO:0015992 proton transport
4.33 1.34e-02 GO:0009145 purine nucleoside triphosphate biosynthetic process
4.33 1.34e-02 GO:0009201 ribonucleoside triphosphate biosynthetic process
4.31 3.12e-02 GO:0006818 hydrogen transport
4.20 1.87e-02 GO:0009142 nucleoside triphosphate biosynthetic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 43 entries
Enrichment   P-value GO Accession GO Term
15.08 1.68e-02 GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)
13.20 6.65e-05 GO:0005753 mitochondrial proton-transporting ATP synthase complex
12.06 2.18e-05 GO:0045259 proton-transporting ATP synthase complex
8.64 1.81e-12 GO:0070469 respiratory chain
7.70 2.43e-08 GO:0005746 mitochondrial respiratory chain
6.91 8.14e-05 GO:0005747 mitochondrial respiratory chain complex I
6.91 8.14e-05 GO:0030964 NADH dehydrogenase complex
6.91 8.14e-05 GO:0045271 respiratory chain complex I
6.37 1.56e-13 GO:0044455 mitochondrial membrane part
5.50 7.97e-03 GO:0016469 proton-transporting two-sector ATPase complex
4.90 7.28e-26 GO:0005743 mitochondrial inner membrane
4.85 2.34e-02 GO:0000313 organellar ribosome
4.85 2.34e-02 GO:0005761 mitochondrial ribosome
4.65 2.00e-24 GO:0019866 organelle inner membrane
4.51 1.75e-28 GO:0031966 mitochondrial membrane
4.38 7.37e-28 GO:0005740 mitochondrial envelope
4.07 2.88e-30 GO:0044429 mitochondrial part
3.99 2.18e-07 GO:0005759 mitochondrial matrix
3.25 3.27e-20 GO:0031967 organelle envelope
3.24 2.30e-20 GO:0031975 envelope

Gene overrepresentation in function category:

Showing 1 to 20 of 21 entries
Enrichment   P-value GO Accession GO Term
22.62 2.01e-03 GO:0000104 succinate dehydrogenase activity
22.62 2.01e-03 GO:0004111 creatine kinase activity
7.54 4.57e-02 GO:0000062 fatty-acyl-CoA binding
5.66 3.05e-02 GO:0035254 glutamate receptor binding
5.22 1.10e-03 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
4.64 1.28e-04 GO:0015078 hydrogen ion transmembrane transporter activity
3.39 2.77e-04 GO:0015077 monovalent inorganic cation transmembrane transporter activity
3.23 2.26e-05 GO:0022890 inorganic cation transmembrane transporter activity
2.77 8.26e-03 GO:0050662 coenzyme binding
2.66 5.67e-04 GO:0048037 cofactor binding
2.50 4.52e-07 GO:0008324 cation transmembrane transporter activity
2.37 1.96e-08 GO:0015075 ion transmembrane transporter activity
2.30 5.43e-09 GO:0022891 substrate-specific transmembrane transporter activity
2.24 2.98e-09 GO:0022857 transmembrane transporter activity
2.19 7.38e-09 GO:0022892 substrate-specific transporter activity
2.11 8.23e-06 GO:0016491 oxidoreductase activity
2.11 1.94e-02 GO:0005216 ion channel activity
2.07 9.77e-09 GO:0005215 transporter activity
2.06 2.99e-02 GO:0022838 substrate-specific channel activity
1.41 1.69e-02 GO:0000166 nucleotide binding